Mobile terrestrial LiDAR data-sets in a Spatial Database Framework

Mobile Mapping Systems (MMS) have become important and regularly used platforms for the collection of physical-environment data in commercial and governmental spheres. For example, a typical MMS may collect location, imagery, video, LiDAR and air quality data from which models of the built-environment can be generated. Numerous approaches to using these data to generate models can be envisaged which can help develop detailed knowledge in the monitoring, maintanence and development of our built-environment. In this context, the efficient storing of this raw spatial data is a significant problem such that bespoke and dynamic access is possible for the generation of modeling requirements. This fundamental requirement of managing these data, where upwards of 40 gigabytes per hour of spatial-information can be collected from an MMS survey, poses significant challanges in data management alone. Existing methodologies mantain bespoke, survey oriented approaches to data management and model generation where the original MMS spatial data is not generally used or available outside these requirements. Thus, there is a need for an MMS data management framework where effective storage and access solutions can hold this information for use and analysis in any modeling context. Towards this end we detail our storage solution and the experiments where the procedures for high volume navigation and LiDAR MMS-data loading are analysed and optimised for minimum upload times and maximum access efficiency. This solution is built upon a PostgreSQL Relational Database Management System (RDBMS) with the PostGIS spatial extension and pg bulkload data loading utility

LiDAR data management pipeline; from spatial database population to web-application visualization

While the existence of very large and scalable Database Management Systems (DBMSs) is well recognized, it is the usage and extension of these technologies to managing spatial data that has seen increasing amounts of research work in recent years. A focused area of this research work involves the handling of very high resolution Light Detection and Ranging (LiDAR) data. While LiDAR has many real world applications, it is usually the purview of organizations interested in capturing and monitoring our environment where it has become pervasive. In many of these cases, it has now become the de facto minimum standard expected when a need to acquire very detailed 3D spatial data is required. However, significant challenges exist when working with these data sources, from data storage to feature extraction through to data segmentation all presenting challenges relating to the very large volumes of data that exist. In this paper, we present the complete LiDAR data pipeline as managed in our spatial database framework. This involves three distinct sections, populating the database, building a spatial hierarchy that describes the available data sources, and spatially segmenting data based on user requirements which generates a visualization of these data in a WebGL enabled web-application viewer. All work presented is in an experimental results context where we show how this approach is runtime efficient given the very large volumes of LiDAR data that are being managed

Role of Age and Sex in the Effects of Repeated Methamphetamine Exposure on Hedonic Tone in Sprague Dawley Rats

Anhedonia is defined as a reduced or complete loss of pleasure from a previously pleasurable stimulus, and it is comprised of two dimensions: Hedonic anhedonia consists of a distinct loss of pleasure in consumption of a normally pleasurable stimulus. Motivational anhedonia involves the goal directed behavior to obtain a reward. Withdrawal induced anhedonia following use of methamphetamine (METH) is thought to contribute to relapse behaviors1,2 . The anhedonic effects of drug withdrawal largely depend on dose, frequency, and the duration of drug exposure4,5,6. The role of sex and age of exposure in this context has yet to be elucidated

Snake energy analysis and result validation for a mobile laser scanning data-based automated road edge extraction algorithm

© 2008-2012 IEEE. The negative impact of road accidents cannot be ignored in terms of the very sizeable social and economic loss. Road infrastructure has been identified as one of the main causes of the road accidents. They are required to be recorded, located, measured, and classified in order to schedule maintenance and identify the possible risk elements of the road. Toward this, an accurate knowledge of the road edges increases the reliability and precision of extracting other road features. We have developed an automated algorithm for extracting road edges from mobile laser scanning (MLS) data based on the parametric active contour or snake model. The algorithm involves several internal and external energy parameters that need to be analyzed in order to find their optimal values. In this paper, we present a detailed analysis of the snake energy parameters involved in our road edge extraction algorithm. Their optimal values enable us to automate the process of extracting edges from MLS data for tested road sections. We present a modified external energy in our algorithm and demonstrate its utility for extracting road edges from low and nonuniform point density datasets. A novel validation approach is presented, which provides a qualitative assessment of the extracted road edges based on direct comparisons with reference road edges. This approach provides an alternative to traditional road edge validation methodologies that are based on creating buffer zones around reference road edges and then computing quality measure values for the extracted edges. We tested our road edge extraction algorithm on datasets that were acquired using multiple MLS systems along various complex road sections. The successful extraction of road edges from these datasets validates the robustness of our algorithm for use in complex route corridor environments

Extreme heterogeneity in the microrheology of lamellar surfactant gels analyzed with neural networks

The heterogeneity of the viscoelasticity of a lamellar gel network based on cetyl-trimethylammonium chloride (CTAC) and ceto-stearyl alcohol was studied using particle tracking microrheology. A recurrent neural network (RNN) architecture was used for estimating the Hurst exponent, $H$, on small sections of tracks of probe spheres moving with fractional Brownian motion. Thus dynamic segmentation of tracks via neural networks was used in microrheology for the first time and it is significantly more accurate than using mean square displacements. An ensemble of 414 particles produces a mean squared displacement (MSD) that is subdiffusive in time, $t$, with a power law of the form $t^{0.74\pm0.02}$, indicating power law viscoelasticity. RNN analysis of the probability distributions of $H$, combined with detailed analysis of the time-averaged MSDs of individual tracks, revealed diverse diffusion processes belied by the simple scaling of the ensemble MSD, such as caging phenomena, which give rise to the complex viscoelasticity of lamellar gels.Comment: 15 pages without references (17 with references), 13 figure

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repository (NIH MLSMR) in an assay measuring the uptake of the fluorescent lipid DiI from HDL particles. This class of compounds is represented by ML278 (17–11), a potent (average IC50 = 6 nM) and reversible inhibitor of lipid uptake via SR-BI. ML278 is a plasma-stable, noncytotoxic probe that exhibits moderate metabolic stability, thus displaying improved properties for in vitro and in vivo studies. Strikingly, ML278 and previously described inhibitors of lipid transport share the property of increasing the binding of HDL to SR-BI, rather than blocking it, suggesting there may be similarities in their mechanisms of action

GABA-modulating bacteria of the human gut microbiota.

The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of the microbiota2, 23-65% of species residing in the human gut remain uncultured3,4, which is an obstacle for understanding their biological roles. A likely reason for this unculturability is the absence in artificial media of key growth factors that are provided by neighbouring bacteria in situ5,6. In the present study, we used co-culture to isolate KLE1738, which required the presence of Bacteroides fragilis to grow. Bioassay-driven purification of B. fragilis supernatant led to the isolation of the growth factor, which, surprisingly, is the major inhibitory neurotransmitter GABA (γ-aminobutyric acid). GABA was the only tested nutrient that supported the growth of KLE1738, and a genome analysis supported a GABA-dependent metabolism mechanism. Using growth of KLE1738 as an indicator, we isolated a variety of GABA-producing bacteria, and found that Bacteroides ssp. produced large quantities of GABA. Genome-based metabolic modelling of the human gut microbiota revealed multiple genera with the predicted capability to produce or consume GABA. A transcriptome analysis of human stool samples from healthy individuals showed that GABA-producing pathways are actively expressed by Bacteroides, Parabacteroides and Escherichia species. By coupling 16S ribosmal RNA sequencing with functional magentic resonance imaging in patients with major depressive disorder, a disease associated with an altered GABA-mediated response, we found that the relative abundance levels of faecal Bacteroides are negatively correlated with brain signatures associated with depression