The two-nucleon system at next-to-next-to-next-to-leading order

We consider the two-nucleon system at next-to-next-to-next-to-leading order (N^3LO) in chiral effective field theory. The two-nucleon potential at N^3LO consists of one-, two- and three-pion exchanges and a set of contact interactions with zero, two and four derivatives. In addition, one has to take into account various isospin-breaking and relativistic corrections. We employ spectral function regularization for the multi-pion exchanges. Within this framework, it is shown that the three-pion exchange contribution is negligibly small. The low-energy constants (LECs) related to pion-nucleon vertices are taken consistently from studies of pion-nucleon scattering in chiral perturbation theory. The total of 26 four-nucleon LECs has been determined by a combined fit to some np and pp phase shifts from the Nijmegen analysis together with the nn scattering length. The description of nucleon-nucleon scattering and the deuteron observables at N^3LO is improved compared to the one at NLO and NNLO. The theoretical uncertainties in observables are estimated based on the variation of the cut-offs in the spectral function representation of the potential and in the regulator utilized in the Lippmann-Schwinger equation.Comment: 62 pp, 13 fig

A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia After Renal Transplantation

BACKGROUND: Dysglycemia (encompassing impaired glucose tolerance and diabetes mellitus) arising after renal transplantation is common and confers a significant cardiovascular mortality risk. Nonetheless, the pathophysiology of posttransplant dysglycemia is not well described. The aim of this study was to prospectively and comprehensively assess glucose handling in renal transplant recipients from before to 12 months after transplantation to determine the underpinning pathophysiology. MATERIALS AND METHODS: Intravenous and oral glucose tolerance testing was conducted before and at 3 and 12 months posttransplantation. An intravenous glucose tolerance test was also performed on day 7 posttransplantation. We followed up 16 transplant recipients for 3 months and 14 recipients for 12 months. Insulin secretion, resistance and a disposition index (DI (IV)), a measure of β cell responsiveness in the context of prevailing insulin resistance, were also determined. RESULTS: At 12 months, 50% of renal transplant recipients had dysglycemia. Dysglycemia was associated with a dramatic fall in DI (IV) and this loss in β cell function was evident as early as 3 months posttransplantation (23.5 pretransplant; 6.4 at 3 months and 12.2 at 12 months posttransplant). Differences in the β cell response to oral glucose challenge were evident pretransplant in those destined to develop dysglycemia posttransplant (2-hour blood glucose level 5.6 mmol/L versus 6.8 mmol/L; P < 0.01). CONCLUSIONS: Dysglycemia after renal transplantation is common, and the loss of insulin secretion is a major contributor. Subclinical differences in glucose handling are evident pretransplant in those destined to develop dysglycemia potentially heralding a susceptible β cell which under the stressors associated with transplantation fails

The Cambrian System in the Arrowie Basin, Flinders Ranges, South Australia

The lower to ?middle Cambrian rocks (Terreneuvian, Series 2 and possibly Miaolingian) of the Arrowie Basin are exposed superbly in the Flinders Ranges of South Australia. They comprise two major sedimentary packages: a lower carbonate-rich succession (Hawker Group and correlates) and an upper siliciclastic-dominated succession (Billy Creek Formation, Wirrealpa Limestone and Lake Frome Group). These rocks form one of the most complete lower Cambrian (Terreneuvian and Series 2) successions globally. They contain one of the most diverse known early Cambrian biotas in the world, with trilobites, archaeocyaths, bradoriides, brachiopods, some of the earliest known coralomorphs, small shelly fossils, molluscs, hyoliths, acritarchs and trace fossils. Series divisions, based on ranges of shelly fossils and archaeocyath biostratigraphy are currently being established. Ancient reef structures are prominent in several areas. Syndepositional faulting and diapiric activity affected sedimentation in places. The global significance of the region is enhanced by the presence of tuff horizons at some levels, which provide the opportunity to link the biostratigraphic zones with radiometric dates and carbon isotope curves