Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters

The results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which are new compounds, is reported. All compounds were subjected to in vitro antimicrobial testing. In silico studies were carried out calculating physico-chemical, pharmacokinetic and toxicological properties, providing more data as additional guidance for further research

Monotone iterative procedure and systems of a finite number of nonlinear fractional differential equations

The aim of the paper is to present a nontrivial and natural extension of the comparison result and the monotone iterative procedure based on upper and lower solutions, which were recently established in (Wang et al. in Appl. Math. Lett. 25:1019-1024, 2012), to the case of any finite number of nonlinear fractional differential equations.The author is very grateful to the reviewers for the remarks, which improved the final version of the manuscript. This article was financially supported by University of Łódź as a part of donation for the research activities aimed at the development of young scientists, grant no. 545/1117

Synthesis, Antimicrobial Activity and in silico Studies on Thymol Esters

Derivatisation of parent structure in terpenoids often results in enhancement of biological activity of newly obtained compounds. Thymol, a naturally occurring phenol biosynthesized through the terpene pathway, is a well known biocide with strong antimicrobial attributes and diverse therapeutic activities. We have aimed our study on a single modification of phenolic functionality in thymol in order to obtain a small focused library of twenty thymyl esters, ten of which were new compounds. All compounds were involved in in vitro antimicrobial testing. Another important aspect of current study was implementation of in silico calculation of physico-chemical, harmacokinetic and toxicological properties, which could be helpful by giving an additional guidance in further research

Many Labs 5:Testing pre-data collection peer review as an intervention to increase replicability

Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3?9; median total sample = 1,279.5, range = 276?3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (?r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00?.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19?.50)

Crossbreeding of cattle: effects on milk production

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EFFECT OF PERIPARTUM DIETARY ENERGY SUPPLEMENTATION ON THYROID HORMONES, INSULIN-LIKE GROWTH FACTOR-I AND ITS BINDING PROTEINS IN EARLY LACTATION DAIRY COWS

only on day 60 after parturition (p&lt;0.01, respectivel