243 research outputs found
Haematological and pathological findings of pigs experimentally inoculated with a Chilean isolate of porcine reproductive and respiratory syndrome virus
The aims of this study were to characterize the haematological and bone marrow changes, gross and microscopic lesions of pigs
experimentally inoculated with the Chilean isolate of porcine reproductive and respiratory syndrome virus. Twelve 3-week-old pigs
were divided in 4 groups of 3, one of which corresponded to the negative control group sacrificed at 0 days post-inoculation (dpi),
and the 3 remaining groups corresponded to the inoculated pigs sacrificed at 7, 14 and 21 dpi. For each sampling period blood was
collected for complete haemograme and at the necropsy time gross lesions were registered and samples for both bone marrow smears
and histopathology were taken. The results of this study revealed haematological alterations characterized by a significant reduction
(P<0.05) in the haematocrit and a significant increase (P<0.05) in the total leukocyte count associated with an increase in the
monocytes and baciliforms. The bone marrow did not show significant variations in the ratio of myeloid to erythroid cells (P>0.05).
At the same time, the gross lesions were mild and mainly characterized by the presence of conjunctivitis, periocular edema and a
slight increase in the size of the lymph nodes. Microscopic lesions were characterized by the presence of interstitial pneumonia,
depletion and necrosis in lymphoid organs, rhinitis, hepatitis, myocarditis and non-purulent encephalitis. These findings suggest that
the Chilean isolate of the vPRRS to a strain with a low virulenc
Strong tunable coupling between a superconducting charge and phase qubit
We have realized a tunable coupling over a large frequency range between an
asymmetric Cooper pair transistor (charge qubit) and a dc SQUID (phase qubit).
Our circuit enables the independent manipulation of the quantum states of each
qubit as well as their entanglement. The measurements of the charge qubit's
quantum states is performed by resonant read-out via the measurement of the
quantum states of the SQUID. The measured coupling strength is in agreement
with an analytic theory including a capacitive and a tunable Josephson coupling
between the two qubits.Comment: 5 page
Coherent frequency conversion in a superconducting artificial atom with two internal degrees of freedom
By adding a large inductance in a dc-SQUID phase qubit loop, one decouples
the junctions' dynamics and creates a superconducting artificial atom with two
internal degrees of freedom. In addition to the usual symmetric plasma mode
({\it s}-mode) which gives rise to the phase qubit, an anti-symmetric mode
({\it a}-mode) appears. These two modes can be described by two anharmonic
oscillators with eigenstates and for the {\it s}
and {\it a}-mode, respectively. We show that a strong nonlinear coupling
between the modes leads to a large energy splitting between states
and . Finally, coherent frequency
conversion is observed via free oscillations between the states
and
Genes Suggest Ancestral Colour Polymorphisms Are Shared across Morphologically Cryptic Species in Arctic Bumblebees
email Suzanne orcd idCopyright: © 2015 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Patrimoine de marque : le passé au service du management de la marque
Researchers and practitioners talk about brand heritage even though its meaning and its difference from related concepts are not entirely clear. Through a review of the multidisciplinary literature, this article distinguishes brand heritage from the concepts of inheritance, retro, nostalgia, and authenticity. This article defines brand heritage as a dynamic construct based on an inherited or borrowed past, with a view to supporting brand identity and being transmitted. A total of 11 research propositions are presented within an inclusive framework that paves the way for future research and contributes to research on brand management and the role of consumers in creating value
The Role of Phosphatidic Acid and Cardiolipin in Stability of the Tetrameric Assembly of Potassium Channel KcsA
In this study, the roles of two anionic phospholipids—phosphatidic acid (PA), which is an important signaling molecule, and cardiolipin (CL), which plays a crucial role in the bioenergetics of the cell—in stabilizing the oligomeric structure of potassium channel KcsA were determined. The stability of KcsA was drastically increased as a function of PA or CL content (mol%) in phosphatidylcholine (PC) bilayers. Deletion of the membrane-associated N terminus significantly reduced channel stability at high levels of PA content; however, the intrinsic stability of this protein was marginally affected in the presence of CL. These studies indicate that the electrostatic-hydrogen bond switch between PA and N terminus, involving basic residues, is much stronger than the stabilizing effect of CL. Furthermore, the unique properties of the PA headgroup alter protein assembly and folding properties differently from the CL headgroup, and both lipids stabilize the tetrameric assembly via their specific interaction on the extra- or the intracellular side of KcsA
- …