INDUTORES E EFEITOS DO DESENVOLVIMENTO DO ENOTURISMO NAS VINÍCOLAS: A PERSPECTIVA DAS CAPACIDADES DINÂMICAS

No contexto organizacional das vinícolas, o enoturismo envolve a entrada dessas empresas no setor terciário da economia, por meio de um conjunto de serviços e atividades turísticas. Este estudo baseia-se na abordagem de capacidades dinâmicas ao propor que as vinícolas propositadamente criam, ampliam e modificam os seus processos, construindo e utilizando capacidades dinâmicas-chave para desenvolver o enoturismo na sua unidade de negócio. Formularam-se dois objetivos para este estudo. O primeiro objetivo é compreender em que medida os níveis de capacidades dinâmicas contribuem para o desenvolvimento do enoturismo nas vinícolas. O segundo objetivo é analisar os efeitos do desenvolvimento do enoturismo no desempenho organizacional. A abordagem Partial Least Squares (PLS), o Modelo de Equações Estruturais (SEM) e os dados de uma pesquisa quantitativa são aplicados nas vinícolas da região do Alentejo, Portugal. Este estudo mostra os indutores das capacidades dinâmicas sobre o comportamento das vinícolas para desenvolver o enoturismo e o efeito do enoturismo no desempenho organizacional. O resultado mostra que as vinícolas renovam e alargam as suas capacidades operacionais. Um conjunto de novas capacidades-chave (detectar, aprender, integrar, coordenar e reconfigurar) contribuem simultaneamente, e de forma diferente, para o desenvolvimento do enoturismo. Além disso, o desenvolvimento do enoturismo tem impacto positivo no desempenho das vinícolas

Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life

TRF1 as a major contributor for telomeres’ shortening in the context of obesity

Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids). Telomeres are structures that protect chromosome ends and are associated with a six-protein complex called the shelterin complex and subject to regulation. Under pro-oxidant conditions, telomere attrition and the altered expression of the shelterin proteins are central for the establishment of many pathophysiological conditions such as obesity. Thus, considering that individuals with obesity display a systemic oxidative stress profile that may compromise the telomeres length or its regulation, the aim of this study was to investigate telomere homeostasis in patients with obesity and explore broad/systemic associations with the expression of shelterin genes and the plasma redox state. We performed a cross-sectional study in 39 patients with obesity and 27 eutrophic subjects. Telomere length (T/S ratio) and gene expression of shelterin components were performed in peripheral blood mononuclear cells by qPCR

Motivations of tourists in wine regions: the case of La Rioja, Spain

Purpose This paper addresses the motivations of tourists who visit the region of La Rioja, Spain, which is well known for its internationally recognized, high-quality wines, yet remains understudied as a wine tourism destination. The paper aims to ascertain whether tourists are attracted to La Rioja because of its famous wines and wine-related activities or if other motivations exist. Design/methodology/approach The data were derived from 217 questionnaires regarding tourists' motivations. A tourist survey was applied in La Rioja's capital city, Logrono, and segmentation analysis was undertaken. The data were first grouped into five factors regarding motivations for one's visit. These factors were then used to create two clusters: "wine tourists" and "other tourists". Findings The results enabled us to detect different segments of tourists. The existence of two clusters suggests that tourists are motivated to visit the region for various reasons that are not necessarily wine-related. Thus, the region should be marketed to tourists beyond the theme of wine, as there is a demand for diverse experiences. Originality/value Using the push and pull theory, this study contributes to the literature on the profile of visitors to wine tourism destinations by identifying differences in terms of motivations and other personal characteristics between "wine tourists" and the "other tourists". It also adds to the few existing studies on wine tourism segmentation in Spain through its focus on La Rioja, which is one of the most famous Spanish wine tourism destinations.info:eu-repo/semantics/publishedVersio

Causes and effects of wine tourism development in wineries: the perspective of institutional theory

Purpose - This study aims to propose that the institutional environment exerts pressure on the behavior of wineries toward wine tourism development (WTD) and the effect of this influence confers legitimacy to the business of wine tourism.Design/methodology/approach - Structural equation modeling through partial least squares was applied to estimate and validate a model using data from a quantitative survey in the universe of 62 wineries with a wine tourism component along the Alentejo Wine Route in Portugal. The proposed model is based on institutional theory through an inter-organizational perspective of wineries.Findings - The results show that WTD coexists with a highly institutionalized environment, exerting distinctive mechanisms of external pressure together with the search for social legitimacy through actions and practices on the part of the involved wineries. However, the relationship between legitimacy and organizational performance in wineries with wine tourism is not validated.Research limitations/implications - The specific sample of the Alentejo wine companies does not allow the results to be generalized. Future studies should replicate the proposed research model using other geographic areas.Practical implications - The results are particularly interesting for managers of wineries and should be considered in the decision-making and strategic processes regarding wine tourism.Originality/value - The use of institutional theory in the wine tourism context is novel and original. This study fills a research gap by conducting an empirical investigation of wine tourism based on institutional theory, which allows the identification of exogenous factors that can influence and impose restrictions on the organizational behavior of winery companies toward wine tourism