Design and characterisation of food grade powders and inks for microstructure control using 3D printing

Additive Manufacturing techniques have been previously applied to food materials with direct consumption in mind, as opposed to creating structural ingredients as shown in this study. First, semi-crystalline cellulose was mechanically treated by ball milling to render an amorphous powder, which has been characterised. Requirements for the subsequent recrystallization of this powder with a view to structuring have been determined through the control of moisture and thermal energy. Food inks based on xanthan gum have been formulated to enable successful jetting with a FujiFilm Dimatix ink jet printer. The polymer inks were subsequently jetted onto the amorphous cellulose powder to observe powder-binder interactions. Material combinations and parameters were optimised to produce cohesive geometric structures. The results of this study are promising when looking towards using these materials in a binder jetting additive manufacturing technique using designer particles and inks to create structures for use in food products

Printability, microstructure, and flow dynamics of phase-separated edible 3D inks

Personalizing the nutrition and sensorial attributes of 3D printed foods primarily requires various multiscale properties to be individually tailored. Herein, multiscale inks are produced by segregative phase separation, a candidate for further 3D inks texture control, of gellan gum (GG), and whey protein isolate (WPI). The inks microstructure, rheological properties, flow dynamics, their impact on printability, and properties-variables interactions are analyzed using experimental design and clustering. The gels are a GG matrix structured with WPI beads or fibers ranging from 100??m in diameter. A straightforward, six-step printability test determines that high-quality prints require increasing viscosity, which is obtained by reducing the size and length of the WPI beads. Also, flow dynamics and rheology models predict the shear stress and extrusion force, according to the print settings and food-inks fluid properties. The phase-separated inks enable printing at high speed (>25/50?mm/s) upon low extrusion forces (<50?N) and low shear stresses (<500?Pa), according to the calculations and model validation. These printability evaluation methodologies and fabrication of phase-separated inks are particularly interesting for 3D food printing, bioprinting, or biomaterials applications.Nanotechnology-based functional solutions project, funded by ERDF and CCDR-N, under the call Norte2020 (Ref. NORTE-01-0145-FEDER-000019) and Enhance Microalgae (High added-value industrial opportunities for microalgae in the Atlantic Area), funded by ERDF, under the Call Interreg Atlantic Area 2014–2020 (Ref. EAPA_338/2016)info:eu-repo/semantics/publishedVersio

Intérêt du dossier pharmaceutique lors de la rétrocession dans un Centre de Lutte Contre le Cancer : contribution dans l’analyse des interactions médicamenteuses

Largement déployé, le dossier pharmaceutique (DP) contribue à sécuriser la prise en charge médicamenteuse du patient sous chimiothérapie orale, lorsqu’elle est dispensée à l’hôpital et tracée. Notre objectif est de mettre en place le DP en rétrocession, d’évaluer sa contribution comme support à l’analyse des interactions (IAM) et d’estimer la pérennité de cette démarche.Notre étude prospective, descriptive et monocentrique a été menée pendant 5 mois. Tous les patients venant en rétrocession étaient éligibles. Après leur avoir proposé le DP et l’avoir alimenté, des IAM ont été recherchées à l’aide de 7 sources. Si l'impact était considéré comme significatif, une intervention pharmaceutique était transmise au médecin référent de l’établissement et enregistrée dans le dossier patient informatisé.Le DP a été proposé à 497 patients âgés en moyenne de 63 ans, soit 87% des patients éligibles. Lors de la 1ère rencontre, seuls 34 patients connaissaient le DP et 358 en avaient un d’ouvert. Au total, 395 DP ont été incrémentés au moins une fois, dont 41 que nous avons créés. Un quart des rétrocessions n’a pas été tracé et 419 ordonnances ont été analysées. Au total, 99 IAM à risque ont été détectées avec le médicament rétrocédé, principalement avec le posaconazole. Drugs® est la source la plus pertinente. Cette démarche prend de 1min à 1h. Facile à mettre en place, le DP est un outil intéressant pour identifier les IAM en rétrocession. Pour garantir la pérennité de cette démarche, la recherche des IAM est à présent réservée aux initiations de traitement. La présentation du DP a aussi permis d’ouvrir le dialogue avec le patient, notamment sur les produits complémentaires

Fertilité après embolisation des artères utérines pour hémorragie du post-partum

PARIS-BIUM (751062103) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocSudocFranceF

Développement de pseudoparticules rétrovirales dérivées du virus de la fièvre hémorragique de Crimée-Congo

LYON1-BU Santé (693882101) / SudocSudocFranceF

Contraintes réglementaires liées à l'utilisation des rayonnements ionisants en pratique médicale

LYON1-BU Santé (693882101) / SudocRENNES1-BU Santé (352382103) / SudocSudocFranceF

A review of melioidosis cases imported into Europe

WOS:000476492200003Melioidosis is a tropical bacterial infection, rarely encountered, and poorly known by clinicians. In non-endemic areas, a misdiagnosis can lead to a fatal outcome. This study aims to identify the main characteristics of imported and diagnosed melioidosis cases in Europe to increase clinician's awareness of this diagnosis. A literature review of imported and diagnosed human melioidosis cases in Europe was performed. PubMed and Web of Science search engines were used for retrieving articles from 2000 to November 2018. Seventy-seven cases of imported melioidosis into Europe described in the literature were identified. More than half of the cases were acquired in Thailand (53%) by men (73%). Patients were usually exposed to Burkholderia pseudomallei during a holiday stay (58%) of less than 1 month (23%) and were hospitalized during the month following their return to Europe (58%). Among travelers, melioidosis is less often associated with risk factor (16%), diabetes being the most frequently comorbidity related (19%). The clinical presentation was multifaceted, pneumonia being the most common symptom (52%), followed by cardiovascular form (45%) and skin and soft tissues damages (35%). The diagnosis was obtained by culture (92%), often supplemented by morphological, biochemical, and molecular identification (23%). Misdiagnoses were common (21%). Over half of the patients received a complete and adapted treatment (56%). Mortality is lower for returning traveler (6%). Imported melioidosis cases into Europe have their own characteristics. This possibility should be considered in patients with pneumonia, fever, and/or abscess returning from endemic areas even years after