Design and implementation of synchrotron radiation masks for LEP2

Estimates of photon flux for LEP2 have predicted unacceptable background levels within the detectors of the four LEP experiments. As part of the solution to this problem, synchrotron radiation masks have been installed within the experimental vacuum Chambers close to the interaction points. The photon flux calculations and specification for the masks have been laid-out by von Holtey et.al. [1]. This paper describes the design of the masks and outlines the principal technical issues overcome for their installation and alignment

Mechanical and Vacuum Stability Design Criteria for the LHC Experimental Vacuum Chambers

Four colliding beam experiments are planned for the Large Hadron Collider (LHC) requiring experimental vacuum chambers in the interaction region. The beam pipe should be as transparent as possible to scattered particles and detectors should be as close as possible to the interaction point, resulting in small diameter beam pipes. This, together with the bunched beam structure, makes ion induced pre ssure bump instability, well known from the Intersecting Storage Rings (ISR) at CERN, a potential problem. Adequate conductance, cleanliness of the beam pipes and efficient pumping are required to avo id this instability. Suppression of electron multipacting requires appropriate surface coatings and cleaning procedures. Small beam pipe diameters must provide the required beam stay clear and still a llow margin for alignment and stability inside detectors. Design criteria to ensure both local and global stability under static and dynamic mechanical loads are defined

Vacuum Calculations for the LHC Experimental Beam Chambers

The vacuum stability is studied for the LHC experimental beam vacuum chambers of ALICE, ATLAS, and CMS. The present baseline design includes sputtered Non-Evaporable Getter (NEG) coating over the whole chamber inner surface providing distributed pumping and an antimultipactor coating. The data are presented for the dominant gas species (H2, CH4, CO and CO2) in a baked system. It results that the distributed pumping is necessary for vacuum stability of CO. Lumped pumping with Sputter Ion Pumps (SIP) is also indispensable for the stability of CH4. The operational constraints with NEG technology are described

Installation and commissioning of vacuum systems for the LHC particle detectors

The LHC collider has recently completed commissioning at CERN. At four points around the 27 km ring, the beams are put into collision in the centre of the experiments ALICE, ATLAS, CMS and LHCb which are installed in large underground caverns. The ‘experimental vacuum systems’ which transport the beams through these caverns and collision points are a primary interface between machine and experiment and were developed and installed as one project at CERN. Each system has a different geometry and materials as required by the experiment. However, they all have common requirements from the machine, and use many common technologies developed for the project. In this paper we give an overview of the four systems. We explain the technologies that were developed and applied for the installation, test, bakeout and subsequent closure of the experimental vacuum systems. We also discuss lessons learnt from the project

Design Aspects of the RF Contacts for the LHC Beam Vacuum Interconnects

The LHC requires a very low longitudinal and transverse beam coupling impedance, in particular at low frequencies. This implies an admissible DC contact resistance of less than 0.1 m$\Omega$ for the RF contacts inside the vacuum bellows which must carry the image current (up to 50 A peak) of the beam at each vacuum chamber interconnect. Technological aspects, measurement methods and test results are presented for the contacts which will be used in the LHC. The modified mechanical design and the justifications for specific choices will be discusse

Beam Vacuum Interconnects for the LHC Cold Arcs

The design of the beam vacuum interconnect is described in this paper. Features include a novel RF bridge design to maximise lateral flexibility during cryostat Cold arcs of the LHC will consist of twin aperture dipole, quadrupole and corrector magnets in cryostats, operating at 1.9 K. Beam vacuum chambers, along with all connecting elements require flexible 'interconnects' between adjacent cryostats to allow for thermal and mechanical offsets foreseen during machine operation and alignment. In addition, the beam vacuum chambers contain perforated beam screens to intercept beam induced heat loads at an intermediate temperature. These must also be connected with low impedance RF bridges in the interconnect zones.alignment and so-called 'nested' bellows to minimise the required length of the assembly

The Preparation of the Cryomagnets and the Assembly of the LHC Test String 2

The numerous complex activities required to prepare the cryomagnets for the installation in String 2 are described. These include the configuration of the mechanical interfaces, thee conditioning of the beam tubes, the installation of beam screens and the instrumentation as well as the final checks. The preparation of the cryomagnets for String 2 has been a dress rehearsal for the preparation that the cryomagnets will undergo before their installation in the tunnel. After a description of the interconnection procedures of the components for String 2, the tests carried-out to release the String for operation are described. A brief account of the lessons learnt is also given

Exposure to natural environments during pregnancy and birth outcomes in 11 european birth cohorts

Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, part of the LifeCycle project, was based on a total sample size of 69,683 newborns with harmonised data. For each participant, we calculated seven indicators of residential exposure to natural environments: surrounding greenspace in 100m, 300m, and 500m using Normalised Difference Vegetation Index (NDVI) buffers, distance to the nearest green space, accessibility to green space, distance to the nearest blue space, and accessibility to blue space. Measures of birth weight and small for gestational age (SGA) were extracted from hospital records. We used pooled linear and logistic regression models to estimate associations between exposure to the natural environment and birth outcomes, controlling for the relevant covariates. We evaluated the potential effect modification by socioeconomic status (SES) and region of Europe and the influence of ambient air pollution on the associations. In the pooled analyses, residential surrounding greenspace in 100m, 300m, and 500m buffer was associated with increased birth weight and lower odds for SGA. Higher residential distance to green space was associated with lower birth weight and higher odds for SGA. We observed close to null associations for accessibility to green space and exposure to blue space. We found stronger estimated magnitudes for those participants with lower educational levels, from more deprived areas, and living in the northern European region. Our associations did not change notably after adjustment for air pollution. These findings may support implementing policies to promote natural environments in our cities, starting in more deprived areas. © 2022Funding text 1: This project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, grant agreement No 733206; EUCAN-Connect grant agreement No 824989). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. For more information of each cohort individual funding, see Supplementary Material s, Information S2. ; Funding text 2: We would like to thanks to all the mothers, fathers, and children for their generous contribution as participants in the cohorts that are part of the LifeCycle project. For more information of each cohort individual acknowledgment, see Supplementary Materials, Information S1. This project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, grant agreement No 733206; EUCAN-Connect grant agreement No 824989). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. For more information of each cohort individual funding, see Supplementary Materials, Information S2. DAL has received support from Medtronic Ltd and Roche Diagnostics for research unrelated to this study. All the other authors declare that they have no competing interests

In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children

Background The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only partially understood. Here, we aimed to identify multi-layer molecular signatures associated with exposure to tobacco smoke in these two exposure windows. Methods We investigated the associations of maternal smoking during pregnancy and childhood secondhand smoke (SHS) exposure with molecular features measured in 1203 European children (mean age 8.1 years) from the Human Early Life Exposome (HELIX) project. Molecular features, covering 4 layers, included blood DNA methylation and gene and miRNA transcription, plasma proteins, and sera and urinary metabolites. Results Maternal smoking during pregnancy was associated with DNA methylation changes at 18 loci in child blood. DNA methylation at 5 of these loci was related to expression of the nearby genes. However, the expression of these genes themselves was only weakly associated with maternal smoking. Conversely, childhood SHS was not associated with blood DNA methylation or transcription patterns, but with reduced levels of several serum metabolites and with increased plasma PAI1 (plasminogen activator inhibitor-1), a protein that inhibits fibrinolysis. Some of the in utero and childhood smoking-related molecular marks showed dose-response trends, with stronger effects with higher dose or longer duration of the exposure. Conclusion In this first study covering multi-layer molecular features, pregnancy and childhood exposure to tobacco smoke were associated with distinct molecular phenotypes in children. The persistent and dose-dependent changes in the methylome make CpGs good candidates to develop biomarkers of past exposure. Moreover, compared to methylation, the weak association of maternal smoking in pregnancy with gene expression suggests different reversal rates and a methylation-based memory to past exposures. Finally, certain metabolites and protein markers evidenced potential early biological effects of postnatal SHS, such as fibrinolysis

Exposure to natural environments during pregnancy and birth outcomes in 11 European birth cohorts

Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, part of the LifeCycle project, was based on a total sample size of 69,683 newborns with harmonised data. For each participant, we calculated seven indicators of residential exposure to natural environments: surrounding greenspace in 100m, 300m, and 500m using Normalised Difference Vegetation Index (NDVI) buffers, distance to the nearest green space, accessibility to green space, distance to the nearest blue space, and accessibility to blue space. Measures of birth weight and small for gestational age (SGA) were extracted from hospital records. We used pooled linear and logistic regression models to estimate associations between exposure to the natural environment and birth outcomes, controlling for the relevant covariates. We evaluated the potential effect modification by socioeconomic status (SES) and region of Europe and the influence of ambient air pollution on the associations. In the pooled analyses, residential surrounding greenspace in 100m, 300m, and 500m buffer was associated with increased birth weight and lower odds for SGA. Higher residential distance to green space was associated with lower birth weight and higher odds for SGA. We observed close to null associations for accessibility to green space and exposure to blue space. We found stronger estimated magnitudes for those participants with lower educational levels, from more deprived areas, and living in the northern European region. Our associations did not change notably after adjustment for air pollution. These findings may support implementing policies to promote natural environments in our cities, starting in more deprived areas