152 research outputs found
Metodologia de Baixo Custo para Registro de Imagens do Arco Voltaico de Soldagem
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"
- Author
- A Gibson
- A Nakanishi
- A Robichaud
- AD Gruber
- BU Pauli
- C Desnos
- CP Vaughn
- D Jethwaney
- DA Knight
- DA Kuperman
- DF Rogers
- DF Rogers
- F Thevenod
- G Candiano
- GB Smith
- GJ Evans
- GJ Evans
- GM Langford
- H Lin
- HP Hauber
- HQ Sun
- I Leverkoehne
- J Birkenfeld
- J Holst
- J Park
- JV Fahy
- KC Kim
- KW Lin
- L Mundhenk
- M de Graauw
- M Singer
- M Wills-Karp
- PC Yang
- PR Clarke
- RD Burgoyne
- SL Reck-Peterson
- SM Peterman
- TM Krunkosky
- TT Wu
- V Delanote
- Y Brunner
- Y Guo
- Y Li
- YA Chen
- Publication venue
- BioMed Central
- Publication date
- 01/09/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Excess mucus in the airways leads to obstruction in diseases such as chronic bronchitis, asthma, and cystic fibrosis. Mucins, the highly glycosolated protein components of mucus, are stored in membrane-bound granules housed in the cytoplasm of airway epithelial "goblet" cells until they are secreted into the airway lumen via an exocytotic process. Precise mechanism(s) of mucin secretion, including the specific proteins involved in the process, have yet to be elucidated. Previously, we have shown that the Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) protein regulates mucin secretion by orchestrating translocation of mucin granules from the cytosol to the plasma membrane, where the granules dock, fuse and release their contents into the airway lumen. Associated with MARCKS in this process are chaperone (Heat Shock Protein 70 [HSP70], Cysteine string protein [CSP]) and cytoskeletal (actin, myosin) proteins. However, additional granule-associated proteins that may be involved in secretion have not yet been elucidated.</p> <p>Methods</p> <p>Here, we isolated mucin granules and granule membranes from primary cultures of well differentiated human bronchial epithelial cells utilizing a novel technique of immuno-isolation, based on the presence of the calcium activated chloride channel hCLCA1 (the human ortholog of murine Gob-5) on the granule membranes, and verified via Western blotting and co-immunoprecipitation that MARCKS, HSP70, CSP and hCLCA1 were present on the granule membranes and associated with each other. We then subjected the isolated granules/membranes to liquid chromatography mass spectrometry (LC-MS/MS) to identify other granule associated proteins.</p> <p>Results</p> <p>A number of additional cytoskeletal (e.g. Myosin Vc) and regulatory proteins (e.g. Protein phosphatase 4) associated with the granules and could play a role in secretion were discovered. This is the first description of the airway goblet cell "granulome."</p
Anxiety, depression, perceived social support and quality of life in Malaysian breast cancer patients: a 1-year prospective study
- Author
- A OâNeil
- A Yusuf
- AGY Ăzpolat
- Ahmad Hatim Sulaiman
- AS Zigmond
- C Burgess
- CG Ng
- Chong Guan Ng
- CP Langford
- Faizah Harun
- G Ferrandina
- GD Zimet
- H Baumeister
- H Schleife
- JE Jang
- JR Fann
- K HĂ€rtl
- KM Trevino
- L Stafford
- M Abu-Helalah
- M Ceyhan
- M Heijer den
- M HĂ€rter
- M Mollica
- M Reich
- Maznah Dahlui
- Mee Hoong See
- MR Hassan
- N Huttera
- N Ibrahim
- N Yusoff
- NA Mohd Taib
- NB Dastan
- NK Aaronson
- Nor Zuraida Zainal
- Nur Aishah Taib
- NZ Zainal
- NZ Zainal
- P Lueboonthavatchai
- PL Chui
- S Cohen
- S Rizalar
- SA McLachlan
- Salina Mohamed
- SH Shaharudin
- SSM Ho
- T Pietras
- TL Albrecht
- V Cicero
- WKW So
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Female gamersâ experience of online harassment and social support in online gaming: a qualitative study
- Author
- A Cote
- A Holz Ivory
- A Lewis
- A Salter
- AK Przybylski
- AL Day
- BN Uchino
- BR Sarason
- C Steinfield
- CE Cutrona
- CK Olson
- CP Langford
- D Williams
- DA Olson
- DE Jacobson
- DR Winemiller
- DW Russell
- E Domahidi
- E Domahidi
- E O'Connor
- F Dalisay
- F Zhang
- H Cole
- H Longman
- H Wang
- I Kawachi
- I Möller
- I Voulgari
- J Fox
- J Fox
- J Holt-Lunstad
- J Jansz
- J Park
- JH Kuznekoff
- JK Kiecolt-Glaser
- JS House
- JS House
- JT Cacioppo
- K Lucas
- K Miyata
- KL Gray
- L Blinka
- L McLean
- L Vermeulen
- L Vermeulen
- L Vermeulen
- Lavinia McLean
- LF Pendry
- LK Kaye
- LK Kaye
- M Barrera
- M Kasumovic
- M Lourel
- M MartonÄik
- M Watson
- Mark D. Griffiths
- MD Griffiths
- ME Ballard
- N Bolger
- N Denzin
- N Yee
- NK Baym
- NK Semmer
- PA Thoits
- R Kowert
- S Chess
- S Cohen
- S Cohen
- S Cohen
- S Herring
- S Holmes
- S Trepte
- S Trepte
- T Hartmann
- TV Pollet
- V Clarke
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/07/2018
- Field of study
Female gaming is a relatively under-researched area, and female gamers often report experiencing harassment whilst playing online. The present study explored female experiences of social support while playing online video games, because of the previous research suggesting that females often experience harassment and negative interactions during game play. Data were collected from an online discussion forum, and comprised posts drawn from 271 female gamers. Thematic analysis of the discussions suggested that a lack of social support and harassment frequently led to female gamers playing alone, playing anonymously, and moving groups regularly. The female gamers reported experiencing anxiety and loneliness due to this lack of social support, and for many, this was mirrored in their experiences of social support outside of gaming. The female gamers frequently accepted the incorporation into their gaming of specific coping strategies to mitigate online harassment, including actively hiding their identity and avoiding all forms of verbal communication with other players. These themes are discussed in relation to relevant research in the area, along with recommendations for future research and consideration of possible explanations for the themes observed
Recurrent SARS-CoV-2 mutations in immunodeficient patients
- Author
- Aanensen DM
- Aggarwal D
- Aigrain L
- Amato R
- Ariani CV
- Barrett JC
- Bashton M
- Beckett AH
- Beckwith SM
- Bonsall D
- Bucca G
- Bull M
- Burns PJ
- Byott M
- Carabelli AM
- Chand M
- Connor TR
- Corden S
- Cortes N
- Cottrell S
- Curran MD
- Darby AC
- de Angelis D
- de Silva TI
- Eastick K
- Estee Torok M
- Fairley DJ
- Frampton D
- Glaysher S
- Golubchik T
- Gonçalves S
- Goodfellow IG
- Gunson RN
- Gupta RK
- Hamilton WL
- Harrison EM
- Hassan-Ibrahim MO
- Holden MTG
- Houlihan C
- Jackson DK
- Jackson LM
- Johnston I
- Kele B
- Kwiatkowski D
- Langford CF
- Levett LJ
- Liggett S
- Lillie PJ
- Livett R
- Loman NJ
- Loose MW
- Loveson KF
- Ludden C
- Lythgoe K
- Mahungu TW
- Martincorena I
- Martinez Nunez RT
- Moore C
- Moore N
- Moses S
- Murray A
- Nastouli E
- Nebbia G
- Nicholls S
- Osman H
- OâGrady J
- Pacchiarini N
- Page AJ
- Parker MD
- Parmar S
- Paterson S
- Peacock TP
- Pope CF
- Prieto JA
- Pybus OG
- Rambaut A
- Randell P
- Robertson DL
- Robson SC
- Rogan F
- Saeed K
- Shepherd JG
- Sheridan LA
- Sillitoe J
- Simpson DA
- Singleton D
- Smith CP
- Smith DL
- Snell LB
- Sparks N
- Templeton KE
- Thomas C
- Thomson EC
- Underwood AP
- Volz EM
- Wang D
- Watkins J
- Wilkinson SAJ
- Williams C
- Witney AA
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in immunodeficient patients are an important source of variation for the virus but are understudied. Many case studies have been published which describe one or a small number of long-term infected individuals but no study has combined these sequences into a cohesive dataset. This work aims to rectify this and study the genomics of this patient group through a combination of literature searches as well as identifying new case series directly from the COVID-19 Genomics UK (COG-UK) dataset. The spike gene receptor-binding domain and N-terminal domain (NTD) were identified as mutation hotspots. Numerous mutations associated with variants of concern were observed to emerge recurrently. Additionally a mutation in the envelope gene, T30I was determined to be the second most frequent recurrently occurring mutation arising in persistent infections. A high proportion of recurrent mutations in immunodeficient individuals are associated with ACE2 affinity, immune escape, or viral packaging optimisation.There is an apparent selective pressure for mutations that aid cellâcell transmission within the host or persistence which are often different from mutations that aid inter-host transmission, although the fact that multiple recurrent de novo mutations are considered defining for variants of concern strongly indicates that this potential source of novel variants should not be discounted
Perception of social support by individuals with diabetes mellitus and foot ulcers
- Author
- Allen SM
- Bishop A
- Boulton AJ
- Cheng TY
- Chobanian AV
- Cisneros LL
- Coelho MS
- Dias Ribeiro de Paula Lima E
- Fisher L
- Flaherty JA
- Fox A
- Franks P
- Gomes-Villas Boas LC
- Hanestad BR
- Heitzmann CA
- House JS
- House JS
- Iversen MM
- Kim ES
- Langford CP
- Martin IS
- Martins RM
- Mayberry LS
- Ramos MP
- Silva I
- Stewart MJ
- Tavares DM
- Toljamo M
- Vieira-Santos IC
- Yun JO
- Zou KH
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2012
- Field of study
Apoio social Ă mulher mastectomizada: um estudo de revisĂŁo
- Author
- Angell KL
- Armstrong D
- Awadalla AW
- Barbosa RCM
- Barnes J
- Beyea SC
- Biffi RG
- Caetano EA
- Carver CS
- Castro R
- Cohen S
- Daniela Cristina Mucinhato AmbrĂłsio
- DCM
- Fabbro MRC
- Ganong LH
- Gonçalves TR
- Guedea MTD
- Gustafson DH
- Hoffmann FS
- Hupcey JE
- Hutchison C
- Hwang SY
- King G
- Klassen AC
- Langford CP
- Macleod U
- Manoel AntĂŽnio dos Santos
- Matsukura TS
- Mendes KDS
- Minayo MCS
- Moscheta MS
- Packer AL
- Peres RS
- Pinheiro CP
- Roman AR
- Salles CACC
- Sanchez KOL
- Santos FMG
- Sarason IG
- Stanton AL
- Tavares JSC
- Vaux A
- Wise M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The impact of viral mutations on recognition by SARS-CoV-2 specific TÂ cells.
- Author
- Aanensen DM
- Abudahab K
- Adams A
- Adams H
- Adeniji K
- Afifi S
- Aggarwal D
- Agranoff D
- Agwuh K
- Ahmad SSY
- Ahmed KA
- Aigrain L
- Ail D
- Alcolea-Medina A
- Aldera EL
- Alegria A
- Alex B
- Alikhan N-F
- Allara E
- Allen S
- Amato R
- Andrikopoulos P
- Angus B
- Angyal A
- Annett T
- Aplin S
- Ariani CV
- Armstrong JA
- Asad H
- Ash A
- Ashfield P
- Ashford F
- Ashish A
- Ashworth M
- Asiimwe IG
- Atkinson D
- Atkinson L
- Attwood SW
- Auckland C
- Aydin A
- Bach B
- Baillie JK
- Baker DJ
- Baker P
- Bakshi S
- Balcazar CE
- Ball J
- Barclay WS
- Bari S
- Barlow G
- Barlow SL
- Barnass S
- Barrett JC
- Barrett N
- Barrow M
- Barton E
- Bashton M
- Bassett AR
- Bassford C
- Basude S
- Batra R
- Baxter C
- Baxter D
- Bayzid N
- Beadsworth M
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Bernatoniene J
- Berridge J
- Berry C
- Berry L
- Bertolusso B
- Best A
- Best N
- Betteridge E
- Bibby D
- Bicknell K
- Binns D
- Birchley A
- Bird PW
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bogaert D
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Booth L
- Boswell T
- Bosworth A
- Bothma P
- Bourgeois Y
- Boyd O
- Bradley DT
- Breen C
- Brennan B
- Bresner C
- Breuer J
- Bridgett S
- Brittain-Long R
- Bronner IF
- Brooks E
- Broos A
- Brown JR
- Brown R
- Bucca G
- Buchan SL
- Buck D
- Bull M
- Bullock K
- Bulteel N
- Burden T
- Burns PJ
- Burtenshaw A
- Burton-Fanning S
- Byaruhanga T
- Byott M
- Campbell S
- Carabelli AM
- Cargill JS
- Carlile M
- Carlucci N
- Carracedo AD
- Carson G
- Caruth V
- Carvalho SF
- Casey A
- Cass E
- Castigador A
- Catalan J
- Catterall BWA
- Chadwick D
- Chadwick D
- Chalker V
- Chaloner NJ
- Chambler D
- Chand M
- Chand M
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry Y
- Chechi K
- Chee N
- Child J
- Chukkambotla S
- Churcher CM
- Clark G
- Clark JJ
- Clark T
- Clarke EA
- Clarke P
- Clohisey S
- Cogger BJ
- Cole K
- Cole S
- Cole S
- Collini P
- Collins J
- Colquhoun R
- Connor M
- Connor TR
- Cook KF
- Cooke GS
- Coombes J
- Cooper L
- Corden S
- Cormie C
- Correia GDS
- Cortes N
- Cosgrove C
- Cotic M
- Cotton S
- Cottrell S
- Coupland L
- Cox A
- Cox H
- Cox M
- Craine N
- Crawford L
- Cross A
- Crown MR
- Crudgington D
- Cumley N
- Cupitt J
- Curran MD
- Curran T
- Cutino-Moguel M-T
- da Silva Filipe A
- da Silva Filipe A
- Dabrera G
- Dalton J
- Darby AC
- Dark P
- Davidson RK
- Davies A
- Davies RM
- Davis C
- Davis T
- Dawson C
- de Angelis D
- De Lacy E
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Denton-Smith R
- Dervisevic S
- Dervisevic S
- Dewar R
- Dey J
- Dias J
- Dincarslan O
- Dobie D
- Docherty AB
- Donegan C
- Dong D
- Dong T
- Donnison P
- Donohue C
- Dorman MJ
- Douthwaite S
- Downing F
- Driscoll M
- Drummond A
- du Plessis L
- Duckworth N
- Dumas M-E
- Dunachie S
- Dunn C
- Dunning J
- DuRand I
- Durham J
- Dushianthan A
- Dyer P
- Dyer T
- Eastick K
- Easton LJ
- Eccles R
- Edgeworth J
- Edwards S
- El Bouzidi K
- Eldirdiri S
- Ellaby N
- Elliott A
- Elliott S
- Eltringham G
- Ensell L
- Erkiert MJ
- Essex S
- Evans A
- Evans C
- Evans C
- Evans JM
- Everson W
- Eziefula C
- Fairley DJ
- Fallon K
- Fanaie A
- Farr BW
- Fearn C
- Fegan C
- Feltwell T
- Ferguson L
- Fina L
- Finch L
- Finn A
- Fisher LWS
- Flaherty L
- Flaviani F
- Fleming VM
- Fletcher T
- Forrest S
- Foster T
- Foster-Nyarko E
- Foulkes BH
- Foulser L
- Fragakis M
- Frampton D
- Francois S
- Fraser C
- Freeman TM
- Fryer H
- Fuchs M
- Fuller W
- Fullerton D
- Gajee K
- Galai K
- Gallagher A
- Gallagher E
- Gallagher MD
- Gallis M
- Gamble C
- Garcia-Dorival I
- Garg A
- Garg S
- Garg S
- Gaskin A
- Gatica-Wilcox B
- Geidelberg L
- Gemmell M
- Georgana I
- George RP
- Gifford L
- Gilbert L
- Girgis ST
- Girvan M
- Gkrania-Klotsas E
- Glaysher S
- Godden J
- Goldsmith A
- Goldstein EJ
- Golubchik T
- Gomes AN
- Gonçalves S
- Goodfellow IG
- Goodwin S
- Goudarzi S
- Gourtovaia M
- Graham C
- Graham C
- Graham L
- Grant PR
- Green A
- Green CA
- Green LR
- Greenaway J
- Greenhalf W
- Gregory R
- Griffin JL
- Griffiths F
- Guest M
- Gunning P
- Gunson RN
- Gupta RK
- Gupta RK
- Gutierrez B
- Haldenby ST
- Halpin S
- Hamilton WL
- Hansford SE
- Haque T
- Hardwick H
- Hardy E
- Harris KA
- Harrison EM
- Harrison EM
- Harrison I
- Harrison J
- Hart J
- Hartley C
- Hartley JA
- Hartshorn S
- Harvey D
- Harvey M
- Harvey WT
- Hassan-Ibrahim MO
- Havalda P
- Hawcutt DB
- Heaney J
- Helmer T
- Henderson JH
- Hendry R
- Hesketh AR
- Hey J
- Heyburn D
- Higginson EE
- Hill JD
- Hill V
- Hilson RA
- Hilvers E
- Hiscox JA
- Hobrok M
- Hodgson L
- Holden MTG
- Hollis A
- Holmes A
- Holmes AH
- Holmes CW
- Holmes N
- Hopes R
- Horby PW
- Hormis A
- Hornsby HR
- Hosmillo M
- Houlihan C
- Howson-Wells HC
- Hsu NS
- Hubb J
- Huckson H
- Hughes J
- Hughes M
- Hughes W
- Hutchings S
- Idle G
- Ijaz S
- Illingworth CJ
- Impey R
- Irish-Tavares D
- Iturriza-Gomara M
- Izuagbe R
- Jackson B
- Jackson C
- Jackson C
- Jackson DK
- Jackson KA
- Jackson LM
- Jacobs M
- Jahun AS
- Jain S
- James K
- James V
- Jeanes C
- Jeffries AR
- Jennings P
- Jensen RL
- Jeremiah S
- Jermy A
- John M
- Johnson K
- Johnson R
- Johnston I
- Jones CB
- Jones CR
- Jones H
- Jones N
- Jones O
- Jones S
- Jones TR
- Joseph A
- Judges S
- Kaliappan A
- Kasipandian V
- Kay GL
- Kay S
- Keating S
- Keatley J-P
- Keeley AJ
- Kegg S
- Kelsey M
- Kendall J
- Kenyon A
- Kermack LM
- Kerrison C
- Kerslake I
- Khakh M
- Khandaker S
- Khoo S
- Kidd SP
- Kimuli M
- King K
- Kirk S
- Kitchen C
- Kitchman K
- Kiy RT
- Klenerman P
- Knight BA
- Knight JC
- Koch O
- Koduri G
- Koshy C
- Koshy G
- Koukorava C
- Kraemer MUG
- Kumziene-Summerhayes S
- Kwiatkowski D
- Lackenby A
- Laha S
- Laing KG
- Laird S
- Lake A
- Lampejo T
- Langford CF
- Lant S
- Larkin S
- Latawiec D
- Lavelle-Langham L
- Lavin D
- Law A
- Law A
- Lawton AI
- Le-Viet T
- Lee D
- Lee J
- Lee J
- Leeming G
- Lefteri D
- Leiner T
- Lensing SV
- Leonard S
- Lett L
- Levett LJ
- Lewis J
- Lewis K
- Lewis MR
- Liddle J
- Liggett S
- Liggi S
- Lillie P
- Lillie PJ
- Lim WS
- Limb J
- Lindsey BB
- Linnett V
- Lister MM
- Little J
- Liu G
- Livett R
- Livoti LA
- Lo S
- Loman NJ
- Loose MW
- Louka SF
- Loveson KF
- Lowdon S
- Lowe H
- Lowe HL
- Lucaci AO
- Ludden C
- Lynch J
- Lyons RA
- Lythgoe K
- Lyttle M
- Machin NW
- MacIntyre-Cockett G
- Mack A
- Macklin B
- Maclean A
- MacLean A
- MacMahon M
- Macnaughton E
- MacNaughton E
- Madona P
- Maes M
- Maftei L
- Mahanama AIK
- Mahungu TW
- Maini MK
- Mair D
- Maksimovic J
- Malone CS
- Maloney D
- Mancini M
- Manesis N
- Mankregod R
- Manley R
- Mantzouratou A
- Marchbank A
- Mariappan A
- Marsh L
- Martincorena I
- Martinez Nunez RT
- Maslen L
- Massey H
- Masson H
- Mather AE
- Matovu E
- Maxwell P
- Mayhew M
- Maziere N
- Mbisa T
- McCafferty S
- McCann CM
- McCarthy SA
- McCluggage K
- McClure PC
- McCrone JT
- McCullough K
- McDonald S
- McDonald SE
- McEvoy L
- McEwen R
- McHugh MP
- McKenna JP
- McKerr C
- McLauchlan J
- McManus GM
- McMurray C
- McMurray CL
- McNally A
- Meadows L
- Meda M
- Medd N
- Megram O
- Menegazzo M
- Mentzer AJ
- Mentzer AJ
- Merrick I
- Merson L
- Metelmann S
- Meynert AM
- Miah NS
- Michell SL
- Michelsen ML
- Middleton J
- Mills G
- Minton J
- Mirfenderesky M
- Mirfenderesky M
- Mirza J
- Miskelly J
- Mitchell J
- Mohandas K
- Mok Q
- Moles-Garcia E
- Moll RJ
- Molnar Z
- Monahan IM
- Mondani M
- Mookerjee S
- Moon J
- Moore C
- Moore C
- Moore E
- Moore J
- Moore N
- Moore SC
- Moore SC
- Morcrette H
- Morgan M
- Morgan P
- Morgan S
- Mori M
- Morrice K
- Morris C
- Morriss A
- Mortimore K
- Moses S
- Moses S
- Mower C
- Mpenge M
- Muir P
- Mukaddas A
- Mulla R
- Munemo F
- Munn R
- Murphy EG
- Murphy L
- Murphy M
- Murray A
- Murray DR
- Murray LJ
- Mutingwende M
- Myers R
- Nagarajan T
- Nagel M
- Nastouli E
- Nebbia G
- Nelson A
- Nelson C
- Nelson M
- Nicholls S
- Nichols J
- Nicodemi R
- Nomikou K
- Norris L
- Noursadeghi M
- O'Brien S
- O'Shea MK
- Odedra M
- Ogg G
- Ohemeng-Kumi N
- Olanipekun M
- Oliver K
- Oosthuyzen W
- Openshaw PJM
- Orton RJ
- Osagie A
- Osman H
- Ostermann M
- Otahal I
- OâGrady J
- Pacchiarini N
- Padgett D
- Page AJ
- Pais M
- Palmarini M
- Palmieri C
- Palmieri C
- Panchatsharam S
- Papakonstantinou D
- Papineni P
- Paraiso H
- Park EJ
- Park NR
- Parker MD
- Parmar S
- Partridge DG
- Pascall D
- Patel A
- Patel B
- Patel B
- Paterson S
- Pattison N
- Paxton WA
- Payne BAI
- Peacock SJ
- Pearson C
- Pelosi E
- Peng Y
- Penrice-Randal R
- Pepperell J
- Percival B
- Perkins J
- Perry M
- Peters M
- Phull M
- Pilgrim J
- Pinckert ML
- Pintus S
- Planche T
- Platt S
- Plotkin D
- Podplomyk O
- Pohare M
- Pollakis G
- Pond M
- Pooni JS
- Pope CF
- Poplawski R
- Post F
- Powell J
- Poyner J
- Prestwood L
- Price A
- Price D
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- Publication venue
- iScience
- Publication date
- 01/01/2021
- Field of study
We identify amino acid variants within dominant SARS-CoV-2 TÂ cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific TÂ cells assessed by IFN-Îł and cytotoxic killing assays. Complete loss of TÂ cell responsiveness was seen due to Q213K in the Aâ01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the Bâ27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the Aâ03:01/Aâ11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ TÂ cell lines unable to recognize variant epitopes have diverse TÂ cell receptor repertoires. These data demonstrate the potential for TÂ cell evasion and highlight the need for ongoing surveillance for variants capable of escaping TÂ cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC â IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC
Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at root s=13 TeV
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- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim A
- Abdullin S
- Abercrombie D
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- Wieland S
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- Wightman A
- Williams A
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer B
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf R
- Wong K
- Wong W
- Wood D
- Wozniak K
- Wozniewski S
- Wright D
- Wu Hy
- Wu Z
- Wuchterl S
- Wulz C
- Wunsch S
- Wyslouch B
- WĂŒrthwein F
- Xiang Y
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang H
- Yang S
- Yang U
- Yang Y
- Yao Y
- Yarar H
- Yates B
- Yazgan E
- Ye Z
- Yetkin E
- Yi K
- Yigitbasi E
- Yohay R
- Yoo H
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu G
- Yu I
- Yu Pr
- Yu S
- Yuan L
- Yuan S
- Yuldashev B
- Yumiceva F
- Yzquierdo AP
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli A
- Zeinali M
- Zeuner W
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu R
- Ziemons T
- Zipper N
- Zoi I
- Zolkapli Z
- Zorbakir I
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2022
- Field of study
- âŠ