Perfil sociodemográfico e índice de qualidade de vida de cuidadores de pessoas com deficiência física

The study objective was to identify the socio-demographic profile and the level of quality of life of caregivers of persons with disabilities met with the Foundation to Support Integrated Patient with Physical Disabilities (FUNAD) in the city of Joao Pessoa, in the state Paraíba, Brazil. The study had 51 participants, caregivers of people with disabilities in the age group 19-63 years (36.29±11.10). For the evaluation, we used two instruments: a structured form, with questions about personal and social profiles, and World Health Organization Quality of Life (WHOQOL-bref), to analyze the level of quality of life. The results showed that most caregivers were women (92.2%), mothers (68.6%), single (43.1%) and had attended up to elementary school (47%). Statistical significance (pO objetivo do estudo foi identificar o perfil sociodemográfico e o nível de qualidade de vida de cuidadores de pessoas com deficiência física atendidas na Fundação Centro Integrado de Apoio ao Portador de Deficiência Física (FUNAD) no município de João Pessoa (PB). Participaram do estudo 51 cuidadores de pessoas com deficiência física, na faixa etária de 19 a 63 anos (36,29±11,10). Para a avaliação foram utilizados dois instrumentos: um formulário estruturado, com questões sobre o perfil pessoal e social dos cuidadores e o World Health Organization Quality of Life (WHOQOL-bref), para a análise do nível de qualidade de vida. Os resultados apontaram que a maioria dos cuidadores eram mulheres (92,2%), mães (68,6%), solteiras (43,1%) e haviam frequentado a escola até o Ensino Fundamental incompleto (47%). Houve significância estatística (

Relação entre perfil psicomotor e estilo de vida de crianças de escolas do município de João Pessoa, PB

The purpose of the study was to assess whether schoolchildren psychomotor development is related to lifestyle - the latter estimated by performance of school and non-school leisure activities. Seventy-four children (38 girls, 36 boys) aged 9 to 12 (10.5±1.2) years old were selected among those enrolled in public and private schools in João Pessoa, PB. They were assessed by means of the Picq & Vayer test battery and by a questionnaire on school and non-school leisure activities. Results show that, among the 74 sample children, 63 (85%) presented developmental disorder, mostly attending public schools. Among school activities, 35% of children with delay said they"do nothing" during recreation; among typical-development children, none said doing nothing and 36% said they practised sport (vs 5% of disordered children). As to non-school activities, television, internet and electronic games were singled out as favourites by 44.3% of children with delay, and by none among typical ones. The fact that children with psychomotor disorders preferably engage in less lively, physical, activities suggests an association between lifestyle and psychomotor profile.O objetivo do estudo foi comparar o grau de desenvolvimento psicomotor e o estilo de vida de crianças matriculadas nas redes pública e privada de ensino do município de João Pessoa, PB. O estilo de vida foi estimado pelo desempenho de atividades escolares e não-escolares. Participaram do estudo 74 crianças de 9 a 12 anos (10,5±1,2 anos), 38 meninas e 36 meninos. Para avaliação, foi aplicada a bateria de testes psicomotores de Picq e Vayer e um formulário com questões sobre atividades desempenhadas na escola e fora dela. Os dados revelam que, das 74 crianças avaliadas, 63 (85%) apresentavam distúrbios no desenvolvimento psicomotor, com maior incidência nas escolas da rede pública. Dentre as atividades escolares, 35% das crianças com distúrbio psicomotor indicaram não fazer atividade alguma no recreio; das que apresentaram desenvolvimento típico, nenhuma disse não fazer atividade alguma e 36% indicaram fazer esporte (contra 5% daquelas com distúrbio); quanto às atividades não-escolares, televisão, jogos eletrônicos e internet foram apontadas como preferidas por 44,3% das crianças com distúrbio, e por nenhuma com desenvolvimento típico. A preferência das crianças que apresentaram distúrbio por atividades mais estáticas sugere associação entre estilo de vida e perfil psicomotor

Pre-treatment strategies based on aqueous two-phase systems comprising ionic liquids to improve the adrenal cancer diagnosis

ancer remains the cause of millions of deaths every year worldwide, and reliable early-stage diagnosis methods are essential to prevent them. Cancer biomarkers quantification in human fluids has gained relevance in detecting cancer in an early-stage. Among these, the levels of the biomarkers epinephrine, norepinephrine and vanillylmandelic acid in urine have been used for the diagnosis of adrenal cancer. However, due to their low levels in human fluids, expensive and multistep pretreatment methods are necessary to increase their concentration to meet the detection limits of the analytical equipments. In this work, we propose the use of aqueous two-phase systems (ATPS) composed of ionic liquids (ILs), K3PO4 and synthetic/natural urine as an alternative pretreatment strategy to improve the concentration of adrenal cancer biomarkers from human fluids. The ATPS ternary phase diagrams, as well as the respective tie-lines and tie-line lengths, were determined at 25 °C. The performance of these IL-based ATPS for the extraction and concentration of epinephrine, norepinephrine and vanillylmandelic acid from human urine was then evaluated. The obtained results show that in the studied systems, with the exception of IL-based ATPS constituted by ILs with longer alkyl side chains at the cation, all the studied cancer biomarkers preferably migrate to the IL-rich phase. The best ATPS investigated is constituted by 1-ethyl-3-methylimidazolium methylsulfate ([C2mim][CH3SO4]) that allows the complete extraction of all cancer biomarkers to the IL-rich phase in a single-step and a concentration factor up to 500-fold. All biomarkers were accurately quantified in the IL-rich phase after the extraction from urine and the concentration step by UHPLC. According to the obtained results, IL-based ATPS could be used as a novel and effective method for the pretreatment and concentration of cancer biomarkers from human fluids to improve cancer diagnosispublishe

Whole-Body Vibration Associated with Strength Training on the Lower-Limb Blood Flow and Mobility in Older Adults with Type 2 Diabetes: A Study Protocol for a Randomized Controlled Trial

Vascular endothelium insults caused by high serum glucose levels affect the oxygen supply to tissues, via the microvascular endothelium, resulting in an increased perfusion heterogeneity. These insults may lead to the underuse of blood capillaries, while other vessels are overused and effectively overload their oxygen supply capacity, which eventually causes damages to distal parts of the peripheral nervous system. Therefore, the proprioceptive and exteroceptive feedback information will be gradually lost and contribute to a mobility reduction. This study aims to assess the efficacy of whole-body vibration (WBV) associated with strength training (ST) on lower-limb blood flow and mobility in older adults with type 2 diabetes (DM2). Methods and analyses: This is a protocol (1st version) for Pa single-blind, randomized, controlled clinical trial guided by the SPIRIT guidelines. Our sample will consist of 51 older adults with DM2 randomly allocated to three groups: low frequency WBV (16–26 Hz) associated to ST (G1), WBV sham (G2) and nonintervention control (G3). The study protocol is set for a 12-week (three times per week) schedule. Primary outcomes: skin temperature using infrared thermographic imaging (ITI); mean peripheral arterial blood flow velocity (MBF) by a handheld Doppler ultrasound (DU), and functional mobility by Timed Up and Go (TUG) test. Secondary outcomes: quasi-static posture using the DX100 BTS Smart optoelectronic system, and plantar pressure and body balance using the MPS stabilometric platform. Data will be collected and analyzed at baseline and post-intervention, considering p-value < 0.05 level of significance. The analyses will also be conducted with an intention-to-treat method and effect size. Dissemination: All results will be published in peer-reviewed journals as well as presented in conferences

<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight: bold" lang="EN-US">Evaluation<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US"> <span style="mso-bidi-font-size:15.0pt; font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US">of<span style="mso-bidi-font-size:15.0pt;font-weight: normal;mso-bidi-font-weight:bold" lang="EN-US"> <span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight: bold" lang="EN-US">Antimicrobial and Modulatory activity<span style="mso-bidi-font-size:15.0pt;font-weight:normal;mso-bidi-font-weight:bold" lang="EN-US"> of the extract of <i style="mso-bidi-font-style:normal">Richardia brasiliensis</i> Gomes </span></span></span></span></span></span>

619-622The emergence of resistant microorganisms and also the toxicity associated with antimicrobial drugs increase the need of research for new active principles. Richardia brasiliensis, a weed used popularly as an expectorant, antiemetic, and diaphoretic. The extracts have coumarins, flavonoids, steroids, triterpenoids, alkaloids and resin, as secondary metabolites. The present study aimed to test the potential antimicrobial and modulator of the ethanolic and hexanic extracts of R. brasiliensis. The ethanolic and hexanic extracts were tested for their antimicrobial effect and in combination with aminoglycosides and antifungal against standard and multi-resistant microorganisms by the broth microdilution method with culture medium Brain Heart Infusion (BHI). It was observed that the association between antibiotics and ethanolic and hexanic extracts showed clinically relevant results on the tests with multi-resistant bacteria. The natural products from R. brasiliensis demonstrated a modulating action against the microorganisms used. These results can represent a new effort to combat antibiotic resistant bacteria. </span

Effectiveness of Whole-Body Vibration Combined with Multicomponent Training on the Risk of Falls and Quality of Life in Elderly Women with Osteoporosis: Study Protocol for a Randomized Controlled Clinical Trial

Osteoporosis and the risk of falls increase the risk of fractures and events of falls. Prescriptions and programs for different forms of exercise have different impacts on the risk of falls, and exercises from multiple categories of whole-body vibration can be effective. This study aims to evaluate the effectiveness of whole-body vibration (WBV) protocol combined with multicomponent training (MCT) in elderly women with osteoporosis and their history of falls. Our proposal is a protocol for a randomized clinical trial, divided into two stages: First, development of a protocol for WVB combined with MCT for elderly women with osteoporosis and a history of falls, under the Guidelines of the American College of Sports Medicine, and following the recommendations of the Standard Protocol Items Recommendations for Interventional Trials (SPIRIT), and second, a randomized controlled clinical trial following the Consolidated Standards of Reporting Trials (CONSORT). This trial will have implications for the effectiveness of a vibration protocol combined with multicomponent exercise on the risk of falls and quality of life for older women with osteoporosis. We expect that adding full-body vibration to an exercise protocol will decrease the risk of falls and improve participants’ quality of life, as well as their strength, balance, and functional capacity

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data