Investigations of excitation energy transfer and intramolecular interactions in a nitrogen corded distrylbenzene dendrimer system.

The photophysics of an amino-styrylbenzene dendrimer (A-DSB) system is probed by time-resolved and steady state luminescence spectroscopy. For two different generations of this dendrimer, steady state absorption, emission, and photoluminescence excitation spectra are reported and show that the efficiency of energy transfer from the dendrons to the core is very close to 100%. Ultrafast time-resolved fluorescence measurements at a range of excitation and detection wavelengths suggest rapid (and hence efficient) energy transfer from the dendron to the core. Ultrafast fluorescence anisotropy decay for different dendrimer generations is described in order to probe the energy migration processes. A femtosecond time-scale fluorescence depolarization was observed with the zero and second generation dendrimers. Energy transfer process from the dendrons to the core can be described by a Förster mechanism (hopping dynamics) while the interbranch interaction in A-DSB core was found to be very strong indicating the crossover to exciton dynamics

The structure of the infinite models in integer programming

The infinite models in integer programming can be described as the convex hull of some points or as the intersection of halfspaces derived from valid functions. In this paper we study the relationships between these two descriptions. Our results have implications for corner polyhedra. One consequence is that nonnegative, continuous valid functions suffice to describe corner polyhedra (with or without rational data)

Adaptive policies for perimeter surveillance problems

We consider the problem of sequentially choosing observation regions along a line, with an aim of maximising the detection of events of interest. Such a problem may arise when monitoring the movements of endangered or migratory species, detecting crossings of a border, policing activities at sea, and in many other settings. In each case, the key operational challenge is to learn an allocation of surveillance resources which maximises successful detection of events of interest. We present a combinatorial multi-armed bandit model with Poisson rewards and a novel filtered feedback mechanism - arising from the failure to detect certain intrusions - where reward distributions are dependent on the actions selected. Our solution method is an upper confidence bound approach and we derive upper and lower bounds on its expected performance. We prove that the gap between these bounds is of constant order, and demonstrate empirically that our approach is more reliable in simulated problems than competing algorithms

Status of the FETS Project

The Front End Test Stand (FETS) under construction at RAL is a demonstrator for front end systems of a future high power proton linac. Possible applications include a linac upgrade for the ISIS spallation neutron source, new future neutron sources, accelerator driven sub-critical systems, high energy physics proton drivers etc. Designed to deliver a 60mA H-minus beam at 3MeV with a 10% duty factor, FETS consists of a high brightness ion source, magnetic low energy beam transport (LEBT), 4-vane 324MHz radio frequency quadrupole, medium energy beam transport (MEBT) containing a high speed beam chopper and non-destructive laser diagnostics. This paper describes the current status of the project and future plans

A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma

Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease. Current treatment is surgery followed by radiation and intravenous chemotherapy. However, drawbacks for current chemotherapeutics lie in the fact that they develop resistance and do not achieve therapeutic concentrations in the lymphatic system. We hypothesize that a three-drug nanoscale drug delivery system, tailored for lymphatic uptake, administered subcutaneously, will have decreased drug resistance and therefore offer better therapeutic outcomes. We prepared and characterized nanoparticles (NPs) with docetaxel, everolimus, and LY294002 in polyethyleneglycol-block-poly(ε-caprolactone) (PEG-PCL) polymer with different charge distributions by modifying the ratio of anionic and neutral end groups on the PEG block. These NPs are similarly sized (~48nm), with neutral, partially charged, or fully charged surface. The NPs are able to load ~2mg/mL of each drug and are stable for 24h. The NPs are assessed for safety and efficacy in two transgenic metastatic melanoma mouse models. All the NPs were safe in both models based on general appearance, weight changes, death, and blood biochemical analyses. The partially charged NPs are most effective in decreasing the number of melanocytes at both the proximal (sentinel) lymph node (LN) and the distal LN from the injection site. The neutral NPs are efficacious at the proximal LN, while the fully charged NPs have no effect on either LNs. Thus, our data indicates that the NP surface charge and lymphatic efficacy are closely tied to each other and the partially charged NPs have the highest potential in treating metastatic melanoma