Polymers for dye transfer inhibition in laundry applications

The deposition of dyes onto lightly colored garments, or onto lighter sections of multicolored garments, during laundry results in fabric discoloration. In particular, there is a requirement to restrict indigo dye transfer between garments. Polymers may be added to detergent formulations as dye transfer inhibitors to prevent dye transfer by blocking the deposition of fugitive dyes in aqueous solution. This article reports the generation of a range of dye transfer inhibitors produced by condensation reactions that are effective in preventing the transfer of unbound indigo dye to a variety of fiber types. Key design rules relating to polymer hydrophilicity and pendant polymer functionality were established for the creation of effective dye transfer inhibitors. Remarkably, polymers at concentrations as low as 0.1 mg/ml were found to be effective in inhibiting indigo deposition on a variety of fiber types, offering great promise for their inclusion within laundry detergent formulations as dye transfer inhibitors

What we talk about when we talk about "global mindset": managerial cognition in multinational corporations

Recent developments in the global economy and in multinational corporations have placed significant emphasis on the cognitive orientations of managers, giving rise to a number of concepts such as “global mindset” that are presumed to be associated with the effective management of multinational corporations (MNCs). This paper reviews the literature on global mindset and clarifies some of the conceptual confusion surrounding the construct. We identify common themes across writers, suggesting that the majority of studies fall into one of three research perspectives: cultural, strategic, and multidimensional. We also identify two constructs from the social sciences that underlie the perspectives found in the literature: cosmopolitanism and cognitive complexity and use these two constructs to develop an integrative theoretical framework of global mindset. We then provide a critical assessment of the field of global mindset and suggest directions for future theoretical and empirical research

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.

We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC

Improved garment longevity and reduced microfibre release are important sustainability benefits of laundering in colder and quicker washing machine cycles

The global impact of laundering clothing is significant, with high levels of water, energy use, and pollution associated with this consumer care process. In this research, the impacts of washing temperature and washing time on garment colour loss (dye fading), colour transfer (dye staining), and microfibre release were evaluated using retail consumer clothing. Significantly greater colour loss and greater colour transfer were observed for a 40 °C, 85 min wash cycle compared to a cold-quick (25 °C; 30 min) cycle. Desorbing dyes were found to mainly be reactive dyes. From fundamental kinetic studies, it was observed that significant increases in both rate of dye desorption and total dye desorption occurred when increasing from 20 °C to 40 °C, but the difference in dye release between 40 °C and 60 °C was not as significant; the same kinetic trends were observed for dye transfer. Microfibre release was significantly greater for the 40 °C, 85 min cycle in comparison with the cold-quick cycle, and this effect continued with further washes. These results mean that reducing time and temperature in laundry could have a significant impact in terms of extended garment longevity and reduced dye and microfibre liberation into the environment, in addition to energy savings