Lipid emulsions in parenteral nutrition: does one size fits all?

Dietary lipids significantly contribute to preserve the efficiency of human metabolism and restore it during disease. Therefore, in the absence of absolute contraindications, it would not appear reasonable to exclude lipid emulsions when prescribing parenteral nutrition (PN). The metabolic role of lipids has been elucidated, and is far more complex than a mere energy-dense source. Indeed, it is now clear that fatty acids impact differently on the inflammatory and immune responses, either promoting or blunting them. Omega-6 fatty acids are the substrate for the production of potent mediators of inflammation, whereas omega-3 fatty acids promote the synthesis of less active factors. Omega-9 fatty acids exert a more neutral impact on immune and inflammatory responses. These specific metabolic activities should therefore be considered when prescribing lipid emulsions in PN. Ideally, the metabolic profile of patients should guide the prescription of lipid emulsions in order to promote the inflammatory response or blunt it according to the clinical needs. This new approach would wholly exploit the metabolic activities of lipid emulsions by providing patients not only with an energy-dense source, but also by priming and/or modulating the immune and inflammatory responses in order to favour healing.Keywords: lipid emulsions; metabolism; parenteral nutrition; immune response; inflammatio

Evidence of a new low field cross-over in the vortex critical velocity of type-II superconducting thin films

We measure current-voltage characteristics as function of magnetic field and temperature in Nb strips of different thickness and width. The instability voltage of the flux flow state related to the vortex critical velocity v* is studied and compared with the Larkin-Ovchinnikov theory. Beside the usual power-law dependence v* ~ B^-1/2, in the low field range a new cross-over field, Bcr1, is observed below which v* decreases by further lowering the external magnetic field B. We ascribe this unexpected cross-over to vortex channeling due to a fan-like penetration of the applied magnetic field as confirmed by magneto-optic imaging. The observation of Bcr1 becomes a direct evidence of a general feature in type-II superconducting films at low fields, that is a channel-like vortex motion induced by the inhomogeneous magnetic state caused by the relatively strong pinning

A new apparatus for deep patterning of beam sensitive targets by means of high-energy ion beam

The paper reports on a high precision equipment designed to modify over 3-dimensions (3D) by means of high-energy gold ions the local properties of thin and thick films. A target-moving system aimed at creating patterns across the volume is driven by an x-y writing protocol that allows one to modify beam sensitive samples over micrometer-size regions of whatever shape. The apparatus has a mechanical resolution of 15 nm. The issue of the local fluence measurement has been particularly addressed. The setup has been checked by means of different geometries patterned on beam sensitive sheets as well as on superconducting materials. In the last case the 3D modification consists of amorphous nanostructures. The nanostructures create zones with different dissipative properties with respect to the virgin regions. The main analysis method consists of magneto-optical imaging that provides local information on the electrodynamics of the modified zones. Features typical of non-linear current flow hint at which pattern geometry is more functional to applications in the framework of nanostructures across superconducting films.Comment: 7 page

Synthesis and characterization of magnetic and antibacterial nanoparticles as filler in acrylic cements for bone cancer and comorbidities therapy

In this work an innovative formulation of bone cement for the treatment of bone tumor and its associated complications has been designed by preparing a new class of Fe3O4–Ag nanostructures, using gallic acid as a reducing agent. The obtained nanoparticles have been introduced in polymethyl methacrylate (PMMA)-based composite cement evaluating the insertion of different amounts and the use of different mixing methods. The morphology, the composition and the antibacterial effect of Fe3O4–Ag nanostructures have been investigated together with the morphology, the composition, the mechanical properties of the nanoparticles-containing composite cements as well as their antibacterial effect. The obtained results revealed a good antimicrobial effect of Fe3O4–Ag nanostructures, a significant influence of their amount and of the used mixing method on the particles dispersion and agglomeration in the PMMA matrix and, as a result, on the mechanical properties. In particular, a better dispersion of nanoparticles was obtained by using the mechanical mixing, reducing the tendency to agglomerate. The increase of nanoparticles amount induced a slight decrease of the mechanical properties; however, the introduction of 10% w/w of Fe3O4–Ag allowed to improve the composites ability to reduce the bacteria adhesion

Screening magnetic fields by a superconducting disk: a simple model

We introduce a simple approach to evaluate the magnetic field distribution around superconducting samples, based on the London equations; the elementary variable is the vector potential. This procedure has no adjustable parameters, only the sample geometry and the London length, $\lambda$, determine the solution. The calculated field reproduces quantitatively the measured induction field above MgB$_2$ disks of different diameters, at 20K and for applied fields lower than 0.4T. The model can be applied if the flux line penetration inside the sample can be neglected when calculating the induction field distribution outside the superconductor. Finally we show on a cup-shape geometry how one can design a magnetic shield satisfying a specific constraint

Control of bulk superconductivity in a BCS superconductor by surface charge doping via electrochemical gating

The electrochemical gating technique is a powerful tool to tune the surface conduction properties of various materials by means of pure charge doping, but its efficiency is thought to be hampered in materials with a good electronic screening. We show that, if applied to a metallic superconductor (NbN thin films), this approach allows observing reversible enhancements or suppressions of the bulk superconducting transition temperature, which vary with the thickness of the films. These results are interpreted in terms of proximity effect, and indicate that the effective screening length depends on the induced charge density, becoming much larger than that predicted by standard screening theory at very high electric fields

Magneto-plasmonic heterodimers: Evaluation of different synthesis approaches

Nanomedicine has gained huge attention in recent years with new approaches in medical diagnosis and therapy. Particular consideration has been devoted to the nanoparticles (NPs) in theranostic field with specific interest for magnetic and gold NPs (MNPs and GNPs) due to their peculiar properties under exposition to electromagnetic fields. In this paper, we aim to develop magneto-plasmonic heterodimer by combining MNPs and GNPs through a facile and reproducible synthesis and to investigate the influence of different synthesis parameters on their response to magnetic and optical stimuli. In particular, various syntheses were performed by changing the functionalization step and using or not a reducing agent to obtain stable NP suspensions with tailored properties. The obtained heterodimers were characterized through physical, chemical, optical, and magnetic analysis, in order to evaluate their size, shape, plasmonic properties, and superparamagnetic behavior. The results revealed that the shape and dimensions of the nanocomposites can be tuned by MNPs surface functionalization, as well as by the use of a reducing agent, giving rise to nanoplatform suitable for biomedical application, exploiting the gold absorbing peak in the specific gold absorbing range of GNPs, while maintaining the superparamagnetic behavior typical of the MNPs. The obtained nanocomposites can be proposed as potential candidates for cancer theranostics

Universal temperature scaling of flux line pinning in high-temperature superconducting thin films

Dissipation-free current transport in high-temperature superconductors is one of the most crucial properties of this class of materials which is directly related to the effective inhibition of flux line movement by defect structures. In this respect epitaxially grown thin films of YBa2Cu3O7-d (YBCO) are proving to be the strongest candidates for many widescale applications that are close to realization. We show that the relation between different defect structures and flux line pinning in these films exhibits universal features which are clearly displayed in a detailed analysis of the temperature-dependent behaviour of local critical currents. This allows us to identify different pinning mechanisms at different temperatures to be responsible for the found critical currents. Additionally, the presence of grain boundaries with very low misorientation angles affects the temperature stability of the critical currents which has important consequences for future applications.Comment: 5 pages, 4 figures To be published in Journal of Physics: Condensed matte

nutritional cancer care slowly evolving clinical practice reveals regional and professional hcp variability

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