Association between amyloid plasma levels and sleep behaviors in on-call Psychiatrists

Wir untersuchten, ob Amyloid-Spiegel im Plasma mit einer Schlaf-Fragmentierung oder der Schlafdauer bei Ärzten im nächtlichen Bereitschaftsdienst in Zusammenhang stehen. Das Ausmaß der Schlaf-Fragmentierung verminderte die physiologische Reduktion der Aβ42-Plasmaspiegel während der Nacht, genauso auch das Zwischenprodukt der Aβ42-Produktion und der genetische Risikofaktor der Alzheimer-Krankheit. Unter Berücksichtigung, dass die Berufserfahrung in Jahren in dieselbe Richtung zeigte, wird die äußerst wichtige sozioökonomische Frage aufgeworfen, ob die Tätigkeit im Nachtdienst mit einem erhöhten Risiko für die Entwicklung der Alzheimer-Krankheit in Zusammenhang stehen könnte.We examined whether amyloid plasma levels are associated with sleep duration or sleep fragmentation in on-call Psychiatrists. The extent of sleep fragmentation diminished the physiological reduction of Aβ42 plasma levels during night in the same direction as the intermediate product of the production of Aβ42 and the genetic risk factor for Alzheimer’s disease. Considering that the years of professional experience also pointed in the same direction raises the utmost important socioeconomic question whether on-call duty might be associated with an altered risk of developing Alzheimer’s disease

The Multi-Trajectory Theory of Adult Firesetting (M-TTAF)

The assessment and treatment of adults who set fires deliberately are underdeveloped relative to other areas of forensic-clinical psychology. From a scientist–practitioner perspective, all clinical assessment and treatment should be guided by a theoretical and empirically based understanding of the presenting clinical phenomena. In this paper, we critically review current typologies, motives, and theories regarding the etiological features of deliberate adult firesetting. Then, using a theory knitting perspective, we synthesize the prime parts of this information into a comprehensive multifactorial framework of deliberate firesetting. The resulting Multi-Trajectory Theory of Adult Firesetting (M-TTAF) is an integration of current theory, typological, and research knowledge into a comprehensive etiological theory of firesetting along with its maintenance, and desistence. In addition to this overall theoretical framework, we summarize five associated prototypical firesetting trajectories (or patterns of characteristics leading to the firesetting behavior) that stem from our theoretical work. We examine this new theory according to key evaluative components associated with theory construction and conclude by highlighting the M-TTAF's potential application in future research and practice innovation with adult firesetters