MApping the Most Massive Overdensities Through Hydrogen (MAMMOTH) I: Methodology

Modern cosmology predicts that a galaxy overdensity is associated to a large reservoir of the intergalactic gas, which can be traced by the Ly$\alpha$ forest absorption. We have undertaken a systematic study of the relation between Coherently Strong intergalactic Ly$\alpha$ Absorption systems (CoSLAs), which have highest optical depth ($\tau$) in $\tau$ distribution, and mass overdensities on the scales of $\sim$ 10 - 20 $h^{-1}$ comoving Mpc. On such large scales, our cosmological simulations show a strong correlation between the effective optical depth ($\tau_{\rm{eff}}$) of the CoSLAs and the 3-D mass overdensities. In moderate signal-to-noise spectra, however, the profiles of CoSLAs can be confused with high column density absorbers. For $z>2.6$, where the corresponding Ly$\beta$ is redshifted to the optical, we have developed the technique to differentiate between these two alternatives. We have applied this technique to SDSS-III quasar survey at $z = 2.6$ - 3.3, and we present a sample of five CoSLA candidates with $\tau_{\rm{eff}}$ on 15 $h^{-1}$ Mpc greater than $4.5\times$ the mean optical depth. At lower redshifts of $z < 2.6$, where the background quasar density is higher, the overdensity can be traced by intergalactic absorption groups using multiple sight lines. Our overdensity searches fully utilize the current and next generation of Ly$\alpha$ forest surveys which cover a survey volume of $> (1\ h^{-1}$ Gpc)$^3$. In addition, systems traced by CoSLAs will build a uniform sample of the most massive overdensities at $z > 2$ to constrain the models of structure formation, and offer a unique laboratory to study the interactions between galaxy overdensities and the intergalactic medium.Comment: 24 pages, 30 figures, 8 tables, submitted to the Astrophysical Journa

Effects of Relative Humidity on Meat Quality in Dry Aged Beef

During dry- aging, water is transferred from the interior to the meat surface and is subsequently evaporated to the surrounding environment. Th ere is a common belief in the meat industry that rapid drying creates a hard crust on the meat surface, which would act as a protective barrier against moisture loss, holding moisture on the inside of the product. Th is phenomenon is called case hardening. If this hypothesis is correct, drying at low relative humidity would be recommended in order to get case hardening and avoid excessive yield loss. Th is study was conducted to evaluate the effects of relative humidity on moisture loss and flavor in dry- aged beef. No case hardening effects occurred, even at 50% relative humidity. Results suggest lower relative humidity results in more rapid moisture loss at the beginning of the aging process without significantly affecting the total amount of moisture loss. Lower relative humidity tended to associate with more desirable flavor notes

Plant-microbe eco-evolutionary dynamics in a changing world

Both plants and their associated microbiomes can respond strongly to anthropogenic environmental changes. These responses can be both ecological (e.g. a global change affecting plant demography or microbial community composition) and evolutionary (e.g. a global change altering natural selection on plant or microbial populations). As a result, global changes can catalyse eco-evolutionary feedbacks. Here, we take a plant-focused perspective to discuss how microbes mediate plant ecological responses to global change and how these ecological effects can influence plant evolutionary response to global change. We argue that the strong and functionally important relationships between plants and their associated microbes are particularly likely to result in eco-evolutionary feedbacks when perturbed by global changes and discuss how improved understanding of plant-microbe eco-evolutionary dynamics could inform conservation or even agriculture.</p

Polygons, points, or voxels?:stimuli selection for crowdsourcing aesthetics preferences of 3D shape pairs

Visual aesthetics is one of the fundamental perceptual properties of 3D shapes. Since the perception of shape aesthetics can be subjective, we take a data-driven approach and consider the human preferences of shape aesthetics. Previous work has considered a pairwise data collection approach, in which pairs of 3D shapes are shown to human participants and they are asked to choose one from each pair that they perceive to be more aesthetic. In this research, we study the question of whether the 3D modeling representation (e.g. polygon, points, or voxels) affects how people perceive the aesthetics of shape pairs. We find surprising results: for example the single-view and multi-view of shape pairs lead to similar user aesthetics choices; and a relatively low resolution of points or voxels is comparable to polygon meshes as they do not lead to significantly different user aesthetics choices. Our results has implications towards the data collection process of pairwise aesthetics data and the further use of such data in shape modeling problems

Rapid onset of collectivity in the vicinity of 78Ni

gamma-rays following the B and B-n decay of the very neutron rich 84Ga produced by photo-fission of 238U have been studied at the newly built ISOL facility of IPN Orsay: ALTO. Two activities were observed and assigned to two B-decaying states: 84gGa, I = (0\^-) and 84mGa, I = (3\^-, 4\^-). Excitation energies of the 2+1 and 4+1 excited states of 84Ge were measured at E(2+1) = 624.3 keV and E(4+1) = 1670.1 keV. Comparison with HFB+GCM calculations allows to establish the collective character of this nucleus indicating a substantial N=50 core polarization. The excitation energy of the 1/2+1 state in 83Ga known to carry a large part of the neutron 3s1/2 strength was measured at 247.8keV. Altogether these data allow to confirm the new single particle state ordering which appears immediately after the double Z=28 and N=50 shell closure and to designate 78Ni as a fragile and easily polarized doubly-magic core.Comment: 4 pages, ReVTe

Phenotypic microarrays suggest Escherichia coli ST131 is not a metabolically distinct lineage of extra-intestinal pathogenic E. coli

Extraintestinal pathogenic E. coli (ExPEC) are the major aetiological agent of urinary tract infections (UTIs) in humans. The emergence of the CTX-M producing clone E. coli ST131 represents a major challenge to public health worldwide. A recent study on the metabolic potential of E. coli isolates demonstrated an association between the E. coli ST131 clone and enhanced utilisation of a panel of metabolic substrates. The studies presented here investigated the metabolic potential of ST131 and other major ExPEC ST isolates using 120 API test reagents and found that ST131 isolates demonstrated a lower metabolic activity for 5 of 120 biochemical tests in comparison to non-ST131 ExPEC isolates. Furthermore, comparative phenotypic microarray analysis showed a lack of specific metabolic profile for ST131 isolates countering the suggestion that these bacteria are metabolically fitter and therefore more successful human pathogens

MAPPING the MOST MASSIVE OVERDENSITY THROUGH HYDROGEN (MAMMOTH). I. METHODOLOGY

Modern cosmology predicts that a galaxy overdensity (e.g., protocluster) will be associated with a large intergalactic medium gas reservoir, which can be traced by Lyα forest absorption. We have undertaken a systematic study of the relation between Coherently Strong intergalactic Lyα Absorption systems (CoSLAs), which have the highest optical depth (τ) in the τ distribution, and mass overdensities on the scales of ~10–20 h −1 comoving Mpc. On such large scales, our cosmological simulations show a strong correlation between the effective optical depth (τ eff) of the CoSLAs and the three-dimensional mass overdensity. In spectra with moderate signal-to-noise ratio, however, the profiles of CoSLAs can be confused with individual high column density absorbers. For z > 2.6, where the corresponding Lyβ is redshifted to the optical, we have developed a selection technique to distinguish between these two alternatives. We have applied this technique to ~6000 sight lines provided by Sloan Digital Sky Survey III quasar survey at z = 2.6–3.3 with a continuum-to-noise ratio greater than 8, and we present a sample of five CoSLA candidates with τ eff on 15 h −1 Mpc greater than 4.5× the mean optical depth. At lower redshifts of z 1 (h −1 Gpc)3. Systems traced by CoSLAs will yield a uniform sample of the most massive overdensities at z > 2 to provide stringent constraints to models of structure formation

An Interactive App for Color Deficient Viewers

Color deficient individuals have trouble seeing color contrasts that could be very apparent to individuals with normal color vision. For example, for some color deficient individuals, red and green apples do not have the striking contrast they have for those with normal color vision, or the abundance of red cherries in a tree is not immediately clear due to a lack of perceived contrast. We present a smartphone app that enables color deficient users to visualize such problematic color contrasts in order to help them with daily tasks. The user interacts with the app through the touchscreen. As the user traces a path around the touchscreen, the colors in the image change continuously via a transform that enhances contrasts that are weak or imperceptible for the user under native viewing conditions. Specifically, we propose a transform that shears the data along lines parallel to the dimension corresponding to the affected cone sensitivity of the user. The amount and direction of shear are controlled by the user'sfinger movement over the touchscreen allowing them to visualize these contrasts. Using the GPU, this simple transformation, consisting of a linear shear and translation, is performed efficiently on each pixel and in real-time with the changing position of the user's finger. The user can use the app to aid daily tasks such as distinguishing between red and green apples or picking out ripe bananas

Seagulls and Beaches as Reservoirs for Multidrug-Resistant Escherichia coli

A variety of extended-spectrum β-lactamase–producing Escherichia coli isolates, with a high rate of cefotaximase-15 resistance, were identified in seagull feces from Porto, Portugal, beaches. Beaches may therefore present a risk to public health because of the potential pathogen-spreading capacity of migratory birds

Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice

This study investigated the mechanisms underlying tubular apoptosis in diabetes by identifying proapoptotic genes that are differentially upregulated by reactive oxygen species in renal proximal tubular cells (RPTCs) in models of diabetes. Total RNAs isolated from renal proximal tubules (RPTs) of 20-week-old heterozygous db/m+, db/db, and db/db catalase (CAT)-transgenic (Tg) mice were used for DNA chip microarray analysis. Real-time quantitative PCR assays, immunohistochemistry, and mice rendered diabetic with streptozotocin were used to validate the proapoptotic gene expression in RPTs. Cultured rat RPTCs were used to confirm the apoptotic activity and regulation of proapoptotic gene expression. Additionally, studies in kidney tissues from patients with and without diabetes were used to confirm enhanced proapoptotic gene expression in RPTs. Bcl-2–modifying factor (Bmf) was differentially upregulated (P < 0.01) in RPTs of db/db mice compared with db/m+ and db/db CAT-Tg mice and in RPTs of streptozotocin-induced diabetic mice in which insulin reversed this finding. In vitro, Bmf cDNA overexpression in rat RPTCs coimmunoprecipated with Bcl-2, enhanced caspase-3 activity, and promoted apoptosis. High glucose (25 mmol/L) induced Bmf mRNA expression in RPTCs, whereas rotenone, catalase, diphenylene iodinium, and apocynin decreased it. Knockdown of Bmf with small interfering RNA reduced high glucose–induced apoptosis in RPTCs. More important, enhanced Bmf expression was detected in RPTs of kidneys from patients with diabetes. These data demonstrate differential upregulation of Bmf in diabetic RPTs and suggest a potential role for Bmf in regulating RPTC apoptosis and tubular atrophy in diabetes