El queso con Denominación de Origen Protegida Salers (Francia). La diversidad y las paradojas de los saberes locales en indicaciones geográficas protegidas

Our case study of Salers cheese production in south-central France highlights how place-specific knowledge grounds the various networks shaping the rise of geographical indications (GI) in food production. In 1961, Salers cheese producers created a “Protected Designation of Origin” (PDO). To preserve the distinctive character of their product, they opted to require use of the gerle, a traditional wooden vat, and an on-farm cheese making process. The gerle came recently under scrutiny from French governmental hygiene regulation enforcement, and the subsequent public controversy jeopardized the entire supply chain and destabilized Salers cheese-making methods. Prevailing in their efforts to protect Salers, producers established the gerle as mandatory and have since set up a governance board to ensure PDO brand integrity. Our analysis suggests that the diversity of technical choices and associated set of knowledge in Salers cheese production has paradoxically been both its strength and weakness. Local agricultural know-how forges links among participants in Salers networks, connecting cheese producers and consumers, to cattle, microbes, landscapes, wooden tools, and cheeses. Yet, diversity of local expertise creates a tension among producers who must collaborate to achieve unified standards within a PDO while resisting homogeneity. Such results contribute to discussing on PDO governance: an arena to share, compare, and unite local knowledge is critical for GI and thus for sustainable agricultural systems.Nuestro caso de estudio sobre producción de queso de Salers, en el centro-sur de Francia, ilustra cómo los saberes específicos locales explican el origen de la formación de una indicación geográfica (IG). En 1961, los productores del queso de Salers crearon una denominación de origen protegida (DOP). Para preservar el carácter distintivo de sus productos, optaron por requerir como condiciones necesarias tanto el uso de la «gerle», una cuba de madera tradicional, como el hecho de que la producción del queso se haga en la propia finca por el ganadero y con la leche de sus propios animales. El uso de la «gerle» fue objeto de examen por parte de las autoridades regionales francesas desde el punto de vista de la aplicación del Reglamento de higiene en la producción de quesos. La subsecuente controversia pública sobre la idoneidad higiénica de las cubas polpuso en peligro toda la cadena de producción y desestabilizó los métodos de fabricación de queso de Salers. En sus esfuerzos para proteger el queso, los productores establecieron la obligatoriedad de utilizar la «gerle» y se creó un Consejo Regulador para garantizar la calidad específica de la marca colectiva de la DOP. El artículo sugiere que la diversidad de opciones técnicas y el conjunto de saberes asociados a la producción local de queso de Salers han constituido, paradójicamente, tanto su fuerza como su debilidad. El saber agrícola local forja vínculos entre los participantes en las redes del queso de Salers, conectando a los productores con los consumidores, el ganado, los microbios, los paisajes, las herramientas de madera y los quesos. Sin embargo, la diversidad de saberes expertos locales constituye un elemento de tensión entre los productores que les obliga a colaborar entre sí para alcanzar estándares unificados dentro de la DOP. Los resultados del trabajo contribuyen al debate sobre la gobernanza de una DOP: un espacio para compartir, comparar y unificar el saber local es un factor clave para el buen desarrollo de una IG y, por tanto, para construir sistemas agrícolas sostenibles

Epidemiology of sexually transmitted infections among female sex workers in Switzerland: a local, exploratory, cross-sectional study

Female sex workers are often considered highly vulnerable to sexually transmitted infections (STIs). However, data on STI epidemiology in female sex workers are lacking in Switzerland. Our main goal was to evaluate the prevalence of six STIs (human immunodeficiency virus [HIV], hepatitis B, hepatitis C, Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis) among local female sex workers in Lausanne. A local, exploratory, cross-sectional study was conducted on a convenience sample of adult (≥18 years) Female sex workers in Lausanne, Switzerland, from 1 April 2015 to 31 December 2016. female sex workers who worked in street sex venues, massage parlours and brothels were approached for recruitment by a local non-governmental organisation. They were then invited to present at the Lausanne University Hospital, where they were offered a free STI screening and hepatitis A and B vaccination. We enrolled 96 female sex workers. They were predominantly undocumented immigrants (60%) from Africa and Eastern Europe with no health insurance; only one participant (1%) was Swiss born. During the study, 15 (16%; 95% confidence interval [CI] 9–23%) participants were newly confirmed to have an STI: six (6%; 95% CI 1–11%) had C. trachomatis, five (5%; 95% CI 0.6-9%) latent syphilis and four (4%; 95% CI 0.1–8%) hepatitis B (three with chronic active infection and one with past exposure). No human immunodeficiency virus (HIV) infections were newly diagnosed among the participants. Nineteen (20%) of the female sex workers were already vaccinated against hepatitis B, and 73 (76%) initiated vaccination against hepatitis A and hepatitis B during the study. Forty-four (46%) of the female sex workers required translation and assistance from social services

Bifeo3 Harmonic Nanoparticle (Bfo-Hnps) Use for the Stem Cell Tracking: Labeling Investigation by Non Linear Microscopy and X-Ray Fluorescence

Duchenne Muscular Dystrophy is the most common form of degenerative muscle disease; currently, there is no effective treatment. In 2011, our group showed that an adult stem cell population (MuStem) isolated from healthy dog skeletal muscle induces long-term muscle repair and striking clinical efficacy after its systemic delivery in clinically relevant dystrophic dog. During last years, our group isolated the human counterparts (hMuStem) [1]. To achieve the full therapeutic potential of the hMuStem cells, their homing process, survival and engraftment post-transplantation must be clearly understood. BiFeO3 harmonic nanoparticles (BFO-HNPs) were used as probes for the hMuStem cell tracking [2]. We demonstrate the possibility of identifying <100 nm BFO-HNPs in depth of muscle tissue at more than 1 mm from the surface by multiphoton microscopy. Based on this successful assessment, we monitor over 14 days any modification on proliferation and morphology features of the hMuStem cells upon exposure to BFO-HNPs revealing their high biocompatibility. To complete these studies, the stability of BFO-HNPs was followed in the labeled hMuStem cells by investigation of Bi and Fe X-ray fluorescence mapping on both Nanoscopium (Soleil, Gif-sur-Yvette, France) and ID16B (ESRF, Grenoble, France) beamlines. In this work, correlation between non-linear microscopy and X-Ray fluorescence was done. Bi and Fe X-Ray fluorescence allowed us to localize with high resolution the BFO-HNPs in the labeled hMuStem cells and the variation of Bi/Fe ratio was analyzed to detect possible dissociation of the nanoparticles in the labeled cells

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Bifeo3 Harmonic Nanoparticle (Bfo-Hnps) Use for the Stem Cell Tracking: Labeling Investigation by Non Linear Microscopy and X-Ray Fluorescence

Duchenne Muscular Dystrophy is the most common form of degenerative muscle disease; currently, there is no effective treatment. In 2011, our group showed that an adult stem cell population (MuStem) isolated from healthy dog skeletal muscle induces long-term muscle repair and striking clinical efficacy after its systemic delivery in clinically relevant dystrophic dog. During last years, our group isolated the human counterparts (hMuStem) [1]. To achieve the full therapeutic potential of the hMuStem cells, their homing process, survival and engraftment post-transplantation must be clearly understood. BiFeO3 harmonic nanoparticles (BFO-HNPs) were used as probes for the hMuStem cell tracking [2]. We demonstrate the possibility of identifying <100 nm BFO-HNPs in depth of muscle tissue at more than 1 mm from the surface by multiphoton microscopy. Based on this successful assessment, we monitor over 14 days any modification on proliferation and morphology features of the hMuStem cells upon exposure to BFO-HNPs revealing their high biocompatibility. To complete these studies, the stability of BFO-HNPs was followed in the labeled hMuStem cells by investigation of Bi and Fe X-ray fluorescence mapping on both Nanoscopium (Soleil, Gif-sur-Yvette, France) and ID16B (ESRF, Grenoble, France) beamlines. In this work, correlation between non-linear microscopy and X-Ray fluorescence was done. Bi and Fe X-Ray fluorescence allowed us to localize with high resolution the BFO-HNPs in the labeled hMuStem cells and the variation of Bi/Fe ratio was analyzed to detect possible dissociation of the nanoparticles in the labeled cells

The MUSE Hubble Ultra Deep Field surveys: Data release II

We present the second data release of the MUSE Hubble UDF surveys, which includes the deepest spectroscopic survey ever performed. The MUSE data, with their 3D content, amazing depth, wide spectral range, and excellent spatial and medium spectral resolution, are rich in information. This update of the first release incorporates a new 141-hour adaptive-optics-assisted MXDF field (1' diameter FoV) in addition to the reprocessed 10-hour mosaic (3'x3') and the single 31-hour deep field (1'x1'). We have securely identified and measured the redshift of 2221 sources, an increase of 41% compared to the first release. With the exception of 8 stars, the collected sample consists of 25 nearby galaxies (z 3, the difference is even more striking, with a factor of 65 increase (1308 vs 20). We compared the measured redshifts against three published photometric redshift catalogs and find the photo-z accuracy to be lower than the constraints provided by photo-z fitting codes. 80% of the galaxies have an HST counterpart. They are on average faint, with a median magnitude of 25.7 and 28.7 for the OII and Ly-alpha emitters, respectively. SED fits show that these galaxies tend to be low-mass star-forming galaxies, with a median stellar mass of 6.2 10**8 M and a median SFR of 0.4 M/yr. 20% of our catalog, or 424 galaxies, have no HST counterpart. The vast majority of these new sources are high EQW z>2.8 LAEs that are detected by MUSE thanks to their bright and asymmetric broad Ly-alpha line. We release advanced data products, specific software, and a web interface to select and download data sets

The MUSE Hubble Ultra Deep Field surveys: Data release II

We present the second data release of the MUSE Hubble UDF surveys, which includes the deepest spectroscopic survey ever performed. The MUSE data, with their 3D content, amazing depth, wide spectral range, and excellent spatial and medium spectral resolution, are rich in information. This update of the first release incorporates a new 141-hour adaptive-optics-assisted MXDF field (1' diameter FoV) in addition to the reprocessed 10-hour mosaic (3'x3') and the single 31-hour deep field (1'x1'). We have securely identified and measured the redshift of 2221 sources, an increase of 41% compared to the first release. With the exception of 8 stars, the collected sample consists of 25 nearby galaxies (z 3, the difference is even more striking, with a factor of 65 increase (1308 vs 20). We compared the measured redshifts against three published photometric redshift catalogs and find the photo-z accuracy to be lower than the constraints provided by photo-z fitting codes. 80% of the galaxies have an HST counterpart. They are on average faint, with a median magnitude of 25.7 and 28.7 for the OII and Ly-alpha emitters, respectively. SED fits show that these galaxies tend to be low-mass star-forming galaxies, with a median stellar mass of 6.2 10**8 M and a median SFR of 0.4 M/yr. 20% of our catalog, or 424 galaxies, have no HST counterpart. The vast majority of these new sources are high EQW z>2.8 LAEs that are detected by MUSE thanks to their bright and asymmetric broad Ly-alpha line. We release advanced data products, specific software, and a web interface to select and download data sets