Remotely sensing the morphometrics and dynamics of a cold region dune field using historical aerial photography and airborne LIDAR data

© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Remote Sensing 10 (2018): 792, doi:10.3390/rs10050792.This study uses an airborne Light Detection and Ranging (LiDAR) survey, historical aerial photography and historical climate data to describe the character and dynamics of the Nogahabara Sand Dunes, a sub-Arctic dune field in interior Alaska’s discontinuous permafrost zone. The Nogahabara Sand Dunes consist of a 43-km2 area of active transverse and barchanoid dunes within a 3200-km2 area of vegetated dune and sand sheet deposits. The average dune height in the active portion of the dune field is 5.8 m, with a maximum dune height of 28 m. Dune spacing is variable with average crest-to-crest distances for select transects ranging from 66–132 m. Between 1952 and 2015, dunes migrated at an average rate of 0.52 m a−1. Dune movement was greatest between 1952 and 1978 (0.68 m a−1) and least between 1978 and 2015 (0.43 m a−1). Dunes migrated predominantly to the southeast; however, along the dune field margin, net migration was towards the edge of the dune field regardless of heading. Better constraining the processes controlling dune field dynamics at the Nogahabara dunes would provide information that can be used to model possible reactivation of more northerly dune fields and sand sheets in response to climate change, shifting fire regimes and permafrost thaw.Funding for this research was provided by the U.S. Geological Survey Land Change Science and Land Remote Sensing programs, the U.S. Fish andWildlife Service and the University of Alaska Fairbanks

Arctic and Atlantic waters in the Norwegian Basin, between year variability and potential ecosystem implications

The ocean climate of the southern Norwegian Sea - the Norwegian Basin - is largely set by the relative amount of Atlantic Water in the eastern and Arctic Water in the western region. Here we utilized hydrographic data from repeated sections, together with annually gridded survey data of the upper 1000 m, to resolve the main hydrographic changes over the period 1995-2019. Based on integrated heat -and freshwater content, we divide into three periods. The first period 1995-2005, denoted Arctic, is characterized by relative fresh and cold Atlantic Water overlaying Arctic Intermediate Water that basically covers the whole Norwegian Basin. Differently, the conditions during the period 2006-2016, denoted Atlantic, are warmer and more saline, and the extent and thickness of Arctic Intermediate Water is greatly reduced. During the most recent period denoted Fresh, 2017-2019, there has been a major freshening of the Atlantic waters, the layer of Arctic Intermediate Water has not recovered, but instead a layer of warmer but relative fresh Arctic Water has expanded. We find that increased abundance of the Arctic zooplankton Calanus hyperboreus in the southern and eastern Norwegian Basin coincides with increased extent of Arctic Water. We also note that the overall mesozooplankton biomass in the Norwegian Basin is significantly higher during periods of relative high amount of Arctic Water. Furthermore, we show that both nitrate and silicate winter (pre-bloom) concentrations are significantly higher in the Arctic Water compared to Atlantic Water, and that there is a reduction in nutrients from the Arctic period compared subsequent Atlantic and Fresh periods. Since these nutrients can be interpreted as the potential for new production, changes in the influx of western Arctic waters are expected to have a bottom-up effect on the Norwegian Sea. Hence, this study indicates that the amount of Arctic waters and their concentration of nutrients and zooplankton are more important for the Norwegian Basin ecosystem functioning rather than the temperature of the Atlantic waters.publishedVersio

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue. However, the molecular mechanisms governing this pathway are poorly understood. Here, we show that the urokinase plasminogen activator receptor–associated protein (uPARAP)/Endo180, a novel mesenchymally expressed member of the macrophage mannose receptor family of endocytic receptors, is a key player in this process. Fibroblasts from mice with a targeted deletion in the uPARAP/Endo180 gene displayed a near to complete abrogation of collagen endocytosis. Furthermore, these cells had diminished initial adhesion to a range of different collagens, as well as impaired migration on fibrillar collagen. These studies identify a central function of uPARAP/Endo180 in cellular collagen interactions

The effect of protein and glycemic index on children's body composition: the DiOGenes randomized study

OBJECTIVE: To investigate the effect of protein and glycemic index (GI) on body composition among European children in the randomized, 6-month dietary intervention DiOGenes (diet, obesity, and genes) family-based study. PATIENTS AND METHODS: In the study, 827 children (381 boys and 446 girls), aged 5 to 18 years, completed baseline examinations. Families with parents who lost >= 8% of their weight during an 8-week run-in low-calorie diet period were randomly assigned to 1 of 5 ad libitum diets: low protein (LP)/low glycemic index (LGI); LP/high GI (HGI); high protein (HP)/LGI; HP/HGI; and control diet. The target difference was 15 GI U between the LGI/HGI groups and 13 protein percentage points between the LP/HP groups. There were 658 children examined after 4 weeks. Advice on food-choice modification was provided at 6 visits during this period. No advice on weight loss was provided because the focus of the study was the ability of the diets to affect outcomes through appetite regulation. Anthropometric measurements and body composition were assessed at baseline, week 4, and week 26. RESULTS: In the study, 465 children (58.1%) completed all assessments. The achieved differences between the GI and protein groups were 2.3 GI U and 4.9 protein percentage points, respectively. The LP/HGI group increased body fat percentage significantly more than the other groups (P = .040; partial eta(2) = 0.039), and the percentage of overweight/obese children in the HP/LGI group decreased significantly during the intervention (P = .031). CONCLUSIONS: Neither GI nor protein had an isolated effect on body composition. However, the LP/HGI combination increased body fat, whereas the HP/LGI combination was protective against obesity in this sample of children

A multicentre weight loss study using a low-calorie diet over 8 weeks: regional differences in efficacy across eight European cities

PRINCIPLES: The efficacy of low-calorie diets (LCDs) has not been investigated in large-scale studies or among people from different regions, who are perhaps unaccustomed to such methods of losing weight. The aim of the present study was to investigate changes in obesity measures among overweight/obese adults from eight European cities (from Northern, Central and Southern Europe) during the 8-week LCD phase of the DiOGenes study (2006–2007), a family-based, randomised, controlled dietary intervention. METHODS: 938 overweight/obese adults completed baseline examinations and underwent an 8-week LCD, providing 3.3–4.2 MJ/day to replace all meals. Anthropometric measurements and body composition were assessed at baseline and post-LCD. RESULTS: 773 (82.4%) adults (mean age, 43.1 y) completed the LCD successfully. The highest drop-out rate was observed in Southern (24.9%) and the lowest in Northern (13.3%) European cities. Overall, the LCD induced favourable changes in all outcomes, including an approximate 11.0% reduction in body weight and body fat percentage. Changes in outcomes differed significantly between regions, with North- and Central-European cities generally achieving higher percentage reductions in most anthropometric measurements assessed. Nonetheless, participants in Southern Europe reduced their body fat percentage significantly more than participants in Northern Europe (–11.8 vs. –9.5%, P = 0.017). CONCLUSIONS: The LCD significantly improved anthropometric and body composition measurements in all cities participating in DiOGenes

Nationwide Survival Benefit after Implementation of First-Line Immunotherapy for Patients with Advanced NSCLC—Real World Efficacy

SIMPLE SUMMARY: The expected change in overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC) after the clinical implementation of immune checkpoint inhibitor therapy (ICI) has not been substantially investigated in large real-world cohorts outside randomized controlled trials (RCTs). In this nationwide study, we compared OS before and after the implementation of ICI and found that 3-year OS tripled from 6% to 18%. Patients receiving ICI had a lower OS than demonstrated in RCTs, except for patients with performance status (PS) 0. More than a fifth of the patients progressed early within the first six ICI cycles. Adverse prognostic factors were PS ≥ 1 and metastases to the bone and liver. ABSTRACT: Background The selection of patients with non-small cell lung cancer (NSCLC) for immune checkpoint inhibitor (ICI) treatment remains challenging. This real-world study aimed to compare the overall survival (OS) before and after the implementation of ICIs, to identify OS prognostic factors, and to assess treatment data in first-line (1L) ICI-treated patients without epidermal growth factor receptor mutation or anaplastic lymphoma kinase translocation. Methods Data from the Danish NSCLC population initiated with 1L palliative antineoplastic treatment from 1 January 2013 to 1 October 2018, were extracted from the Danish Lung Cancer Registry (DLCR). Long-term survival and median OS pre- and post-approval of 1L ICI were compared. From electronic health records, additional clinical and treatment data were obtained for ICI-treated patients from 1 March 2017 to 1 October 2018. Results The OS was significantly improved in the DLCR post-approval cohort (n = 2055) compared to the pre-approval cohort (n = 1658). The 3-year OS rates were 18% (95% CI 15.6–20.0) and 6% (95% CI 5.1–7.4), respectively. On multivariable Cox regression, bone (HR = 1.63) and liver metastases (HR = 1.47), performance status (PS) 1 (HR = 1.86), and PS ≥ 2 (HR = 2.19) were significantly associated with poor OS in ICI-treated patients. Conclusion OS significantly improved in patients with advanced NSCLC after ICI implementation in Denmark. In ICI-treated patients, PS ≥ 1, and bone and liver metastases were associated with a worse prognosis

Report on the observational potential of the TMAs

Assessment of the impact of upper-ocean measurements and of coherent integration of O2 measurements (as example for non-physical EOVs) for transports and fluxes in the Atlantic TMAs and synergies with the wider Atlantic Observing System. One workshop will be held to prepare the report and foster the cooperation on cross-TMA analyse

Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT

Contains fulltext : 65628.pdf ( ) (Open Access)BACKGROUND: Around 80% of intrauterine growth restricted (IUGR) infants are born at term. They have an increase in perinatal mortality and morbidity including behavioral problems, minor developmental delay and spastic cerebral palsy. Management is controversial, in particular the decision whether to induce labour or await spontaneous delivery with strict fetal and maternal surveillance. We propose a randomised trial to compare effectiveness, costs and maternal quality of life for induction of labour versus expectant management in women with a suspected IUGR fetus at term. METHODS/DESIGN: The proposed trial is a multi-centre randomised study in pregnant women who are suspected on clinical grounds of having an IUGR child at a gestational age between 36+0 and 41+0 weeks. After informed consent women will be randomly allocated to either induction of labour or expectant management with maternal and fetal monitoring. Randomisation will be web-based. The primary outcome measure will be a composite neonatal morbidity and mortality. Secondary outcomes will be severe maternal morbidity, maternal quality of life and costs. Moreover, we aim to assess neurodevelopmental and neurobehavioral outcome at two years as assessed by a postal enquiry (Child Behavioral Check List-CBCL and Ages and Stages Questionnaire-ASQ). Analysis will be by intention to treat. Quality of life analysis and a preference study will also be performed in the same study population. Health technology assessment with an economic analysis is part of this so called Digitat trial (Disproportionate Intrauterine Growth Intervention Trial At Term). The study aims to include 325 patients per arm. DISCUSSION: This trial will provide evidence for which strategy is superior in terms of neonatal and maternal morbidity and mortality, costs and maternal quality of life aspects. This will be the first randomised trial for IUGR at term. TRIAL REGISTRATION: Dutch Trial Register and ISRCTN-Register: ISRCTN10363217

Mathematical Modelling as a Proof of Concept for MPNs as a Human Inflammation Model for Cancer Development

<p><b>Left:</b> Typical development in stem cells (top panel A) and mature cells (bottom panel B). Healthy hematopoietic cells (full blue curves) dominate in the early phase where the number of malignant cells (stipulated red curves) are few. The total number of cells is also shown (dotted green curves). When a stem cell mutates without repairing mechanisms, a slowly increasing exponential growth starts. At a certain stage, the malignant cells become dominant, and the healthy hematopoietic cells begin to show a visible decline. Finally, the composition between the cell types results in a takeover by the malignant cells, leading to an exponential decline in hematopoietic cells and ultimately their extinction. The development is driven by an approximately exponential increase in the MPN stem cells, and the development is closely followed by the mature MPN cells. <b>Right:</b> B)The corresponding allele burden (7%, 33% and 67% corresponding to ET, PV, and PMF, respectively) defined as the ratio of MPN mature cells to the total number of mature cells.</p