493 research outputs found
Stroke patients and long-term training: is it worthwhile? A randomized comparison of two different training strategies after rehabilitation
Objective: To find out if there were any differences in improvement and maintenance of motor function, activity of daily living and grip strength between patients with first-ever stroke receiving two different strategies of physical exercise during the first year after stroke.
Design: A longitudinal randomized controlled stratified trial.
Setting: Rehabilitation institutions, community, patients' homes and nursing homes.
Subjects: Seventy-five male and female first-time-ever stroke patients: 35 in an intensive exercise group and 40 in a regular exercise group.
Intervention: The intensive exercise group received physiotherapy with focus on intensive exercises in four periods during the first year after stroke. The regular exercise group patients were followed up according to their subjective needs during the corresponding year.
Main outcome measures: Motor Assessment Scale, Barthel Index of Activities of Daily Living, and grip strength.
Results: Both groups improved significantly up to six months when function stabilized. The groups did not differ significantly on any test occasions. The difference of improvement from admission to discharge was significant in favour of the intensive exercise group, in the Motor Assessment Scale total score (intensive exercise group 7.5; regular exercise group 1.7, P = 0.01), and in the Barthel Index of Activities of Daily Living total score (17.4 versus 8.9, P = 0.04).
Conclusion: Motor function, activities of daily living functions and grip strength improved initially and were maintained during the first year after stroke in all patients irrespective of exercise regime. This indicates the importance of motivation for regular exercise in the first year following stroke, achieved by regular check-ups
Probing ferroelectricity in highly conducting materials through their elastic response: persistence of ferroelectricity in metallic BaTiO3-d
The question whether ferroelectricity (FE) may coexist with a metallic or
highly conducting state, or rather it must be suppressed by the screening from
the free charges, is the focus of a rapidly increasing number of theoretical
studies and is finally receiving positive experimental responses. The issue is
closely related to the thermoelectric and multiferroic (also magnetic)
applications of FE materials, where the electrical conductivity is required or
spurious. In these circumstances, the traditional methods for probing
ferroelectricity are hampered or made totally ineffective by the free charges,
which screen the polar response to an external electric field. This fact may
explain why more than 40 years passed between the first proposals of FE metals
and the present experimental and theoretical activity. The measurement of the
elastic moduli, Young's modulus in the present case, versus temperature is an
effective method for studying the influence of doping on a FE transition
because the elastic properties are unaffected by electrical conductivity. In
this manner, it is shown that the FE transitions of BaTiO3-d are not suppressed
by electron doping through O vacancies; only the onset temperatures are
depressed, but the magnitudes of the softenings, and hence of the piezoelectric
activity, are initially even increased
Asthma, asthma control and risk of ischemic stroke:The HUNT study
Background: Asthma, a chronic inflammatory airway disease, shares common pathophysiological mechanisms with ischemic stroke. The aim of the study is to assess the association between asthma, levels of asthma control and ischemic stroke risk in men and women and by smoking habits. Methods: This prospective population-based cohort study utilized data on 58 712 adults from HUNT Study in Norway free from stroke. Self-reported asthma was categorized as ever asthma, non-active asthma and active asthma (i.e., being on asthma medication within 12 months of the baseline). Asthma control was defined ac-cording to the Global Initiative for Asthma questionnaire and was categorized into controlled and not controlled asthma. Stroke was ascertained by linking HUNT data with Nord-Trøndelag hospital records and the Norwegian Patient Registry. Results: During a mean follow-up of 17.3 �5.3 years, 2619 participants (4.5%) had a first stroke. Not controlled asthma was associated with a modest increased risk of stroke (adjusted HR 1.34, 95%CI 1.03–1.73). Subgroup analyses revealed that the respective association was stronger among those with history of smoking (HR 1.48, 95%CI 1.10–2.00) and males (HR 1.55, 95%CI 1.12–2.16) while absent in non-smokers (HR 1.02, 95%CI 0.61–1.70) and females (HR 1.05, 95%CI 0.69–1.60). Likewise, active asthma was associated with similar increased stroke risk among smokers and males and absent in non-smokers and females. Conclusions: Symptomatic and active asthma was associated with a modest increased relative risk for ischemic stroke in smokers and males. Future studies should clarify the difference in risks and mechanisms between different phenotypes of asthma
Repetitive arm functional tasks after stroke (RAFTAS): a pilot randomised controlled trial
Background
Repetitive functional task practise (RFTP) is a promising treatment to improve upper limb recovery following stroke. We report the findings of a study to determine the feasibility of a multi-centre randomised controlled trial to evaluate this intervention.
Methods
A pilot randomised controlled trial was conducted. Patients with new reduced upper limb function were recruited within 14 days of acute stroke from three stroke units in North East England. Participants were randomised to receive a four week upper limb RFTP therapy programme consisting of goal setting, independent activity practise, and twice weekly therapy reviews in addition to usual post stroke rehabilitation, or usual post stroke rehabilitation. The recruitment rate; adherence to the RFTP therapy programme; usual post stroke rehabilitation received; attrition rate; data quality; success of outcome assessor blinding; adverse events; and the views of study participants and therapists about the intervention were recorded.
Results
Fifty five eligible patients were identified, 4-6% of patients screened at each site. Twenty four patients participated in the pilot study. Two of the three study sites met the recruitment target of 1-2 participants per month. The median number of face to face therapy sessions received was 6 [IQR 3-8]. The median number of daily repetitions of activities recorded was 80 [IQR 39-80]. Data about usual post stroke rehabilitation were available for 18/24 (75%). Outcome data were available for 22/24 (92%) at one month and 20/24 (83%) at three months. Outcome assessors were unblinded to participant group allocation for 11/22 (50%) at one month and 6/20 (30%) at three months. Four adverse events were considered serious as they resulted in hospitalisation. None were related to study treatment. Feedback from patients and local NHS therapists about the RFTP programme was mainly positive.
Conclusions
A multi-centre randomised controlled trial to evaluate an upper limb RFTP therapy programme provided early after stroke is feasible and acceptable to patients and therapists, but there are issues which needed to be addressed when designing a Phase III study. A Phase III study will need to monitor and report not only recruitment and attrition but also adherence to the intervention, usual post stroke rehabilitation received, and outcome assessor blinding
Shrinking-Hole Colloidal Lithography: Self-Aligned Nanofabrication of Complex Plasmonic Nanoantennas
Plasmonic nanoantennas create locally strongly enhanced electric fields in so-called hot spots. To place a relevant nanoobject with high accuracy in such a hot spot is crucial to fully capitalize on the potential of nanoantennas to control, detect, and enhance processes at the nanoscale. With state-of-the-art nanofabrication, in particular when several materials are to be used, small gaps between antenna elements are sought, and large surface areas are to be patterned, this is a grand challenge. Here we introduce self-aligned, bottom-up and self-assembly based Shrinking-Hole Colloidal Lithography, which provides (i) unique control of the size and position of subsequently deposited particles forming the nanoantenna itself, and (ii) allows delivery of nanoobjects consisting of a material of choice to the antenna hot spot, all in a single lithography step and, if desired, uniformly covering several square centimeters of surface. We illustrate the functionality of SHCL nanoantenna arrangements by (i) an optical hydrogen sensor exploiting the polarization dependent sensitivity of an Au-Pd nanoantenna ensemble; and (ii) single particle hydrogen sensing with an Au dimer nanoantenna with a small Pd nanoparticle in the hot spot
An air-liquid interphase approach for modeling the early embryo-maternal contact zone
We developed an air-liquid interphase culture procedure for mammalian oviduct
epithelial cells leading to the formation of functional epithelial tissues,
which generate oviduct fluid surrogates. These in vitro oviduct epithelia can
be co-cultured with living zygotes and enable embryonic development up to the
blastocyst stage without addition of embryo culture medium. The described
strategy is broadly applicable to analyze early embryo-maternal interactions
under standardized in vitro conditions
Living on the edge of stability, the limits of the nuclear landscape
A first-principles description of nuclear systems along the drip lines
presents a substantial theoretical and computational challenge. In this paper,
we discuss the nuclear theory roadmap, some of the key theoretical approaches,
and present selected results with a focus on long isotopic chains. An important
conclusion, which consistently emerges from these theoretical analyses, is that
three-nucleon forces are crucial for both global nuclear properties and
detailed nuclear structure, and that many-body correlations due to the coupling
to the particle continuum are essential as one approaches particle drip lines.
In the quest for a comprehensive nuclear theory, high performance computing
plays a key role.Comment: Contribution to proceedings of Nobel Symposium 152: Physics with
radioactive beams, June 2012, Gothenburg, Swede
Upright activity within the first week after stroke is associated with better functional outcome and health-related quality of life: A Norwegian multi-site study
- …