3,658 research outputs found
Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics
We revisit the dynamics of a gene repressed by its own protein in the case
where the transcription rate does not adapt instantaneously to protein
concentration but is a dynamical variable. We derive analytical criteria for
the appearance of sustained oscillations and find that they require degradation
mechanisms much less nonlinear than for infinitely fast regulation.
Deterministic predictions are also compared with stochastic simulations of this
minimal genetic oscillator
Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics
We revisit the dynamics of a gene repressed by its own protein in the case
where the transcription rate does not adapt instantaneously to protein
concentration but is a dynamical variable. We derive analytical criteria for
the appearance of sustained oscillations and find that they require degradation
mechanisms much less nonlinear than for infinitely fast regulation.
Deterministic predictions are also compared with stochastic simulations of this
minimal genetic oscillator
High Resolution HST-STIS Spectra of CI and CO in the Beta Pictoris Circumstellar Disk
High resolution FUV echelle spectra showing absorption features arising from
CI and CO gas in the Beta Pictoris circumstellar (CS) disk were obtained on
1997 December 6 and 19 using the Space Telescope Imaging Spectrograph (STIS).
An unsaturated spin-forbidden line of CI at 1613.376 A not previously seen in
spectra of Beta Pictoris was detected, allowing for an improved determination
of the column density of CI at zero velocity relative to the star (the stable
component), N = (2-4) x 10^{16} cm^{-2}. Variable components with multiple
velocities, which are the signatures of infalling bodies in the Beta Pictoris
CS disk, are observed in the CI 1561 A and 1657 A multiplets. Also seen for the
first time were two lines arising from the metastable singlet D level of
carbon, at 1931 A and 1463 A The results of analysis of the CO A-X (0-0),
(1-0), and (2-0) bands are presented, including the bands arising from {13}^CO,
with much better precision than has previously been possible, due to the very
high resolution provided by the STIS echelle gratings. Only stable CO gas is
observed, with a column density N(CO) = (6.3 +/- 0.3) x 10^{14} cm{-2}. An
unusual ratio of the column densities of {12}^CO to {13}^CO is found (R = 15
+/- 2). The large difference between the column densities of CI and CO
indicates that photodissociation of CO is not the primary source of CI gas in
the disk, contrary to previous suggestion.Comment: 13 pages, including 6 figures. LaTex2e (emulateapj5.sty). Accepted
for publication in Ap
Apparent yield stress in rigid fibre suspensions: the role of attractive colloidal interactions
International audienceThis work is focused on the modelling of the shear and normal stresses in fibre suspensions that are subjected to a simple shear flow in the presence of short-range lubrication forces, van der Waals and electrostatic forces, as well as solid friction forces between fibres. All these forces are weighed by the contact probability. The theory is developed for attractive fibres with van der Waals interaction dominating over electrostatic repulsion. The model predicts a simple Bingham law for both the shear stress and the first normal stress difference with the apparent shear and normal yield stresses proportional, respectively, to the second and the third power of particle volume fraction. The model is applied to the experimental data of Rakatekar et al. Adv. Mater 21, 874-878 (2009) and Natale et al. AIChE J. 60, 1476-1487 (2014) on the suspensions of carbon nanotubes dispersed in a Newtonian epoxy resin. It reproduces well the quadratic dependency of the apparent yield stress on particle volume fraction (σ Y ∝φ^2) for average particle aspect ratios of r=160 and 1200, while it underpredicts the power-law exponent for rD80 (always predictingφ^2 behaviour instead of φ^3.2
ISO observations toward the reflection nebula NGC 7023: A nonequilibrium ortho- to para-H2 ratio
We have observed the S(0), S(1), S(2), S(3), S(4) and S(5) rotational lines
of molecular hydrogen (H2) towards the peak of the photodissociation region
(PDR) associated with the reflection nebula NGC 7023. The observed H2 line
ratios show that they arise in warm gas with kinetic temperatures ~300 - 700 K.
However, the data cannot be fitted by an ortho- to para- (OTP) ratio of 3. An
OTP ratio in the range ~1.5 - 2 is necessary to explain our observations. This
is the first detection of a non-equilibrium OTP ratio measured from the H2
pure-rotational lines in a PDR. The existence of a dynamical PDR is discussed
as the most likely explanation for this low OTP ratio.Comment: 4 pages, 3 figure
The flow of plasma in the solar terrestrial environment
The overall goal of our NASA Theory Program was to study the coupling, time delays, and feedback mechanisms between the various regions of the solar-terrestrial system in a self-consistent, quantitative manner. To accomplish this goal, it will eventually be necessary to have time-dependent macroscopic models of the different regions of the solar-terrestrial system and we are continually working toward this goal. However, with the funding from this NASA program, we concentrated on the near-earth plasma environment, including the ionosphere, the plasmasphere, and the polar wind. In this area, we developed unique global models that allowed us to study the coupling between the different regions. These results are highlighted in the next section. Another important aspect of our NASA Theory Program concerned the effect that localized 'structure' had on the macroscopic flow in the ionosphere, plasmasphere, thermosphere, and polar wind. The localized structure can be created by structured magnetospheric inputs (i.e., structured plasma convection, particle precipitation or Birkland current patterns) or time variations in these input due to storms and substorms. Also, some of the plasma flows that we predicted with our macroscopic models could be unstable, and another one of our goals was to examine the stability of our predicted flows. Because time-dependent, three-dimensional numerical models of the solar-terrestrial environment generally require extensive computer resources, they are usually based on relatively simple mathematical formulations (i.e., simple MHD or hydrodynamic formulations). Therefore, another goal of our NASA Theory Program was to study the conditions under which various mathematical formulations can be applied to specific solar-terrestrial regions. This could involve a detailed comparison of kinetic, semi-kinetic, and hydrodynamic predictions for a given polar wind scenario or it could involve the comparison of a small-scale particle-in-cell (PIC) simulation of a plasma expansion event with a similar macroscopic expansion event. The different mathematical formulations have different strengths and weaknesses and a careful comparison of model predictions for similar geophysical situations provides insight into when the various models can be used with confidence
Cell Cycle-Dependent Differentiation Dynamics Balances Growth and Endocrine Differentiation in the Pancreas
Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine, ductal, and acinar cells but become bipotent by embryonic day 13.5, giving rise to endocrine cells and ductal cells. However, the dynamics of individual progenitors balancing self-renewal and lineage-specific differentiation has never been described. Using three-dimensional live imaging and in vivo clonal analysis, we reveal the contribution of individual cells to the global behaviour and demonstrate three modes of progenitor divisions: symmetric renewing, symmetric endocrinogenic, and asymmetric generating a progenitor and an endocrine progenitor. Quantitative analysis shows that the endocrine differentiation process is consistent with a simple model of cell cycle-dependent stochastic priming of progenitors to endocrine fate. The findings provide insights to define control parameters to optimize the generation of β-cells in vitro
SUMER: Solar Ultraviolet Measurements of Emitted Radiation
The SUMER (solar ultraviolet measurements of emitted radiation) experiment is described. It will study flows, turbulent motions, waves, temperatures and densities of the plasma in the upper atmosphere of the Sun. Structures and events associated with solar magnetic activity will be observed on various spatial and temporal scales. This will contribute to the understanding of coronal heating processes and the solar wind expansion. The instrument will take images of the Sun in EUV (extreme ultra violet) light with high resolution in space, wavelength and time. The spatial resolution and spectral resolving power of the instrument are described. Spectral shifts can be determined with subpixel accuracy. The wavelength range extends from 500 to 1600 angstroms. The integration time can be as short as one second. Line profiles, shifts and broadenings are studied. Ratios of temperature and density sensitive EUV emission lines are established
The Excitation of Extended Red Emission: New Constraints on its Carrier From HST Observations of NGC 7023
The carrier of the dust-associated photoluminescence process causing the
extended red emission (ERE) in many dusty interstellar environments remains
unidentified. Several competing models are more or less able to match the
observed broad, unstructured ERE band. We now constrain the character of the
ERE carrier further by determining the wavelengths of the radiation that
initiates the ERE. Using the imaging capabilities of the Hubble Space
Telescope, we have resolved the width of narrow ERE filaments appearing on the
surfaces of externally illuminated molecular clouds in the bright reflection
nebula NGC 7023 and compared them with the depth of penetration of radiation of
known wavelengths into the same cloud surfaces. We identify photons with
wavelengths shortward of 118 nm as the source of ERE initiation, not to be
confused with ERE excitation, however. There are strong indications from the
well-studied ERE in the Red Rectangle nebula and in the high-|b| Galactic
cirrus that the photon flux with wavelengths shortward of 118 nm is too small
to actually excite the observed ERE, even with 100% quantum efficiency. We
conclude, therefore, that ERE excitation results from a two-step process. While
none of the previously proposed ERE models can match these new constraints, we
note that under interstellar conditions most polycyclic aromatic hydrocarbon
(PAH) molecules are ionized to the di-cation stage by photons with E > 10.5 eV
and that the electronic energy level structure of PAH di-cations is consistent
with fluorescence in the wavelength band of the ERE. Therefore, PAH di-cations
deserve further study as potential carriers of the ERE. (abridged)Comment: Accepted for Publication in the Ap
Phonons and Colossal Thermal Expansion Behavior of Ag3Co(CN)6 and Ag3Fe(CN)6
Recently colossal positive volume thermal expansion has been found in the
framework compounds Ag3Co(CN)6 and Ag3Fe(CN)6. Phonon spectra have been
measured using the inelastic neutron scattering technique as a function of
temperature and pressure. The data has been analyzed using ab-initio
calculations. We find that the bonding is very similar in both compounds. At
ambient pressure modes in the intermediate frequency part of the vibrational
spectra in the Co compound are shifted to slightly higher energies as compared
to the Fe compound. The temperature dependence of the phonon spectra gives
evidence for large explicit anharmonic contribution to the total anharmonicity
for low-energy modes below 5 meV. We found that modes are mainly affected by
the change in the size of unit cell, which in turn changes the bond lengths and
vibrational frequencies. Thermal expansion has been calculated via the volume
dependence of phonon spectra. Our analysis indicates that Ag phonon modes in
the energy range from 2 to 5 meV are strongly anharmonic and major contributors
to thermal expansion in both compounds. The application of pressure hardens the
low-energy part of the phonon spectra involving Ag vibrations and confirms the
highly anharmonic nature of these modes.Comment: 19 pages, 14 figures and one tabl
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