Desarrollo de una herramienta digital para la simulación de recorridos en plantas industriales

El equipo docente de la cátedra de Industrias de Transformación Química abordó la posibilidad de elaborar una aplicación móvil y una aplicación web que permitan realizar una simulación de recorrido interactivo por las etapas de los procesos industriales de obtención de pulpa celulósica y la formación de la hoja de papel. Esta decisión obedeció al contexto de clases virtuales debido a la pandemia de COVID19 y con el aprendizaje del primer año bajo ASPO, en el cual no se pudieron realizar los viajes de estudio habitualmente planificados para las distintas unidades temáticas de la asignatura en las que se abordan los complejos procesos mencionados. Así, esta nueva herramienta se ofrece como una alternativa dentro del esquema de virtualización de la enseñanza, configurando una opción pedagógica diferente de la educación convencional.Especialización en Docencia UniversitariaFacultad de Ciencias Agrarias y Forestale

Técnicas de apicodentometría : ¿Cuál elegir?

La apicodentometría es el procedimiento por el cual se determina la longitud del endodonto. En este trabajo se busca comparar las diferentes técnicas para determinar cuál es más adecuada. Se seleccionó un universo de 120 piezas, que se dividieron en tres grupos, y a cada uno se le aplicó una técnica diferente (Presuntivo digital, Convencional radiográfico y con localizadores electrónicos). Al primer grupo se le realizó con lima lisa tipo “K” calibre 15 la conductometría presuntiva. Al segundo se le realizo igual tarea con toma radiográfica, y en el tercero se utilizó localizador apical (Propex II).Facultad de Odontologí

Identification of MOR-Positive B Cell as Possible Innovative Biomarker (Mu Lympho-Marker) for Chronic Pain Diagnosis in Patients with Fibromyalgia and Osteoarthritis Diseases

Fibromyalgia (FM) diagnosis follows the American College of Rheumatology (ACR) criteria, based on clinical evaluation and written questionnaires without any objective diagnostic tool. The lack of specific biomarkers is a tragic aspect for FM and chronic pain diseases in general. Interestingly, the endogenous opioid system is close to the immune one because of the expression of opioid receptors on lymphocytes membrane. Here we analyzed the role of the Mu opioid receptor on B lymphocytes as a specific biomarker for FM and osteoarthritis (OA) patients. We enrolled three groups of females: FM patients, OA patients (chronic pain control group) and healthy subjects (pain-free negative control group). We collected blood samples to apply immunophenotyping analysis. Written tests were administrated for psychological analysis. Data were statistically analyzed. Final results showed that the percentage of Mu-positive B cells were statistically lower in FM and OA patients than in pain-free subjects. A low expression of Mu-positive B cell was not associated with the psychological characteristics investigated. In conclusion, here we propose the percentage of Mu-positive B cells as a biological marker for an objective diagnosis of chronic pain suffering patients, also contributing to the legitimacy of FM as a truly painful disease

Importancia de la rehabilitación post-endodóntica en relación a la permanencia y funcionalidad de las piezas en boca

La micro filtración coronaria es una causa potencial de fracaso endodóntico. Ésta, junto a la caries recurrente o restauraciones fracturadas, permiten la re contaminación del sistema de conductos. La exposición de la gutapercha coronaria a la cavidad oral puede provocar la migración de bacterias hacia el ápice en cuestión de días y sus endotoxinas lo hacen con aún mayor velocidad. Por lo que se recomienda realizar la restauración lo más inmediatamente posible del diente, aunque sea con una “barrera intracoronaria” de composite o ionómero vítreo sobre la entrada a los conductos.Facultad de Odontologí

An observational study on chronic pain biomarkers in fibromyalgia and osteoarthritis patients:.which role for mu opioid receptor’s expression on NK cells.

The evaluation of chronic pain is challenging because of the lack of specific biomarkers. We identified the Mu opioid receptor-positive (Mu+) B cell percentage of expression, named Mu-Lympho-Marker (MLM), as a candidate marker for chronic pain in fibromyalgia (FM) and osteoarthritis (OA) patients. Here, we investigate the role of MLM on natural killer (NK) cells in the same patients. Twenty-nine FM and twelve OA patients were analyzed, and twenty-three pain-free subjects were considered as the control group. Blood samples were collected to perform immunophenotyping and Western blot analysis. Biological and clinical data were statistically analyzed. The final results showed that the percentage of NK cells expressing Mu was statistically lower in FM and OA patients than in pain-free subjects, as already demonstrated for B cells. A Western blot analysis was performed in order to detect NK cells' functional status. Moreover, the correlation analysis of MLM expression with pharmacological therapy did not show any significant results. In conclusion, here, we confirm the role of MLM as a suitable marker for chronic pain and underline NK cells as a new possible immune cell type involved in the "Mu opioid receptor reserve theory"

Potencial de especies, clones puros e híbridos de Eucaliptos para elaboración de carbón vegetal

En un contexto de cambio climático y mayor demanda de energía, la biomasa se vuelve particularmente valiosa como fuente energética para el reemplazo de los combustibles fósiles por alternativas tales como la leña y el carbón vegetal. En particular, la madera del género Eucalyptus puede ser muy relevante en este proceso, siendo el noreste de Entre Ríos uno de sus mayores núcleos productivos. El objetivo del presente trabajo fue caracterizar diversas propiedades dendroenergéticas de la madera y el carbón de diferentes especies y clones puros e híbridos del género Eucalyptus. Con respecto a la madera, los materiales se ubicaron dentro del rango de maderas livianas y semipesadas, cuyas características analizadas presentaron órdenes de magnitud similares a los reportados por trabajos referentes a este género botánico. En cuanto al carbón, se encontraron resultados contrastantes en función de la variable considerada. Los valores de densidad aparente relativa, contenido de cenizas y poder calorífico encontraron correspondencia con aquellos rangos comúnmente reportados para este género, mientras que el contenido de volátiles resultó sensiblemente superior al referido por la bibliografía. Se remarca la necesidad de continuar con los análisis, empleando diferentes protocolos, a fin de corroborar los valores obtenidos, los cuales resultan de gran importancia para establecer el potencial dendroenergético para su uso doméstico e industrial.EEA ConcordiaFil: Gauna, Juan Marcelo. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales. Cátedra de Industrias de Transformación Química; ArgentinaFil: Raffaeli, Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales. Cátedra de Industrias de Transformación Química; ArgentinaFil: Tonello, María Laura. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales. Cátedra de Industrias de Transformación Química; ArgentinaFil: Harrand, Leonel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concordia; ArgentinaFil: Mastrandrea, Ciro Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concordia; ArgentinaFil: Matinez, Matías S. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concordia; ArgentinaFil: Oberschelp, Gustavo Pedro Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concordia; ArgentinaFil: Barotto, José. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales. Cátedra de Industrias de Transformación Química; Argentin

Barriers to Health Service Access: A Study on Conditioning Factors of Self-Health and Illness Perception in Argentina

Aims: To determine self-health image and illness perception as potential barriers to health services access among inhabitants of La Plata, Buenos Aires, Argentina. Methods: A cross-sectional study, where survey, “Brief IllnessPerception Questionnaire” and basic medical examination were performed on 2430 participants at homes. Results: Although men showed a better concept of their state of health, they perceived their illness worse and belatedly. Only 45% of participants perceived symptoms disease, and from them, 48% finally decided to consult to the health system. Hence, from every 100 sick people, only 21 had access to a health institution. Higher level of education achieved, better socio-economic conditions or holding health insurance were significantly associated with appropriate health seeking, and access to health service. Conclusions: Self-health image and disease perception affected people’s access to health services. Participants of this study showed suboptimal disease perception, manifested as meager and delayed demand for care. These results demonstrate the weakness of current health care model based on people’s spontaneous demand. It is necessary to adopt a new health system for the entire population, regardless of the self-awareness that people may have about their own health/disease status. It would be a more inclusive, effective and efficient healthcare model.Fil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Vetere, Pablo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Marin, Lupe. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Giangreco, Lucia. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Dalto, Santiago. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Garcia, Gladys. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Alconada Magliano, Juan. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Marin, Gina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Ferrero, María Laura. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Bourgeois, Marcelo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Madonia, María Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Moran, Virginia. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Jauregui, Aylen. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Madeo, Aldo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Gygli, Silvina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Soibelzon, Laura. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Marin, Cloe. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Rivadulla, Patricia. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Raffaeli, Maria. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Sbattella, Daniela. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Agueda, Jorge. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Haag, Griselda. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Etchegoyen, Graciela. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Wright, Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Pracilio, Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Arinavarreta, Adriana. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentin

recommendations by the Conect4Children expert advice group

Funding Information: Competing interests: A.V.R. has received Speaker fees/Consultant for Abbvie, Novartis, UCB, SOBI, Eli Lilly and Roche. N.M. reports grants outside the submitted work in the last five years from the Medical Research Council, National Institute of Health Research, March of Dimes, British Heart Foundation, HCA international, Health Data Research UK, Shire Pharmaceuticals, Chiesi Pharmaceuticals, Prolacta Life Sciences, and Westminster Children’s Research Fund; N.M. is a member of the Nestle Scientific Advisory Board and accepts no personal remuneration for this role. N.M. reports travel and accommodation reimbursements from Chiesi, Nestle and Shire. N.M. is a member of C4C, International Neonatal Collaboration (INC), UK National Research Ethics Advisory Service and MHRA advisory groups and/or working parties. S.W. has received compensation as a member of the scientific advisory board of AM Pharma, Novartis and Khondrion and receives research funding from IMI2 for the Conect4children project. B.A. has worked for GlaxoSmithKline between October 2006 and September 2009 and holds company shares. Between October 2009 and May 2015, she has worked for Novartis. M.S. has recieved research grant and honoraria for meetings and Advisory Boards from Alexion, Sanofi/Genzyme, Takeda, CHIESI, Ultragenix, Orchard, Orphazyme. P.I. is a permanent employee of Bayer AG, Germany. M.V. has received compensation for Advisory boards or Steering committes from Roche, Novartis, Achillion, Apellis, Retrophin/Travere, Alexion pharmaceuticals. C.M. has been a consultant to or has received honoraria from Janssen, Angelini, Servier, Nuvelution, Otsuka, Lundbeck, Pfizer, Neuraxpharm and Esteve outside the submitted work. She declares conflicts of interest unrelated to the present work. M.C. had advisory roles for AstraZeneca, Bayer, Bristol Myers Squibb, Eisai, Lilly, and Roche in the last 2 years (outside the topic of the submitted work, for oncology drugs). M.J. has received research grants from Shire and has been engaged as a speaker or consultant by Shire, Ginsana, PCM Scientific Evolan, and New Nordic, all unrelated to the present work. P.S. has received speaker fees and participated at advisory boards for Biomarin, Zogenyx, GW Pharmaceuticals, and has received research funding by ENECTA BV, GW Pharmaceuticals, Kolfarma srl., Eisai. E.R. has received speaker fees and participated at advisory boards for Eisai and has received research funding by GW Pharmaceuticals, Pfizer, Italian Ministry of Health (MoH) and the Italian Medicine Agency (AIFA). This work was developed within the framework of the DINOGMI Department of Excellence of MIUR 2018-2022 (legge 232 del 2016). M.A.R. is a member of the c4c Ethics Expert Group and received compensation for ethical consulting activities from Bayer AG Wallace Crandall is employee of Eli Lilly and Co. P.C. is an employee of UCB, and owns stock in the company. She was previously an employee of GSK and owns stock in the company. N.R. has received honoraria for consultancies or speaker bureaus from the following pharmaceutical companies in the past 3 years: Ablynx, Amgen, Astrazeneca-Medimmune, Aurinia, Bayer, Bristol Myers and Squibb, Cambridge Healthcare Research (CHR), Celgene, Domain therapeutic, Eli-Lilly, EMD Serono, Glaxo Smith and Kline, Idorsia, Janssen, Novartis, Pfizer, Sobi, UCB. The IRCCS Istituto Giannina Gaslini (IGG), where NR works as full-time public employee has received contributions from the following industries in the last 3 years: Bristol Myers and Squibb, Eli-Lilly, F Hoffmann-La Roche, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties. M.L. receives/has received consultation fees from CSL Behring, Novartis, Roche and Octopharma, travel grants from Merck Serono, and been awarded educational grants to organise meetings by Novartis, Biogen Idec, Merck Serono and Bayer. All other authors have no disclosures. Funding Information: Conect4children has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777389. The Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. The views expressed in this article are the personal views of the author(s) and should not be interpreted as made on behalf of, or reflecting the position of, the regulatory agency/agencies or organisations with which the author(s) is/are employed/affiliated . Publisher Copyright: © 2021, The Author(s).Background: The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but has also triggered new ways of working, stimulated novel approaches in clinical research and reinforced the value of previous innovations. Conect4children (c4c, www.conect4children.org) is a large collaborative European network to facilitate the development of new medicines for paediatric populations, and is made up of 35 academic and 10 industry partners from 20 European countries, more than 50 third parties, and around 500 affiliated partners. Methods: We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equity. Findings: We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equityWe provide examples of research innovation, and follow this with recommendations to improve the efficiency of future trials, drawing on industry perspectives, regulatory considerations, infrastructure requirements and parent–patient–public involvement. We end with a comment on progress made towards greater international harmonisation of paediatric research and how lessons learned from COVID-19 studies might assist in further improvements in this important area.publishersversionepub_ahead_of_prin

Barriers to Health Service Access: A Study on Conditioning Factors of Self-Health and Illness Perception in Argentina

Aims: To determine self-health image and illness perception as potential barriers to health services access among inhabitants of La Plata, Buenos Aires, Argentina. Methods: A cross-sectional study, where survey, “Brief Illness- Perception Questionnaire” and basic medical examination were performed on 2430 participants at homes. Results: Although men showed a better concept of their state of health, they perceived their illness worse and belatedly. Only 45% of participants perceived symptoms disease, and from them, 48% finally decided to consult to the health system. Hence, from every 100 sick people, only 21 had access to a health institution. Higher level of education achieved, better socio-economic conditions or holding health insurance were significantly associated with appropriate health seeking, and access to health service. Conclusions: Self-health image and disease perception affected people’s access to health services. Participants of this study showed suboptimal disease perception, manifested as meager and delayed demand for care. These results demonstrate the weakness of current health care model based on people’s spontaneous demand. It is necessary to adopt a new health system for the entire population, regardless of the self-awareness that people may have about their own health/disease status. It would be a more inclusive, effective and efficient healthcare model.Facultad de Ciencias Médica

Integrated Smart TV-Based Personal e-Health System

This paper discusses the design and experimental implementation of an integrated system for the delivery of health related services, based on different technologies and devices. The idea is to create a unique point of access for the user, towards both a cloud-based remote service for the consultation of medical reports, and a personal local service that allows to collect and display data from biomedical sensors, to manage user's reminders for medicines, and to monitor the patient's dietary habits. The proposed system employs suitable technologies to simplify the user interaction, such as Near Field Communications enabled devices, and a smart TV equipment. By this way, it is possible to effectively deliver telehealth services also to users who may be less familiar with technological equipments, such as older adults, or people living in rural communities. The experimental implementation proves the feasibility of the proposed service, and the possibility to gain users' adherence and compliance, through proper design criteria