Effect of diets supplemented with different conjugated linoleic acid (CLA) isomers on protein expression in C57/BL6 mice

The individual genetic variations, as a response to diet, have recently caught the attention of several researchers. In addition, there is also a trend to assume food containing beneficial substances, or to supplement food with specific compounds. Among these, there is the conjugated linoleic acid (CLA), which has been demonstrated to reduce fat mass and to increase lean mass, even though its mechanism of action is still not known. We investigated the effect of CLA isomers (CLA c9,t11 and CLA t10,c12) on the proteomic profile of liver, adipose tissue, and muscle of mouse, with the aim of verifying the presence of a modification in fat and lean mass, and to explore the mechanism of action

Analytical and numerical study of the ground-track resonances of Dawn orbiting Vesta

The aim of Dawn mission is the acquisition of data from orbits around two bodies, (4)Vesta and (1)Ceres, the two most massive asteroids. Due to the low thrust propulsion, Dawn will slowly cross and transit through ground-track resonances, where the perturbations on Dawn orbit may be significant. In this context, to safety go the Dawn mission from the approach orbit to the lowest science orbit, it is essential to know the properties of the crossed resonances. This paper analytically investigates the properties of the major ground-track resonances (1:1, 1:2, 2:3 and 3:2) appearing for Vesta orbiters: location of the equilibria, aperture of the resonances and period at the stable equilibria. We develop a general method using an averaged Hamiltonian formulation with a spherical harmonic approximation of the gravity field. If the values of the gravity field coefficient change, our method stays correct and applicable. We also discuss the effect of one uncertainty on the C20 and C22 coefficients on the properties of the 1:1 resonance. These results are checked by numerical tests. We determine that the increase of the eccentricity appearing in the 2:3 resonance is due to the C22 and S22 coefficients. Our method can be easily adapted to missions similar to Dawn because, contrarily to the numerical results, the analytical formalism stays the same and is valid for a wide range of physical parameters of the asteroid (namely the shape and the mass) as well as for different spacecraft orbits. Finally we numerically study the probability of the capture in resonance 1:1. Our paper reproduces, explains and supplements the results of Tricarico and Sykes (2010).Comment: 34 pages, 9 figures, 10 Table

Migração AM para FM: caminhos para o reposicionamento de produto a partir do planejamento de comunicação: estudo de caso de uma emissora de Rádio AM

Esta pesquisa investiga caminhos para o reposicionamento de produto/serviço (programação), em uma emissora de rádio AM que irá migrar para FM, condição de 1.439 rádios AMs do país que já optaram pela migração. Para chegar a esse objetivo, se utiliza de um estudo de caso de uma emissora de rádio AM, que fará a migração para o FM convencional; de pesquisa de opinião para identificar o perfil do público e analisar as suas principais demandas; de pesquisa bibliográfica; de observação participante da pesquisadora e de grupo focal com os funcionários. A partir destes estudos, sugere-se como um destes caminhos que na migração para FM, a emissora aplique um modelo de reposicionamento de sua grade de programas do tipo reativo e propositivo de produto/serviço, indicado para organizações que já têm a liderança de mercado no seu segmento. Este tipo de ação mercadológica se aplica para a emissora que detém 39% de preferência do público na praça local e 45% na praça regional, mas que teria potencial para ampliar a audiência, aproveitando a suposta melhoria na qualidade de transmissão em frequência modulada, forma de transmissão preferida por 74% dos ouvintes de rádio no país. Este reposicionamento visa atender demandas de um público com perfil adulto entre 31 e 60 anos; ouvintes com predominância no sexo feminino; usuários que têm ensino médio completo; que acompanham a rádio preferencialmente de manhã; que têm como preferência uma programação que se destine às notícias locais e regionais; onde mais de 80% dos entrevistados ainda ouvem rádio no aparelho convencional; onde 73% ouvem rádio todo dia e 65% dos ouvintes preferem música sertaneja. Para apresentar essas alterações, a pesquisa propõe utilizar um Plano Resumido de Marketing de reposicionamento de produto, com objetivo de fidelizar o vínculo com os ouvintes e ampliar a audiência em pelo menos 10% (meta) no prazo de dois meses, mantendo uma grade de programas generalista, mas com maior dinamismo. Portanto, este estudo conclui que o reposicionamento da grade de programas é um dos caminhos que podem ser seguidos na migração para FM, que pode ser uma oportunidade para as emissoras AMs

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENDAPATAN USAHA BUDI DAYA IKAN AIR TAWAR DALAM PERSPEKTIF EKONOMI ISLAM ( Studi pada usaha budi daya ikan air tawar di Dusun Rantau Tijang Kabupaten Tanggamus)

ABSTRAK Kehidupan manusia tidak dapat dipisahkan dari aktivitas ekonomi,dimana salah satunya usaha pembudidayaan ikan mas memiliki Peluang yang cukup besar.Yuniarum Fatin Laili (2020) “analisis faktor-faktor yang mempengaruhi pendapatan umkm sentra batik di kotapekalongan pada penelitian nya menyatakan bahwa modal,tenaga kerja, pendidikan, lama usaha” berpengaruh positif dan signifikan terhadap pendapatan UMKM Sentra Batik di Kota Pekalongan.Faktor pertama adalah faktor modal seringkali memberikan pengaruhyang besar terhadap suatu usaha termasuk usaha budi daya ikan air tawar, dimana dapat berdampak pada timbulnya permasalahan lain. Selain itu lama usaha juga menjadi salah satu faktor dimana bahwa lamanya seseorang pedagang menekuni usahanya maka akan meningkat pula penegetahuannya dan memiliki konsumen tetap (langganan) yang setiap harinya pedagang menjual ikan ke pada mereka (konsumen). Permasalahan dalam penelitian ini yaitu faktor apa saja yang dapat mempengaruhi pendapatan pemilik usaha budidaya ikan air tawar dalam perspektif Ekonomi Islam.Tujuan dalam penelitian ini yaitu untuk mengetahui pandangan Ekonomi Islam tentang analisis faktor-faktor yang mempengaruhi tingkat pendapatan usaha budi daya ikan air. Metode dalampenelitian ini adalahpenelitian kualitatif, dimana jenis penelitian nya yaitupenelitian lapangan (field research) dengan sifat penelitian deskriptif analisis. dengan teknik pengumpulan data menggunakan metode observasi, wawancara dan dokumentasiserta pengolahan data yang dilakukan dengan analisi data berupa Reduksi data, penyajian data dan penarikan kesimpulan. Berdasarkan hasil penelitian Modal yang digunakan merupakan modalpribadi dan menggunakan sistem hutang piutang kepada pemiliktookpakan ikan, semakin besar modal yang dikeluarkan maka akansemakin besar pula keuntungan yang didapat.Semakin lamapengusaha menjalani usahanya, maka semakin banyak pengalamanyang didapatkannya serta semakin luas relasi bisnis nya,hal tersebutdapat menjadi salah satu faktor yang dapat meningkatkan pendapatanusaha. Berdasarkan prinsip ekonomi Islam pada penelitian ini bahwamodal dan lama usaha yang digunakan sudah sesuai dengan syariatislam, yaitu pada prinsip tauhid dan prinsip tauhid Kata Kunci : Modal, Lama Usaha, Pendapatan, Ekonomi Islam iii ABSTRACT Human life cannot be separated from economic activities, one of which is the goldfish cultivation business which has quite large opportunities. Yuniarum Fatin Laili(2020) "analysis of factors that influence the incomeof batik center MSMEs in Pekalongan City in her research states that capital, labor, education, length of business" have a positive and significant effect on the income of Batik Center MSMEs in Pekalongan City. The first factor is that capital often has abig influence on a business, including freshwater fish cultivation, which can have an impact on the emergence of other problems. Apart from that, the length of business is also a factor where the longera trader is in his business, his knowledge will alsoincrease and he will have regular customers (subscribers) who every day the trader sells fish to them (consumers). The problem in this research is what factors can influence the income of freshwater fish cultivation business owners from an Islamic Economics perspective. The aim of this research is to find out the Islamic Economics view regarding the analysis of factors that influence the income level of aquatic fish farming businesses. The method in thisresearch is qualitative research, where the type of research is field research with the nature of descriptive analysis research. with data collection techniques using observation,interviews and documentation methods as well as data processing carried outby data analysis in the form of data reduction, data presentation and drawing conclusions. Based on the research results, the capital used is capital personal and uses a accounts payable system to shop ownersfish feed,the greaterthe capital spent, the morethe greater the profits obtained.The longerentrepreneurs run their business, the more experience they havethat he gets and the wider his business relationships, that iscan be one of the factors that can increase incomebusiness. Based on Islamic economic principles in this research thatThe capital and length of business used are in accordance with the Shari'aIslam,namely the principle of monotheism and the principle of maslahah Keywords: Capital, Length of Business, Income, Islamic Economic

Implementing an LGBTQ Training for Teen Pregnancy Prevention Facilitators

Teen pregnancy and sexually transmitted infections remain a major health concern and are linked to a number of poor outcomes. Lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth are particularly at risk for these issues. Although evidence-based teen pregnancy prevention (TPP) programs exist, they are not necessarily tailored to meet the needs of LGBTQ youth. This paper reports on the development and implementation of a LGBTQ training for TPP facilitators working for the Augusta Partnership for Children in Augusta, GA. The four-hour workshop covered a range of topics including terminology, identity, intersectionality, and risk/resilience factors through a combination of lecture, video clips, and interactive activities. The training was well-received with most facilitators rating the training as excellent on satisfaction surveys completed one-week after the training. Qualitative comments were also largely positive; areas for improvement included discussion of the legal context around LGBTQ issues and the impact of race on LGBTQ issues. Future work is needed to expand on these findings by examining the impact of such trainings on TPP program implementation and, ultimately, on LGBTQ youth

Implementing an LGBTQ Training for Teen Pregnancy Prevention Facilitators

Teen pregnancy and sexually transmitted infections remain a major health concern and are linked to a number of poor outcomes. Lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth are particularly at risk for these issues. Although evidence-based teen pregnancy prevention (TPP) programs exist, they are not necessarily tailored to meet the needs of LGBTQ youth. This paper reports on the development and implementation of a LGBTQ training for TPP facilitators working for the Augusta Partnership for Children in Augusta, GA. The four-hour workshop covered a range of topics including terminology, identity, intersectionality, and risk/resilience factors through a combination of lecture, video clips, and interactive activities. The training was well-received with most facilitators rating the training as excellent on satisfaction surveys completed one-week after the training. Qualitative comments were also largely positive; areas for improvement included discussion of the legal context around LGBTQ issues and the impact of race on LGBTQ issues. Future work is needed to expand on these findings by examining the impact of such trainings on TPP program implementation and, ultimately, on LGBTQ youth

The mass-metallicity-kinematics relation of the stellar components of EAGLE galaxies

In this work, we study the stellar mass -- stellar metallicity relation as a function of the morpho-kinematics of galaxies in {\sc{eagle}} cosmological simulations. According to our findings, at a given stellar mass ($M_\star$), stellar metallicity shows a secondary dependence on the morpho-kinematics of galaxies, which is more evident towards high masses. At the high-mass end ($M_\star \gtrsim 10^{10}~\rm{M}_\odot$), dispersion-supported systems show lower metallicities, on average. In addition, low-mass galaxies with higher rotational support are somewhat more metal-poor. More massive galaxies tend to exhibit flatter morphologies, being prolate systems less metal-enriched, on average. As the redshift $z$ increases, those aforementioned dependences of metallicity on kinematics and morphology tend to become stronger at high masses. These trends are consistent with the dependences of the stellar mass -- gas-phase metallicity relation on gas fraction, star formation rate and stellar age, and the relation of the latter quantities with galaxy morpho-kinematics.Fil: Zenocratti, Lucas Jesús. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: de Rossi, Maria Emilia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Lara López, Maritza Arlene. Universidad de Copenhagen; DinamarcaFil: Theuns, Tom. University Of Durham. Dep.of Physics; Reino Unid

Study of Electrochemical and Biological Characteristics of As-Cast Ti-Nb-Zr-Ta System Based on Its Microstructure

[EN] The quaternary Ti-Nb-Zr-Ta (TNZT) alloy was successfully cast-fabricated with the objective to be used in the medical field. Samples' microstructure was compared to CP-Ti and Ti-6Al-4V (control samples) and related to corrosion, ion release and biological properties. As-cast TNZT was formed with large grain sizes (285 m) compared to the ultrafine grain sizes of CP-Ti (11 m) and the + ultrafine grain sizes of 1.45 m and 0.74 m. Hardness and flexural elastic moduli (94 HV and 43 GPa) came close to the biological structures, such as dentin and enamel values. The ion release mechanism of as-cast TNZT was significantly lesser than CP-Ti and Ti-6Al-4V, which can be related to the difference in samples¿ grain sizes and chemical compositions. However, the corrosion rate was higher than for the control samples; this way offers corrosion properties inferior with respect to the properties obtained in the reference materials. Biological assays demonstrated that the two-cell (hDPSCs and MG-63) lineage studied presented good adhesion and capability to differentiate in bone cells on the as-cast TNZT surface, and no cytotoxicity effects were found. Details and reasons based on samples¿ microstructure are discussed.The authors thank the Spanish Ministerio de Economia y Competitividad for Research Project RTI2018-097810-B-I00 and the European Commission for FEDER funds.Correa Rossi, M.; Navarro, B.; Milian Medina, L.; Vicente-Escuder, Á.; Amigó, V. (2022). Study of Electrochemical and Biological Characteristics of As-Cast Ti-Nb-Zr-Ta System Based on Its Microstructure. Metals. 12(3):1-25. https://doi.org/10.3390/met1203047612512

Guidelines for the monitoring of Rosalia alpina

Rosalia alpina (Linnaeus, 1758) is a large longhorn beetle (Coleoptera: Cerambycidae) which is protected by the Habitats Directive and which typically inhabits beech forests characterised by the presence of mature, dead (or moribund) and sun-exposed trees. A revision of the current knowledge on systematics, ecology and conservation of R. alpina is reported. The research was carried out as part of the LIFE MIPP project which aims to find a standard monitoring method for saproxylic beetles protected in Europe. For monitoring this species, different methods were tested and compared in two areas of the Apennines, utilising wild trees, logs and tripods (artificially built with beech woods), all potentially suitable for the reproduction of the species. Even if all methods succeeded in the survey of the target species, these results showed that the use of wild trees outperformed other methods. Indeed, the use of wild trees allowed more adults to be observed and required less intensive labour. However, monitoring the rosalia longicorn on wild trees has the main disadvantage that they can hardly be considered “standard sampling units”, as each tree may be differently attractive to adults. Our results demonstrated that the most important factors influencing the attraction of single trunks were wood volume, sun-exposure and decay stage. Based on the results obtained during the project LIFE MIPP, as well as on a literature review, a standard monitoring method for R. alpina was developed

Pentaplex PCR as screening assay for jellyfish species identification in food product

Salted jellyfish, a traditional food in Asian Countries, is nowadays spreading on the Western markets. In this work, we developed a Pentaplex PCR for the identification of five edible species (Nemopilema nomurai, Rhopilema esculentum, Rhizostoma pulmo, Pelagia noctiluca, and Cotylorhiza tuberculata), which cannot be identified by a mere visual inspection in jellyfish products sold as food. A common degenerated forward primer and five specie-specific reverse primers were designed to amplify COI gene regions of different lengths. Another primer pair targeted the 28SrRNA gene and was intended as common positive reaction control. Considering the high level of degradation in the DNA extracted from acidified and salted products, the maximum length of the amplicons was set at 200 bp. The PCR was developed using 66 reference DNA samples. It gave successful amplifications in 85.4% of 48 ready to eat products (REs) and in 60% of 30 classical salted products (CPs) collected on the market