Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Рredictors of behavioral strategy choice among Russians in intercultural conflict

The article describes the main results of the study investigating the predictors of the behavioral strategy choice among Russians in an imaginary conflict with a representative of the North Caucasus ethnic groups. The theoretical and methodological basis of the research includes the dual concern model, the refined theory of personal values by S. Schwartz and the concept of intergroup anxiety by W. Stefan and C. Stefan. As the predictors of the behavioral strategy choice in a conflict, following personal values were considered: Openness to change, Conservation, Self-Transcendence and Self-Enhancement. The role of intergroup anxiety was tested as a moderator affecting the link between values and behavior in the conflict. Cultural identity and self-esteem were considered as control variables. The study involved 214 ethnic Russians living in Russia (73 men, 141 women, age M = 31.96, SD = 10.21). Respondents were involved in the study helping by “snowball” method. The following methods were used: Organizational Conflict Inventory by M. Rahim in the modification of J. Oetzel, PVQ-R by S. Schwartz, the intercultural communication apprehension scale by J. Neulep and D. McKrosky, and the certain scales from the MIRIPS questionnaire. The results of the path analysis showed that the choice of the competing is positively related to the values of Self-Enhancement and is negative with the values of Self-Transcendence. The choice of collaborating strategy has a positive relation with the values of Self-Transcendence and Openness to change. The choice of an avoiding strategy is positively related to the values of Conservation and intergroup anxiety. The choice of the accommodating did not reveal a significant influence of values but this strategy is in positive connection with cultural identity and in a negative connection with self-esteem. Intergroup anxiety is a moderator of the relationship between the value of Openness to change and the collaborating strategy. The obtained results can be used in the development of recommendations in the field of intercultural communication and in the settlement of intercultural conflicts

Impact of Parents' Motivation for Ethnocultural Continuity and Acculturation Strategies on Acculturation of Children in Russian Families in Latvia

The paper presents outcomes of an empirical research on the relationship between motivation for ethnocultural continuity and acculturation strategies in ethnocultural minorities (with Russians in Latvia as an example). Since acculturation is a process that affects several generations, we adopted a research plan that involved representatives of two generations of a family (parents and children). 112 Russian families participated in the research (parents: N=112, age 35—59, Me=42; children: N=112, age 16—24, Me=17). A questionnaire we used included J. Berry's acculturation strategies, scales of satisfaction with life and oneself, and the Motivation for Ethnocultural Continuity scale by C. Ward. The employed structural modeling revealed that acculturation strategies of the children correlate significantly with those of their parents as well as with their own motivation for ethnicultural continuity. The adolescents' choice of integration strategy is positively related to their satisfaction with themselves; however, in the cases of marginalization and assimilation this relation is negative

Sr-Nd-Pb isotopic systematic and geochronology of ultramafic alkaline magmatism of the southwestern margin of the Siberian Craton: Metasomatism of the sub-continental lithospheric mantle related to subduction and plume events

© 2020 To provide new insights into the origin and evolution of ultramafic lamprophyres (UMLs) and their mantle source, we examined two UML (aillikite and damtjernite) occurrences of different ages in the western portion of the Siberian Craton (Ilbokich and Chadobets). New age, mineral and rock geochemistry, along with Sr–Nd–Pb–C–O isotope data was obtained. Our new 206Pb/238U perovskite age (399 ± 4 Ma) confirms the previously published Early Devonian age of the Ilbokich aillikite. Rb[sbnd]Sr isochron and 40Ar/39Ar dating yielded a Middle Triassic age (243 ± 3 Ma and 241 ± 1 Ma, respectively) for the Chadobets aillikites, indicating post-Trap emplacement of these rocks. Both UMLs are characterized by incompatible elements, including light rare earth element (LREE) enrichments (La is up to ×200 chondrite concentration), and strong fractionation of REEs ((La/Yb)n: 33–84). Despite the close geochemical affinity of both UMLs, the Nd isotopic compositions of aillikites, as well as the Pb isotopic composition of Chadobets and Ilbokich UMLs, do not overlap and are distinctly different from each other. The initial Sr and Nd isotopic compositions of the Ilbokich UMLs fall in within a narrow 87Sr/86Sr0 range (0.7032–0.7042) and εNd(T) (4.03–3.97). Chadobets UMLs have a similar Sr isotopic signature (87Sr/86Sr0: 0.7031–0.7043) and a more depleted Nd isotopic signature (εNd(T) 4.09–5.08). The initial Pb isotope compositions of the Chadobets UMLs are moderately radiogenic, ranging between 206Pb/204Pb = 18.4–19.0, 208Pb/204Pb = 38.3–38.8, and are characterized by a narrow 207Pb/204Pb ratio between 15.5 and 15.6. The Ilbokich Pb isotope compositions are less variable and range between 206Pb/204Pb = 18.0–18.4, 208Pb/204Pb = 37.8–38.4 and 207Pb/204Pb ratios between 15.5 and 15.6. The oxygen isotopic composition of carbonate from both UMLs is characterized by highly variable δ18O values from +12.1 and up to +20.5‰ (SMOW). The isotopic composition of δ13C values range from −1.3‰ to −7.1. Based on the minor impact of crustal contamination in both aillikites, it is inferred that their radiogenic isotope composition reflects a mantle source signature. The mantle source of the Chadobets aillikites is likely to include carbonatitic magma as a metasomatic agent. In contrast, phlogopite-rich metasomes within the lithospheric mantle could have contributed more significantly to the Ilbokich aillikites. These metasomes could be formed during the Caledonian orogeny, which did not only affect the southwestern boundary of the Siberian Craton, but also expanded to the craton interior. This study provides additional support for the evolution of the south-western portion of the Siberian SCLM, ranging from mantle containing phlogopite enrichment domains during the Early Devonian to hydrous-phase reduced mantle in the Triassic due to the thermal impact of the Siberian Traps