Una nueva asociación de vegetación halófila en el sureste de la península ibérica (España): Limonio Majoris-Sarcocornietum fruticosae

Como resultado del estudio de la vegetación de los humedales salinos en Andalucía, se muestra la descripción y caracterización de una nueva asociación halófila desarrollada en los saladares de la Hoya de Baza (Granada). Se trata de una fitocenosis dominada por Sarcocornia fruticosa (L.) A. J. Scott, junto a otros nanofanerófitos suculentos y hemicriptófitos rosulados entre los que destaca el endemismo local Limonium majus (Boiss.) Erben. La asociación Limonio majoris-Sarcocornietum fruticosae ass. nova es propia del distrito Guadiciano-Bastetano (sector Guadiciano-Bacense, provincia Bética) en el piso bioclimático mesomediterráneo semiárido.A new halophytic vegetation association in southeastern Iberian Peninsula (Spain): Limonio majoris-Sarcocornietum fruticosae. As a result of the research on the vegetation of Andalusian saline wetlands, a new halophytic association in the Baza depression (Granada) is characterized and described. This phytocoenoses is mainly dominated by Sarcocornia fruticosa (L.) A. J. Scott, together with other succulent nanophanerophytes and rosulate hemicryptophytes, highlighting the existence of the local endemic taxon Limonium majus (Boiss.) Erben. The new association is named Limonio majoris-Sarcocornietum fruticosae ass. Nova being exclusive of the Guadician-Bastetan district territories (Guadician-Bacensean sector, Baetic province) and developing in the Mesomediterranean semiarid bioclimatic belt.Junta de Andalucía. Consejería de Economía, Innovación y CienciaJunta de Andalucía. Consejería de Medio Ambient

Estudio florístico de los medios húmedos salinos de Andalucía (S. de España). Catálogo y análisis de la flora vascular halófila

El objetivo del presente estudio es el conocimiento de la composición florística de los medios húmedos salinos andaluces. Entre 2003 y 2008 se han inventariado un total de 162 especies y subespecies de plantas vasculares que son propias de los medios salinos andaluces, entre las que se encuentran 41 taxones amenazados y/o protegidos y 6 taxones alóctonos. Para cada uno de los taxones se indica el nombre aceptado, sinónimos más usados, familia a la que pertenece, tipo de vegetación en el que suele aparecer, afinidad fitosociológica, ecología, biotipo, termotipo, distribución general y distribución en el área de estudio por unidades fitogeográficas. Finalmente se indica si la especie es invasora en el territorio o si la especie se considera amenazada.Floristic study of the Andalusian saline wetlands (S. Spain). Checklist and floristic analysis of the halophytic vascular flora. The aim of this study is to contribute to the knowledge of the floristic composition of Andalusian saline wetlands. A total of 162 halophytic vascular plant species and subspecies has been recorded between 2003 and 2008, comprising 41 threatened and/or protected taxa and 6 allochthonous species. For each taxon the accepted name, most usual synonyms, botanic family, vegetation type where it usually appears, phytosociologic affinity, ecology, biotype, termotype, general distribution and phytogeographic distribution in the study area is provided. Finally, it is pointed out whether the species is considered invasive or threatened in the territory.Junta de Andalucía. Consejería de Economía, Innovación y CienciaEmpresa de Gestión Medioambiental (EGMASA

Análisis de la flora vascular endémica y amenazada de los medios salinos de Andalucía (S. España)

Se analiza la flora vascular halófila endémica y amenazada presente en los medios salinos de Andalucía, a partir del catálogo florístico elaborado en el territorio entre los años 2003 y 2008. De un total de 162 especies y subespecies de plantas vasculares que fueron detectados en los ecosistemas halófilos andaluces, 43 taxones son endémicos y 41 taxones están amenazados y/o protegidos por la legislación a un nivel local, regional o nacional.Analysis of endemic and threatened vascular flora in saline environments of Andalusia (S. Spain). An analysis on the endemic and endangered halophyte vascular flora of saline environments of Andalusia is carried out, starting out from the catalog of flora recorded in the territory between the years 2003 and 2008. A total amount of 162 species and subspecies of vascular plants were detected in Andalusian saline environ - ments, 43 of them being endemics and 41 threatened and/or protected by law at different levels: local, regional and nationalConsejería de Economía, Innovación y Ciencia de la Junta de Andalucí

Rotational Doppler Effect in Magnetic Resonance

We compute the shift in the frequency of the spin resonance in a solid that rotates in the field of a circularly polarized electromagnetic wave. Electron spin resonance, nuclear magnetic resonance, and ferromagnetic resonance are considered. We show that contrary to the case of the rotating LC circuit, the shift in the frequency of the spin resonance has strong dependence on the symmetry of the receiver. The shift due to rotation occurs only when rotational symmetry is broken by the anisotropy of the gyromagnetic tensor, by the shape of the body, or by magnetocrystalline anisotropy. General expressions for the resonance frequency and power absorption are derived and implications for experiment are discussed.Comment: 8 pages, 4 figure

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids

Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. For this purpose, serum and lung tissue miRNAs of OCS and non-OCS asthmatic individuals were evaluated by miRNAs-Seq, and subsequently miRNA validation was performed using RT-qPCR. Additionally, pathway enrichment analysis of deregulated miRNAs was conducted. We observed altered expression by the next-generation sequencing (NGS) of 11 miRNAs in serum, of which five (hsa-miR-148b-3p, hsa-miR-221-5p, hsa-miR-618, hsa-miR-941, and hsa-miR-769-5p) were validated by RT-qPCR, and three miRNAs in lung tissue (hsa-miR-144-3p, hsa-miR-144-5p, and hsa-miR-451a). The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR-221-5p and hsa-miR-769-5p. Expression of hsa-miR-148b-3p and hsa-miR-221-5p correlated with FEV/FVC (%) and these altered miRNAs act in key signaling pathways for asthma disease and the regulated expression of some genes (FOXO3, PTEN, and MAPK3) involved in these pathways. In conclusion, there are miRNA profiles differentially expressed in OCS-treated individuals with asthma and could be used as biomarkers of OCS treatment

Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids

Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. For this purpose, serum and lung tissue miRNAs of OCS and non-OCS asthmatic individuals were evaluated by miRNAs-Seq, and subsequently miRNA validation was performed using RT-qPCR. Additionally, pathway enrichment analysis of deregulated miRNAs was conducted. We observed altered expression by the next-generation sequencing (NGS) of 11 miRNAs in serum, of which five (hsa-miR-148b-3p, hsa-miR-221-5p, hsa-miR-618, hsa-miR-941, and hsa-miR-769-5p) were validated by RT-qPCR, and three miRNAs in lung tissue (hsa-miR-144-3p, hsa-miR-144-5p, and hsa-miR-451a). The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR-221-5p and hsa-miR-769-5p. Expression of hsa-miR-148b-3p and hsa-miR-221-5p correlated with FEV1/FVC (%) and these altered miRNAs act in key signaling pathways for asthma disease and the regulated expression of some genes (FOXO3, PTEN, and MAPK3) involved in these pathways. In conclusion, there are miRNA profiles differentially expressed in OCS-treated individuals with asthma and could be used as biomarkers of OCS treatment