Human Papillomavirus Awareness, Vaccine Status, and Risk Factors in Female Emergency Patients

Introduction: A vaccine targeting high-risk human papillomavirus (HPV) strains can effectively prevent HPV-associated cervical cancer risk. However, many girls and women do not receive the vaccine, more often those impacted by health disparities associated with race and/or socioeconomic status. This same disparate population has also been shown to be at higher risk for cervical cancer. Many of these women also rely on the emergency department (ED) as a safety net for their healthcare. This study sought to gather information pertaining to HPV and cervical cancer risk factors, awareness of HPV and the vaccine, as well as HPV vaccine uptake in female patients presenting to an ED.Methods: We obtained 81 surveys completed by female ED patients. Demographics included age, race, income, insurance status, primary care provider status, and known cervical-cancer risk factors. Subsequent survey questions explored respondents’ knowledge, familiarity, and attitudes regarding HPV, cervical cancer, and the HPV vaccine, including vaccination uptake rates. We analyzed data using descriptive statistics and Fisher’s exact test.Results: Approximately one in seven respondents (14.8%) had never previously heard of HPV and 32.1% were unaware of the existence of a HPV vaccine. Minority patients, including those who were Black and Hispanic patients, low income patients, and uninsured and publicly insured patients were less likely to be aware of HPV and the vaccine and likewise were less likely to be offered and receive the vaccine. More than 60% of all respondents (61.3%) had never previously been offered the vaccine, and only 24.7% of all respondents had completed the vaccine series.Conclusion: Female ED patients may represent an at-risk cohort with relatively low HPV awareness and low HPV vaccine uptake. The ED could represent a novel opportunity to access and engage high-risk HPV populations

Measuring the conservation attitudes of local communities towards the African elephant Loxodonta africana, a flagship species in the Mara ecosystem.

Gaining insights into local people's views, values and preferences for different conservation management options are increasingly gaining importance among conservationists and decision-makers. This can be achieved through the assessment and understanding of conservation attitudes and perceptions of rural communities including demographic characteristics predicting the attitudes to design and implement conservation policies in a more socially acceptable manner. In this study, we developed and validated user-friendly indices to measure attitudes towards the African elephant, a flagship species and its conservation in Trans Mara District. An iterative item reliability analysis was executed on household data from a random sample of 367 respondents using Cronbach's Alpha in SPSS. Results yielded two indices; (i) Elephant Attitude Index (EAI); and (ii) Maasai Mara National Reserve Attitude Index (MAI). The EAI had a Cronbach's Alpha coefficient of 0.73 while the MAI had a Cronbach's Alpha coefficient of 0.77. Data analysis revealed that (i) location of residence; (ii) age of respondent; (iii) number of income sources; (iv) gender of the respondent; and (v) benefit reception were the main determinants of EAI and MAI in TM. Our attitude indices can assist conservation practitioners and decision-makers to prioritise resources, on the assumption that high-scoring individuals are more likely to participate in conservation initiatives. We encourage making available different sources of income for residents and working towards improving the involvement of younger people and women in conservation activities in TM

POWER UP: A Persuasive Writing Strategy for Secondary Students with Emotional and Behavioral Disorders

In the area of written expression, students with emotional and behavioral disorders (EBD) typically perform one to two grades below their same age, non-disabled peers. Unfortunately, there is a lack of research on writing interventions to improve these outcomes. The purpose of this study was to examine the effect of a persuasive writing strategy called POWER UP to improve the quality of persuasive essays for secondary students with EBD. The results suggest that a mnemonic strategy based on the Self-Regulated Strategy Development Model (SRSD) can improve the quality of persuasive writing essays for secondary students with EBD

Examining Inclusive Practices in Nicaraguan Schools

The purpose of this study was to examine Nicaraguan teachers’ efficacy for inclusive practices and current teaching practices in Nicaraguan schools as the first step in developing a special education training program. Sixty-one teachers in 15 schools completed the Teacher Efficacy of Inclusive Practice (TEIP) survey to determine their confidence in inclusive practices, collaboration and dealing with disruptive behaviors. Classroom observations were also completed to examine the environment, teaching/ learning strategies, student behaviors, learning materials, and time distribution in the classroom. Results from the TEIP indicated Nicaraguan teachers were highly efficacious in inclusive practices. The survey and observation data collected provided a baseline to develop goals and objectives for a two-year special education training

Valuing and judging investments in electric vehicle chargepoints “in the wild”

The impact of Climate Change has accelerated technological advancements in vehicles in an effort to reduce effects. One such technology, is the introduction of alternative modes of transport, namely in the shape of the Electric Vehicle. A chargepoint is a new piece of technology, needed to support the transition to EVs. There are three actors vital to chargepoint installation: service providers, service hosts, and service users. These three actors will hold different valuation and judgement systems, which will influence the success of a chargepoint. This project has investigated the valuation and evaluation of chargepoints, namely its value, as a service, as a concept, and as an opportunity to fulfil a green agenda. These perspectives are particularly influenced by context, and this project has been in partnership with a service provider, Charge My Street, a community benefit society installing chargepoints in underserved locations in Cumbria. Understanding the different valuation and judgement systems at play between the three actors is key to understanding the value produced at chargepoints, both physically and conceptually. Defining value is difficult, as it often relates to contemporary capitalism, this research has extended the scope for value beyond the capitalistic perspective of ‘worth’. The project has identified the different decision tools used by service hosts to install a chargepoint, specifically the collision of values including social, environmental, and economic. Tools such as visualisations of value, ZapMap, and community creation, could improve the success of chargepoint installation for service providers such as Charge My Street. Using an autoethnographic perspective, interviews, and twelve months immersed in the role as a service provider, has informed on the different valuation systems produced by the actors, the impactful calculative agencies which inform on decision processes, and how those involved perceive the chargepoint and its value

Bringing the Tiger Back from the Brink—The Six Percent Solution

This article does not have an abstract

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015:a systematic review and modelling study

Background: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. Methods: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. Findings: We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6–50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7–3·8) hospital admissions, and 59 600 (48 000–74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2–1·7) hospital admissions, and 27 300 (UR 20 700–36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600–149 400). Incidence and mortality varied substantially from year to year in any given population. Interpretation: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group