Coordination polymers of 5-substituted isophthalic acid

This work was funded by the British Heart Foundation (NH/11/8/29253) and the EPSRC (EP/K005499/1).The synthesis and characterisation of five coordination polymers - Ni2(mip)2(H2O)8·2H2O ( 1 ), Zn6(mip)5(OH)2(H2O)4·7.4H2O ( 2 ), Zn6(mip)5(OH)2(H2O)2·4H2O ( 3 ), Mn(HMeOip)2 ( 4 ), and Mn3(tbip)2(Htbip)2(EtOH)2 ( 5 ) - are reported. Preliminary nitric oxide release data on compounds 2 and 3 are also given.Publisher PDFPeer reviewe

Compact, modular and in-plane AOSLO for high-resolution retinal imaging

The adaptive optics scanning laser ophthalmoscope (AOSLO) was first developed in 2002 and since then the technology has been adopted in several laboratories around the world, for both clinical and psychophysical research. There have been a few major design implementations of the AOSLO. The first used on-axis tilted spherical mirrors in a planar arrangement, and the second minimized the build up of astigmatism present in the first design by using a non-planar arrangement. Other designs have avoided astigmatism by using custom-made toroidal mirrors or by using lenses on-axis, rather than mirrors. We present a new design implementation for an AOSLO that maintains a planar optical alignment without the build up astigmatism using compact, reconfigurable modules based on an Offner relay system. We additionally use an off-the-shelf digital oscilloscope for data capture and custom-written Python code for generating and analyzing the retinal images. This design results in a compact system that is simple to align and, being composed of modular relays, has the potential for additional components to be added. We show that this system maintains diffraction-limited image quality across the field of view and that cones are clearly resolved in the central retina. The modular relay design is generally applicable to any system requiring one or more components in the pupil conjugate plane. This is likely to be useful for any point-scanned system, such as a standard scanning laser ophthalmoscope or non-ophthalmic confocal imaging system

Development of the research lifecycle model for library services

Can the niche services of individual librarians across multiple libraries be developed into a suite of standard services available to all scientists that support the entire research lifecycle

Is Geriatric Care Associated with Less Emergency Department Use?

Emergency department (ED) use among seniors increased substantially in recent years. This study examined whether community and nursing home (NH) residents treated by a geriatrician were less likely to use the ED than patients treated by other physicians

Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme

INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1537, 1183, and 851 people with dementia, and 1277, 977, and 749 caregivers at baseline, 12 and 24 months, respectively. Addenbrooke's Cognitive Examination-III and Functional Activities Questionnaire were used to measure cognition and iADL, respectively. Scores were converted to deciles. RESULTS: Self-rated iADL declined on average by -0.08 (-0.25, 0.08) decile points per timepoint more than cognition. Informant-rated iADL declined on average by -0.31 (-0.43, -0.18) decile points per timepoint more than cognition. DISCUSSION: Cognition and self-rated iADL declined at a similar rate. Informant-rated iADL declined at a significantly greater rate than cognition. Therefore, either cognition and perceived iADL decline at different rates or informants overestimate increasing iADL difficulties compared to both cognition and self-ratings. Highlights: Self-ratings of the degree of functional difficulties were consistent with cognition Decline in self-rated everyday activities was consistent with cognitive decline Informant-ratings of everyday activities declined more than cognition

Studio u dubrovačkim kućama prve polovice 15. stoljeća

Drvodjeljski radovi ugovoreni između 1425. i 1435. godine otkrivaju mnoge podatke o unutarnjem prostoru i uređenju dubrovačkih kuća. Izradom fiksnog namještaja određuje se i namjena pojedinih prostorija, među kojima se pojavljuje i studio. Ta riječ može značiti i zasebnu sobu ali i komad pokućstva sastavljen od pisaćeg stola, sjedala i polica za knjige. Po mjestu na kojem se unutar dubrovačkih kuća studio nalazi – na prvom ili na nekom od viših katova, uočena je podudarnost s opisom kuće »savršenog trgovca« Benedikta Kotrulja iz 1458. godine. On i nazivljem razlikuje »zajedničku pisarnicu« (scriptore ili scrittoio comune) »pogodnu za poslove«, koja je na prvom katu, od »male pisarnice« (scriptoreto separato ili studiolo a parte), koja je »u spavaćoj sobi ili blizu nje«, a služi onome »koji uživa u knjizi«

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

SummaryAmino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA stimulates Rab1A GTP binding and interaction with mTORC1 and Rheb-mTORC1 interaction in the Golgi. Rab1A overexpression promotes mTORC1 signaling and oncogenic growth in an AA- and mTORC1-dependent manner. Conversely, Rab1A knockdown selectively attenuates oncogenic growth of Rab1-overexpressing cancer cells. Moreover, Rab1A is overexpressed in colorectal cancer (CRC), which is correlated with elevated mTORC1 signaling, tumor invasion, progression, and poor prognosis. Our results demonstrate that Rab1 is an mTORC1 activator and an oncogene and that hyperactive AA signaling through Rab1A overexpression drives oncogenesis and renders cancer cells prone to mTORC1-targeted therapy

Educational Brochures Influence Beliefs and Knowledge Regarding Exercise during Pregnancy: A Pilot Study

International Journal of Exercise Science 12(3): 581-589, 2019. Women who are pregnant report receiving little or no advice about physical activity during pregnancy from their obstetric provider. The purpose of this study was to assess the effectiveness of an evidence-based educational brochure on both immediate and two-week retention of knowledge about exercise during pregnancy. Thirty-two women of childbearing age (age: 25.0 ± 4.0 years, body mass index: 29.5 ± 6.5 kg/m2, 93.7% Caucasian, 83.4% had at least some college) completed a survey before exposure to an evidence-based educational brochure regarding exercise during pregnancy. Post surveys were taken immediately after viewing the educational brochure and again 2-weeks later. After exposure to educational brochures, survey scores on both surveys were significantly higher immediately-post and two-weeks post compared to baseline survey scores (Survey 1 (assessing beliefs) – pre: 79.2 ± 8.9%, post: 92.6 ± 7.4%, 2-weeks post: 92.0 ± 6.5%, p \u3c 0.001; Survey 2 (assessing knowledge) – pre: 65.3 ± 16.4%, post: 81.3 ± 14.9%, 2-weeks post: 78.8 ± 12.4%, p \u3c 0.001). No significant differences detected between immediate post and 2-weeks post for either Survey 1 (p = 0.72) or Survey 2 (p = 0.52); suggesting the information was retained. An evidence-based educational brochure is effective for improving and retaining information 2-weeks later regarding exercise during pregnancy. However, replication studies in more diverse populations are needed to confirm the results of this pilot study. The long-term goal for this line of research is to urge health care providers to consider providing patients with educational information in order to improve knowledge and patient-provider communication on this topic

A Team Approach to Library Services for Interdisciplinary Science

In the summer of 2011, a group of five librarians from the University of North Carolina at Chapel Hill (UNC-CH) Health Sciences and Kenan Science Libraries formed the Health and Natural Sciences (HNS) team to discuss library services and methods of service delivery to scientific researchers. The team’s charge was to determine what services subject librarians were currently providing to their respective constituencies, what services were most important to researchers, and how to develop individual specialties into a suite of standard services that could be offered to all scientists and clinicians across the university. The team tackled these questions with a multifaceted approach that led to the development of a new service model based on the research lifecycle