Archaea at St Andrews

A report of the Biochemical Society meeting 'The Molecular Biology of Archaea', St Andrews, UK, 19-21 August 2008

Meta-Analysis of Geospatial Estimates in the Case of Malaysian Airlines Flight MH370

This study performs a meta-analysis of 38 studies providing geospatial estimates for the final location of MH370, investigates the spatial characteristics of antennas as a potential source of additional useful spatial information and direction sensing, and makes an independent assessment of the impact of the Global Aeronautical Distress and Safety System implementation on the reduction of the probability of future oceanic hull loss accidents with high spatial uncertainty. The meta-analysis finds that those studies derived from ocean drift modelling are statistically homogenous, while those derived from satellite communications observations are statistically heterogenous. This heterogeneity may be explained by the multimodal nature of the solution space when making use of the Doppler-based Burst Frequency Offset measurements. Inclusion in a physical model of the known variation in peak gain for the MH370 aircraft's MSS antenna as a function of apparent satellite elevation and azimuth, as an additional direction sensing technique, is shown to reduce the bimodality and multimodality of the BFO-only solutions when the two are combined, however the technique is not sufficiently powerful under the present model to isolate a single trajectory for the flight. The most coherent trajectories terminate around 34-37S latitude. Probability distributions are estimated for future oceanic hull losses with high spatial uncertainty during the period 2020-2030, through Monte Carlo simulation of scenarios related to the GADSS implementation. The risk of a loss with high spatial uncertainty such as was encountered with Air France 447 and Malaysian Airlines 370 is forecast to be reduced but far from eliminated

Internationalism, Regionalism, and National Culture: Music Control in Bavaria, 1945–1948

For many Germans in the immediate postwar period, all that remained of their country was its art. Subjugation, destruction, the pain of unfathomable guilt: these had ripped away at the national psyche, severing nation from nationalism, person from people, the present from the past. “We are,” wrote Wolfgang Borchert in 1946, “a generation without a homecoming, because we have nothing to which we can return.” Nation: what would that word now mean? An occupied state no longer possessing statehood, a conquered people starved even of the moral strength that might come from resisting. Even if the institutions of national governance could be recreated, they could have no historical legitimacy; if Bonn were not to be Weimar, it would equally not be the kaisers’ or the Führer’s Berlin. For many, refuge from the shaming of the nation lay, as Theodor Heuss reflected, in a “decentralizing of the emotions,” in a “flight” to those fields “where the violence of the great political world shake-up is not felt so directly.” This drove literate Germans back to Goethe and music lovers to the endlessly-performed postwar symphonic cycles of Brahms and Beethoven. And yet, escaping into what Jost Hermand aptly termed “the protective wall of self-absorption” did not completely preclude connection to the national community of Germans. In fact, a powerful communion with the whole might still come through the personal enjoyment of a shared art or culture. In art might reside the essence of the national community, a stateless collectivity, without territories perhaps, but with borders and guardians nonetheless

Supplementary material to "Replacement of GroEL in Escherichia coli by the group II chaperonin from the archaeon Methanococcus maripaludis"

Supplementary material to "Replacement of GroEL in Escherichia coli by the group II chaperonin from the archaeon Methanococcus maripaludis

Impact of incomplete percutaneous revascularization in patients With multivessel coronary artery disease: a systematic review and meta-analysis

Background: Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for complete revascularization (CR) versus incomplete revascularization in patients undergoing percutaneous coronary intervention, and its prognostic impact using meta‐analysis. Methods and Results: A search of PubMed, EMBASE, MEDLINE, Current Contents Connect, Google Scholar, Cochrane library, Science Direct, and Web of Science was conducted to identify the association of CR in patients with multivessel coronary artery disease undergoing percutaneous coronary intervention with major adverse cardiac events and mortality. Random‐effects meta‐analysis was used to estimate the odds of adverse outcomes. Meta‐regression analysis was conducted to assess the relationship with continuous variables and outcomes. Thirty‐eight publications that included 156 240 patients were identified. Odds of death (OR 0.69, 95% CI 0.61‐0.78), repeat revascularization (OR 0.60, 95% CI 0.45‐0.80), myocardial infarction (OR 0.64, 95% CI 0.50‐0.81), and major adverse cardiac events (OR 0.63, 95% CI 0.50‐0.79) were significantly lower in the patients who underwent CR. These outcomes were unchanged on subgroup analysis regardless of the definition of CR. Similar findings were recorded when CR was studied in the chronic total occlusion (CTO) subgroup (OR 0.65, 95% CI 0.53‐0.80). A meta‐regression analysis revealed a negative relationship between the OR for mortality and the percentage of CR. Conclusion: CR is associated with reduced risk of mortality and major adverse cardiac events, irrespective of whether an anatomical or a score‐based definition of incomplete revascularization is used, and this magnitude of risk relates to degree of CR. These results have important implications for the interventional management of patients with multivessel coronary artery disease

[Letter] Size selection of liquid-exfoliated 2D nanosheets

Here we present a size selection model for liquid-exfoliated two-dimensional nanosheets. The ability to consistently select exfoliated nanosheets with desired properties is important for development of applications in all areas. The model presented facilitates determination of centrifugation parameters for production of dispersions with controlled size and thickness for different materials, solvents and exfoliation processes. Importantly, after accounting for the influence of viscosity on exfoliation, comparisons of different solvents are shown to be well described by the surface tension and Hansen parameter matching. This suggests that previous analyses may have overestimated the relative performance of more viscous solvents. This understanding can be extended to develop a model based on the force balance of nanosheets falling under viscous drag during centrifugation. By considering the microscopic aspect ratio relationships, this model can be both calibrated for size selection of nanosheets and compare the exfoliation processes themselves

Use of Surface Motion Characteristics Determined by InSAR to Assess Peatland Condition

Peatland surface motion is a key property of peatland that relates to condition. However, field‐based techniques to measure surface motion are not cost‐effective over large areas and long time periods. An alternative method that can quantify peatland surface motion over large areas is interferometric synthetic aperture radar. Although field validation of the accuracy of this method is difficult, the value of InSAR as a means of quantifying peat condition can be tested. To achieve this the characteristics of InSAR time series measured over an18‐month period at 22 peatland sites in the Flow Country northern Scotland were compared to site condition assessment based on plant functional type and site management history. Sites in good condition dominated by Sphagnum display long‐term stability or growth and a seasonal cycle with maximum uplift and subsidence in Aug‐Nov and April‐June respectively. Drier and partially drained sites dominated by shrubs display long‐term subsidence with maximum uplift and subsidence in July‐Oct and Feb‐June respectively. Heavily degraded sites with large bare peat extent display subsidence with no distinct seasonal oscillations. Seasonal oscillation in surface motion at sites with a dominant non‐vascular plant community is interpreted as resulting from changes in seasonal evaporative demand. On sites with extensive vascular plants cover and falling water table, surface oscillations are interpreted as representing sustained drawdown during the growing season and subsequent recharge in late winter. This study highlights the potential to use InSAR to characterize peatland condition and provide a new view of the surface dynamics of peatland landscapes

Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise.

OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds. RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes

Effects of synchronous music on treadmill running among elite triathletes

This is the post-print version of the final paper published in Journal of Science and Medicine in Sport. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2011 Elsevier B.V.Objectives: Music can provide ergogenic, psychological, and psychophysical benefits during physical activity, especially when movements are performed synchronously with music. The present study developed the train of research on synchronous music and extended it to elite athletes. Design: Repeated-measures laboratory experiment. Method: Elite triathletes (n = 11) ran in time to self-selected motivational music, a neutral equivalent and a no-music control during submaximal and exhaustive treadmill running. Measured variables were time-to-exhaustion, mood responses, feeling states, RPE, blood lactate concentration, oxygen consumption and running economy. Results: Time-to-exhaustion was 18.1% and 19.7% longer, respectively, when running in time to motivational and neutral music, compared to no music. Mood responses and feeling states were more positive with motivational music compared to either neutral music or no music. RPE was lowest for neutral music and highest for the no-music control. Blood lactate concentrations were lowest for motivational music. Oxygen consumption was lower with music by 1.0%–2.7%. Both music conditions were associated with better running economy than the no-music control. Conclusions: Although neutral music did not produce the same level of psychological benefits as motivational music, it proved equally beneficial in terms of time-to-exhaustion and oxygen consumption. In functional terms, the motivational qualities of music may be less important than the prominence of its beat and the degree to which participants are able to synchronise their movements to its tempo. Music provided ergogenic, psychological and physiological benefits in a laboratory study and its judicious use during triathlon training should be considered.QAS Centre of Excellence for Applied Sport Science Researc