Resource targets for advanced underground coal extraction systems

Resource targets appropriate for federal sponsorship of research and development of advanced underground coal mining systems are identified. A comprehensive examination of conventional and unconventional coals with particular attention to exceptionally thin and thick seams, steeply dipping beds, and multiple seam geometry was made. The results indicate that the resource of primary importance is flat lying bituminous coal of moderate thickness, under moderate cover, and located within the lower 48 states. Resources of secondary importance are the flat lying multiple seams and thin seams (especially those in Appalachia). Steeply dipping coals, abandoned pillars, and exceptionally thick western coals may be important in some regions of subregions, but the limited tonnage available places them in a position of tertiary importance

Enterprise architecture driven design of an artefact to support strategic Information Technology decision-making of Small Enterprises in Nigeria and South Africa

Information Technology (IT) is inevitably influencing the way enterprises operate, compete, and grow. The contemporary disruption has not excluded small companies. Small enterprises play a significant role in the growth of every economy but are hindered by limited skills, time, and money. The attributes of small enterprises influence the strategic and day-to-day operations. Small enterprise owners are often the managers who make the strategic decisions in order to solve specific problems. The decision style of small enterprise owner-managers limits the leveraging of IT. To ensure the sustainability of small enterprises in a contemporary business ecosystem, it is pertinent to strategise IT investment decisions. Enterprise architecture is a well-known approach to business and IT alignment. This study aimsto discover and develop how the complex enterprise architecture principles can strategise the IT decisionmaking process in small enterprises with limited resources and informal structures. The pragmatic philosophic stance was the premise for understanding the decision challenges and the development of a roadmap to intervene the problems the researcher identified. The Vaishnavi and Kuechler design science research methodology guided this study. The qualitative research approach was employed to collect verbal data with eleven small enterprise ownermanagers to understand the processes and the challenges of making IT decision in small enterprises. A thematic analysis of the findings revealed that lack of formalisation, limited information, and lack of IT skill created a critical bottleneck of IT investment decisions in small enterprises. An enterprise architecture-driven framework was developed to overcome the bounded rationality approach to IT choices in small enterprises. The framework holistically assesses organisational business-IT capabilities, constraints, and criteria to guide the decisionmaker's choice. The characteristics of small enterprises limit the successful implementation of the enterprise architecture-driven framework as a theoretical guideline for making optimal IT decisions in small enterprises. This study further developed an online IT decision-assistive tool informed by the framework. The instantiation artefact was demonstrated with six small enterprise owners from Nigeria and South Africa. The findings affirmed the prospect, potential, and relevance of an enterprise architecture-driven artefact as a tool to optimise strategic IT decisions in small manufacturing, service, and retail enterprises. The artefact developed in this study provided a practical intervention to the challenges of IT investment decisions in small enterprises

Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study

Dietary fibers are of particular interest in the prevention and management of obesity and consequent pathologies. Among the proposed mechanisms of action of fiber is the modulation of nutrient uptake from the small intestine. We have used a crossover study design in human subjects to monitor the uptake of glucose, cholesterol, and triacylglycerols in human subjects with normal and high body mass index. Our data demonstrate that uptakes of glucose, triacylglycerols, and cholesterol are all increased with increasing body fat. We demonstrate that treatment with a 1.5-g dose of a strong-gelling alginate may restore uptake of cholesterol and glucose to the levels of healthy subjects. These data indicate a potential therapeutic application of gelling fibers. (C) 2008 Published by Elsevier Inc

Primary physical education, coaches and continuing professional development

This is an Author's Accepted Manuscript of an article published in Sport, Education and Society, 16(4), 485 - 505, 2011, copyright @ Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/13573322.2011.589645.Physical education (PE) in primary schools has traditionally been taught by qualified primary teachers. More recently, some teaching of PE in primary schools has been undertaken by coaches (mostly football coaches). These coaches hold national governing body awards but do not hold teaching qualifications. Thus, coaches may not be adequately prepared to teach PE in curriculum time. The purpose of this study was to evaluate the perceptions of a group of community-based football coaches working in primary schools for the impact of a Continuing Professional Development (CPD) programme on their ability to undertake ‘specified work’ to cover PE in primary schools. The programme focused on four areas identified as important to enable coaches to cover specified work: short- and medium-term planning, pedagogy, knowledge of the curriculum and reflection. Results showed that for the majority of coaches the CPD programme had made them more aware of the importance of these four areas and had helped to develop their knowledge and ability to put this into practice in covering planning, preparation and assessment time. However, further input is still required to develop coaches’ knowledge and understanding in all four areas, but especially their curriculum knowledge, as well as their ability to put these into practice consistently. These findings are discussed in relation to the implications of employing coaches to cover the teaching of PE in primary schools and, if employed, what CPD coaches need to develop the necessary knowledge, skill and understanding for covering specified work in schools

Assessing the Reliability of Stryd 27 for Variable Speed Running

Wearable technology is beneficial when it comes to tracking and optimizing performance. The Stryd 27 is a wearable footpod marketed as being more responsive in measuring power during running than the previous version (Stryd 25). However, the reliability of this newer device to return consistent values has not been determined. PURPOSE: This study aimed to observe whether Stryd 27 gives reliable metrics during variable speed running. METHODS: Sixteen participants (N = 16; 50% female; height = 174.1 ± 8.1 cm; mass = 73.0 ± 12.4 kg) were recruited, each equipped with two Stryd 27 footpods (updated to the same software version) affixed to the shoelaces of their running shoes. The researchers recorded data using the Stryd app on a mobile device that was connected to the Stryd 27 via Bluetooth. Recording on both devices were started and stopped at the same time. Each participant completed two, 10-minute runs on an indoor track. The initial run was used to establish a baseline. Following a 5-minute rest period, participants proceeded with the second run, during which they alternated between faster and slower intervals. The pace for these intervals was set to be 20% faster and 20% slower than what each participant’s average pace was during the first run. Reliability of power, cadence, form power, ground contact time (GCT), vertical oscillation (VO), leg spring stiffness (LSS), and stride length during the interval run was determined using coefficient of variation (CV) and intraclass correlation coefficient (ICC), with CV0.70 (p \u3c 0.05) being considered evidence of reliability. RESULTS: Reliability data are shown in Table 1. The following measures were found to be reliable: power, cadence, form power, GCC, and VO. The measures of LSS and stride length were not found to be reliable. CONCLUSION: Runners using the new Stryd 27 can have confidence that most measures return reliable values (power, cadence, form power, GCT, and VO). Unfortunately, two measures were observed to not meet the threshold for reliability (LSS and stride length). Athletes interested in these measures should be cautious when interpreting their data

The Effectiveness of Running Power as a Metric of Exercise Intensity During Running Interval Training

Wearable power meters are increasingly popular among runners with Coros and Stryd offering running power as a real-time, trackable of a metric. PURPOSE: This study compared running power (RP) to physiological measures, heart rate (HR) and oxygen consumption (VO2), across high and low intensity running intervals. METHODS: Thirteen adult participants (n = 6 male; height = 174.9 ± 6.9 cm; mass = 72.5 ± 12.0 kg) were equipped with a Stryd 27 RP meter, a Polar H10 HR monitor, and a Cosmed K5 portable metabolic unit. Participants’ self-selected RP was obtained during a 10-min run on an indoor track (10 laps/mile). After resting for five minutes, participants ran another 10 min, alternating between equal intervals of RP 20% higher and 20% lower than self-selected RP: 120 s × 2, 60 s × 2, 30 s × 4, and 15 s × 8. All devices were started simultaneously before each run. RP (W/kg) was sampled at 1 Hz. HR (bpm) and VO2 (mL/kg/min) were sampled at 0.1 Hz throughout the interval run. Data were analyzed from the 60 s mark through the end of the run. HR and VO2 data were interpolated to 1 Hz, and cross correlations (max lag = 60 s) were used to compare RP, HR, and VO2 (mean values in Table 1). RESULTS: There were weak to moderate correlations between RP and VO2 (r = 0.351; lag = -29.1 s), RP and HR (r = 0.475; lag = 9.38 s), and HR and VO2 (r = 0.572; lag = -29.1 s; Table 2). CONCLUSION: HR showed the strongest correlation and smallest time delay with RP. This may be practically useful because HR data is more readily available to runners than VO2. However, the correlation is only moderate. While related, the three metrics of running intensity are fundamentally different. When exercising at a moderate intensity, changes in HR or VO2, which take seconds to minutes to stabilize, may be less evident than changes in mechanical power, which are immediate. Thus, it is possible that HR and VO2 would show a stronger relationship with RP across intervals longer than the 120 s maximum observed here. While RP can be a useful metric, it may not be informative about physiological responses to running especially over short intervals or when running at high intensity

The diversity of bioactive proteins in Australian snake venoms

Australian elapid snakes are among the most venomous in the world. Their venoms contain multiple components that target blood hemostasis, neuromuscular signaling, and the cardiovascular system. We describe here a comprehensive approach to separation and identification of the venom proteins from 18 of these snake species, representing nine genera. The venom protein components were separated by two-dimensional PAGE and identified using mass spectrometry and de novo peptide sequencing. The venoms are complex mixtures showing up to 200 protein spots varying in size from 10. These include many proteins identified previously in Australian snake venoms, homologs identified in other snake species, and some novel proteins. In many cases multiple trains of spots were typically observed in the higher molecular mass range (> 20 kDa) (indicative of post-translational modification). Venom proteins and their post-translational modifications were characterized using specific kantibodies, phosphoprotein- and glycoprotein-specific stains, enzymatic digestion, lectin binding, and antivenom reactivity. In the lower molecular weight range, several proteins were identified, but the predominant species were phospholipase A(2) and alpha-neurotoxins, both represented by different sequence variants. The higher molecular weight range contained proteases, nucleotidases, oxidases, and homologs of mammalian coagulation factors. This information together with the identification of several novel proteins (metalloproteinases, vespryns, phospholipase A(2) inhibitors, protein-disulfide isomerase, 5'-nucleotidases, cysteinerich secreted proteins, C-type lectins, and acetylcholinesterases) aids in understanding the lethal mechanisms of elapid snake venoms and represents a valuable resource for future development of novel human therapeutics

Stryd 25 vs. Stryd 27: Comparing Running Metrics Between a Predecessor and “The Next Gen Stryd”

Wearable technology has claimed the top spot in the Worldwide Survey of Fitness Trends in all but two years since 2016. A popular wearable among runners is the Stryd power meter. The company markets its latest model, the Stryd 27, as 5x more responsive in measuring running power. Yet, it is unclear whether the new model performs differently than its predecessor. PURPOSE: This study aimed to compare running metrics of the Stryd 25 and Stryd 27 in self-paced and interval runs. METHODS: Participants consented (N = 16; 50% female; height = 174.1 ± 8.1 centimeters [cm]; mass = 73.0 ± 12.4 kilograms) and were equipped with the Stryd 25 and Stryd 27, attached randomly to the left and right shoelaces. Each Stryd was paired with a separate mobile device using the Stryd app. Researchers started and stopped recording on each Stryd simultaneously. Participants ran for 10 minutes at a self-selected pace counterclockwise around an indoor track (10 laps/mile) before resting for five minutes. Then participants ran 10 more minutes, alternating between fast and slow intervals: 120 seconds (s) × 2, 60 s × 2, 30 s × 4, and 15 s × 8. Fast and slow intervals were 20% faster and 20% slower, respectively, than the participant’s mean pace of the first run. The Stryd app recorded power in watts (W), cadence in steps per minute (spm), vertical oscillation (VO) in cm, and stride length in meters (m). Four independent t-tests were run to compare these measurements between the two Stryd models for the self-paced and interval runs. The alpha level was .05, and the effect size was Cohen’s d (0.2 small, 0.5 medium, 0.8 large). RESULTS: See Table 1. CONCLUSION: Four running metrics were statistically similar between the Stryd 25 and Stryd 27 during two indoor runs. Runners using the predecessor indoors can be confident it returns similar data to the newest model

Non-homologous end joining in class switch recombination: the beginning of the end

Immunoglobulin class switch recombination (CSR) is initiated by a B-cell-specific factor, activation-induced deaminase, probably through deamination of deoxycytidine residues within the switch (S) regions. The initial lesions in the S regions are subsequently processed, resulting in the production of DNA double-strand breaks (DSBs). These breaks will then be recognized, edited and repaired, finally leading to the recombination of the two S regions. Two major repair pathways have been implicated in CSR, the predominant non-homologous end joining (NHEJ) and the alternative end-joining (A-EJ) pathways. The former requires not only components of the ‘classical’ NHEJ machinery, i.e. Ku70/Ku80, DNA-dependent protein kinase catalytic subunit, DNA ligase IV and XRCC4, but also a number of DNA-damage sensors or adaptors, such as ataxia–telangiectasia mutated, γH2AX, 53BP1, MDC1, the Mre11–Rad50–NBS1 complex and the ataxia telangiectasia and Rad3-related protein (ATR). The latter pathway is not well characterized yet and probably requires microhomologies. In this review, we will focus on the current knowledge of the predominant NHEJ pathway in CSR and will also give a perspective on the A-EJ pathway

Adorno?s Grey, Taussig?s Blue: Colour, Organization and Critical Affect

In this article we seek to open up the study of affect and organization to colour. Often simply taken for granted in organizational life and usually neglected in organizational thought, colour is an affective force by default. Deploying and interweaving the languages of affect theory, critical theory, and organization studies, we discuss colour as a primary phenomenon for the study of ?critical affect?. We then trace colour?s affect in conditioning the unfolding of organization in two particular ?colour/spaces? ? Adorno?s grey and Taussig?s blue of our title ? and discuss both its ambiguity and critical potential. Finally, we ponder what colour might do to the style of an organizational scholarship attuned to affect, where sentences blur with things and forces more than they seek to represent them