El espacio arquitectónico frente al espacio perspectivo. La Iglesia Parroquial de la Inmaculada Concepción en Huelma, obra experimental de Andrés de Vandelvira

[EN] The architectural space, compared to the space in painting, in addition to working with the rules of perspective, has to respond to technical and executive requirements linked to the process of implementation.There are many examples that we can point out from the study of the main sacred works of the south of the peninsula in the 16th century; although, within the contributions of Vandelvira, due to its experimental nature, it is worth mentioning the proposal for the church of Huelma, modifying the course of the works that had been started by Francisco del Castillo “el viejo”. For this reason, in this paper, we will review the geometric, spatial, technical and constructive concepts that, from an abstract point of view, could be found in this work for a better understanding of the thinking of these great masters, where Vandelvira has a prominent place.[ES] El espacio arquitectónico, a diferencia del pictórico, además de enfrentarse a las reglas de composición exigidas por la perspectiva, tiene que responder frente a requerimientos técnicos y ejecutivos vinculados con el proceso de puesta en obra.Son muchos los ejemplos que podemos extraer a partir del estudio de las principales realizaciones sacras del sur peninsular en el XVI; si bien, dentro de las aportaciones de Vandelvira, por su carácter experimental, merece la pena pausarnos sobre la propuesta proyectada por el maestro en la iglesia de Huelma, modificando el rumbo de los trabajos que habían sido iniciados por Domingo de Tolosa y Francisco del Castillo “el viejo”. Así, en este artículo, revisaremos los conceptos geométricos, espaciales, técnicos y constructivos que, desde un posicionamiento abstracto, cabrían ser extraídos de esta obra para, después, comprender mejor la forma de pensar de estos grandes maestros, entre los que ocupa una silla destacada Andrés de Vandelvira.Estepa Rubio, A.; Estepa Rubio, J.; León Torres, FJ. (2021). Architectural space versus perspective space. The church of the Immaculate Conception in Huelma as an experimental work by Andrés de Vandelvira. EGA Expresión Gráfica Arquitectónica. 26(42):66-75. https://doi.org/10.4995/ega.2021.14903OJS6675264

Efectos de un programa de entrenamiento de fuerza sobre la composición corporal y la fuerza máxima en jóvenes entrenados

El objetivo de este estudio fue conocer las adaptaciones en composición corporal, fuerza máxima y resistencia muscular local de un programa de entrenamiento de fuerza en circuito intermitente con sobrecargas. Método: Se seleccionaron 8 varones jóvenes entrenados en musculación (24,07 ± 3,12 años, 77,96 ± 7,5 kg, 173 ± 0,2 cm y 14,50 ± 2,00 meses de experiencia). Todos los sujetos firmaron un consentimiento por escrito de participación. Se realizó una valoración antropométrica, 10 tests de una repetición máxima (1RM) y un test de resistencia muscular local. Posteriormente se llevó a cabo un programa de entrenamiento de fuerza de 8 semanas de duración con la característica de ser en circuito intermitente con sobrecargas, 3 veces por semana, entre el 62 y el 72% de 1RM. Pasado este tiempo se realizó una valoración final con las mismas características de la valoración inicial. Resultados: Los resultados mostraron una disminución en los porcentajes de grasa corporal en torno al 9,46%, mejoras en fuerza máxima en torno al 3-31% según el grupo muscular, y un aumento en la resistencia muscular local del 1,42%. Conclusiones: El entrenamiento en circuito intermitente con sobrecargas tras 8 semanas de duración ofrece adaptaciones a nivel de composición corporal, de fuerza máxima y resistencia muscular local para sujetos entrenados. Aunque se requieren estudios con muestras más amplias, se presenta como una alternativa de metodología dentro de la sala de musculación.Actividad Física y Deport

Discovery of mature thermogenic hydrocarbons in ferromanganese nodules from the Gulf of Cadiz: a new tool for oil and gas exploration

Ferromanganese nodules were firstly collected during the Tasyo Project cruises from mudcarbonate mounds and mud volcanoes at the Guadalquivir Diapiric Ridge (Central Eastern Atlantic). The mineralogical and geochemical studies have revealed their genesis, linked to the anaerobic oxidation of hydrocarbons and organic matter via bio-mineralization processe

Coronavirus fear of contagion and compliance with social distancing measures: evidence for a sample of a Spanish university community

Background. Social distancing measures have been one of the core pillars of the strategy against COVID-19 in all the countries. This study aims at understanding what motivates behaviours and compliance with social distancing measures among students and workers from a Spanish public university. Methods. We carry out two logistics models considering two different dependent variables: not maintaining social relation with non-cohabiting people and not to leave home except for emergencies (n = 507, sample is formed by students and workers from the University of Cantabria in the North of Spain). Results. Being very concerned about getting ill suggests higher risk of not maintaining social relation with non-cohabiting people. Getting older increase the probability of not leaving home except for emergencies as happens with those who are very concerned about getting ill. Young people often living with vulnerable older relatives may affect students' behaviour. Conclusions. Our findings suggest that compliance with social distancing measures depends on several factors related to age, the number or kind of cohabiting people and level of concern about getting ill. Policies should address all these factors through a multidisciplinary perspective

Guidelines for Conservation and Restoration of Historic PolychromePlasterwork: the Church of St María la Blanca in Seville, Spain

Carrying out an intervention for the conservation and restoration of architectural heritage, focused on the preservation of decorative elements such as polychromed plasterwork, implies following a methodology to study the materials and techniques used in each case to establish an intervention proposal according to the circumstances. This work offers some methodological guidelines necessary to approach the conservation of plasterwork and its polychromies, applied in a recent case study according to the criteria established by the 14th General Assembly of ICOMOS in 2003, the Law 14/2007 of Andalusian Historical Heritage, the Law 16/1985 of the Spanish Historical Heritage, and indications contained in the ECCO Guidelines. The novelty of the paper is that it presents the conservation decisions on a real case from the beginning until the end — showing the entire process and validating the proposed methodology — by using current restoration techniques and digital tools for the reconstruction of plasterwork

Hydrocarbons and biomarkers in mud-breccia sediments from new mud volcanoes discovered in the Gulf of Cadiz: preliminary results

This work presents the preliminary results on hydrocarbons and other biomarkers analyzed in mud-breccia sediments from three new mud volcanoes discovered in the Gulf of Cadiz during the MVSEIS_08 cruise on-board R/VHespérides (ESF EuroCORE-EuroMARGINS programme). Two mud volcanoes are located in the Moroccan Margin and named as Madrid, aligned along a main strike-slip fault; and MVSEIS mud volcano, found at the front of one thrust ridge. The third mud volcano is located in the Spanish Margin and it was named as Gazul, sited at only 380 m water depth, and also related to active fault

La grabación histórica como herramienta para el conocimiento en el aula

Depto. de MusicologíaFac. de Geografía e HistoriaFALSEsubmitte

Distribución actualizada del género Cerambyx Linnaeus, 1758 (Coleoptera: Cerambycidae) en Extremadura: desde los registros históricos al muestreo a escala regional

The genus Cerambyx (Coleoptera: Cerambycidae) includes 13 species with a western Palaearctic distribution, seven present in Europe and four in the Iberian Peninsula, all of them also recorded in Extremadura: C. cerdo Linnaeus, 1758, C. welensii (Küster, 1845), C. miles Bonelli, 1812 and C. scopolii Fuessly, 1775. Larvae are primary xylophagous, tunnelling the living wood of healthy or decayed trees. Like other cerambycids, they are included in the diverse assemblage of saproxylic insects, a functional group essential in wood degradation and biodiversity enhancement. They have also been reported as pests, being able to cause significant physiological, mechanical and structural damages. The impact of xylophagous on oaks in Extremadura has increased alarmingly in recent decades. Damages have usually been attributed to C. welensii, but accumulated evidence shows that this statu quo is unrealistic, and that C. cerdo is also involved in oak decline. The scarce chorological information available prevents risk analysis of the potential impact of these species, being necessary a detailed knowledge of their regional distribution. Thus, 1826 feeding traps (Regional Sampling Network) were placed throughout Extremadura over five years (2017-‍2021) during May-August in holm oak, cork oak and pyrenean oakwoodlands. Traps covered 437 10 × 10 km UTM squares representing an equivalent sampled area of ​​40,430 km2 (97% of Extremadura). Trap records were completed with other unpublished and bibliographic records. The data showed: 1) that records prior to 1980s were occasional, 2) that C. miles and C. scopolii are rare and localized species, 3) that C. welensii is a ubiquitous species, consistent with its pest status, 4) that C. cerdo exhibits a widespread and often abundant distribution, and 5) that distribution and population sizes depended on host tree, highlighting that C. welensii was almost 5 times more abundant than C. cerdo in cork oak, and that C. cerdo was 3-‍4 times more abundant in holm oak than in cork oak or pyrenean oak. Results indicate that damage by large xylophagous in Extremadura oak open woodlands is caused by both C. welensii and C. cerdo, refute that C. cerdo is a rare and threatened species in the region, and suggest that the Habitats Directive requires an urgent reappraisal in order to eliminate or mitigate the conflict of interests between the protection of C. cerdo and that of the dehesa ecosystem in Extremadura.El género Cerambyx (Coleoptera: Cerambycidae) incluye 13 especies con distribución paleártica occidental, siete presentes en Europa y cuatro en la Península Ibérica, todas ellas también registradas en Extremadura: C. cerdo Linnaeus, 1758, C. welensii (Küster, 1845), C. miles Bonelli, 1812 y C. scopolii Fuessly, 1775. Las larvas son xilófagas primarias, perforando la madera viva de árboles sanos o decaídos. Como otros cerambícidos, se incluyen en el diverso ensamble de insectos saproxílicos, un grupo funcional esencial en la degradación de la madera y la potenciación de la biodiversidad. También se han descrito como plagas, pudiendo provocar importantes daños fisiológicos, mecánicos y estructurales. El impacto de los xilófagos en las quercíneas extremeñas ha aumentado alarmantemente en las últimas décadas. Los daños se han atribuido usualmente a C. welensii, pero la evidencia acumulada muestra que este statu quo no es realista, y que C. cerdo contribuye igualmente al decaimiento del arbolado. La escasa información corológica disponible impide efectuar análisis de riesgos del impacto potencial de dichas especies, siendo necesario un conocimiento detallado de su distribución regional. Así, se dispusieron 1826 trampas alimenticias (Red Regional de Muestreo) por toda Extremadura a lo largo de cincoaños (2017-‍2021) durante mayo-agosto en dehesas de encina, alcornoque y melojo. Las trampas cubrieron 437 cuadrículas UTM de 10 × 10 km con una superficie equivalente muestreada de 40.430 km2 (97% de Extremadura). Los registros de las trampas se completaron con otros registros inéditos y bibliográficos. Los datos mostraron: 1) que los registros anteriores a 1980s fueron ocasionales, 2) que C. miles y C. scopolii son especies escasas y localizadas, 3) que C. welensii es una especie ubicua, consistente con su estatus de plaga, 4) que C. cerdo exhibe una distribución generalizada y a menudo abundante, y 5) que la distribución y efectivos poblacionales dependieron del árbol hospedador, destacando que C. welensii fue casi 5 veces más abundante que C. cerdo en alcornoque, y que C. cerdo fue 3-‍4 veces más abundante en encina que en alcornoque o melojo. Los resultados indican que los daños por grandes xilófagos en las dehesas extremeñas tienen como agente causal tanto a C. welensii como a C. cerdo, refutan que C. cerdo es una especie rara y amenazada en la región, y sugieren que la Directiva Hábitats requiere una revisión urgente con el objetivo de eliminar o mitigar el conflicto de intereses entre la protección de C. cerdo y la del ecosistema de dehesa en Extremadura

Clinical follow-up of long nontapered sirolimus-eluting coronary stent in real-world patients with de novo lesions. The Billar registry

Introduction and objectives: Coronary lesions with stent overlapping are associated with higher neointimal proliferation that leads to more restenosis. Furthermore, the tapering of coronary arteries is a major challenge when treating long coronary lesions. This study attempted to assess the safety and clinical level of performance of long nontapered sirolimus-eluting coronary stent systems (> 36 mm) to treat long and diffused de novo coronary lesions in real-world scenarios. Methods: This was a prospective, non-randomized, multicentre study that included 696 consecutive patients treated with the long nontapered BioMime sirolimus-eluting coronary stent system in long and diffused de novo coronary lesions. The safety endpoint was major adverse cardiovascular events defined as a composite of cardiac death, myocardial infarction, clinically driven target lesion revascularization, stent thrombosis, and major bleeding at the 12-month follow-up. Results: Of a total of 696 patients, 38.79% were diabetic. The mean age of all the patients was 64.6 +/- 14 years, and 80% were males. The indication for revascularization was acute coronary syndrome in 63.1%. A total of 899 lesions were identified out of which 742 were successfully treated with long BioMime stents (37 mm, 40 mm, 44 mm, and 48 mm). The cumulative incidence of major adverse cardiovascular events was 8.1% at the 12-month follow-up including cardiac death (2.09%), myocardial infarction (1.34%), and total stent thrombosis (0.5%). Conclusions: This study confirms the safety and good performance of long nontapered BioMime coronary stents to treat de novo coronary stenosis. Therefore, it can be considered a safe and effective treatment for long and diffused de novo coronary lesions in the routine clinical practice

Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease with a wide range of genetic inheritance patterns. The disease-associated gene GDAP1 encodes for a mitochondrial outer membrane protein. Mouse and insect models with mutations in Gdap1 have reproduced several traits of the human disease. However, the precise function in the cell types affected by the disease remains unknown. Here, we use induced-pluripotent stem cells derived from a Gdap1 knockout mouse model to better understand the molecular and cellular phenotypes of the disease caused by the loss-of-function of this gene. Gdap1-null motor neurons display a fragile cell phenotype prone to early degeneration showing (1) altered mitochondrial morphology, with an increase in the fragmentation of these organelles, (2) activation of autophagy and mitophagy, (3) abnormal metabolism, characterized by a downregulation of Hexokinase 2 and ATP5b proteins, (4) increased reactive oxygen species and elevated mitochondrial membrane potential, and (5) increased innate immune response and p38 MAP kinase activation. Our data reveals the existence of an underlying Redox-inflammatory axis fueled by altered mitochondrial metabolism in the absence of Gdap1. As this biochemical axis encompasses a wide variety of druggable targets, our results may have implications for developing therapies using combinatorial pharmacological approaches and improving therefore human welfare.This work was funded by a collaborative joint project awarded by IRDiRC and funded by ISCIII grant IR11/TREAT-CMT, Instituto de Salud Carlos III (to JT and FP). JP was supported by postdoctoral fellowships from Fundación Alfonso Martín Escudero and Generalitat Valenciana (VALi+d 2019 program).Peer reviewe