15 research outputs found
Should I Stay or Should I Go: Stellar Wind Retention and Expulsion in Massive Star Clusters
- Author
- Abbott
- Badalyan
- Barmby
- Bastian
- Bastian
- Bastian
- Bastian
- Bastian
- Bastian
- Bastian
- Beasley
- Bekki
- Bekki
- Birkinshaw
- Bloecker
- Bloecker
- Bondi
- Bowers
- Boyer
- Briley
- Brüns
- Cabrera-Ziri
- Cabrera-Ziri
- Cabrera-Ziri
- Caldwell
- Calura
- Camilo
- Cannon
- Carretta
- Carretta
- Carretta
- Carretta
- Carretta
- Carretta
- Cassisi
- Charbonnel
- Charbonnel
- Choi
- Cohen
- Cohen
- Cohen
- Cohen
- Conroy
- Conroy
- Conroy
- Cranmer
- D N C Lin
- Dalgarno
- Debes
- Decressin
- Decressin
- Decressin
- Demircan
- Denissenkov
- de Jager
- de Juan Ovelar
- de Mink
- de Silva
- Dickey
- Doherty
- Doherty
- Dupree
- Dupree
- Dupree
- Dupree
- D’Antona
- D’Ercole
- D’Ercole
- D’Ercole
- E Ramirez-Ruiz
- Elmegreen
- Evans
- Evans
- Faulkner
- Fenner
- Ferraro
- Frail
- Frank
- Fryxell
- Gerssen
- Gnat
- Goudfrooij
- Gratton
- Gratton
- Harris
- Heiles
- Hollyhead
- Hopkins
- Hopwood
- Hopwood
- Hueyotl-Zahuantitla
- Hénault-Brunet
- Ivans
- J P Naiman
- Kalirai
- Kalirai
- Karakas
- Karakas
- Kerr
- Kerr
- Knapp
- Knapp
- Knapp
- Kraft
- Krause
- Krause
- Kroupa
- Kroupa
- Kruijssen
- Külebi
- Lada
- Larsen
- Leigh
- Leon
- Li
- Longmore
- Longmore
- Loup
- Lynch
- Lynch
- Maeder
- Marcolini
- Marigo
- Marino
- Martell
- Martell
- Martocchia
- Mauas
- McDonald
- McDonald
- McNamara
- Milone
- Moore
- Morin
- Mucciarelli
- Mucciarelli
- Mészáros
- Naiman
- Naiman
- Nyman
- Odenkirchen
- Origlia
- Pancino
- Pancino
- Pasquato
- Paxton
- Peacock
- Perren
- Pflamm-Altenburg
- Piatti
- Piotto
- Pooley
- Pooley
- Portegies Zwart
- Prantzos
- Prantzos
- Priestley
- Quataert
- Reimers
- Robinson
- Rodríguez-González
- Rogers
- Ruiz-Lara
- Scally
- Schaerer
- Searle
- Smith
- Smith
- Smith
- Smith
- Smith
- Sneden
- Tayler
- Tenorio-Tagle
- Trancho
- Troland
- Truelove
- Usher
- van Loon
- van Loon
- Vassiliadis
- Ventura
- Ventura
- Ventura
- Ventura
- Vesperini
- Villanova
- Villaver
- Villaver
- Waters
- Whitmore
- Wilkin
- Wood
- Wünsch
- Zhao
- Zhu
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 09/04/2018
- Field of study
Mass and energy injection throughout the lifetime of a star cluster
contributes to the gas reservoir available for subsequent episodes of star
formation and the feedback energy budget responsible for ejecting material from
the cluster. In addition, mass processed in stellar interiors and ejected as
winds has the potential to augment the abundance ratios of currently forming
stars, or stars which form at a later time from a retained gas reservoir. Here
we present hydrodynamical simulations that explore a wide range of cluster
masses, compactnesses, metallicities and stellar population age combinations in
order to determine the range of parameter space conducive to stellar wind
retention or wind powered gas expulsion in star clusters. We discuss the
effects of the stellar wind prescription on retention and expulsion
effectiveness, using MESA stellar evolutionary models as a test bed for
exploring how the amounts of wind retention/expulsion depend upon the amount of
mixing between the winds from stars of different masses and ages. We conclude
by summarizing some implications for gas retention and expulsion in a variety
of compact (σv≳20kms−1) star clusters including
young massive star clusters (105≲M/M⊙≲107, age≲500~Myrs), intermediate age clusters (105≲M/M⊙≲107, age≈1−4~Gyrs), and globular clusters (105≲M/M⊙≲107, age≳10~Gyrs).Comment: 18 pages, 14 figures, version resubmitted to MNRAS after minor
referee comment
Depressive symptoms from kindergarten to early school age: Longitudinal associations with social skills deficits and peer victimization
- Author
- A Nishina
- AD Pellegrini
- AF Newcomb
- AS Masten
- C Segrin
- C Segrin
- CC Epkins
- CL Fox
- D Olweus
- D Olweus
- D Schwartz
- DA Cole
- DF Hay
- DF Hay
- DF Hay
- DG Perry
- DG Perry
- DJ Pepler
- DSJ Hawker
- EA Storch
- EJ Dill
- EVE Hodges
- EVE Hodges
- F Alsaker
- F Alsaker
- F Alsaker
- FD Alsaker
- FD Alsaker
- Françoise D Alsaker
- G Bohlin
- G Groen
- G Ladd
- GW Ladd
- GW Ladd
- H Gazelle
- H Kraemer
- H Kraemer
- HF Clarizio
- JB Asendorpf
- JC Coyne
- JD Coie
- JWR Twisk
- K Deater-Deckard
- K Rigby
- K Rigby
- KD Rudolph
- KR Wentzel
- L Arseneault
- L Henricsson
- L Henricsson
- LD Hanish
- LD Hanish
- LD Hanish
- LD Hanish
- M Döpfner
- ME Lara
- MR Goodman
- N Eisenberg
- P Gjerde
- PD Hastings
- PM Lewinsohn
- R Veenstra
- R von Grünigen
- RM Baron
- S Graham
- S Perren
- S Perren
- S Perren
- S Perren
- S Perren
- S Perren
- S Perren
- SN Elliott
- Sonja Perren
- SR Asher
- WM Bukowski
- WW Hartup
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Background: Depressive symptoms in children are associated with social skills deficits and problems with peers. We propose a model which suggests different mechanisms for the impact of deficits in self-oriented social skills (assertiveness and social participation) and other-oriented social skills (pro-social, cooperative and non-aggressive behaviors) on children's depressive symptoms. We hypothesized that deficits in self-oriented social skills have a direct impact on children's depressive symptoms because these children have non-rewarding interactions with peers, whereas the impact of deficits in other-oriented social skills on depressive symptoms is mediated through negative reactions from peers such as peer victimization.
Method: 378 kindergarten children (163 girls) participated at two assessments (Age at T1: M = 5.8, T2: M = 7.4). Teachers completed questionnaires on children's social skills at T1. Teacher reports on peer victimization and depressive symptoms were assessed at both assessment points.
Results: Our study partially confirmed the suggested conceptual model. Deficits in self-oriented social skills significantly predicted depressive symptoms, whereas deficits in other-oriented social skills were more strongly associated with peer victimization. Longitudinal associations between other-oriented social skills and depressive symptoms were mediated through peer victimization.
Conclusion: The study emphasizes the role of deficits in self-oriented social skills and peer victimization for the development of internalizing disorders
Engineering Tertiary Chirality in Helical Biopolymers
- Author
- Publication venue
- Publication date
- 25/09/2023
- Field of study
Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks, but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here we employ the DNA tensegrity triangle as a model system to locate the tipping points in chirality inversion at the tertiary level by X-ray diffraction. We engineer tensegrity triangle crystals with incremental rotational steps between immobile junctions from 3 to 28 base pairs (bp). We construct a mathematical model that accurately predicts and explains the molecular configurations in both this work and previous studies. Our design framework is extendable to other supramolecular assemblies of helical biopolymers and can be used in the design of chiral nanomaterials, optically-active molecules, and mesoporous frameworks
Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation
- Author
- Alejandro González-Castro
- Alexandra López
- Ana Tizón
- Anna Arnau
- Antònia Vázquez
- Burns
- Carles Subirà
- Carmen Sánchez
- Carolina García
- Cecilia Hermosa
- César Laborda
- Elena Keough
- Ely
- Esteban
- Esteban
- Esteban
- Esteban
- Esteban
- Eva Tenza
- Ezingeard
- Gonzalo Hernández
- Jaber
- Lara Ventura
- Liang
- Maria del Mar Fernández
- Maria-Carmen de la Torre
- Matic
- Olga Rubio
- Perren
- Peñuelas
- Rafael Fernández
- Raquel Rodríguez-García
- Sara Cabañes
- Schmidt
- Sklar
- Thille
- Tobin
- Vallverdú
- Vanesa Arauzo
- Victoria Lacueva
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- Field of study
Updates in biological therapies for knee injuries: bone
- Author
- A Nauth
- A Nauth
- AE Gross
- AH Reddi
- AL Jones
- B McKibbin
- B Mollon
- B Peterson
- BR Olsen
- Bruno Bellaguarda Batista
- C Evans
- D Dallari
- DE Komatsu
- DR Carter
- E Fukada
- E Green
- E Gruskin
- E Jones
- F Tortelli
- FR Nelson
- G Cox
- GE Friedlaender
- GM Calori
- GP Lyritis
- J Alsousou
- J Chrastil
- J Li
- J Li
- J Ristiniemi
- JA Buckwalter
- JA Buckwalter
- JC Wang
- JF Keating
- JH Kuhne
- JM Kanczler
- JO Hollinger
- KE Ozturan
- KM Dupont
- Marcello Teixeira Castiglia
- Mauricio Kfuri
- MI Santos
- MM Mc Donald
- MR Urist
- MT Ghazavi
- MW Laschke
- N Kimelman
- NC Keramaris
- NM Pounder
- OP Gautschi
- P Aspenberg
- P Hernigou
- P Lichte
- P Matter
- Paulo Henrique Araújo
- PV Giannoudis
- PV Giannoudis
- Q Kang
- R Marsell
- Rafael Lara de Freitas
- Ricardo Antonio Tavares
- RJ Williams III
- RM Neer
- Rodrigo Salim
- S Aryee
- S Bukata
- S Govender
- S Graham
- S Kumar
- SL Sherman
- SM Perren
- ST Nathan
- T Asahara
- T Goff
- T Kokubo
- TA Russell
- TE Mroz
- TO Acarturk
- U Sheth
- X Li
- XL Griffin
- XL Griffin
- YF Li
- YM Alkhiary
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ovarian Cancer Relapse: Experimental Therapies
- Author
- A Ashworth
- AA Garcia
- AA Garcia
- AA Secord
- AN Gordon
- B Hennessy
- B Liu
- B Wu
- BC Cooper
- BY Karlan
- C Aghajanian
- C Bouchardy
- C Shih
- CA Townsley
- CA Townsley
- Cancer Genome Atlas Research Network
- CD Scharer
- CK McCann
- CN Landen Jr
- CP Leamon
- D Hanahan
- D Matei
- D Mavroudis
- DD Bowtell
- DM Keefe
- DS Miller
- E Dean
- EL Eisenhauer
- EM Posadas
- ES Santos
- F Hilpert
- FA Scappaticci
- FS Hodi
- G Freyer
- G Toffoli
- GH Shen
- GM Abu-Jawdeh
- H Elnakat
- H Farmer
- H Hirte
- H Lassus
- H Yang
- HA Maas
- HE Bryant
- HS Nimeiri
- I Vergote
- J Ledermann
- J Li
- J Oliner
- J Schmitt
- J Sehouli
- JA Engelman
- JA Konner
- JA Ledermann
- JA Meyerhardt
- JD Iglehart
- JE Riggs
- JH Lewis
- JJ Biagi
- JK Chan
- JM Lee
- K Behbakht
- K Gudmundsdottir
- K Mross
- KA Gelmon
- KC Sokol
- KH Baumann
- KJ Kimball
- KR Kalli
- KW Yee
- L Martin
- L Repetto
- L Talarico
- L Zhang
- LA Gloeckler
- LA Hefler
- LE Kandalaft
- LF Hutchins
- LG Presta
- LM Randall
- M Friedlander
- M Javle
- M Kozloff
- M Markman
- M Rouleau
- MA Bookman
- MM Tanner
- MP Smerdel
- MS Gordon
- MS Tetsche
- MV Seiden
- MW Audeh
- N Keen
- N McCabe
- NS Azad
- NS Horowitz
- P Sabbatini
- PA Vasey
- PC Fong
- PN Lara Jr
- PW Ingham
- Q Sheng
- Q Sheng
- R Bhattacharya
- R Siegel
- R Yancik
- R Zeineldin
- RA Burger
- RA Burger
- RA Burger
- RJ Schilder
- RT Penson
- S Anand
- S Barni
- S Campos
- S Campos
- S Makhija
- S Pignata
- S Pignata
- S Yamamoto
- SA Cannistra
- SB Kaye
- SP Ivy
- SS Ramalingam
- SV Blank
- T Susini
- T Thigpen
- TJ Perren
- TP Diaz-Montes
- U Blank
- U Matulonis
- U Wagner
- UA Matulonis
- UA Matulonis
- UA Matulonis
- UA Matulonis
- W Gonsalves
- WH Gotlieb
- WP Tew
- YG Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer
- Author
- Abdi Ehtesham
- Abraham Jean
- Abreu Miguel
- Adams Sylvia
- Aktan G.
- Al Baghdadi Tareq
- Allerton Rozenn
- Allison Magnuson
- Altena Renske
- Alés Martínez Jose Enrique
- Anampa Mesias Jesus
- Andreopoulou Eleni
- Ansari Bilal
- Antill Yoland
- Aogi Kenjiro
- Aragones Antonia Marquez
- Arahmani A.
- Armstrong A.C.
- Armstrong Anne
- Armstrong Deborah
- Armstrong Deborah
- Arnedos M.
- Arrick Bradley
- Asaad Shonda
- Aydogdu Mustafa
- Baez-Diaz Luis
- Bahadur Shakeela
- Bakker Sandra
- Balmaña J.
- Barrett Sophie
- Bartsch Rupert
- Bañuelos Juan Cueva
- Bear Harry
- Bechtner Christina
- Bella Santiago
- Bergh J.
- Bermejo de las Heras Begoña
- Bernardo Antonio
- Bertrán Ana Santaballa
- Bianchini Giampaolo
- Biganzoli Laura
- Blajman Cesar
- Bliss J.
- Boadle David
- Bobolis Kristie
- Bonetti Andrea
- Bordeleau Louise
- Borges Virginia
- Borley Annabel
- Borms Marleen
- Borrego Manuel Ruiz
- Boyle L.E.
- Braga Sofia
- Brain Etienne
- Braybrooke Jeremy
- Brescia Frank
- Brufsky A.M.
- Brufsky Adam
- Bucci Eraldo
- Burhani Nafisa
- Busch Steffi
- Cameron D.
- Campbell C.
- Cannon George
- Cannon George
- Canon Jean-Luc
- Cao María González
- Cardoso Catarina
- Cardoso Fátima
- Carlson Jay
- Carlson Jay
- Carney Jennifer Fu
- Carrasco Fernando Henao
- Casa-Nova Mafalda
- Cescon Terrence
- Chacón López-Muñiz José Ignacio
- Chae Yee Soo
- Chakiba-Brugere Camille
- Chalchal Haji
- Chan Stephen
- Chang Brian
- Chang Yuan-Ching
- Charles William
- Chen Shang-Hung
- Chen Shin-Cheh
- Chen Shou-Tung
- Chiu Chang-Fang
- Cho Eun Kyung
- Chowdhury Nabila
- Chung Wei-Pang
- Ciccarese Mariangela
- Ciruelos Gil Eva María
- Cobleigh Melody
- Cole John
- Cole John
- Cole John
- Cole John
- Colleoni M.A.
- Colleoni Marco
- Company Jesús Alarcon
- Conejero Raquel Andrés
- Conibear John
- Constanzo Maria Victoria
- Conte Pierfranco
- Copson Ellen
- Copur Mehmet
- Cortesi Laura
- Cortijo Lucía González
- Cretella Elisabetta
- Cristofanilli Massimo
- Crusades Gema Llort
- Cui K.
- Curtit Elsa
- Dakhil Shaker
- Dakhil Shaker
- Dalivoust Philippe
- Darsow Maren
- Dayao Zoneddy
- de Boer Maaike
- de la Haba Juan
- de Laurentiis Michelino
- Decker Thomas
- Dedes Konstantin
- Delaloge S.
- Delaloge Suzette
- Delgado Mingorance Juan Ignacio
- Deming Richard
- Denittis Albert
- Deryal Mustafa
- Desbiens Christine
- Deveras Ruby Anne E.
- Dewar Joanna
- Dewitz Thomas
- Dieterich Max
- Domchek S.M.
- Domchek Susan
- Doster John
- Doyle Thomas
- Duhoux François
- Durna Lara
- Egle Daniel
- Einhorn Harvey
- Eisen A.
- Eisen Andrea
- Eisenberg Peter
- Ellis Robert
- Elsafy F.
- Emde Till-Oliver
- Erdkamp Franciscus
- Estevez Laura García
- Extra Jean-Marc
- Faller Bryan
- Fan Z.
- Fan Zhimin
- Fasching Peter
- Fehm Tanja
- Fein L.E.
- Fein Luis
- Ferrario Cristiano
- Ferrero Jean-Marc
- Feusner James
- Fielding A.
- Flaum Lisa
- Flynn Patrick
- Flynn Patrick
- Ford J.M.
- Forstmeyer Dirk
- Friday Bret E.B.
- Friedlander Michael
- Friedman S.
- Fu Peifen
- Fuchs David
- Ganz Patricia
- Garber J.E.
- Garber Judy
- Garber Judy
- García Sáenz José Ángel
- Gayle Arlene
- Gebbia Vittorio
- Gelber R.D.
- Gelmon K.A.
- Gelmon Karen
- Gelpi Judith Balmaña
- Geng Cuizhi
- George Mathew
- Gerds Aaron
- Geyer C.E.
- Giacchetti Sylvie
- Gianni L.
- Gianni Lorenzo
- Gil Amaryllis
- Gnant M.
- Gomez Elena Álvarez
- González-Santiago Santiago
- Goodwin Annabel
- Gori Stefania
- Grafe Andrea
- Graffunder Gerd
- Gratet Alain
- Greil Richard
- Grischke Eva Maria
- Gross Howard
- Gross Howard
- Gross Howard
- Gross Howard
- Gross Howard
- Gröll Isolde
- Göhring Uwe-Jochen
- Hackmann John
- Hahn Antje
- Hahn Olwen
- Hallbeck Anna-Lotta
- Hanson David
- Harbeck Nadia
- Hardy-Bessard Anne-Claire
- Harkness Cameron
- Haslbauer Ferdinand
- Hauke Ralph
- Hauke Ralph
- Hayward Richard
- Heibl Sonja
- Heijns Joan
- Heinrich Bernhard
- Helfgott Ruth
- Herbolsheimer Pia
- Hesse Tobias
- Hickish Tamas
- Hilton Christie
- Hoffmann Oliver
- Hofstatter Erin
- Hofstatter Erin
- Hofstatter Erin
- Hollingsworth S.J.
- Hoskins Kent
- Hou Ming-Feng
- Huang Chiun-Sheng
- Huober Jens
- Hurwitz Jane
- Huynh Chanh
- Huzarski Tomasz
- Höffkes Heinz-Gert
- Im S.-A.
- Im Seock-Ah
- Isaacs Claudine
- Ishida Kazushige
- Ito Mitsuya
- Iwata Hiroji
- Jackisch Christian
- Jacot William
- Jager A.
- Jager Agnes
- Janni W.
- Jañez Noelia Martínez
- Jegannathen Apurna
- Jens-Uwe Blohmer Jan Schröder
- Jerusalem Guy
- Jiang Zefei
- Jiménez Miguel Martín
- Johannsson Oskar
- Jones Catherine
- Jones Cheryl
- Joris Sofie
- Joshi Abhishek
- Jubelirer Steven
- Julian Thomas
- Jung K.H.
- Jung Kyung Hae
- Jurado Josefina Cruz
- Jóhannsson Ó. Þ
- Kaen Diego
- Kalinka Ewa
- Kalra Maitri
- Kannourakis George
- Karwal Mark
- Kast Karin
- Kaufman B.
- Kaufman Bella
- Kelleher Muireann
- Khosla Pam
- Kim Jee Hyun
- Kinoshita Takayuki
- Klare Peter
- Kolberg Hans-Christian
- Korde L.
- Krabisch Petra
- Kroep Judith
- Kurian Sobha
- Kuzma Charles
- Kühn Thorsten
- Kümmel Sherko
- Kümmel Sherko
- l'Haridon Tiffenn
- Lakhani S.R.
- Lambiase Elyse
- Landherr László
- Lanza Angels Arcusa
- Lazzaro Mauricio Fernández
- Ledwon Peter
- Lee Keun Seok
- Lee Kyoung Eun
- Lerzo Guillermo
- Lescure Álvaro Rodríguez
- Leu Kirsten M.H.
- Levine Edward
- Levitt Nicola
- Liao Ning
- Linderholm B.
- Linderholm Barbro
- Liu T.-W.
- Lo Shelly
- Loibl S.
- Loman N.
- Loman Niklas
- Lortholary Alain
- Lu Min
- Lu Min
- Lucas P.C.
- Luce Sylvie
- Lévy Christelle
- López Isabel Álvarez
- Mackey John
- Mackiewicz Jacek
- Mahtani Reshma
- Mahtani Reshma
- Mailliez A.
- Mailliez Audrey
- Mansoor Abdul
- Marcom Paul
- Marmé F.
- Martinez de Dueñas E.
- Martinez Lourdes Calvo
- Martínez de Dueñas Eduardo
- Masuda Norikazu
- Mau Christine
- Mccarron Edward
- Mccarthy Nicole
- Mcconnell R.
- Mege Alice
- Meisel Jane
- Menter Alex
- Merkel Douglas
- Mita Monica
- Molins Agusti Barnadas
- Mosconi Anna Maria
- Mouret-Reynier Marie-Ange
- Mukai Hirofumi
- Murillo Serafín Morales
- Murray Nicholas
- Müller Volkmar
- Nagy T.
- Nagy Tünde
- Nakamura Rikiya
- Nakamura Seigo
- Nakayama Takahiro
- Nangia Julie
- Naoi Yasuto
- Nave Mónica
- Neven Patrick
- Niraula Saroj
- Noeding Stefanie
- Noesselt Thomas
- Novak Urban
- Nowecki Zbigniew
- O'Connor Brian
- Ochoa Augusto
- Ochoa Augusto
- Ofori Samuel
- Olabisi Foluso
- Oliff Ira
- Openshaw Thomas
- Openshaw Thomas
- Openshaw Thomas
- Ortega Adela Fernández
- Ortega Ana Laura
- Osaki Akihiko
- Padró Josep Gumà
- Paepke Stefan
- Pang D.
- Pang Da
- Papadimitriou Konstantinos
- Park Y.H.
- Park Yeon Hee
- Park-Simon Tjoung-Won
- Parton M.
- Parton Marina
- Pasterk Claudia
- Patel Tejal
- Patocskai Erica
- Penzinger Monika
- Perren Timothy
- Perrin Christophe
- Petit Thierry
- Phillips K.-A.
- Phillips Kelly-Anne
- Piccart M.
- Pilnik Norma
- Pinotti Graziella
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Potenberg Jochem
- Pottier Virginie
- Prady Catherine
- Pristauz-Telsnigg Gunda
- Puthillath Ajithkumar
- Qamar Rubina
- Qamar Rubina
- Qamar Rubina
- Qamar Rubina
- Quaghebeur Claire
- Quiroga Vanesa
- Raben Adam
- Radford James
- Rai Yoshiaki
- Ramaswamy Bhuvaneswari
- Rastogi P.
- Rautenberg Beate
- Razaq W.
- Razaq Wajeeha
- Rea Daniel
- Reeder Jennifer
- Rhiem Kerstin
- Riseberg David
- Robin Erwin
- Rodríguez César
- Rohatgi Nitin
- Rom Joachim
- Roodenbeke Daphné T’kint De
- Ross L.
- Rossi G.
- Rovito Marc
- Roylance Rebecca
- Ruddy Kathryn
- Ruggeri Enzo Maria
- Rumpold Holger
- Ryan Matthew
- Salat Christoph
- Salkeni Mohamad
- Sami Amer
- Santisteban Marta
- Sarosiek Tomasz
- Sato Nobuaki
- Schallenkamp John
- Schmatloch Sabine
- Schmidt M.
- Schmidt Marcus
- Schmutzler R.
- Schott Anne
- Schreiber Carsten
- Seaward Samantha
- Seaward Samantha
- Seeger Grant
- Senkus E.
- Senkus Elżbieta
- Sevelda Paul
- Shao Z.
- Shao Zhimin
- Sharma P.
- Sharma Priyanka
- Sharma Ruby
- Shen Kunwei
- Shenk Robert
- Shenk Robert
- Shenk Robert
- Siegel Robert
- Siggelkow Wulf
- Sigurdson Elin
- Silander Gustav
- Simon Hélène
- Simon Michael
- Singer C.F.
- Singer Christian
- Smith Ron
- Sohn Joo Hyuk
- Song Chuangui
- Sonke G.S.
- Sonke Gabe
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- Specht Jennifer
- Spector David
- Steen Preston
- Stefek Andrea
- Stickeler E.
- Stickeler Elmar
- Stockham Abigail
- Storniolo Anna M.V.
- Strasser-Weippl Kathrin
- Stöger Herbert
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Sugimoto Takeki
- Sui Xingwei
- Sumida Kenneth N.M.
- Sumida Kenneth N.M.
- Sumrall Bradley
- Sun Q.
- Sun Qiang
- Słowińska Anna
- T Benjamin
- Taboada M.
- Takada Masahiro
- Takahashi Masato
- Takano Toshimi
- Tan Antoinette
- Tato-Varela Sara
- Telli Melinda
- Tennevet I.
- Tennevet Isabelle
- Terhaag Jürgen
- Thiel Irene
- Thomalla Jörg
- Thomssen Christoph
- Tiley Susan
- Tinchon Christoph
- Tio Joke
- Tkaczuk Katherine H.R.
- Toi M.
- Tokuda Yutaka
- Tokunaga Eriko
- Tomé Oliver
- Tondini Carlo
- Toppmeyer Deborah
- Tormo Salvador Blanch
- Torres Antonio Antón
- Toyama Tatsuya
- Traina T.A.
- Tredan Olivier
- Trehan Shruti
- Tseng Ling-Ming
- Tsugawa Koichiro
- Tutt A.N.J.
- Tutt Andrew
- Uleer Christoph
- Unnikrishnan Madhu
- Urquhart Alexander
- Uziely Beatrice
- Vachhani Hetal
- Vakhariya Cynthia
- Valdes-Albini Frances
- van der Westhuizen Andre
- van Haelst Carol
- Vanderwoude Amy
- Varadarajan Ramya
- Varela Mirta
- Venat-Bouvet Laurence
- Verusio Claudio
- Viale G.
- Villaró Gemma Viñas
- Virani Shamsuddin
- Vogel Victor
- von Wachenfeldt Väppling Anna
- Wade James
- Wade James
- Wagner Harald
- Waisman James
- Wang Shui
- Wang Yongsheng
- Watanabe Junichiro
- Weigel Michael
- Weltermann Angsar
- Weniger Steffi
- Wette Viktor
- Wilbur Deborah
- Wilkinson Mary
- Winter Matthew
- Wolf Sütterlin Marc
- Wong Derrick
- Wong Lucas
- Wood Marie
- Wood Marie
- Woodward Natasha
- Wüllner Michaela Penelope
- Xu Binghe
- Yamauchi Hideko
- Yan Fengting
- Yanagita Yasuhiro
- Yang H.
- Yang Hongjian
- Yeh Dah-Cherng
- Yerushalmi R.
- Yerushalmi Rinat
- Yothers G.
- Yu Jyh-Cherng
- Zahm Dirk
- Zakalik Dana
- Zamagni Claudio
- Zaman Khalil
- Zarba Juan Jose
- Zera Richard
- Zera Richard
- Zhang J.
- Zhang Jin
- Zheng Hong
- Zhuo Ying
- Zimbler Harvey
- Zoppoli G.
- Öhler Leopold
- Španić T.
- Publication venue
- Elsevier
- Publication date
- 01/12/2022
- Field of study
International audienc
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- Acock Alan
- Acs Gregory
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- Adams Ryan
- Adler Marina A.
- Adler-Baeder Francesca
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- Riggio Heidi R.
- Riley David
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- Roche Kathleen
- Rogers Stacy J.
- Romich Jennifer L.
- Rosenbaum Alan
- Rosenblatt Paul C.
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- Rovine Michael
- Rubin Donald B.
- Sabatelli Ronald M.
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- Sanders Gregory F.
- Sanderson Stephen
- Sano Yoshie
- Sarkisian Natalia A.
- Sassler Sharon L.
- Saunders Daniel G.
- Schaefer Earl
- Scheuble Laurie
- Schmeeckle Maria
- Schmitt David P.
- Schmitz Mark
- Schneider Barbara
- Schoen Robert
- Schoenberg Nancy E.
- Schoppe-Sullivan Sarah J.
- Schumm Walter R.
- Scott Andrea
- Scott Brent
- Scott Ellen K.
- Shackelford Todd K.
- Shah Anisha
- Shanahan Lilly
- Shapiro Adam
- Sharp Elizabeth A.
- Shebloski Barbara
- Sherkat Darren
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- Smith Suzanne R.
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- Umberson Debra J.
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- Van Gaalen Ruben I.
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- Weeden Kim A.
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- Wenger G. Clare
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- Wethington Elaine
- Whitchurch Gail G.
- White James M.
- White-Stephan Cookie
- Whiteman Shawn
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- Wieting Stephen
- Wilcox W. Bradford
- Wildsmith Elizabeth
- Williams Kristi
- Wills Jeremiah
- Willson Andrea
- Wilmoth Janet
- Wilson John
- Winkler Celia C.
- Winslow Sarah
- Wojtkiewicz Roger A.
- Wolfinger Nicholas H.
- Wright Eric R.
- Yabiku Scott T.
- Yagla Mack Kristin
- Yancey George A.
- Yang Frances
- Yeh Hsin-Chen
- Yeung Wei-Jun Jean
- Yount Kathryn
- Zabin Laurie
- Zhang Zhenmei
- Zuo Jiping
- Zweig Janine
- Publication venue
- Publication date
- 01/12/2005
- Field of study
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
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- Aisa Tharwat
- Akimoto Takako
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- Alexandre Kévin
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- Ali Imran
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- Artaud-Macari Elise
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- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
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- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
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- Azoulay Cecile
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- Baillie J. Kenneth
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- Bal Andriy
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- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
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- Barclay Wendy S.
- Barnikel Michaela
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- Barrigoto Cleide
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- Beane Abigail
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- Beljantsev Aleksandr
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- Beluze Marine
- Benech Nicolas
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- Bento Luís
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- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
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- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
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- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
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- Collins Michael
- Colombo Sebastiano Maria
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- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
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- Cousse Stéphanie
- Cregan Rachel
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- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
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- da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
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- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
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- Deplanque Dominique
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- Dishon Yael
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- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
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- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
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- Fuentes Yuli V.
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
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- Gamble Carrol
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- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
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- Gaymard Alexandre
- Gebauer Johannes
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- Glikman Daniel
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- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González Víctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
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- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hasan Mohd Shahnaz
- Hashmi Junaid
- Hashmi Madiha
- Hayat Muhammad
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
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- Higgins Eibhilin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hitoto Hikombo
- Ho Antonia
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- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Imran Mohammad
- Imtiaz Aftab
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Ivulich Daniel
- Iñiguez Jonathan Samuel Chávez
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaquet Pierre
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Jego Florence
- Jenum Synne
- Jiménez Miguel Pedrera
- Joseph Cédric
- Joseph Mark
- Joshi Swosti
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Juzar Dafsah
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandel Chris
- Kanwal Darakhshan
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- Kataria Anant
- Katz Kevin
- Kay Christy
- Keane Hannah
- Keating Seán
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- Kennon Kalynn
- Kernan Maeve
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- Keshav Sharma
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- Khalid Osama
- Khalil Antoine
- Khan Coralie
- Khan Irfan
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- Khan Rashid Nasim
- Khanal Sushil
- Khatak Abid
- Khawaja Amin
- Kho Michelle E.
- Khoo Saye
- Khoso Nasir
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
- Koirala Sabin
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Kruglova Oksana
- Kumar Deepali
- Kumar Mukesh
- Kuriakose Dinesh
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kutsyna Galyna
- Kyriakoulis Konstantinos
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lakhey Sanjay
- Lalueza Antonio
- Lambert Marc
- Lamontagne François
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- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
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- Lasry Stéphane
- Latif Naveed
- Launay Odile
- Laureillard Didier
- Lavie-Badie Yoan
- Law Andrew
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- Le Bihan Clément
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- Le Turnier Paul
- Le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemeur Anthony
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- Lesens Olivier
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- Lester-Grant Amy
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- Liegeon Geoffrey
- Lim Wei Shen
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- Liu Keibun
- Livrozet Marine
- Lizotte Patricia
- Loforte Antonio
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- Lopes Diogo
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lovelace-Macon Lara
- Lowik Marije
- Lucet Jean Christophe
- Luna Carlos M.
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
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- Macheda Gabriel
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- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Malfertheiner Maximilian
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- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
- Mankikian Julie
- Manning Edmund
- Manuel Aldric
- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshal Megan
- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martinot Martin
- Martins Ana
- Martins João
- Martins Nuno
- Martucci Gennaro
- Martynenko Olga
- Marwali Eva Miranda
- Maslove David
- Mason Sabina
- Masood Sobia
- Matan Moshe
- Mathew Meghena
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Maxwell Michael
- Maynar Javier
- Mazzoni Thierry
- Mc Evoy Natalie
- Mc Sweeney Lisa
- McArthur Colin
- McArthur Colin
- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A.
- McNally Paul
- McNicholas Bairbre
- McPartlan Elaine
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Meher Maqsood
- Mele Ferruccio
- Melo Luis
- Memon Kashif
- Mendes Joao Joao
- Menkiti Ogechukwu
- Menon Kusum
- Mentré France
- Mentzer Alexander J.
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
- Mesquita António
- Metwally Osama
- Meybeck Agnès
- Meyer Dan
- Meynert Alison M.
- Meysonnier Vanina
- Meziane Amina
- Mezidi Mehdi
- Michelanglei Céline
- Michelet Isabelle
- Mihnovit Vladislav
- Mohammed Nassima Si
- Mohd-Hanafiah Farah Nadia
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- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona C.
- Morlaes Louis Gerbaud
- Moro Lucia
- Motherway Catherine
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mufti Aisha Kalsoom
- Mullaert Jimmy
- Munblit Daniel
- Muneeb Syed
- Munir Nadeem
- Murphy Aisling
- Murphy Aisling
- Murphy Lorna
- Murris Marlène
- Murthy Srinivas
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- Myrodia Dimitra Melia
- Müller Fredrik
- Müller Karl Erik
- Nagpal Dave
- Nagrebetsky Alex
- Narayanan Nageswaran
- Nazerali-Maitland Alasdair
- Neant Nadège
- Nekliudov Nikita
- Neto Ary Serpa
- Neto Raul
- Neumann Emily
- Ng Pauline Yeung
- Nghi Anthony
- Nguyen Duc
- Nichol Alistair
- Nitayavardhana Prompak
- Nonas Stephanie
- Nor Basri Mat
- Nor Basri Mat
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- Notari Alessandra
- Noursadeghi Mahdad
- Nowinski Adam
- Nseir Saad
- Nunez Jose I.
- Nurnaningsih Nurnaningsih
- Nyamankolly Elsa
- Occhipinti Giovanna
- OConnor Derbrenn
- Ogston Tawnya
- Ogura Takayuki
- Oliveira João
- Oliveira Larissa
- Olliaro Piero L.
- Ong David S. Y.
- Oosthuyzen Wilna
- Opavsky Anne
- Openshaw Peter
- Orakzai Saijad
- Orozco-Chamorro Claudia Milena
- Ortoleva Jamel
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Oziol Eric
- O’Callaghan Annmarie
- O’Donnell Max
- O’Halloran Sophie
- O’Hearn Katie
- O’Shea Linda
- O’Sullivan Miriam
- Pagadoy Maïder
- Pages Justine
- Palacios Amanda
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Paneru Hem
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- Parke Rachael
- Parker Melissa
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- Patterson Lisa
- Pattnaik Rajyabardhan
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William A.
- Payen Jean-François
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
- Peltan Ithan D.
- Pereira Rui
- Perez Daniel
- Periel Luis
- Perpoint Thomas
- Perrot Clara Mouton
- Pesenti Antonio
- Pestre Vincent
- Petrou Lenka
- Petrov-Sanchez Ventzislava
- Petrovic Michele
- Pettersen Frank Olav
- Peytavin Gilles
- Pharand Scott
- Picard Walter
- Picone Olivier
- Pierobon Carola
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- Pinto Raquel
- Pires Catarina
- Pironneau Isabelle
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- Pius Riinu
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- Poissy Julien
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- Poli Sergio
- Pollakis Georgios
- Ponscarme Diane
- Post Andra-Maris
- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Preau Sébastien
- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
- Pudota Sravya
- Pulicken Mathew
- Purcell Gregory
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- Quist-Paulsen Else
- Quraishi Mohammed
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- Rafael Aldo
- Rafiq Marie
- Rahutullah Arsalan
- Rainieri Fernando
- Ramachandran Pratheema
- Ramakrishnan Nagarajan
- Ramalho José
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- Rana Asim
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- Rapp Christophe
- Rashan Aasiyah
- Rashan Thalha
- Rasheed Ghulam
- Rasmin Menaldi
- Rau Cornelius
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- Real Andre
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- Redl Sarah
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- Rehman Attaur
- Reid Liadain
- Reid Liadain
- Reikvam Dag Henrik
- Reis Renato
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- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rios Ana L.
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L.
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
- Roger Pierre-Marie
- Rojek Amanda
- Rojo Jaime Cruz
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
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- Rosenberger Dorothea
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- Rossetti Matteo
- Rossignol Bénédicte
- Rossignol Patrick
- Rousset Stella
- Roy Carine
- Roze Benoît
- Rusmawatiningtyas Desy
- Russell Clark D.
- Ryan Maeve
- Ryan Maria
- Ryckaert Steffi
- Rätsep Indrek
- Saba Isabela
- Sadaf Sairah
- Sadat Musharaf
- Sahraei Valla
- Saidani Nadia
- Saint-Gilles Maximilien
- Sakiyalak Pranya
- Salahuddin Nawal
- Salazar Leonardo
- Saleem Jodat
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandhu Zulfiqar
- Sandrine Pierre-François
- Sandulescu Oana
- Sanharawi Mohammed El
- Sant Ceila Maria
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- Santos Marta Leal
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Satyapriya Sree
- Satyawati Rumaisah
- Saviciute Egle
- Schaffer Justin
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvanayagam Jaganathan
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shah Naseem Ali
- Shamsah Mohammad
- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A.
- Shaw Victoria
- Sheharyar Ashraf
- Shetty Rajesh Mohan
- Shi Haixia
- Shiekh Mohiuddin
- Shimizu Keiki
- Shrapnel Sally
- Shrestha Pramesh Sundar
- Shrestha Shubha Kalyan
- Shukeri Wan Fadzlina Wan Muhd
- Shum Hoi Ping
- Sibiude Jeanne
- Siddiqui Atif
- Sigfrid Louise
- Sikander Rana Imran
- Sillaots Piret
- Silva Catarina
- Silva Maria Joao
- Silva Rogério
- Sin Wai Ching
- Singh Budha Charan
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- Singh Punam
- Sitompul Pompini Agustina
- Skeie Linda Gail
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Coilin
- Smyth Michelle
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Sobrino José Luis Bernal
- Solomon Joshua
- Solomon Tom
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- Sommet Agnès
- Song Myung Jin
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- Song Tae
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- Soum Edouard
- Sousa Ana Chora
- Sousa Marta
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- Spinuzza Elisabetta
- Sriskandan Shiranee
- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Surovcová Magdalena
- Svistunov Andrey
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tanaka Hiroyuki
- Taqdees Huda
- Taqi Arshad
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari
- Tawfik Hassan
- Tedder Richard S.
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
- Torre Marta
- Torres Antoni
- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Treoux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre K. vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart S. verine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-H. lène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller K. vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- de Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- de Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier K. vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet J. rôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou F. lix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival C. line
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou H. lène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz M. rio
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira S. lvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko C. line
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião S. rgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González V. ctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard C. cile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj J. rémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
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- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
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- Hammond Terese
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- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
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- Hashmi Junaid
- Hashmi Madiha
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- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
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- Holter Jan Cato
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- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-S. bastien
- Humaid Felwa Bin
- Huo Stella
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- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
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- Imtiaz Aftab
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- Jego Florence
- Jenum Synne
- Jiménez Miguel Pedrera
- Joseph C. dric
- Joseph Mark
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- Kho Michelle E.
- Khoo Saye
- Khoso Nasir
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
- Koirala Sabin
- Kosgei Caroline
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- Kumar Deepali
- Kumar Mukesh
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- Kurtzman Ethan
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- Lacoste Marie
- Laffey John G.
- Lagrange Marie
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- Langlois Vincent
- Lantang Eka Yudha
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- Laouénan C. dric
- Laribi Samira
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- le Bihan Clément
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- le Mestre Soizic
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- le Nagard Hervé
- le Turnier Paul
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- Leal Ema
- Leathlobhair Niamh Ni
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Leeming Gary
- Lefebvre B. nédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
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- Lellouche François
- Lemaignen Adrien
- Lemee V. ronique
- Lemeur Anthony
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- Lester-Grant Amy
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- Lim Wei Shen
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- Lopes Diogo
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
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- Luna Carlos M.
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- l’Her Erwan
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- Marsh Laura
- Marshal Megan
- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
- Martin-Blondel Guillaume
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- Martucci Gennaro
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- Mathew Meghena
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
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- Maynar Javier
- Mazzoni Thierry
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- McArthur Colin
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- McDonald Sarah E.
- McElroy Aine
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- McLean Kenneth A.
- McNally Paul
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- McPartlan Elaine
- Meaney Edel
- Mear-Passard C. cile
- Mechlin Maggie
- Meher Maqsood
- Mele Ferruccio
- Melo Luis
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- Mentré France
- Mentzer Alexander J.
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
- Mesquita António
- Metwally Osama
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- Meyer Dan
- Meynert Alison M.
- Meysonnier Vanina
- Meziane Amina
- Mezidi Mehdi
- Michelanglei C. line
- Michelet Isabelle
- Mihnovit Vladislav
- Mohammed Nassima Si
- Mohd-Hanafiah Farah Nadia
- Moin Asma
- Molina David
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- Molloy Brenda
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- Montrucchio Giorgia
- Moore Sarah
- Moore Shona C.
- Morlaes Louis Gerbaud
- Moro Lucia
- Motherway Catherine
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mufti Aisha Kalsoom
- Mullaert Jimmy
- Munblit Daniel
- Muneeb Syed
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- Murphy Aisling
- Murphy Lorna
- Murris Marlène
- Murthy Srinivas
- Musaab Himed
- Muvindi Himasha
- Myrodia Dimitra Melia
- Müller Fredrik
- Müller Karl Erik
- Nagpal Dave
- Nagrebetsky Alex
- Narayanan Nageswaran
- Nazerali-Maitland Alasdair
- Neant Nadège
- Nekliudov Nikita
- Neto Ary Serpa
- Neto Raul
- Neumann Emily
- Ng Pauline Yeung
- Nghi Anthony
- Nguyen Duc
- Nichol Alistair
- Nitayavardhana Prompak
- Nonas Stephanie
- Nor Basri Mat
- Nor Basri Mat
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowinski Adam
- Nseir Saad
- Nunez Jose I.
- Nurnaningsih Nurnaningsih
- Nyamankolly Elsa
- Occhipinti Giovanna
- OConnor Derbrenn
- Ogston Tawnya
- Ogura Takayuki
- Oliveira João
- Oliveira Larissa
- Olliaro Piero L.
- Ong David S. Y.
- Oosthuyzen Wilna
- Opavsky Anne
- Openshaw Peter
- Orakzai Saijad
- Orozco-Chamorro Claudia Milena
- Ortoleva Jamel
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Oziol Eric
- O’Callaghan Annmarie
- O’Donnell Max
- O’Halloran Sophie
- O’Hearn Katie
- O’Shea Linda
- O’Sullivan Miriam
- Pagadoy Maïder
- Pages Justine
- Palacios Amanda
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Paneru Hem
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parke Rachael
- Parker Melissa
- Parra Briseida
- Pasha Taha
- Pasquier J. rémie
- Pastene Bruno
- Patauner Fabian
- Patricio Patricia
- Patrier Juliette
- Patrão Luís
- Patterson Lisa
- Pattnaik Rajyabardhan
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William A.
- Payen Jean-François
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
- Peltan Ithan D.
- Pereira Rui
- Perez Daniel
- Periel Luis
- Perpoint Thomas
- Perrot Clara Mouton
- Pesenti Antonio
- Pestre Vincent
- Petrou Lenka
- Petrov-Sanchez Ventzislava
- Petrovic Michele
- Pettersen Frank Olav
- Peytavin Gilles
- Pharand Scott
- Picard Walter
- Picone Olivier
- Pierobon Carola
- Piersma Djura
- Pimentel Carlos
- Pinto Raquel
- Pires Catarina
- Pironneau Isabelle
- Piroth Lionel
- Pius Riinu
- Plantier Laurent
- Poissy Julien
- Pokeerbux Ryadh
- Poli Sergio
- Pollakis Georgios
- Ponscarme Diane
- Post Andra-Maris
- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Preau S. bastien
- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
- Pudota Sravya
- Pulicken Mathew
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quinones-Cardona Vilmaris
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rabindrarajan Ebenezer
- Rafael Aldo
- Rafiq Marie
- Rahutullah Arsalan
- Rainieri Fernando
- Ramachandran Pratheema
- Ramakrishnan Nagarajan
- Ramalho José
- Rammaert Blandine
- Ramos Grazielle Viana
- Rana Asim
- Rangappa Rajavardhan
- Ranjan Ritika
- Rapp Christophe
- Rashan Aasiyah
- Rashan Thalha
- Rasheed Ghulam
- Rasmin Menaldi
- Rau Cornelius
- Raza Ali
- Real Andre
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rehman Attaur
- Reid Liadain
- Reid Liadain
- Reikvam Dag Henrik
- Reis Renato
- Rello Jordi
- Remppis Jonathan
- Remy Martine
- Ren Hongru
- Renk Hanna
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Tiago
- Ribeiro Ana Freitas
- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rios Ana L.
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L.
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
- Roger Pierre-Marie
- Rojek Amanda
- Rojo Jaime Cruz
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz M. lanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
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- Rossignol Patrick
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- Russell Clark D.
- Ryan Maeve
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- Ryckaert Steffi
- Rätsep Indrek
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- Sadaf Sairah
- Sadat Musharaf
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- Saint-Gilles Maximilien
- Sakiyalak Pranya
- Salahuddin Nawal
- Salazar Leonardo
- Saleem Jodat
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- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandhu Zulfiqar
- Sandrine Pierre-François
- Sandulescu Oana
- Sanharawi Mohammed El
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- Sarton Benjamine
- Satyapriya Sree
- Satyawati Rumaisah
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- Schaffer Justin
- Schermer Tjard
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- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvanayagam Jaganathan
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senneville Eric
- Sequeira Filipa
- Sequeira T. nia
- Shadowitz Ellen
- Shah Naseem Ali
- Shamsah Mohammad
- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A.
- Shaw Victoria
- Sheharyar Ashraf
- Shetty Rajesh Mohan
- Shi Haixia
- Shiekh Mohiuddin
- Shimizu Keiki
- Shrapnel Sally
- Shrestha Pramesh Sundar
- Shrestha Shubha Kalyan
- Shukeri Wan Fadzlina Wan Muhd
- Shum Hoi Ping
- Sibiude Jeanne
- Siddiqui Atif
- Sigfrid Louise
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- Silva Rogério
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- Singh Punam
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- Smyth Michelle
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- Sobrino José Luis Bernal
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- Solomon Tom
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- Sommet Agnès
- Song Myung Jin
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- Song Tae
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- Soum Edouard
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- Sousa Marta
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- Spinuzza Elisabetta
- Sriskandan Shiranee
- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Surovcová Magdalena
- Svistunov Andrey
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tanaka Hiroyuki
- Taqdees Huda
- Taqi Arshad
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari
- Tawfik Hassan
- Tedder Richard S.
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
- Torre Marta
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- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Treoux Théo
- Tromeur C. cile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- van der Vekens Nicky
- van der Voort Peter
- van der Werf Sylvie
- van Gulik Laura
- van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira C. sar
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik C. cile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable