Large deviations for a damped telegraph process

In this paper we consider a slight generalization of the damped telegraph process in Di Crescenzo and Martinucci (2010). We prove a large deviation principle for this process and an asymptotic result for its level crossing probabilities (as the level goes to infinity). Finally we compare our results with the analogous well-known results for the standard telegraph process

Congestive heart failure : more common as well as an important cardiovascular outcome: reply

Non peer reviewe

Polarization and dispersion properties of elliptical hole golden spiral photonic crystal fiber

An elliptical air-hole golden spiral photonic crystal fiber (EGS-PCF) is analyzed with the full-vectorial finite element method. The air-holes in the EGS-PCF are arranged in a spiral pattern governed by the Golden Ratio, where the design has been inspired by the optimal arrangement of seeds found in nature. The EGS-PCF exhibits extremely high birefringence (∼0.022 at operating wavelength 1550 nm) which is particularly useful for generating a polarization stable supercontinuum (SC). The fiber can also be designed to have a Zero Dispersion Wavelength (ZDW) at a suitable wavelength for only one polarization and large negative dispersion for the other, leading to a single-polarization SC. In addition, the fiber dispersion can be designed to obtain ZDWs at 800 nm and 1064 nm simultaneously, which can facilitate broadband supercontinuum generation (SCG) through multi-wavelength pumping

Thermal seasons in northern Europe in projected future climate

Global warming acts to prolong thermal summers and shorten winters. In this work, future changes in the lengths and timing of four thermal seasons in northern Europe, with threshold temperatures 0 and 10 degrees C, are derived from bias-adjusted output data from 23 CMIP5 global climate models. Three future periods and two Representative Concentration Pathway (RCP) scenarios are discussed. The focus is on the period 2040-2069 under RCP4.5, which approximately corresponds to a 2 degrees C global warming relative to the preindustrial era. By the period 2040-2069, the average length of the thermal summer increases by nearly 30 days relative to 1971-2000, and the thermal winter shortens by 30-60 days. The timing of the thermal springs advances while autumns delay. Within the model ensemble, there is a high linear correlation between the modelled annual-mean temperature increase and shifts in the thermal seasons. Thermal summers lengthen by about 10 days and winters shorten by 10-24 days per 1 degrees C of local warming. In the mid-21st century, about two-thirds of all summers (winters) are projected to be very long (very short) according to the baseline-period standards, with an anomaly greater than 20 days relative to the late-20th century temporal mean. The proportion of years without a thermal winter increases remarkably in the Baltic countries and southern Scandinavian peninsula. Implications of the changing thermal seasons on nature and human society are discussed in a literature review.Peer reviewe

A modelling framework for the assessment of the impacts of alternative policy and management options on the sustainability of Finnish agrifood systems

Recently, a new project focussing on integrated assessment modelling of agrifood systems (IAM-Tools) has been launched at MTT Agrifood Research Finland to gather, evaluate, refine and develop these component models and to link tem in an IAM framework for Finnish conditions

Pre-migration traumatic experiences, post-migration perceived discrimination and substance use among Russian and Kurdish migrants-a population-based study

Background and aims The associations between traumatic events, substance use and perceived discrimination have been rarely studied among migrants in host countries. We examined whether pre-migration potentially traumatic experiences (PTEs) or perceived discrimination (PD) are associated with substance use among migrants with voluntary (Russians) and forced (Kurds) migration backgrounds. Design Cross-sectional interview and health examination data from the Finnish Migrant Health and Wellbeing Study were used. The target sample (n = 1000 for each group) was drawn from the national population register using stratified random sampling by participants' country of birth and native language. Setting Population-based data were collected from six cities in Finland during 2010-12. Participants The participation rates were 68% (Russians) and 59% (Kurds). The analytical sample size varied (Russians n = 442-687, Kurds n = 459-613), as some participants completed only interview, health examination or short interview. The majority of Kurds had a refugee background (75%) while Russians had mainly migrated for other reasons (99%). Measurements The three main outcomes were self-reported binge drinking, daily smoking and life-time cannabis use. PTEs and PD were self-reported in the interview. Socio-demographic background, migration-related factors and current affective symptoms were adjusted for. Findings Among Kurds, PTEs were associated with binge drinking [adjusted odds ratio (aOR) = 2.65, 95% confidence interval (CI) = 1.30-5.42] and PD was associated with life-time cannabis use (aOR = 3.89, 95% CI = 1.38-10.97) after adjusting for contextual factors. Among Russians, PTEs were associated with life-time cannabis use adjusting for contextual factors (aOR = 2.17, 95% CI = 1.12-4.18). Conclusions In Finland, pre-migration traumatic experiences appear to be associated with life-time cannabis use among the Russian migrant population (voluntary migration) and binge drinking among the Kurdish migrant population (forced migration). Perceived discrimination in Finland appears to be associated with life-time cannabis use among Kurdish migrants.Peer reviewe

Estimation of optimal number of gates in dual gated ¹⁸F-FDG cardiac PET

Gating of positron emission tomography images has been shown to reduce the motion effects, especially when imaging small targets, such as coronary plaques. However, the selection of optimal number of gates for gating remains a challenge. Selecting too high number of gates results in a loss of signal-to-noise ratio, while too low number of gates does remove only part of the motion. Here, we introduce a respiratory-cardiac motion model to determine the optimal number of respiratory and cardiac gates. We evaluate the model using a realistic heart phantom and data from 12 cardiac patients (47–77 years, 64.5 on average). To demonstrate the benefits of our model, we compared it with an existing respiratory model. Based on our study, the optimal number of gates was determined to be five respiratory and four cardiac gates in the phantom and patient studies. In the phantom study, the diameter of the most active hot spot was reduced by 24% in the dual gated images compared to non-gated images. In the patient study, the thickness of myocardium wall was reduced on average by 21%. In conclusion, the motion model can be used for estimating the optimal number of respiratory and cardiac gates for dual gating

Feasibility and preliminary efficacy of motivating eye gaze in young children on autism spectrum through parent-mediated intervention

We studied the feasibility and preliminary efficacy of a brief parent-mediated intervention to improve the orienting towards faces in young autistic children. Twenty (aged 3–6) autistic children were randomly assigned to an intervention or a control group. The intervention group parents were trained to perform three types of practices with their children for four months. The feasibility of recruitment, data collection and analysis procedures, acceptability and adherence were investigated. To study the usability and preliminary efficacy of two outcome measures, eye gaze and state of engagement with parents were observed during a 10-minute free-play session at baseline, after 4–6 months, and after two years. The results indicated support for the feasibility and efficacy, demonstrating a significant increase in eye gaze and engagement in the intervention group but not in the control group. It is an encouraging preliminary finding that the engagement increased after supporting the orientation towards the eye region, indicating beneficial effects for further social-communicative development in autistic children.publishedVersionPeer reviewe

Adjusting bone mass for differences in projected bone area and other confounding variables: an allometric perspective.

The traditional method of assessing bone mineral density (BMD; given by bone mineral content [BMC] divided by projected bone area [Ap], BMD = BMC/Ap) has come under strong criticism by various authors. Their criticism being that the projected bone "area" (Ap) will systematically underestimate the skeletal bone "volume" of taller subjects. To reduce the confounding effects of bone size, an alternative ratio has been proposed called bone mineral apparent density [BMAD = BMC/(Ap)3/2]. However, bone size is not the only confounding variable associated with BMC. Others include age, sex, body size, and maturation. To assess the dimensional relationship between BMC and projected bone area, independent of other confounding variables, we proposed and fitted a proportional allometric model to the BMC data of the L2-L4 vertebrae from a previously published study. The projected bone area exponents were greater than unity for both boys (1.43) and girls (1.02), but only the boy's fitted exponent was not different from that predicted by geometric similarity (1.5). Based on these exponents, it is not clear whether bone mass acquisition increases in proportion to the projected bone area (Ap) or an estimate of projected bone volume (Ap)3/2. However, by adopting the proposed methods, the analysis will automatically adjust BMC for differences in projected bone size and other confounding variables for the particular population being studied. Hence, the necessity to speculate as to the theoretical value of the exponent of Ap, although interesting, becomes redundant