Adaptation to flooding in low‐income urban settlements in the least developed countries: A systems approach

This study aims to use a whole systems approach (1) to understand the processes of adaptation to flooding of the urban poor; (2) to identify new knowledge of how low‐income settlements might better adapt to climatic risks; and (3) to begin to develop appropriate guidance on this. Low‐income urban settlements in the least developed countries (LDCs) present an extreme case where catastrophic natural hazards and chronic social hazards overlap. These low‐income urban populations face the greatest adaptation challenges as they often occupy informal settlements that are particularly exposed to hazards, and have multiple vulnerabilities arising from their lack of basic services. There is a dynamic complexity of issues arising from the many levels of actor involved and multiple social and physical factors. Analysing such a complex phenomenon calls for a specific conceptual framing, and a systems theory approach is suggested to provide a holistic perspective. The case study for this research is located in Dhaka East, where there is both high vulnerability to flooding, and a significant low‐income population. The research has adopted a mixed methods approach involving different data collection methods governed by the different scales and actors being investigated. The research develops new systems understandings of perceptions and experiences of the local population about adaptation processes in low‐income urban settlements, and how these processes may be positively influenced by integrating bottom‐up and top‐down approaches

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL

Background and Purpose—White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease and are highly heritable. To date, large-scale genetic studies have identified only a single locus influencing WMH burden. This might in part relate to biological heterogeneity of sporadic WMH. The current study searched for genetic modifiers of WMH volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease. Methods—We performed a genome-wide association study to identify quantitative trait loci for WMH volume by combining data from 517 CADASIL patients collected through 7 centers across Europe. WMH volumes were centrally analyzed and quantified on fluid attenuated inversion recovery images. Genotyping was performed using the Affymetrix 6.0 platform. Individuals were assigned to 2 distinct genetic clusters (cluster 1 and cluster 2) based on their genetic background. Results—Four hundred sixty-six patients entered the final genome-wide association study analysis. The phenotypic variance of WMH burden in CADASIL explained by all single nucleotide polymorphisms in cluster 1 was 0.85 (SE=0.21), suggesting a substantial genetic contribution. Using cluster 1 as derivation and cluster 2 as a validation sample, a polygenic score was significantly associated with WMH burden (P=0.001) after correction for age, sex, and vascular risk factors. No single nucleotide polymorphism reached genome-wide significance. Conclusions—We found a polygenic score to be associated with WMH volume in CADASIL subjects. Our findings suggest that multiple variants with small effects influence WMH burden in CADASIL. The identification of these variants and the biological pathways involved will provide insights into the pathophysiology of white matter disease in CADASIL and possibly small vessel disease in general

From Poverty to Disaster and Back: a Review of the Literature

Poor people are disproportionally affected by natural hazards and disasters. This paper provides a review of the multiple factors that explain why this is the case. It explores the role of exposure (often, but not always, poor people are more likely to be affected by hazards), vulnerability (when they are affected, poor people tend to lose a larger fraction of their wealth), and socio-economic resilience (poor people have a lower ability to cope with and recover from disaster impacts). Finally, the paper highlights the vicious circle between poverty and disaster losses: poverty is a major driver of people’s vulnerability to natural disasters, which in turn increase poverty in a measurable and significant way. The main policy implication is that poverty reduction can be considered as disaster risk management, and disaster risk management can be considered as poverty reduction

Slums of Hope: Land Tenure Reforms, Local Economic Development and Environmental Improvement in a Kenyan Shanty Town

Kambi Moto is a village shack settlement in Nairobi's vast eastern peripheral slums. Kambi Moto differs from the slum around it, however, as it is in the middle of a community-led slum upgrading programme. This programme has instituted land tenure reform, house building, environmental improvements and has forced the local community to seek economic development. The environmental improvements include permanent, formal houses with electric, water and sanitation infrastructure provision. Roads were also built allowing better access to the community. Experts state that secure tenure leads to economic, health, education and other benefits (Durand-Lasserve & Selod, 2007). This 'In Perspective' case study will investigate the Kambi Moto experience to see if this holds true in practice.