Corporate Financing in Great Britain

Background: The antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have investigated whether ketoconazole affects the cellular uptake and hydrolysis of the endogenous cannabinoid receptor ligand anandamide (AEA). Methodology/Principal Findings: The effects of ketoconazole upon endocannabinoid uptake were investigated using HepG2, CaCo2, PC-3 and C6 cell lines. Fatty acid amide hydrolase (FAAH) activity was measured in HepG2 cell lysates and in intact C6 cells. Ketoconazole inhibited the uptake of AEA by HepG2 cells and CaCo2 cells with IC50 values of 17 and 18 mu M, respectively. In contrast, it had modest effects upon AEA uptake in PC-3 cells, which have a low expression of FAAH. In cell-free HepG2 lysates, ketoconazole inhibited FAAH activity with an IC50 value (for the inhibitable component) of 34 mu M. Conclusions/Significance: The present study indicates that ketoconazole can inhibit the cellular uptake of AEA at pharmacologically relevant concentrations, primarily due to its effects upon FAAH. Ketoconazole may be useful as a template for the design of dual-action FAAH/CYP17 inhibitors as a novel strategy for the treatment of prostate cancer

Long-Term Multiwavelength Studies of High-Redshift Blazar 0836+710

Aims. The observation of gamma -ray flares from blazar 0836+710 in 2011, following a period of quiescence, offered an opportunity to study correlated activity at different wavelengths for a high-redshift (z=2.218) active galactic nucleus. Methods. Optical and radio monitoring, plus Fermi-LAT gamma-ray monitoring provided 2008-2012 coverage, while Swift offered auxiliary optical, ultraviolet, and X-ray information. Other contemporaneous observations were used to construct a broad-band spectral energy distribution. Results. There is evidence of correlation but not a measurable lag between the optical and gamma-ray flaring emission. On the contrary, there is no clear correlation between radio and gamma-ray activity, indicating radio emission regions that are unrelated to the parts of the jet that produce the gamma-rays. The gamma-ray energy spectrum is unusual in showing a change of shape from a power law to a curved spectrum when going from the quiescent state to the active state.Comment: 11 pages, 10 figures, Accepted for publication in A&

Correlation-induced conductance suppression at level degeneracy in a quantum dot

The large, level-dependent g-factors in an InSb nanowire quantum dot allow for the occurrence of a variety of level crossings in the dot. While we observe the standard conductance enhancement in the Coulomb blockade region for aligned levels with different spins due to the Kondo effect, a vanishing of the conductance is found at the alignment of levels with equal spins. This conductance suppression appears as a canyon cutting through the web of direct tunneling lines and an enclosed Coulomb blockade region. In the center of the Coulomb blockade region, we observe the predicted correlation-induced resonance, which now turns out to be part of a larger scenario. Our findings are supported by numerical and analytical calculations.Comment: 5 pages, 4 figure

The transition from the adiabatic to the sudden limit in core level photoemission: A model study of a localized system

We consider core electron photoemission in a localized system, where there is a charge transfer excitation. The system is modelled by three electron levels, one core level and two outer levels. The model has a Coulomb interaction between these levels and the continuum states into which the core electron is emitted. The model is simple enough to allow an exact numerical solution, and with a separable potential an analytic solution. We calculate the ratio r(omega) between the weights of the satellite and the main peak as a function of the photon energy omega. The transition from the adiabatic to the sudden limit takes place for quite small photoelectron kinetic energies. For such small energies, the variation of the dipole matrix element is substantial and described by the energy scale Ed. Without the coupling to the photoelectron, the corresponding ratio r0(omega) is determined by Ed and the satellite excitation energy dE. When the interaction potential with the continuum states is introduced, a new energy scale Es=1/(2Rs^2) enters, where Rs is a length scale of the interaction potential. At threshold there is typically a (weak) constructive interference between intrinsic and extrinsic contributions, and the ratio r(omega)/r0(omega) is larger than its limiting value for large omega. The interference becomes small or weakly destructive for photoelectron energies of the order Es. For larger energies r(omega)/r0(omega) therefore typically has a weak undershoot. If this undershoot is neglected, r(omega)/r0(omega) reaches its limiting value on the energy scale Es.Comment: 18 pages, latex2e, 13 eps figure

Energy-sensitive imaging detector applied to the dissociative recombination of D2H+

We report on an energy-sensitive imaging detector for studying the fragmentation of polyatomic molecules in the dissociative recombination of fast molecular ions with electrons. The system is based on a large area (10 cm x 10 cm) position-sensitive, double-sided Si-strip detector with 128 horizontal and 128 vertical strips, whose pulse height information is read out individually. The setup allows to uniquely identify fragment masses and is thus capable of measuring branching ratios between different fragmentation channels, kinetic energy releases, as well as breakup geometries, as a function of the relative ion-electron energy. The properties of the detection system, which has been installed at the TSR storage ring facility of the Max-Planck Institute for Nuclear Physics in Heidelberg, is illustrated by an investigation of the dissociative recombination of the deuterated triatomic hydrogen cation D2H+. A huge isotope effect is observed when comparing the relative branching ratio between the D2+H and the HD+D channel; the ratio 2B(D2+H)/B(HD+D), which is measured to be 1.27 +/- 0.05 at relative electron-ion energies around 0 eV, is found to increase to 3.7 +/- 0.5 at ~5 eV.Comment: 11 pages, 12 figures, submitted to Physical Review

Light-like noncommutativity and duality from open strings/branes

In this paper we perform some non-trivial tests for the recently obtained open membrane/D-brane metrics and `generalized' noncommutativity parameters using Dp/NS5/M5-branes which have been deformed by light-like fields. The results obtained give further evidence that these open membrane/D-brane metrics and `generalized' noncommutativity parameters are correct. Further, we use the open brane data and supergravity duals to obtain more information about non-gravitational theories with light-like noncommutativity, or `generalized' light-like noncommutativity. In particular, we investigate various duality relations (strong coupling limits). In the light-like case we also comment on the relation between open membrane data (open membrane metric etc.) in six dimensions and open string data in five dimensions. Finally, we investigate the strong coupling limit (high energy limit) of five dimensional NCYM with \Theta^{12}=\Theta^{34}. In particular, we find that this NCYM theory can be UV completed by a DLCQ compactification of M-theory.Comment: 24 pages, Latex. v2:Comments and references added. v3:Version published in JHE

Load-Balancing for Parallel Delaunay Triangulations

Computing the Delaunay triangulation (DT) of a given point set in $\mathbb{R}^D$ is one of the fundamental operations in computational geometry. Recently, Funke and Sanders (2017) presented a divide-and-conquer DT algorithm that merges two partial triangulations by re-triangulating a small subset of their vertices - the border vertices - and combining the three triangulations efficiently via parallel hash table lookups. The input point division should therefore yield roughly equal-sized partitions for good load-balancing and also result in a small number of border vertices for fast merging. In this paper, we present a novel divide-step based on partitioning the triangulation of a small sample of the input points. In experiments on synthetic and real-world data sets, we achieve nearly perfectly balanced partitions and small border triangulations. This almost cuts running time in half compared to non-data-sensitive division schemes on inputs exhibiting an exploitable underlying structure.Comment: Short version submitted to EuroPar 201

Temperature dependence of binary and ternary recombination of H3+ ions with electron

We study binary and the recently discovered process of ternary He-assisted recombination of H3+ ions with electrons in a low temperature afterglow plasma. The experiments are carried out over a broad range of pressures and temperatures of an afterglow plasma in a helium buffer gas. Binary and He-assisted ternary recombination are observed and the corresponding recombination rate coefficients are extracted for temperatures from 77 K to 330 K. We describe the observed ternary recombination as a two-step mechanism: First, a rotationally-excited long-lived neutral molecule H3* is formed in electron-H3+ collisions. Second, the H3* molecule collides with a helium atom that leads to the formation of a very long-lived Rydberg state with high orbital momentum. We present calculations of the lifetimes of H3* and of the ternary recombination rate coefficients for para and ortho-H3+. The calculations show a large difference between the ternary recombination rate coefficients of ortho- and para-H3+ at temperatures below 300 K. The measured binary and ternary rate coefficients are in reasonable agreement with the calculated values.Comment: 15 page

OH far-infrared emission from low- and intermediate-mass protostars surveyed with Herschel-PACS

OH is a key species in the water chemistry of star-forming regions, because its presence is tightly related to the formation and destruction of water. This paper presents OH observations from 23 low- and intermediate-mass young stellar objects obtained with the PACS integral field spectrometer on-board Herschel in the context of the Water In Star-forming Regions with Herschel (WISH) key program. Most low-mass sources have compact OH emission (< 5000 AU scale), whereas the OH lines in most intermediate-mass sources are extended over the whole PACS detector field-of-view (> 20000 AU). The strength of the OH emission is correlated with various source properties such as the bolometric luminosity and the envelope mass, but also with the OI and H2O emission. Rotational diagrams for sources with many OH lines show that the level populations of OH can be approximated by a Boltzmann distribution with an excitation temperature at around 70 K. Radiative transfer models of spherically symmetric envelopes cannot reproduce the OH emission fluxes nor their broad line widths, strongly suggesting an outflow origin. Slab excitation models indicate that the observed excitation temperature can either be reached if the OH molecules are exposed to a strong far-infrared continuum radiation field or if the gas temperature and density are sufficiently high. Using realistic source parameters and radiation fields, it is shown for the case of Ser SMM1 that radiative pumping plays an important role in transitions arising from upper level energies higher than 300 K. The compact emission in the low-mass sources and the required presence of a strong radiation field and/or a high density to excite the OH molecules points towards an origin in shocks in the inner envelope close to the protostar.Comment: Accepted for publication in Astronomy and Astrophysics. Abstract abridge