Integrating the care of the complex COPD patient

The European Seminars in Respiratory Medicine has represented an outstanding series updating new science in respiratory disease from the 1990\u2019s up to the early beginning of this 21st century [1,2]. Its aim is to update issues and current science, focusing on the multidisciplinary approach to patients with respiratory disease. As such, it represents a unique opportunity for specialists in Respiratory Medicine involved in Basic and Clinical Research to discuss topical and debated problems in medical care, at a top level forum guided by an expert panel of authors. The structure of the seminar is based on the following pillars: \u2022 Attendance at the Seminars is strictly limited: selection of participants is based, in order of priority, on scientific curriculum, age (younger specialists are privileged), and early receipt of the application form. \u2022 Each topic is allotted considerable time for presentation and discussion. The first section is devoted to a series of presentations (with adequate time allocated for discussion) by an expert panel of researchers and clinicians. In the second section involves discussions of controversial issues, in a smaller audience format encouraging interaction between the panel and audience. \u2022 \u201cMeet the expert\u201d seminars discuss topical subjects in more depth, utilizing an interactive tutorial

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Integrazione alla misura del Job Burnout: la scala di Sovraccarico Relazionale.

L’accezione più recente del costrutto di job burnout, generalizzabile a tutte le professioni e organizzazioni, riguarda la relazione della persona con il proprio lavoro. Per contribuire allo studio del fenomeno ed enfatizzare la dimensione interpersonale, si è costruita la scala di Sovraccarico Relazionale, di cui sono state studiate le caratteristiche psicometriche nel presente contributo. La ricerca è stata condotta presso un’azienda ospedaliera, somministrando a 1278 soggetti, la versione italiana del MBI – Versione Generale e la scala di Sovraccarico Relazionale. Le analisi fattoriali esploratoria e confermativa, evidenziano la struttura attesa, discriminando le tre sottodimensioni del job burnout e il Sovraccarico Relazionale. Vengono fornite indicazioni per la ricerca futura. The new perspective on job burnout generalizes the construct to different professions and workplaces, and points out the people relationship with their work. In order to contribute to the investigation of the syndrome, the current study focuses on the role played by interpersonal relationship and presents the Interpersonal Overload Scale, built on purpose. The study analyzes the psychometric properties of the scale. The research was conducted in a hospital, 1278 subjects were administered the Italian version of the MBI – General Survey and the Interpersonal Overload Scale. The factorial and the confirmatory factor analysis show the expected structure, distinguishing the three burnout dimensions

Time to initiation of adjuvant chemotherapy in patients with rapidly proliferating early breast cancer

Aim: To evaluate the optimal time interval from definitive surgery to commencing chemotherapy in early breast cancer (EBC).Patients and methods: The relationship between time to initiation of adjuvant chemotherapy (TTC), calculated in weeks, and disease-free (DFS) or overall survival (OS), was assessed in 921 EBC patients with rapidly proliferating tumours (thymidine labelling index > 3% or G3 or Ki67 > 20%), randomised in a phase III clinical trial (NCT01031030) to receive chemotherapy with or without anthracyclines (epirubicin -> cyclophosphamide, methotrexate and fluorouracil (CMF) versus CMF -> epirubicin versus CMF). DFS, OS and 95% confidence intervals (95% confidence interval (CI)) were calculated by the Kaplan-Meier method. Multivariate Cox analysis was performed in relation with nodal involvement, oestrogen receptor and human epidermal growth factor receptor 2 (HER2) status, Ki67 value, type of adjuvant chemotherapy, menopausal status and tumour size.Results: At a median follow-up of 105 months (range 2-188), a prolonged TTC resulted in a significant increase in the risk of relapse: hazard ratio (HR) 1.15 (95% CI 1.02-1.30, p = 0.019). Using a backward elimination procedure, TTC, tumour size and nodal involvement remained significantly associated with DFS. A time-dependent receiver-operating characteristic (ROC) curve analysis was subsequently utilised to evaluate the best cut-off for TTC, identifying 7 weeks as the best threshold for longer OS (p = 0.043): 8-year OS 88% (95% CI 85-90) for patients with a TTC < 7 weeks and 78% (95% CI 68-87) for the other group.Conclusions: Our results confirm that a shorter TTC may reduce relapses and possibly also improve clinical outcome in patients with highly proliferating EBC. (C) 2015 Elsevier Ltd. All rights reserved