37 research outputs found
Hybrid 2D Nanomaterials as Dual-mode Contrast Agents in Cellular Imaging
The design of multifunctional nanofluids is highly desirable for biomedical therapy/cellular imaging applications.[1–4] The emergence of hybrid nanomaterials with specific properties, such as magnetism and fluorescence, can lead to an understanding of biological processes at the biomolecular level.[1] Various hybrid systems have been analyzed in the recent past for several possible biomedical applications.[5–9] Carbon-based hybrid systems such as carbon nanotubes with various nanoparticles are being widely tested for their biological applications because of their ability to cross cell membranes and their interesting thermal and electrical properties.[10,11] Graphene oxide (GO) is a fairly new graphene-based system with a 2D carbon honeycomb lattice decorated with numerous functional groups attached to the backbone: these functional groups make it an excellent platform for further attachment of nanoparticles and synthesis of hybrid materials. Cell viability studies on GO have been recently attempted, showing biocompatibility. [12,13] Moreover, the intrinsic photoluminescence (PL) properties of GO can be utilized for cellular imaging.[13] The large surface area and non-covalent interactions with aromatic molecules make GO an excellent system for biomolecular applications and drug attachment
Hybrid Donor–Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer
Judicious combination
of semiconducting polymers with alternating electron donor (D) and
acceptor (A) segments created hybrid nanoparticles with amplified
energy transfer and red-shifted emission, while simultaneously providing
photothermal capabilities. Hybrid D–A polymer particles (H-DAPPs)
passively localized within orthotopic breast tumors, serving as bright
fluorescent beacons. Laser stimulation induced heat generation on
par with gold nanorods, resulting in selective destruction of the
tumor. H-DAPPs can also undergo multiple thermal treatments, with
no loss of fluorescence intensity or photothermal potential. These
results indicate that H-DAPPs provide new avenues for the synthesis
of hybrid nanoparticles useful in localized detection and treatment
of disease