Extremely narrow spectrum of GRB110920A: further evidence for localised, subphotospheric dissipation

Much evidence points towards that the photosphere in the relativistic outflow in GRBs plays an important role in shaping the observed MeV spectrum. However, it is unclear whether the spectrum is fully produced by the photosphere or whether a substantial part of the spectrum is added by processes far above the photosphere. Here we make a detailed study of the $\gamma-$ray emission from single pulse GRB110920A which has a spectrum that becomes extremely narrow towards the end of the burst. We show that the emission can be interpreted as Comptonisation of thermal photons by cold electrons in an unmagnetised outflow at an optical depth of $\tau \sim 20$. The electrons receive their energy by a local dissipation occurring close to the saturation radius. The main spectral component of GRB110920A and its evolution is thus, in this interpretation, fully explained by the emission from the photosphere including localised dissipation at high optical depths.Comment: 14 pages, 11 figures, accepted to MNRA

Homocysteine and small vessel stroke: A mendelian randomization analysis.

OBJECTIVE: Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). We assessed whether circulating tHcy and B vitamin levels are selectively associated with SVS, but not other stroke subtypes, using Mendelian randomization. METHODS: We used summary statistics data for single-nucleotide polymorphisms (SNPs) associated with tHcy (n = 18), folate (n = 3), vitamin B6 (n = 1), and vitamin B12 (n = 14) levels, and the corresponding data for stroke from the MEGASTROKE consortium (n = 16,952 subtyped ischemic stroke cases and 404,630 noncases). RESULTS: Genetically predicted tHcy was associated with SVS, with an odds ratio of 1.34 (95% confidence interval [CI], 1.13-1.58; p = 6.7 × 10-4 ) per 1 standard deviation (SD) increase in genetically predicted tHcy levels, but was not associated with large artery or cardioembolic stroke. The association was mainly driven by SNPs at or near the MTHFR and MUT genes. The odds ratios of SVS per 1 SD increase in genetically predicted folate and vitamin B6 levels were 0.49 (95% CI, 0.34-0.71; p = 1.3 × 10-4 ) and 0.70 (95% CI, 0.52-0.94; p = 0.02), respectively. Genetically higher vitamin B12 levels were not associated with any stroke subtype. INTERPRETATION: These findings suggest that any effect of homocysteine-lowering treatment in preventing stroke will be confined to the SVS subtype. Whether genetic variants at or near the MTHFR and MUT genes influence SVS risk through pathways other than homocysteine levels and downstream effects require further investigation. Ann Neurol 2019;85:495-501

Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Vitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian randomization study design to examine whether circulating vitamin K₁ (phylloquinone) levels are associated with ischemic stroke. Four single-nucleotide polymorphisms associated with vitamin K₁ levels were used as instrumental variables. Summary-level data for large artery atherosclerotic stroke (n = 4373 cases), small vessel stroke (n = 5386 cases), cardioembolic stroke (n = 7193 cases), and any ischemic stroke (n = 34,217 cases and 404,630 non-cases) were available from the MEGASTROKE consortium. Genetically-predicted circulating vitamin K₁ levels were associated with large artery atherosclerotic stroke but not with any other subtypes or ischemic stroke as a whole. The odds ratios per genetically predicted one nmol/L increase in natural log-transformed vitamin K₁ levels were 1.31 (95% confidence interval (CI) 1.12⁻1.53; p = 7.0 × 10-4) for large artery atherosclerotic stroke, 0.98 (95% CI 0.85⁻1.12; p = 0.73) for small vessel stroke, 1.01 (95% CI 0.90⁻1.14; p = 0.84) for cardioembolic stroke, and 1.05 (95% CI 0.99⁻1.11; p = 0.11) for any ischemic stroke. These findings indicate that genetic predisposition to higher circulating vitamin K₁ levels is associated with an increased risk of large artery atherosclerotic stroke

An M-theory solution generating technique and SL(2,R)

In this paper we generalize the O(p+1,p+1) solution generating technique (this is a method used to deform Dp-branes by turning on a NS-NS B-field) to M-theory, in order to be able to deform M5-brane supergravity solutions directly in eleven dimensions, by turning on a non zero three form A. We find that deforming the M5-brane, in some cases, corresponds to performing certain SL(2,R) transformations of the Kahler structure parameter for the three-torus, on which the M5-brane has been compactified. We show that this new M-theory solution generating technique can be reduced to the O(p+1,p+1) solution generating technique with p=4. Further, we find that it implies that the open membrane metric and generalized noncommutativity parameter are manifestly deformation independent for electric and light-like deformations. We also generalize the O(p+1,p+1) method to the type IIA/B NS5-brane in order to be able to deform NS5-branes with RR three and two forms, respectively. In the type IIA case we use the newly obtained solution generating technique and deformation independence to derive a covariant expression for an open D2-brane coupling, relevant for OD2-theory.Comment: 24 pages, Latex. v2:Sections 3.2 and 3.3 improved. v3:Some clarifications added. Version published in JHE

A low-frequency study of recently identified double-double radio galaxies

In order to understand the possible mechanisms of recurrent jet activity in radio galaxies and quasars, which are still unclear, we have identified such sources with a large range of linear sizes (220 $-$ 917 kpc), and hence time scales of episodic activity. Here we present high-sensitivity 607-MHz Giant Metrewave Radio Telescope (GMRT) images of 21 possible double-double radio galaxies (DDRGs) identified from the FIRST survey to confirm their episodic nature. These GMRT observations show that none of the inner compact components suspected to be hot-spots of the inner doubles are cores having a flat radio spectrum, confirming the episodic nature of these radio sources. We have indentified a new DDRG with a candidate quasar, and have estimated the upper spectral age limits for eight sources which showed marginal evidence of steepening at higher frequencies. The estimated age limits (11 $-$ 52 Myr) are smaller than those of the large-sized ($\sim$ 1 Mpc) DDRGs.Comment: Accepted for publication in MNRAS. 14 pages, 7 figure

Suzaku observations of Markarian 335: evidence for a distributed reflector

We report on a 151 ks net exposure Suzaku observation of the Narrow Line Seyfert 1 galaxy Mrk 335. The 0.5-40 keV spectrum contains a broad Fe line, a strong soft excess below about 2 keV and a Compton hump around 20-30 keV. We find that a model consisting of a power law and two reflectors provides the best fit to the time-averaged spectrum. In this model, an ionized, heavily blurred, inner reflector produces most of the soft excess, while an almost neutral outer reflector (outside ~40 r_g) produces most of the Fe line emission. The spectral variability of the observation is characterised by spectral hardening at very low count rates. In terms of our power-law + two-reflector model it seems like this hardening is mainly caused by pivoting of the power law. The rms spectrum of the entire observation has the curved shape commonly observed in AGN, although the shape is significantly flatter when an interval which does not contain any deep dip in the lightcurve is considered. We also examine a previous 133 ks XMM-Newton observation of Mrk 335. We find that the XMM-Newton spectrum can be fitted with a similar two-reflector model as the Suzaku data and we confirm that the rms spectrum of the observation is flat. The flat rms spectra, as well as the high-energy data from the Suzaku PIN detector, disfavour an absorption origin for the soft excess in Mrk 335.Comment: 13 pages, 13 figures. Accepted for publication in MNRA