Jumpstart 2000—The Maine Economic Improvement Strategy: A Targeted Investment in Research and Development

In recent years Maine has ranked 50th in per capita spending on university-based research and development in the United States, a distinction that an increasing number of Maine policymakers, citizens, business representatives and researchers find alarming. Citing the positive gains R&D investments have shown in other states, not the least of which is improved economic performance, the authors set forth an argument for investing in Maine’s public R&D infrastructure. Whether and how to make such investments have been the subjects of recent debate in many states

A practical approach to monitoring nutrient supplement intake of Australian adults

The adoption, in mid-1995, of the revised food Standard A9, which permits the more liberal addition of nutrients to a range of food products, highlighted the need to obtain information on nutrient intake from supplements to complement the i 995 National Nutrition Survey data on nutrient intake from food. This paper describes the method used to obtain quantitative information on nutrient supplement intake and reports on the prevalence of supplement use in different subgroups of the Australian population. Information on supplement intake was obtained in two Australian Bureau of Statistics Population Survey Monitor surveys in August 1995 and February 1996 using the Therapeutic Goods Administration (TGA) registration numbers to identify individual products. Approximately 18% of men and 29% of women aged 18 years and over reported consuming a nutrient supplement on the day before the survey and these proportions increased to 25% and 35% respectively for consumption during the two weeks before the survey. The prevalence of supplement intake increased with age, education level, socioeconomic status, employment status and with fruit and vegetable intake. The substantial proportion of Australian adults who consume nutrient supplements, and the rapidly changing composition of the Australian food supply in response to changes in food regulation, indicate that there is a need for regular monitoring of nutrient intake from supplements. The use of TGA registration numbers to identify supplements provides a practical way to address this need.<br /

Beam masking to reduce cyclic error in beam launcher of interferometer

Embodiments of the present invention are directed to reducing cyclic error in the beam launcher of an interferometer. In one embodiment, an interferometry apparatus comprises a reference beam directed along a reference path, and a measurement beam spatially separated from the reference beam and being directed along a measurement path contacting a measurement object. The reference beam and the measurement beam have a single frequency. At least a portion of the reference beam and at least a portion of the measurement beam overlapping along a common path. One or more masks are disposed in the common path or in the reference path and the measurement path to spatially isolate the reference beam and the measurement beam from one another

Assessing the public goods provided by organic agriculture: lessons learned from practice

The role of farms as providers of public goods has long been recognised, and measuring performance in this area is of increasing interest to policy makers, in light of the approaching Common Agricultural Policy reform. The Organic Research Centre has been working on this topic in recent years, through the development of sustainability assessment tools. The latest outcome from this process is a ‘Public Goods’ assessment tool, developed through a Natural England funded project which aimed to evaluate the benefits accruing from organic management and entering into an Organic Entry Level Stewardship (OELS) agreement. This paper describes the development of the Public Goods (PG) tool, and what has been learned in the process

Effective-one-body waveforms calibrated to numerical relativity simulations: coalescence of non-precessing, spinning, equal-mass black holes

We present the first attempt at calibrating the effective-one-body (EOB) model to accurate numerical-relativity simulations of spinning, non-precessing black-hole binaries. Aligning the EOB and numerical waveforms at low frequency over a time interval of 1000M, we first estimate the phase and amplitude errors in the numerical waveforms and then minimize the difference between numerical and EOB waveforms by calibrating a handful of EOB-adjustable parameters. In the equal-mass, spin aligned case, we find that phase and fractional amplitude differences between the numerical and EOB (2,2) mode can be reduced to 0.01 radians and 1%, respectively, over the entire inspiral waveforms. In the equal-mass, spin anti-aligned case, these differences can be reduced to 0.13 radians and 1% during inspiral and plunge, and to 0.4 radians and 10% during merger and ringdown. The waveform agreement is within numerical errors in the spin aligned case while slightly over numerical errors in the spin anti-aligned case. Using Enhanced LIGO and Advanced LIGO noise curves, we find that the overlap between the EOB and the numerical (2,2) mode, maximized over the initial phase and time of arrival, is larger than 0.999 for binaries with total mass 30-200Ms. In addition to the leading (2,2) mode, we compare four subleading modes. We find good amplitude and frequency agreements between the EOB and numerical modes for both spin configurations considered, except for the (3,2) mode in the spin anti-aligned case. We believe that the larger difference in the (3,2) mode is due to the lack of knowledge of post-Newtonian spin effects in the higher modes.Comment: 15 pages, 8 figures, typos fixed in Eqs.(7-10

Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families.

IntroductionThe impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at http://www.clinicaltrials.gov ).MethodsIn both studies, patients aged ≥ 2 years with mild to moderate AD per the Investigator's Static Global Assessment were randomly assigned 2:1 to receive crisaborole or vehicle twice daily for 28 days. QoL was assessed using the Children's Dermatology Life Quality Index (CDLQI) (2-15 years), the Dermatology Life Quality Index (DLQI) (≥ 16 years), and the Dermatitis Family Impact Questionnaire (DFI) (parents/caregivers/family of patients aged 2-17 years). Established QoL score severity bands provided clinical context.ResultsGreater mean improvement in QoL was observed in crisaborole-treated patients than in vehicle-treated patients at day 29 [mean change from baseline (∆BL), CDLQI: - 4.6 vs. - 3.0; P &lt; 0.001; DLQI: - 5.2 vs. - 3.5; P = 0.015]. At baseline, more than half the patients had a "moderate effect" or higher of AD on QoL. At day 29, there was a trend toward more crisaborole- than vehicle-treated patients having "small effect" to "no effect", The QoL of parents/caregivers/family improved more for crisaborole-treated than for vehicle-treated patients (∆BL, DFI: - 3.7 vs. - 2.7; P = 0.003).ConclusionCrisaborole treatment results in clinically meaningful improvement in QoL for patients and their parents/caregivers/families.Trial registrationAD-301: http://www.clinicaltrials.gov , NCT02118766; AD-302: http://www.clinicaltrials.gov , NCT02118792.FundingAnacor Pharmaceuticals, Inc., a wholly owned subsidiary of Pfizer Inc., New York, NY

Proteomic analysis of the fish pathogen Flavobacterium columnare

<p>Abstract</p> <p>Background</p> <p><it>Flavobacterium columnare </it>causes columnaris disease in cultured and wild fish populations worldwide. Columnaris is the second most prevalent bacterial disease of commercial channel catfish industry in the United States. Despite its economic importance, little is known about the expressed proteins and virulence mechanisms of <it>F. columnare</it>. Here, we report the first high throughput proteomic analysis of <it>F. columnare </it>using 2-D LC ESI MS/MS and 2-DE MALDI TOF/TOF MS.</p> <p>Results</p> <p>Proteins identified in this study and predicted from the draft <it>F. columnare </it>genome were clustered into functional groups using clusters of orthologous groups (COGs), and their subcellular locations were predicted. Possible functional relations among the identified proteins were determined using pathway analysis. The total number of unique <it>F. columnare </it>proteins identified using both 2-D LC and 2-DE approaches was 621, of which 10.95% (68) were identified by both methods, while 77.29% (480) and 11.76% (73) were unique in 2-D LC and 2-DE, respectively. COG groupings and subcellular localizations were similar between our data set and proteins predicted from the whole genome. Twenty eight pathways were significantly represented in our dataset (<it>P </it>< 0.05).</p> <p>Conclusion</p> <p>Results from this study provide experimental evidence for many proteins that were predicted from the <it>F. columnare </it>genome annotation, and they should accelerate functional and comparative studies aimed at understanding virulence mechanisms of this important pathogen.</p