Evolution of the wall shear stresses during the progressive enlargement of symmetric abdominal aortic aneurysms.

The changes in the evolution of the spatial and temporal distribution of the wall shear stresses (WSS) and gradients of wall shear stresses (GWSS) at different stages of the enlargement of an abdominal aortic aneurysm (AAA) are important in understanding the aetiology and progression of this vascular disease since they affect the wall structural integrity, primarily via the changes induced on the shape, functions and metabolism of the endothelial cells. Particle image velocimetry (PIV) measurements were performed in in vitro aneurysm models, while changing their geometric parameters systematically. It has been shown that, even at the very early stages of the disease, i.e. increase in the diameter ≤ 50%, the flow separates from the wall and a large vortex ring, usually followed by internal shear layers, is created. These lead to the generation of WSS that drastically differ in mean and fluctuating components from the healthy vessel. Inside the AAA, the mean WSS becomes negative along most of the aneurysmal wall and the magnitude of the WSS can be as low as 26% of the value in a healthy abdominal aorta. Two regions with distinct patterns of WSS were identified inside the AAA: the proximal region of flow detachment, characterized by oscillatory WSS of very low mean, and the region of flow reattachment, located distally, where large, negative WSS and sustained GWSS are produced as a result of the impact of the vortex ring on the wall. Comparison of the measured values of WSS and GWSS to an analytical solution, calculated for slowly expanding aneurysms shows a very good agreement, thus providing a validation of the PIV measurements

Amalgamated products and properly 3-realizable groups

In this paper, we show that the class of all properly 3-realizable groups is closed under amalgamated free products (and HNN-extensions) over finite groups. We recall that $G$ is said to be properly 3-realizable if there exists a compact 2-polyhedron $K$ with $\pi_1(K) \cong G$ and whose universal cover $\tilde{K}$ has the proper homotopy type of a 3-manifold (with boundary).Comment: J. Pure Appl. Alg., to appea

Formation of corner waves in the wake of a partially submerged bluff body

We study theoretically and numerically the downstream flow near the corner of a bluff body partially submerged at a deadrise depth Δh into a uniform stream of velocity U, in the presence of gravity, g. When the Froude number, Fr=U/√gΔh, is large, a three-dimensional steady plunging wave, which is referred to as a corner wave, forms near the corner, developing downstream in a similar way to a two-dimensional plunging wave evolving in time. We have performed an asymptotic analysis of the flow near this corner to describe the wave's initial evolution and to clarify the physical mechanism that leads to its formation. Using the two-dimensions-plus-time approximation, the problem reduces to one similar to dam-break flow with a wet bed in front of the dam. The analysis shows that, at leading order, the problem admits a self-similar formulation when the size of the wave is small compared with the height difference Δh. The essential feature of the self-similar solution is the formation of a mushroom-shaped jet from which two smaller lateral jets stem. However, numerical simulations show that this self-similar solution is questionable from the physical point of view, as the two lateral jets plunge onto the free surface, leading to a self-intersecting flow. The physical mechanism leading to the formation of the mushroom-shaped structure is discussed

Elevated immune gene expression is associated with poor reproductive success of urban blue tits

Urban and forest habitats differ in many aspects that can lead to modifications of the immune system of wild animals. Altered parasite communities, pollution, and artificial light at night in cities have been associated with exacerbated inflammatory responses, with possibly negative fitness consequences, but few data are available from free-living animals. Here, we investigate how urbanization affects major immune pathways and experimentally test potentially contributing factors in blue tits (Cyanistes caeruleus) from an urban and forest site. We first compared breeding adults by quantifying the mRNA transcript levels of proteins associated with anti-bacterial, anti-malarial (TLR4, LY86) and anti-helminthic (Type 2 transcription factor GATA3) immune responses. Adult urban and forest blue tits differed in gene expression, with significantly increased TLR4 and GATA3, but not LY86, in the city. We then experimentally tested whether these differences were environmentally induced by cross-fostering eggs between the sites and measuring mRNA transcripts in nestlings. The populations differed in reduced reproductive success, with a lower fledging success and lower fledgling weight recorded at the urban site. This mirrors the findings of our twin study reporting that the urban site was severely resource limited when compared to the forest. Because of low urban survival, robust gene expression data were only obtained from nestlings reared in the forest. Transcript levels in these nestlings showed no (TLR4, LY86), or weak (GATA3), differences according to their origin from forest or city nests, suggesting little genetic or maternal contribution to nestling immune transcript levels. Lastly, to investigate differences in parasite pressure between urban and forest sites, we measured the prevalence of malaria in adult and nestling blood. Prevalence was invariably high across environments and not associated with the transcript levels of the studied immune genes. Our results support the hypothesis that inflammatory pathways are activated in an urban environment and suggest that these differences are most likely induced by environmental factors

Cooperative cell motility during tandem locomotion of amoeboid cells.

Streams of migratory cells are initiated by the formation of tandem pairs of cells connected head to tail to which other cells subsequently adhere. The mechanisms regulating the transition from single to streaming cell migration remain elusive, although several molecules have been suggested to be involved. In this work, we investigate the mechanics of the locomotion ofDictyosteliumtandem pairs by analyzing the spatiotemporal evolution of their traction adhesions (TAs). We find that in migrating wild-type tandem pairs, each cell exerts traction forces on stationary sites (∼80% of the time), and the trailing cell reuses the location of the TAs of the leading cell. Both leading and trailing cells form contractile dipoles and synchronize the formation of new frontal TAs with ∼54-s time delay. Cells not expressing the lectin discoidin I or moving on discoidin I-coated substrata form fewer tandems, but the trailing cell still reuses the locations of the TAs of the leading cell, suggesting that discoidin I is not responsible for a possible chemically driven synchronization process. The migration dynamics of the tandems indicate that their TAs' reuse results from the mechanical synchronization of the leading and trailing cells' protrusions and retractions (motility cycles) aided by the cell-cell adhesions

Weak Z\mathcal Z-structures and one-relator groups

Motivated by the notion of boundary for hyperbolic and $CAT(0)$ groups, M. Bestvina in "Local Homology Properties of Boundaries of Groups" introduced the notion of a (weak) $\mathcal Z$-structure and (weak) $\mathcal Z$-boundary for a group $G$ of type $\mathcal F$ (i.e., having a finite $K(G,1)$ complex), with implications concerning the Novikov conjecture for $G$. Since then, some classes of groups have been shown to admit a weak $\mathcal Z$-structure (see "Weak $\mathcal Z$-structures for some classes of groups" by C.R. Guilbault for example), but the question whether or not every group of type $\mathcal F$ admits such a structure remains open. In this paper, we show that every torsion free one-relator group admits a weak $\mathcal Z$-structure, by showing that they are all properly aspherical at infinity; moreover, in the $1$-ended case the corresponding weak $\mathcal Z$-boundary has the shape of either a circle or a Hawaiian earring depending on whether the group is a virtually surface group or not. Finally, we extend this result to a wider class of groups still satisfying a Freiheitssatz property

Advances in complex systems and their applications to cybersecurity

Cybersecurity is one of the fastest growing and largest technology sectors and is increasingly being recognized as one of the major issues in many industries, so companies are increasing their security budgets in order to guarantee the security of their processes. Successful menaces to the security of information systems could lead to safety, environmental, production, and quality problems. One of the most harmful issues of attacks and intrusions is the ever-changing nature of attack technologies and strategies, which increases the difficulty of protecting computer systems. As a result, advanced systems are required to deal with the ever-increasing complexity of attacks in order to protect systems and information

Dos poéticas de la verdad en el nuevo siglo: Daniel Izquierdo Clavero y Ana Martínez Mongay

En este artículo se plantea el análisis de dos propuestas poéticas del siglo XXI muy diferentes. Por un lado, tenemos a Daniel Izquierdo Clavero, con una poética introspectiva, directa, que enfrenta al poeta y a la palabra con la muerte. Por otro lado, Ana Martínez Mongay recrea el disfrute de una vida basada en los pequeños goces diarios. Estamos ante dos miradas diferentes, casi contrapuestas, que se abren paso en el panorama poético nacional. This article analyses two very different poetic proposals on the XXI century. On one hand, we have Daniel Izquierdo Clavero, with a very introspective, direct poetic, which faces the poet and the word against death. On the other hand, Ana Martinez Mongay recreates the joy of a life based on the little daily pleasures. We are face to face to two very different looks, almost opposing each other, that break into the poetic landscape

Fast Ramping Superconducting Magnet Design Issues for Future Injector Upgrades at CERN

An upgrade of the LHC injection chain, and especially the sequence of PS and SPS, up to an extraction energy of 1 TeV, is one of the steps considered to improve the performance of the whole accelerator complex. The magnets for this upgrade require central magnetic field from 2 T (for a PS upgrade) to 4.5 T (for an SPS upgrade), for which superconducting magnets are a candidate. Due to the fast field sweep rate of the magnets (from about 1.5 T/s to 2.5 T/s), internal heating from eddy and persistent current effects (AC loss) must be minimized. In this paper we discuss a rationale for the design and optimization of fast ramped superconducting accelerator magnets, specifically aimed at the LHC injectors. We introduce a design parameter, the product of bore field and field ramp-rate, providing a measure of the magnet performance, and we apply it to choose the design range for a technology demonstration magnet. We finally discuss the dependence of key design parameters on the bore field and the bore diameter, to provide an approximate scaling and guidelines for critical R&D