Neuroarquitectura y la inclusión social de niños con trastorno espectro autista

En la investigacion planteada con cuyo titulo “Neuroarquitectura y la inclusión social de niños con Trastorno espectro autista en el distrito de San Juan de Miraflores 2019 Caso: Centro educativo especial Cerrito Azul” su principal objetivo fue determinar en que relación hay entre la neuroarquitectura y la inclusión social. En forma detallada se quiere analizar el espacio de las aulas y cómo influye en su percepción multisensorial en beneficio para su educación, comportamiento y confort de los niños que padecen trastorno espectro autista en los centros educativos, según la encuesta realizada a los padres de hijos con TEA en San Juan de Miraflores. La investigación que se empleo fue un diseño que es no experimental, descriptivo-correlacional,de tipo cuantitativa y el método que busca es medir los variables que es neuroarquitectura como inclusión social y como contribuye en mejorar los espacios de las aulas educativas, desarrollando el concepto de un ambiente inclusivo. El proceso en el traspaso de los datos que se utilizó fue mediante el SPSS v.24, con una población de 80 alumnos en el centro educativo especial cerrito azul que tienen trastorno espectro autista ,de lo cual se saco un muestreo de 64 encuestados que estan conpuesto de padres de familia que tiene hijos con autsmo en el distrito de San Juan de Miraflores,en lo cual se encuesto acerca de su conocimiento sobre neuroarquitectura para mejorar la inclusión social en los centros educativos se aplicó la escala de Likert. Para demostrar la confiabilidad en el instrumento que se aplico fue el Alpha de Cronbach. Con su fin academico para poder determinar en que grado existe el vinculo de las dos variables dando como resultado 0,886 en lo cual nos demostro que si existe una relacion entre las variables con un sustento hipotetico que se aplicó

Estudio de prefactibilidad para la instalación de una planta productora de suplementos nutricionales a base de hojas de moringa en cápsulas

The objective of this thesis is to determinate the market, technological, financial and social viability for the implementation of an industrial producing plantsupplements based on moringa, which will provide a solution to the problem of malnutrition suffered by pregnant women of Metropolitan Lima. From the market point of view, the first thing that was determined was that the target market would be women aged 18 to 45 years of socioeconomic levels B, C and D of Metropolitan Lima who are in gestation or lactation period. Analyzing the aforementioned market and the results of the survey, the annual demand for bottles of 120 moringa capsules for the fifth year of the project would be 56,139 bottles. In the evaluation of the engineering of the project, it was determined that a semi automatic production process would be used and the minimum area of production would be 33 m2, this was calculated using the Guerchet method. Considering all the necessary areas in the industrial premises, a plot of 600m2 was defined. In the financial analysis, it was determined that an investment of S/ 873,921 was needed, which would be financed 60% with the help of a bank loan at a rate of 15% and the remaining 40% with contribution from shareholders at a rate of 18% (COK). With this a financial IRR of 69% is obtained, together with a financial NPV of S / 1,138,663, benefit / cost ratio of 1.14 and recovery period of 2 years 11 months, positive indicators in the eyes of any investor. Finally, in the social evaluation it was concluded that the project was beneficial because it generated an added value of S/ 4,619,436 at present value and other positive social indicators.El objetivo de esta tesis es determinar la viabilidad de mercado, tecnológica, financiera y social para la creación de una planta productora de suplementos nutricionales a base de Moringa, la cual brindará una solución al problema de desnutrición que sufren las mujeres gestantes y en período de lactancia de Lima Metropolitana. Desde el punto de vista de mercado, lo primero que se determinó fue que el mercado objetivo serían mujeres de 18 a 45 años de los niveles socioeconómicos B, C y D de Lima Metropolitana que se encuentren en período de gestación o lactancia. Considerando el mercado definido y las encuestas realizadas se calculó que nuestra demanda anual de frascos de 120 cápsulas de moringa para el quinto año del proyecto sería de 56,139 frascos. En la evaluación de la ingeniería del proyecto, se determinó que se usaría un proceso productivo semiautomático y se calculó un área mínima de zona productiva de 33 m2 mediante el método de Guerchet. Considerando todas las áreas necesarias en el recinto industrial, se definió un terreno de 600 m2. Se determinó que se necesitaría una inversión de S/ 873,921, la cuál sería financiada 60 % con ayuda de un préstamo bancario a una tasa del 15 % y el restante 40 % con aporte de los accionistas a una tasa de 18% (COK). Con esto se obtiene un TIR financiero de 69 %, junto con una VAN financiera de S/ 1,138,663, ratio beneficio/costo de 3.26 y periodo de recupero de dos años 11 meses, indicadores positivos a los ojos de cualquier inversionista. Finalmente, en la evaluación social se encontró que el proyecto era beneficioso pues generaba un valor agregado de S/ 4, 619,436 a valor presente, entre otros indicadores sociales positivos

Ceniza de bagazo de caña de azúcar para mejorar las propiedades físico-mecánicas del concreto estructural

La presente tesis tiene como objetivo principal determinar el porcentaje óptimo de ceniza de bagazo de caña de azúcar para mejorar las propiedades físico-mecánicas del concreto estructural. El concreto se ha vuelto uno de los materiales con mayor demanda lo que en consecuencia provoca que aumente la degradación del ambiente, actualmente debido a la alta generación de gases producidos por la fabricación de cementos, se viene proponiendo el uso de residuos industriales con alta capacidad puzolánica que mejoren las propiedades del concreto. Esta investigación emplea el método deductivo, con una orientación aplicada, enfoque cuantitativo, basándose en la intención de obtener resultados que permitan hacer generalizaciones. El porcentaje óptimo para reemplazar el cemento por ceniza de bagazo de caña de azúcar resulta ser al 5%, teniendo en consideración sus características físicas y químicas, las resistencias obtenidas resultan ser superiores a la muestra patrón. Por el contrario, utilizar al 10% de sustitución llega a aproximarse a la muestra patrón, pero disminuye conforme aumenta la dosificación. La temperatura de calcinación arriba de 800 C° es esencial para la presencia rica de sílice en la ceniza. En el Perú el contenido de sílice se aproxima al 67% lo cual resulta ser lo ideal para realización el diseño de mezcla. Para obtener resultados mayores a 280 kg/cm2 se necesitan usar las proporciones en peso de 1: 2.86: 2.25 / 0.52 y un contenido de sílice mayor a 50%

Primary hepatocytes as targets for hepatitis C virus replication

Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry

Prediction of remission and low disease activity in disease-modifying anti-rheumatic drug-refractory patients with rheumatoid arthritis treated with golimumab

OBJECTIVE: To create a tool to predict probability of remission and low disease activity (LDA) in patients with RA being considered for anti-TNF treatment in clinical practice. METHODS: We analysed data from GO-MORE, an open-label, multinational, prospective study in biologic-naïve patients with active RA (DAS28-ESR ⩾3.2) despite DMARD therapy. Patients received 50 mg s.c. golimumab (GLM) once monthly for 6 months. In secondary analyses, regression models were used to determine the best set of baseline factors to predict remission (DAS28-ESR <2.6) at month 6 and LDA (DAS28-ESR ⩽3.2) at month 1. RESULTS: In 3280 efficacy-evaluable patients, of 12 factors included in initial regression models predicting remission or LDA, six were retained in final multivariable models. Greater likelihood of LDA and remission was associated with being male; younger age; lower HAQ, ESR (or CRP) and tender joint count (or swollen joint count) scores; and absence of comorbidities. In models predicting 1-, 3- and 6-month LDA or remission, area under the receiver operating curve was 0.648-0.809 (R(2) = 0.0397-0.1078). The models also predicted 6-month HAQ and EuroQoL-5-dimension scores. A series of matrices were developed to easily show predicted rates of remission and LDA. CONCLUSION: A matrix tool was developed to show predicted GLM treatment outcomes in patients with RA, based on a combination of six baseline characteristics. The tool could help provide practical guidance in selection of candidates for anti-TNF therapy

Sistema Web Aplicado à Genética de Populações

- Este trabalho tem o objetivo de auxiliar, estudantes e pesquisadores, na precisão dos cálculos sobre genética populacional, por meio de um software educativo: o Popgenelation. As técnicas de melhoramento genético trazem diversos benefícios, porém frequentemente para chegar a resultados satisfatórios, é necessária a realização de cálculos de equações complexas e que geralmente são solucionadas, pelos estudantes e pesquisadores, sem o auxilio de um sistema informatizado. Além disso, os sistemas existentes que realizam cálculos similares, porém não específicos para a genética de população, são pagos ou possuem restrições de acesso e não possuem caráter educativo, ou seja, sua usabilidade não é satisfatória. Diante do exposto, verifica-se a necessidade de aumentar a confiabilidade e precisão dos cálculos feitos por pesquisadores (da área de Genética), além de automatizar essa etapa com a ajuda de um sistema informatizado e ainda auxiliar estudantes que necessitam aprender o conteúdo de genética populacional via um software educativo. A pesquisa é metodológica, pois se refere à realidade, e nos leva a caminhos, formas ou procedimentos para alcançar um determinado fim. E aplicada, pois tem um objetivo concreto que é o software de melhoramento genético, que visa sanar um problema real, logo é algo prático, com uma solução concreta. Os resultados encontrados pela análise dos questionários evidenciaram a usabilidade do sistema, caracterizando-o como um software educativo. &nbsp

The role of ETG modes in JET-ILW pedestals with varying levels of power and fuelling

We present the results of GENE gyrokinetic calculations based on a series of JET-ITER-like-wall (ILW) type I ELMy H-mode discharges operating with similar experimental inputs but at different levels of power and gas fuelling. We show that turbulence due to electron-temperature-gradient (ETGs) modes produces a significant amount of heat flux in four JET-ILW discharges, and, when combined with neoclassical simulations, is able to reproduce the experimental heat flux for the two low gas pulses. The simulations plausibly reproduce the high-gas heat fluxes as well, although power balance analysis is complicated by short ELM cycles. By independently varying the normalised temperature gradients (omega(T)(e)) and normalised density gradients (omega(ne )) around their experimental values, we demonstrate that it is the ratio of these two quantities eta(e) = omega(Te)/omega(ne) that determines the location of the peak in the ETG growth rate and heat flux spectra. The heat flux increases rapidly as eta(e) increases above the experimental point, suggesting that ETGs limit the temperature gradient in these pulses. When quantities are normalised using the minor radius, only increases in omega(Te) produce appreciable increases in the ETG growth rates, as well as the largest increases in turbulent heat flux which follow scalings similar to that of critical balance theory. However, when the heat flux is normalised to the electron gyro-Bohm heat flux using the temperature gradient scale length L-Te, it follows a linear trend in correspondence with previous work by different authors

Spectroscopic camera analysis of the roles of molecularly assisted reaction chains during detachment in JET L-mode plasmas

The roles of the molecularly assisted ionization (MAI), recombination (MAR) and dissociation (MAD) reaction chains with respect to the purely atomic ionization and recombination processes were studied experimentally during detachment in low-confinement mode (L-mode) plasmas in JET with the help of experimentally inferred divertor plasma and neutral conditions, extracted previously from filtered camera observations of deuterium Balmer emission, and the reaction coefficients provided by the ADAS, AMJUEL and H2VIBR atomic and molecular databases. The direct contribution of MAI and MAR in the outer divertor particle balance was found to be inferior to the electron-atom ionization (EAI) and electron-ion recombination (EIR). Near the outer strike point, a strong atom source due to the D+2-driven MAD was, however, observed to correlate with the onset of detachment at outer strike point temperatures of Te,osp = 0.9-2.0 eV via increased plasma-neutral interactions before the increasing dominance of EIR at Te,osp &lt; 0.9 eV, followed by increasing degree of detachment. The analysis was supported by predictions from EDGE2D-EIRENE simulations which were in qualitative agreement with the experimental observations

Shattered pellet injection experiments at JET in support of the ITER disruption mitigation system design

A series of experiments have been executed at JET to assess the efficacy of the newly installed shattered pellet injection (SPI) system in mitigating the effects of disruptions. Issues, important for the ITER disruption mitigation system, such as thermal load mitigation, avoidance of runaway electron (RE) formation, radiation asymmetries during thermal quench mitigation, electromagnetic load control and RE energy dissipation have been addressed over a large parameter range. The efficiency of the mitigation has been examined for the various SPI injection strategies. The paper summarises the results from these JET SPI experiments and discusses their implications for the ITER disruption mitigation scheme

New H-mode regimes with small ELMs and high thermal confinement in the Joint European Torus

New H-mode regimes with high confinement, low core impurity accumulation, and small edge-localized mode perturbations have been obtained in magnetically confined plasmas at the Joint European Torus tokamak. Such regimes are achieved by means of optimized particle fueling conditions at high input power, current, and magnetic field, which lead to a self-organized state with a strong increase in rotation and ion temperature and a decrease in the edge density. An interplay between core and edge plasma regions leads to reduced turbulence levels and outward impurity convection. These results pave the way to an attractive alternative to the standard plasmas considered for fusion energy generation in a tokamak with a metallic wall environment such as the ones expected in ITER.&amp; nbsp;Published under an exclusive license by AIP Publishing