52 research outputs found
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
- Author
- A Hutloff
- AK Stanic
- B San Luis
- BB Au-Yeung
- BB Au-Yeung
- CQ Chu
- D Davidson
- DG Pellicci
- DG Pellicci
- DG Wei
- DI Godfrey
- EJ Wherry
- F Scheuplein
- F Scheuplein
- FW McNab
- G Anderson
- G Fu
- G Kollias
- G Seumois
- H Georgiev
- H Watarai
- HS Azzam
- I Engel
- I Engel
- J Henao-Mejia
- J Novak
- J Zikherman
- JL Matsuda
- JL Matsuda
- JM Mason
- K Benlagha
- K Hirota
- K Oleinika
- K Yamamoto
- L Brossay
- L Linsen
- LH Mason
- LM D'Cruz
- M Cruz Tleugabulova
- M Gaya
- M Guma
- M Hashimoto
- M Kronenberg
- M Zhu
- MA Weinreich
- MB Drennan
- MC Leite-De-Moraes
- MC Leite-De-Moraes
- MI Zimmer
- MP Seiler
- N Bottini
- N Sakaguchi
- NA Nagarajan
- R Genolet
- RJ Martinez
- S Akbulut
- S Jung
- S Picelli
- S Sidobre
- SE Levin
- TN Newman
- V Cerundolo
- V Sivakumar
- WY Lee
- X Li
- YJ Lee
- YL Chiu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-gamma-producing iNKT cells (NKT1 cells), suggesting that NKT1 cells may require a lower TCR signal threshold. Zap70 mutant mice develop IL-17-dependent arthritis. In a mouse experimental arthritis model, NKT17 cells are increased as the disease progresses, while NKT1 numbers negatively correlates with disease severity, with this protective effect of NKT1 linked to their IFN-gamma expression. NKT1 cells are also present in the synovial fluid of arthritis patients. Our data therefore suggest that TCR signal strength during thymic differentiation may influence not only IFN-gamma production, but also the protective function of iNKT cells in arthritis
Ocorrência de tuberculose em um hospital psiquiátrico do interior de Goiás
- Author
- Ana Carolina Malaspina
- Clarice Queico Fujimura Leite
- Diaz R
- Eisenach KD
- Fernando Augusto Fiúza de Mello
- Ferrazoli L
- Hermans PW
- Hindenburg Cruvinel Guimarães da Costa
- Kremer K
- Kritski AL
- Kudoh S
- Leite CQ
- Lourenço MCS
- Malaspina A C
- Mathiasi Neto PA
- Melo FFA
- Melo FFA
- Muzy de Souza GR
- Park YK
- Rasolofo-Razanamparany V
- Raviglione MC
- Shih JY
- Soares LCP
- Suffys PN
- Tartaglione T
- Tenover FC
- van Embden JD
- van Soolingen D
- Zeenreich A
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Addepalli SV
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Aizenberg I
- Akbiyik M
- Akesson TPA
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amos KR
- Amrouche CS
- Ananiev V
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- Angerami A
- Anisenkov AV
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- Antonelli M
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- Anulli F
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- Aparo MA
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- Zeitnitz C
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- Zenin O
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- Zhemchugov A
- Zheng Z
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
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- Wallangen V
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- Wyatt TR
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- Xiotidis I
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- Yang Z
- Yao WM
- Yap YC
- Ye H
- Ye J
- Ye S
- Yeletskikh I
- Yexley MR
- Yildiz HD
- Yin P
- Yorita K
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- Zemaityte G
- Zeng JC
- Zenin O
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- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang X
- Zhang Y
- Zhang Z
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- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhou C
- Zhou H
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- Zhu CG
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- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zou W
- Zwalinski L
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-2018 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb(-1), 46.9 fb(-1), and 60.6 fb(-1) respectively of proton-proton collision data at a centre-of-mass energy of 13TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and b-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interaction multiplicities demonstrates how the inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme
One thousand DNA barcodes of piranhas and pacus reveal geographic structure and unrecognised diversity in the Amazon
- Author
- A Machado-Allison
- A Machado-Allison
- A Riedel
- A Zarske
- A Zarske
- AG Muñoz
- AJ Drummond
- AL Cione
- AW Thompson
- B Lehner
- BC Carstens
- C Hoorn
- CH Eigenmann
- CQ Tang
- CT Philbrick
- D Ahrens
- D Darriba
- DL Rabosky
- E Pante
- E Paradis
- F Roxo
- G Talavera
- G Yu
- GS Lim
- HF Júlio Júnior
- I Sazima
- I Sazima
- IP Farias
- IP Farias
- J Bergsten
- J Díaz
- J Pons
- J Sukumaran
- J Zhang
- JA Markert
- JM Padial
- JT Anderson
- K Katoh
- K Lohse
- KO Winemiller
- KO Winemiller
- KP Schliep
- LHG Pereira
- M Jégu
- M Jégu
- M Jégu
- M Kearse
- M Malinsky
- M Mutanen
- M Pentinsaari
- M Pfenninger
- MC Andrade
- MC Andrade
- MC Andrade
- MC Andrade
- MCF Santos
- MD Escobar L.
- MH Sabaj Pérez
- MJ Hickerson
- MT Monaghan
- MV Amado
- MY Stoeckle
- N Hubert
- N Hubert
- N Hubert
- NM Reid
- NTB Mateussi
- NV Ivanova
- OB Vitorino Júnior
- P Kapli
- RA Collins
- RD Ward
- RE Reis
- RE Reis
- RG Leite
- RP Ota
- SDJ Brown
- SE Miller
- T Fujisawa
- T Hrbek
- TNA Pereira
- U Saint-Paul
- WL Fink
- WL Fink
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Piranhas and pacus (Characiformes: Serrasalmidae) are a charismatic but understudied family of Neotropical fishes. Here, we analyse a DNA barcode dataset comprising 1,122 specimens, 69 species, 16 genera, 208 localities, and 34 major river drainages in order to make an inventory of diversity and to highlight taxa and biogeographic areas worthy of further sampling effort and conservation protection. Using four methods of species discovery - incorporating both tree and distance based techniques - we report between 76 and 99 species-like clusters, i.e. between 20% and 33% of a priori identified taxonomic species were represented by more than one mtDNA lineage. There was a high degree of congruence between clusters, with 60% supported by three or four methods. Pacus of the genus Myloplus exhibited the most intraspecific variation, with six of the 13 species sampled found to have multiple lineages. Conversely, piranhas of the Serrasalmus rhombeus group proved difficult to delimit with these methods due to genetic similarity and polyphyly. Overall, our results recognise substantially underestimated diversity in the serrasalmids, and emphasise the Guiana and Brazilian Shield rivers as biogeographically important areas with multiple cases of across-shield and within-shield diversifications. We additionally highlight the distinctiveness and complex phylogeographic history of rheophilic taxa in particular, and suggest multiple colonisations of these habitats by different serrasalmid lineages. © 2018 The Author(s)
Measurement of differential cross sections of isolated-photon plus heavy-flavour jet production in pp collisions at √s=8 TeV using the ATLAS detector
- Author
- Aaboudd M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaitia Y
- Acharya BS
- Adachi S
- Adam ER
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aiellia G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen W
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
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- Kladiva E
- Klapdor-Kleingrothaus T
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- Kotwal A
- Koulouris A
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- Kozanecki W
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- Le Dortz O
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- Thiele F
- Thomas JP
- Thomas-Wilsker J
- Thompson AS
- Thompson PD
- Thomsen LA
- Thomson E
- Tian Y
- Tibbetts MJ
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- Tikhonov YA
- Timoshenko S
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- Tobon CAM
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- Tolley E
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- Torres RET
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- Touchard F
- Tovey DR
- Treado CJ
- Trefzger T
- Tresoldi F
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Tripiana MF
- Trischuk W
- Trocme B
- Trofymov A
- Troncon C
- Trovatelli M
- Truong L
- Trzebinski M
- Trzupek A
- Tsang KW
- Tseng JC-L
- Tsiareshka PV
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
- Tuna AN
- Turchikhin S
- Turgeman D
- Turra R
- Tuts PM
- Ucchielli G
- Ueda I
- Ughetto M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Uno K
- Urbanb J
- Urquijo P
- Urrejola P
- Usai G
- Usui J
- Vacavant L
- Vacek V
- Vachon B
- Vadla KOH
- Vaidya A
- Valderanis C
- Valente M
- Valentinetti S
- Valero A
- Valery L
- Vallier A
- Van den Wollenberg W
- Van der Graaf H
- van Gemmeren P
- Van Nieuwkoop J
- Vanadia M
- Vandelli W
- Vaniachine A
- Vankov P
- vanVulpen I
- vanWoerden MC
- Vardanyan G
- Vari R
- Varnes EW
- Varni C
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vasquez GA
- Vasquez JG
- Vazeille F
- Vazquez Furelos D
- Vazquez JGP
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- Veeraraghavan V
- Veloce LM
- Veloso F
- Veneziano S
- Ventura A
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen AT
- Vermeulen JC
- Vetterli MC
- Viazlo O
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Vigani L
- Villa M
- Villar DIN
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Vishwakarma A
- Vittori C
- Vivarelli I
- Vlachos S
- Vogel M
- Vokac P
- Volpi G
- von Buddenbrock SE
- von der Schmitt H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahlberg H
- Wahrmund S
- Wakamiya K
- Walder J
- Walker R
- Walkowiak W
- Wallangen V
- Walls FMG
- Wang C
- Wang C
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang Q
- Wang R
- Wang R-J
- Wang SM
- Wang T
- Wang W
- Wang W
- Wang Z
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Washbrook A
- Watkins PM
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- Weber SW
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- Weinert B
- Weingarten J
- Weirich M
- Weiser C
- Wells PS
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- Wengler T
- Wenig S
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- Werner MD
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- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
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- White MJ
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- Wickens FJ
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- Wiik-Fuchs LAM
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- Wingerter-Seez I
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- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolter MW
- Wolters H
- Wong KHY
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wotschack J
- Wozniak KW
- Wu M
- Wu SL
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- Wyatt TR
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- Yao W-M
- Yap YC
- Yasu Y
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- Ye J
- Ye S
- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yu J
- Yuen SPY
- Yusuff I
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- Zacharis G
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- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zemla A
- Zeng JC
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- Zenin O
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- Zerwas D
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- Zhemchugov A
- Zhou B
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- Zhu CG
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 10/01/2018
- Field of study
This Letter presents the measurement of differential cross sections of isolated prompt photons produced
in association with a b-jet or a c-jet. These final states provide sensitivity to the heavy-flavour content
of the proton and aspects related to the modelling of heavy-flavour quarks in perturbative QCD. The
measurement uses proton–proton collision data at a centre-of-mass energy of 8 TeV recorded by the
ATLAS detector at the LHC in 2012 corresponding to an integrated luminosity of up to 20.2 fb−1. The
differential cross sections are measured for each jet flavour with respect to the transverse energy of
the leading photon in two photon pseudorapidity regions: |ηγ | < 1.37 and 1.56 < |ηγ | < 2.37. The
measurement covers photon transverse energies 25 < Eγ
T < 400 GeV and 25 < Eγ
T < 350 GeV respectively
for the two |ηγ | regions. For each jet flavour, the ratio of the cross sections in the two |ηγ | regions is also
measured. The measurement is corrected for detector effects and compared to leading-order and nextto-leading-order
perturbative QCD calculations, based on various treatments and assumptions about the
heavy-flavour content of the proton. Overall, the predictions agree well with the measurement, but some
deviations are observed at high photon transverse energies. The total uncertainty in the measurement
ranges between 13% and 66%, while the central γ + b measurement exhibits the smallest uncertainty,
ranging from 13% to 27%, which is comparable to the precision of the theoretical predictions
Mycobacterium bovis, but also M. africanum present in raw milk of pastoral cattle in north-central Nigeria.
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
Item does not contain fulltextUsing deletion typing technique, five mycobacteria isolated from unpasteurised milk samples from cows in north-central Nigeria were characterized as Mycobacterium bovis (n = 4) and M. africanum (n = 1). This report emphasizes that transmission between the animal and human reservoir is a serious threat in Nigeria.1 augustus 201
A força da informação sobre retinoblastoma para a família da criança
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Evaluation of rapid alternative methods for drug susceptibility testing in clinical isolates of Mycobacterium tuberculosis
- Author
- Publication venue
- Instituto Oswaldo Cruz, Ministério da Saúde
- Publication date
- 01/01/2006
- Field of study
A study was carried out to compare the performance of a commercial method (MGIT) and four inexpensive drug susceptibility methods: nitrate reductase assay (NRA), microscopic observation drug susceptibility (MODS) assay, MTT test, and broth microdilution method (BMM). A total of 64 clinical isolates of Mycobacterium tuberculosis were studied. The Lowenstein-Jensen proportion method (PM) was used as gold standard. MGIT, NRA, MODS, and MTT results were available on an average of less than 10 days, whereas BMM results could be reported in about 20 days. Most of the evaluated tests showed excellent performance for isoniazid and rifampicin, with sensitivity and specificity values > 90%. With most of the assays, sensitivity for ethambutol was low (62-87%) whereas for streptomycin, sensitivity values ranged from 84 to 100%; NRA-discrepancies were associated with cultures with a low proportion of EMB-resistant organisms while most discrepancies with quantitative tests (MMT and BMM) were seen with isolates whose minimal inhibitory concentrations fell close the cutoff. MGIT is reliable but still expensive. NRA is the most inexpensive and easiest method to perform without changing the organization of the routine PM laboratory performance. While MODS, MTT, and BMM, have the disadvantage from the point of view of biosafety, they offer the possibility of detecting partial resistant strains. This study shows a very good level of agreement of the four low-cost methods compared to the PM for rapid detection of isoniazid, rifampicin and streptomycin resistance (Kappa values > 0.8); more standardization is needed for ethambutol
Mycobacterium avium restriction fragment lenght polymorphism-IS IS1245 and the simple double repetitive element polymerase chain reaction typing method to screen genetic diversity in Brazilian strains
- Author
- Arbeit RD
- Barbaro G
- Carpenter JCC
- Devallois A
- Eaton T
- Ferreira RM
- Friedman CR
- Gadelha A
- Guerrero C
- Legrand E
- Leila de Souza Fonseca
- Leite CQ
- Mansfield KG
- Maria Helena Féres Saad
- Marlei Gomes da Silva
- Panunto AC
- Patrícia Carvalho de Sequeira
- Pestel-Caron M
- Picardeau M
- Portaels F
- Ritacco V
- Roiz MP
- Saad MH
- Saad MH
- van Soolingen D
- von Reyn CF
- Wallace RJ
- Yoder S
- Publication venue
- Instituto Oswaldo Cruz, Ministério da Saúde
- Publication date
- 01/11/2005
- Field of study
Simple double repetitive element polymerase chain reaction (MaDRE-PCR) and Pvu II-IS1245 restriction fragment length polymorphism (RFLP) typing methods were used to type 41 Mycobacterium avium isolates obtained from 14 Aids inpatients and 10 environment and animals specimens identified among 53 mycobacteria isolated from 237 food, chicken, and pig. All environmental and animals strains showed orphan patterns by both methods. By MaDRE-PCR four patients, with multiple isolates, showed different patterns, suggesting polyclonal infection that was confirmed by RFLP in two of them. This first evaluation of MaDRE-PCR on Brazilian M. avium strains demonstrated that the method seems to be useful as simple and less expensive typing method for screening genetic diversity in M. avium strains on selected epidemiological studies, although with limitation on analysis identical patterns except for one band
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