A Case of Suspected Isotretinoin-Induced Malformation in a Baby of a Mother Who Became Pregnant One Month after Discontinuation of the Drug

Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotreinoin are needed

Fractional exhaled nitric oxide measurements in rhinitis and asthma in children.

Exaled nitric oxide (FeNO) is considered a good noninvasive marker to assess airway inflammation in asthma and allergic rhinitis. In asthma, exhaled NO is very useful to verify adherence to therapy, and to predict upcoming asthma exacerbations. It has been also proposed that adjusting anti-inflammatory drugs guided by the monitoring of exhaled NO, could improve overall asthma control. Other studies showed increased FeNO levels in subjects with allergic rhinitis

High intrinsic biosorption efficiency of cattle manure on Cr(VI): a potential low-cost fibre-rich biosorbent

Fibre-rich manure derived from grass-fed cattle showed significantly higher intrinsic sorption efficiency on Cr(VI) solution as compared to corncob, sawdust and cogon grass. This observation could be attributed to the ligneous nature and rough surface morphology of the cattle manure. Four-factor, three-level, face-centred composite design (FCCD) suggested the process was greatly affected by initial pH of the solution, contact time and sorbent dosage (p50% adsorption efficiency. It is predicted that both physisorption and chemisorption are involved in the sorption process

Physicochemical and sensory analyses of high fibre bread incorporated with corncob powder

The primary objectives of the present work were to produce corncob powder (CCP) from corncobs and incorporate the CCP into bread formulation in order to develop high fibre bread, and to investigate the physicochemical and sensory properties of the produced high fibre bread (HFB). The corncobs were collected and washed before they underwent the grinding and drying processes. The obtained CCP was incorporated into the bread formulation in three different proportions (5, 10 and 20%) to partially substitute bread flour in the formulation. All three bread samples and the control (0% CCP in the formulation) were analysed to obtain their physicochemical and sensory properties. The incorporation of CCP significantly affected the texture, colour and volume attributes of the produced breads. Increasing the content of CCP in the formulation was found to be responsible for firmer, smaller and darker bread loaves as compared to the composite bread samples. The bread formulation incorporated with 10% CCP had the highest mean scores (7.00) of overall acceptability among all the other formulations, and it was comparable to the commercial breads in the current market

A Case of Postoperative Tuberculous Spondylitis with a Bizarre Course

Postoperative infections following spine surgery are usually attributable to bacterial organisms. Staphylococcus aureus is known to be the most common single pathogen leading to this infection, and the number of infections caused by methicillin-resistant Staphylococcus aureus is increasing. However, there is a paucity of literature addressing postoperative infection with Mycobacterium tuberculosis. We encountered a case of tuberculous spondylitis after spine surgery. A man had fever with low back pain three weeks after posterior interbody fusion with instrumentation for a herniated intervertebral disc at the L4-L5 level. He had been treated with antibiotics for an extended period of time under the impression that he had a bacterial infection, but his symptoms and laboratory data had not improved. Polymerase chain reaction for Mycobacterium tuberculosis turned out to be positive. The patient's symptoms finally improved when he was treated with antituberculosis medication

Интернационализация подготовки научных кадров в развитых европейских странах:проблемы и уроки

Показаны формы международного сотрудничества в рамках интернационализации докторского образования, стратегии интернационализации высшего образования в целом и докторского в частности. Описан накопленный опыт, сформулированы основные уроки и полезные идеи, вытекающие из него.Показано форми міжнародного співробітництва у рамках інтернаціоналізації докторської освіти, стратегії інтернаціоналізації вищої освіти загалом та докторської зокрема. Описано накопичений досвід, сформульовано основні уроки та корисні ідеї, що випливають з нього.Forms of international cooperation in internationalization of doctoral education, strategies of internationalization in higher education in general and doctoral education in particular are shown. Experiences accumulated in this field are described; main lessons and useful ideas born from the experiences are outlined