1,518 research outputs found

    Trajectory Synthesis for Fisher Information Maximization

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    Estimation of model parameters in a dynamic system can be significantly improved with the choice of experimental trajectory. For general, nonlinear dynamic systems, finding globally "best" trajectories is typically not feasible; however, given an initial estimate of the model parameters and an initial trajectory, we present a continuous-time optimization method that produces a locally optimal trajectory for parameter estimation in the presence of measurement noise. The optimization algorithm is formulated to find system trajectories that improve a norm on the Fisher information matrix. A double-pendulum cart apparatus is used to numerically and experimentally validate this technique. In simulation, the optimized trajectory increases the minimum eigenvalue of the Fisher information matrix by three orders of magnitude compared to the initial trajectory. Experimental results show that this optimized trajectory translates to an order of magnitude improvement in the parameter estimate error in practice.Comment: 12 page

    A Calibrated Time Domain Envelope Measurement System for the Behavioral Modeling of Power Amplifiers

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    This paper presents a set-up which enables the generation and the calibrated time domain measurements of complex envelopes of modulated signals at both ports of non linear microwave power amplifiers. The architecture of the characterization tool is given. Examples of error corrected time domain envelopes at the input / output RF ports of a 36 dBm output power – 30dB power gain L-band SSPA are shown. Futhermore, the use of this characterization tool and a suitable processing of measurement data are applied to a novel measurement based behavioral modeling approach of non linear devices accounting for memory effects

    Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.

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    The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala. We show that hypocretin-1 levels are maximal during positive emotion, social interaction and anger, behaviours that induce cataplexy in human narcoleptics. In contrast, melanin-concentrating hormone levels are minimal during social interaction, but are increased after eating. Both peptides are at minimal levels during periods of postoperative pain despite high levels of arousal. Melanin-concentrating hormone levels increase at sleep onset, consistent with a role in sleep induction, whereas hypocretin-1 levels increase at wake onset, consistent with a role in wake induction. Levels of these two peptides in humans are not simply linked to arousal, but rather to specific emotions and state transitions. Other arousal systems may be similarly emotionally specialized

    Investigation of the Gravitational Potential Dependence of the Fine-Structure Constant Using Atomic Dysprosium

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    Radio-frequency E1 transitions between nearly degenerate, opposite parity levels of atomic dysprosium were monitored over an eight month period to search for a variation in the fine-structure constant. During this time period, data were taken at different points in the gravitational potential of the Sun. The data are fitted to the variation in the gravitational potential yielding a value of (8.7±6.6)×106(-8.7 \pm 6.6) \times 10^{-6} for the fit parameter kαk_\alpha. This value gives the current best laboratory limit. In addition, our value of kαk_{\alpha} combined with other experimental constraints is used to extract the first limits on k_e and k_q. These coefficients characterize the variation of m_e/m_p and m_q/m_p in a changing gravitational potential, where m_e, m_p, and m_q are electron, proton, and quark masses. The results are ke=(4.9±3.9)×105k_e = (4.9 \pm 3.9) \times 10^{-5} and kq=(6.6±5.2)×105k_q = (6.6 \pm 5.2) \times 10^{-5}.Comment: 6 pages, 3 figure

    Anisotropic Hall Effect in Single Crystal Heavy Fermion YbAgGe

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    Temperature- and field-dependent Hall effect measurements are reported for YbAgGe, a heavy fermion compound exhibiting a field-induced quantum phase transition, and for two other closely related members of the RAgGe series: a non-magnetic analogue, LuAgGe and a representative, ''good local moment'', magnetic material, TmAgGe. Whereas the temperature dependent Hall coefficient of YbAgGe shows behavior similar to what has been observed in a number of heavy fermion compounds, the low temperature, field-dependent measurements reveal well defined, sudden changes with applied field; in specific for HcH \perp c a clear local maximum that sharpens as temperature is reduced below 2 K and that approaches a value of 45 kOe - a value that has been proposed as the T=0T = 0 quantum critical point. Similar behavior was observed for HcH \| c where a clear minimum in the field-dependent Hall resistivity was observed at low temperatures. Although at our base temperatures it is difficult to distinguish between the field-dependent behavior predicted for (i) diffraction off a critical spin density wave or (ii) breakdown in the composite nature of the heavy electron, for both field directions there is a distinct temperature dependence of a feature that can clearly be associated with a field-induced quantum critical point at T=0T = 0 persisting up to at least 2 K.Comment: revised versio

    Tamoxifen acts as a parietal cell protonophore

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    First direct mass-measurement of the two-neutron halo nucleus 6He and improved mass for the four-neutron halo 8He

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    The first direct mass-measurement of 6^{6}He has been performed with the TITAN Penning trap mass spectrometer at the ISAC facility. In addition, the mass of 8^{8}He was determined with improved precision over our previous measurement. The obtained masses are mm(6^{6}He) = 6.018 885 883(57) u and mm(8^{8}He) = 8.033 934 44(11) u. The 6^{6}He value shows a deviation from the literature of 4σ\sigma. With these new mass values and the previously measured atomic isotope shifts we obtain charge radii of 2.060(8) fm and 1.959(16) fm for 6^{6}He and 8^{8}He respectively. We present a detailed comparison to nuclear theory for 6^6He, including new hyperspherical harmonics results. A correlation plot of the point-proton radius with the two-neutron separation energy demonstrates clearly the importance of three-nucleon forces.Comment: 4 pages, 2 figure

    “Anything that benefits the workers should benefit the client”: Opportunities and Constraints in Self-Directed Care during the COVID-19 Pandemic

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    Reuse is restricted to non-commercial and no derivative uses.Self-directed care (SDC) models allow Home and Community Based Services (HCBS) consumers to direct their own care, thus supporting flexible, person-centered care. There are many benefits to the SDC model but access to resources is essential to successful outcomes. Considering the autonomy and flexibility associated with SDC, it is important to understand how SDC responded to the COVID-19 pandemic and the resources available to help manage this situation. We conducted 54 in-depth interviews with HCBS consumers, direct support workers, family caregivers, and providers to examine the impact of COVID-19 on HCBS services in Kansas. Findings illuminate how self-directed consumers carried a lot of employer responsibility, with limited resources and systemic barriers constraining self-determination and contributing to unmet care needs, stress, and burden. Policy flexibilities expanding the hiring of family members were beneficial but insufficient to address under-resourced working conditions and labor shortages that were exacerbated by the pandemic

    First Penning-trap mass measurement in the millisecond half-life range: the exotic halo nucleus 11Li

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    In this letter, we report a new mass for 11^{11}Li using the trapping experiment TITAN at TRIUMF's ISAC facility. This is by far the shortest-lived nuclide, t1/2=8.8mst_{1/2} = 8.8 \rm{ms}, for which a mass measurement has ever been performed with a Penning trap. Combined with our mass measurements of 8,9^{8,9}Li we derive a new two-neutron separation energy of 369.15(65) keV: a factor of seven more precise than the best previous value. This new value is a critical ingredient for the determination of the halo charge radius from isotope-shift measurements. We also report results from state-of-the-art atomic-physics calculations using the new mass and extract a new charge radius for 11^{11}Li. This result is a remarkable confluence of nuclear and atomic physics.Comment: Formatted for submission to PR
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