17 research outputs found
Alien Registration- Lapiene, Josephine (Lewiston, Androscoggin County)
https://digitalmaine.com/alien_docs/27521/thumbnail.jp
Relationships between facebook intensity, friendship contingent self-esteem, and personality in U.S. college students
U.S. college students (N = 200) completed measures of Facebook use, friendship contingent self-esteem, personality, and narcissism. Those who strongly connected their self-esteem with their quality of friendship relationships were predicted to be more active Facebook users. As predicted, a significant positive relationship between Facebook intensity and friendship contingent self-esteem was found. No significant relationships between Facebook use and personality or narcissism were discovered. Implications for how and why college students use social networking media are discussed, including connections to previous research which discuss the relationship between high friendship contingent self-esteem and risk for depressive symptoms. © 2008 Cyberpsychology
Alien Registration- Lapiene, Josephine (Lewiston, Androscoggin County)
https://digitalmaine.com/alien_docs/27521/thumbnail.jp
Alien Registration- Lapiene, Josephine (Lewiston, Androscoggin County)
https://digitalmaine.com/alien_docs/27521/thumbnail.jp
Methyltransferase-directed transfer of activated groups (mTAG) for targeted covalent labeling of DNA
Methyltransferase-directed transfer of activated groups (mTAG) for targeted covalent labeling of DNA
Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG)
Methyltransferases catalyze highly specific transfers of methyl groups from the ubiquitous cofactor S-adenosyl-l-methionine (AdoMet) to various biopolymers like DNA, RNA, and proteins. Here we describe the first synthetic analogue of AdoMet with an activated side chain carrying a primary amino group that permits efficient methyltransferase-directed functionalization of DNA and subsequent amine-specific chemoligations with various reporter groups. The demonstrated two-step sequence-specific labeling of natural DNA offers a facile way to query the methylation status of the target sites and envisions numerous applications in functional studies and medical diagnostics