Unidirectional convective flows of a viscous incompressible fluid with slippage in a closed layer

An exact solution describing the flow of a viscous incompressible fluid in a closed horizontal layer is obtained in view of the Navier slip condition and the inhomogeneous pressure distribution on one of the layer boundaries. The principal possibility of velocity field stratification and the dependence of the number of stratification points on the slip length are demonstrated. © 2019 Author(s)

Features of the analysis of fixed assets the organization

The article examines trends and analysis tools, plant and equipment company, which is one of the most important factors of any production. The authors emphasized that the state and the effective use of fixed assets has a direct impact on the final results of the organization. During the analysis of fixed assets identified existing problems defined reserves of increase of efficiency of managing. Based on the analysis of the results management solutions are being developed that will improve the results of financial and economic activities of the organization

Diagnostics of Intonation Skills in Preschool Children

В статье изучается просодическая организация речи у детей дошкольного возраста с применением скрининг-диагностики.The problem of children's speech development is one of the most important issues of preschool general and special psychology and pedagogy, since speech occupies a special position in the hierarchy of mental and emotional-volitional processes. The prosodic organization of the speech flow is a significant aspect of this issue. Intonation is an integral part of speech. It is one of the most important components of language, which does not only organize oral speech, but also makes the communication process more informative. Timely detection of deviations from the normal course of development of the intonation aspect of speech in preschool children can allow timely organizing logopedic work aimed to form the expressiveness of speech and at the same time wake up the huge compensatory capabilities of the developing child's body to prevent the emergence of typological prosodico-intonational deviations

Features of the analysis of fixed assets the organization

The article examines trends and analysis tools, plant and equipment company, which is one of the most important factors of any production. The authors emphasized that the state and the effective use of fixed assets has a direct impact on the final results of the organization. During the analysis of fixed assets identified existing problems defined reserves of increase of efficiency of managing. Based on the analysis of the results management solutions are being developed that will improve the results of financial and economic activities of the organization

TIF1β is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism

TIF1β is a pleiotropic regulator of a diverse range of cellular processes such as DNA repair or gene repression in stem cells. This functional switch depends on phosphorylation at serine residue 473 and multiple pathways exist to accomplish this. However, the effects of exogenous reactive oxygen species (ROS) generated by bacterial flora and dietary metabolites in the colonic lumen or chemotherapy on TIF1β have not been determined. We report here that exposure of colorectal cancer (CRC) cell lines DLD-1 and HCT116 to hydrogen peroxide specifically induces TIF1β Ser473 phosphorylation. Hydrogen peroxide also induces primarily p38 MAPK and some p42/44 MAPK phosphorylation. Chemical inhibition of p38 MAPK and p42/44 MAPK reduced phosphorylation of TIF1β serine 473 and increased CRC cell death upon peroxide exposure. Taken together, this suggests that it is primarily peroxide-induced p38 MAPK that mediates Ser473 phosphorylation and activation of TIF1β to enable more efficient DNA repair to assist in tumor cell survival against exogenous ROS

Human Rights Risks in the Constitutions of the American Federal States

The article presents the results of a comparative legal analysis of the constitutions of American federal states (Argentina, Brazil, Venezuela, Canada, Mexico, and USA) with a view to identifying the norms that minimize human rights risks. The examination depended on an argumentative way to deal with the revelation of legitimate wonders and cycles utilizing general logical (precise and consistent strategies, investigation and amalgamation) and explicit logical techniques. The declared axiological, functional, and institutional parameters are fully set only in the Constitution of Venezuela. Other constitutions that consider the objective specifics of the historical development of countries reflected the desired formulations in the framework of the axiology of individual rights and freedoms; prohibition of slavery; judicial protection of individual rights; isolation of a special human rights institution, etc. The objectives of the study led to the use of special legal methods. Thus, the comparative legal method contributed to the identification of resources and means of minimizing risks to human right advocacy in the foreign constitutions. The novelty of this research is identifying the norms that minimize human rights risks

Rotational imaging optical coherence tomography for full-body mouse embryonic imaging

Optical coherence tomography (OCT) has been widely used to study mammalian embryonic development with the advantages of high spatial and temporal resolutions and without the need for any contrast enhancement probes. However, the limited imaging depth of traditional OCT might prohibit visualization of the full embryonic body. To overcome this limitation, we have developed a new methodology to enhance the imaging range of OCT in embryonic day (E) 9.5 and 10.5 mouse embryos using rotational imaging. Rotational imaging OCT (RI-OCT) enables full-body imaging of mouse embryos by performing multiangle imaging. A series of postprocessing procedures was performed on each cross-section image, resulting in the final composited image. The results demonstrate that RI-OCT is able to improve the visualization of internal mouse embryo structures as compared to conventional OCT

Features of selecting boundary conditions when describing flows of stratified fluids

The article discusses the selection of boundary conditions at the boundary between adjacent layers in a stratified viscous incompressible fluid. It is shown that the "continuity condition + differentiability condition" pair traditionally used in many disciplines gives physically unjustified properties of the resulting exact solution for the velocity field. Although the condition for the differentiability of velocities is close in mathematical form to the stress continuity condition (by virtue of Newton's law), in terms of physics, taking these conditions into account gives fundamentally different properties of the exact solution of the Navier-Stokes system of equations. It is shown that the consideration of the "the velocity field continuity condition + the stress field continuity condition" pair is more adequate to the physics of the process, which is consistent with the hypothesis of continuity. © 2021 Elsevier B.V.. All rights reserved