1,880 research outputs found
Testing self-report time-use diaries against objective instruments in real time
This study provides a new test of time-use diary methodology, comparing diaries with a pair of objective criterion measures: wearable cameras and accelerometers. A volunteer sample of respondents (n = 148) completed conventional self-report paper time-use diaries using the standard UK Harmonised European Time Use Study (HETUS) instrument. On the diary day, respondents wore a camera that continuously recorded images of their activities during waking hours (approximately 1,500–2,000 images/day) and also an accelerometer that tracked their physical activity continuously throughout the 24-hour period covered by the diary. Of the initial 148 participants recruited, 131 returned usable diary and camera records, of whom 124 also provided a usable whole-day accelerometer record. The comparison of the diary data with the camera and accelerometer records strongly supports the use of diary methodology at both the aggregate (sample) and individual levels. It provides evidence that time-use data could be used to complement physical activity questionnaires for providing population-level estimates of physical activity. It also implies new opportunities for investigating techniques for calibrating metabolic equivalent of task (MET) attributions to daily activities using large-scale, population-representative time-use diary studies
Perturbative Expansion around the Gaussian Effective Potential of the Fermion Field Theory
We have extended the perturbative expansion method around the Gaussian
effective action to the fermionic field theory, by taking the 2-dimensional
Gross-Neveu model as an example. We have computed both the zero temperature and
the finite temperature effective potentials of the Gross-Neveu model up to the
first perturbative correction terms, and have found that the critical
temperature, at which dynamically broken symmetry is restored, is significantly
improved for small value of the flavour number.Comment: 14pages, no figures, other comments Typographical errors are
corrected and new references are adde
Densin-180 controls the trafficking and signaling of L-type voltage-gated Ca_v 1.2 Ca^(2+) channels at excitatory synapses
Voltage-gated Ca_v1.2 and Ca_v1.3 (L-type) Ca^(2+) channels regulate neuronal excitability, synaptic plasticity, and learning and memory. Densin-180 (densin) is an excitatory synaptic protein that promotes Ca^(2+)-dependent facilitation of voltage-gated Ca_v1.3 Ca^(2+) channels in transfected cells. Mice lacking densin (densin KO) exhibit defects in synaptic plasticity, spatial memory, and increased anxiety-related behaviors --phenotypes that more closely match those in mice lacking Ca_v1.2 than Ca_v1.3. Thus, we investigated the functional impact of densin on Ca_v1.2. We report that densin is an essential regulator of Ca_v1.2 in neurons, but has distinct modulatory effects compared to its regulation of Ca_v1.3. Densin binds to the N-terminal domain of Ca_v1.2 but not Ca_v1.3, and increases Ca_v1.2 currents in transfected cells and in neurons. In transfected cells, densin accelerates the forward trafficking of Ca_v1.2 channels without affecting their endocytosis. Consistent with a role for densin in increasing the number of postsynaptic Ca_v1.2 channels, overexpression of densin increases the clustering of Ca_v1.2 in dendrites of hippocampal neurons in culture. Compared to wild-type mice, the cell-surface levels of Ca_v1.2 in the brain as well as Ca_v1.2 current density and signaling to the nucleus are reduced in neurons from densin KO mice. We conclude that densin is an essential regulator of neuronal Ca_v1 channels and ensures efficient Ca_v1.2 Ca^(2+) signaling at excitatory synapses
White Dwarfs in Globular Clusters: HST Observations of M4
Using WFPC2 on the Hubble Space Telescope, we have isolated a sample of 258
white dwarfs (WDs) in the Galactic globular cluster M4. Fields at three radial
distances from the cluster center were observed and sizeable WD populations
were found in all three. The location of these WDs in the color-magnitude
diagram, their mean mass of 0.51()M, and their luminosity
function confirm basic tenets of stellar evolution theory and support the
results from current WD cooling theory. The WDs are used to extend the cluster
main-sequence mass function upward to stars that have already completed their
nuclear evolution. The WD/red dwarf binary frequency in M4 is investigated and
found to be at most a few percent of all the main-sequence stars. The most
ancient WDs found are about 9 Gyr old, a level which is set solely by the
photometric limits of our data. Even though this is less than the age of M4, we
discuss how these cooling WDs can eventually be used to check the turnoff ages
of globular clusters and hence constrain the age of the Universe.Comment: 46 pages, latex, no figures included, figures available at
ftp://ftp.astro.ubc.ca/pub/richer/wdfig.uu size 2.7Mb. To be published in the
Astrophysical Journa
Variational quantum Monte Carlo study of two-dimensional Wigner crystals: exchange, correlation, and magnetic field effects
The two-dimensional Wigner crystals are studied with the variational quantum
Monte Carlo method. The close relationship between the ground-state
wavefunction and the collective excitations in the system is illustrated, and
used to guide the construction of the ground-state wavefunction of the strongly
correlated solid. Exchange, correlation, and magnetic field effects all give
rise to distinct physical phenomena. In the absence of any external magnetic
field, interesting spin-orderings are observed in the ground-state of the
electron crystal in various two-dimensional lattices. In particular,
two-dimensional bipartite lattices are shown not to lead necessarily to an
antiferromagnetic ground-state. In the quantum Hall effect regime, a strong
magnetic field introduces new energy and length scales. The magnetic field
quenches the kinetic energy and poses constraints on how the electrons may
correlate with each other. Care is taken to ensure the appropriate
translational properties of the wavefunction when the system is in a uniform
magnetic field. We have examined the exchange, intra-Landau-level correlation
as well as Landau-level-mixing effects with various variational wavefunctions.
We also determine their dependences on the experimental parameters such as the
carrier effective mass at a modulation-doped semiconductor heterojunction. Our
results, when combined with some recent calculations for the energy of the
fractional quantum Hall liquid including Landau-level-mixing, show
quantitatively that in going from -doping to -doping in
heterojunction systems, the crossover filling factor from the fractional
quantum Hall liquid to the Wigner crystal changes from filling factor to . This lends strong support to the claim that theComment: LaTex file, 14 figures available from [email protected]
Методи управління екологічними ризиками в системі забезпечення економічного розвитку регіону
Метою статті є дослідження методів управління екологічними ризиками в системі забезпечення економічного розвитку регіону
Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals
Electron microscope studies have shown that the switched-off state of myosin II in muscle involves intramolecular interaction between the two heads of myosin and between one head and the tail. The interaction, seen in both myosin filaments and isolated molecules, inhibits activity by blocking actin-binding and ATPase sites on myosin. This interacting-heads motif is highly conserved, occurring in invertebrates and vertebrates, in striated, smooth, and nonmuscle myosin IIs, and in myosins regulated by both Ca(2+) binding and regulatory light-chain phosphorylation. Our goal was to determine how early this motif arose by studying the structure of inhibited myosin II molecules from primitive animals and from earlier, unicellular species that predate animals. Myosin II from Cnidaria (sea anemones, jellyfish), the most primitive animals with muscles, and Porifera (sponges), the most primitive of all animals (lacking muscle tissue) showed the same interacting-heads structure as myosins from higher animals, confirming the early origin of the motif. The social amoeba Dictyostelium discoideum showed a similar, but modified, version of the motif, while the amoeba Acanthamoeba castellanii and fission yeast (Schizosaccharomyces pombe) showed no head-head interaction, consistent with the different sequences and regulatory mechanisms of these myosins compared with animal myosin IIs. Our results suggest that head-head/head-tail interactions have been conserved, with slight modifications, as a mechanism for regulating myosin II activity from the emergence of the first animals and before. The early origins of these interactions highlight their importance in generating the inhibited (relaxed) state of myosin in muscle and nonmuscle cells
UV and FIR selected star-forming galaxies at z=0: differences and overlaps
We study two samples of local galaxies, one is UV (GALEX) selected and the
other FIR (IRAS) selected, to address the question whether UV and FIR surveys
see the two sides ('bright' and 'dark') of the star formation of the same
population of galaxies or two different populations of star forming galaxies.
No significant difference between the L () luminosity
functions of the UV and FIR samples is found. Also, after the correction for
the `Malmquist bias' (bias for flux limited samples), the FIR-to-UV ratio v.s.
L relations of the two samples are consistent with each other. In the
range of 9 \la \log(L_{tot}/L_\sun) \la 12, both can be approximated by a
simple linear relation of \log (L_{60}/L_{FUV})=\log(L_{tot}/L_\sun)-9.66.
These are consistent with the hypothesis that the two samples represent the
same population of star forming galaxies, and their well documented differences
in L and in FIR-to-UV ratio are due only to the selection effect. A
comparison between the UV luminosity functions shows marginal evidence for a
population of faint UV galaxies missing in the FIR selected sample. The
contribution from these 'FIR-quiet' galaxies to the overall UV population is
insignificant, given that the K-band luminosity functions (i.e. the stellar
mass functions) of the two samples do not show any significant difference.Comment: 21 pages, 7 figures. Accepted by Ap
Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy.
TRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD). The cross-sectional data from this large well-characterized dataset provide the opportunity to improve our knowledge of how the underlying neuropathology of HD may contribute to the clinical manifestations of the disease across the spectrum of premanifest (PreHD) and early HD. Two hundred and thirty nine gene-positive subjects (120 PreHD and 119 early HD) from the TRACK-HD study were included. Using voxel-based morphometry (VBM), grey and white matter volumes were correlated with performance in four domains: quantitative motor (tongue force, metronome tapping, and gait); oculomotor [anti-saccade error rate (ASE)]; cognition (negative emotion recognition, spot the change and the University of Pennsylvania smell identification test) and neuropsychiatric measures (apathy, affect and irritability). After adjusting for estimated disease severity, regionally specific associations between structural loss and task performance were found (familywise error corrected, P < 0.05); impairment in tongue force, metronome tapping and ASE were all associated with striatal loss. Additionally, tongue force deficits and ASE were associated with volume reduction in the occipital lobe. Impaired recognition of negative emotions was associated with volumetric reductions in the precuneus and cuneus. Our study reveals specific associations between atrophy and decline in a range of clinical modalities, demonstrating the utility of VBM correlation analysis for investigating these relationships in HD
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