1,332 research outputs found
Distribution of parametric conductance derivatives of a quantum dot
The conductance G of a quantum dot with single-mode ballistic point contacts
depends sensitively on external parameters X, such as gate voltage and magnetic
field. We calculate the joint distribution of G and dG/dX by relating it to the
distribution of the Wigner-Smith time-delay matrix of a chaotic system. The
distribution of dG/dX has a singularity at zero and algebraic tails. While G
and dG/dX are correlated, the ratio of dG/dX and is independent
of G. Coulomb interactions change the distribution of dG/dX, by inducing a
transition from the grand-canonical to the canonical ensemble. All these
predictions can be tested in semiconductor microstructures or microwave
cavities.Comment: 4 pages, RevTeX, 3 figure
A Dynamic Programming Approach to Adaptive Fractionation
We conduct a theoretical study of various solution methods for the adaptive
fractionation problem. The two messages of this paper are: (i) dynamic
programming (DP) is a useful framework for adaptive radiation therapy,
particularly adaptive fractionation, because it allows us to assess how close
to optimal different methods are, and (ii) heuristic methods proposed in this
paper are near-optimal, and therefore, can be used to evaluate the best
possible benefit of using an adaptive fraction size.
The essence of adaptive fractionation is to increase the fraction size when
the tumor and organ-at-risk (OAR) are far apart (a "favorable" anatomy) and to
decrease the fraction size when they are close together. Given that a fixed
prescribed dose must be delivered to the tumor over the course of the
treatment, such an approach results in a lower cumulative dose to the OAR when
compared to that resulting from standard fractionation. We first establish a
benchmark by using the DP algorithm to solve the problem exactly. In this case,
we characterize the structure of an optimal policy, which provides guidance for
our choice of heuristics. We develop two intuitive, numerically near-optimal
heuristic policies, which could be used for more complex, high-dimensional
problems. Furthermore, one of the heuristics requires only a statistic of the
motion probability distribution, making it a reasonable method for use in a
realistic setting. Numerically, we find that the amount of decrease in dose to
the OAR can vary significantly (5 - 85%) depending on the amount of motion in
the anatomy, the number of fractions, and the range of fraction sizes allowed.
In general, the decrease in dose to the OAR is more pronounced when: (i) we
have a high probability of large tumor-OAR distances, (ii) we use many
fractions (as in a hyper-fractionated setting), and (iii) we allow large daily
fraction size deviations.Comment: 17 pages, 4 figures, 1 tabl
The Thermopower of Quantum Chaos
The thermovoltage of a chaotic quantum dot is measured using a current
heating technique. The fluctuations in the thermopower as a function of
magnetic field and dot shape display a non-Gaussian distribution, in agreement
with simulations using Random Matrix Theory. We observe no contributions from
weak localization or short trajectories in the thermopower.Comment: 4 pages, 3 figures, corrected: accidently omitted author in the
Authors list, here (not in the article
GPU-based ultra-fast direct aperture optimization for online adaptive radiation therapy
Online adaptive radiation therapy (ART) has great promise to significantly
reduce normal tissue toxicity and/or improve tumor control through real-time
treatment adaptations based on the current patient anatomy. However, the major
technical obstacle for clinical realization of online ART, namely the inability
to achieve real-time efficiency in treatment re-planning, has yet to be solved.
To overcome this challenge, this paper presents our work on the implementation
of an intensity modulated radiation therapy (IMRT) direct aperture optimization
(DAO) algorithm on graphics processing unit (GPU) based on our previous work on
CPU. We formulate the DAO problem as a large-scale convex programming problem,
and use an exact method called column generation approach to deal with its
extremely large dimensionality on GPU. Five 9-field prostate and five 5-field
head-and-neck IMRT clinical cases with 5\times5 mm2 beamlet size and
2.5\times2.5\times2.5 mm3 voxel size were used to evaluate our algorithm on
GPU. It takes only 0.7~2.5 seconds for our implementation to generate optimal
treatment plans using 50 MLC apertures on an NVIDIA Tesla C1060 GPU card. Our
work has therefore solved a major problem in developing ultra-fast
(re-)planning technologies for online ART
Reflection and transmission of waves in surface-disordered waveguides
The reflection and transmission amplitudes of waves in disordered multimode
waveguides are studied by means of numerical simulations based on the invariant
embedding equations. In particular, we analyze the influence of surface-type
disorder on the behavior of the ensemble average and fluctuations of the
reflection and transmission coefficients, reflectance, transmittance, and
conductance. Our results show anomalous effects stemming from the combination
of mode dispersion and rough surface scattering: For a given waveguide length,
the larger the mode transverse momentum is, the more strongly is the mode
scattered. These effects manifest themselves in the mode selectivity of the
transmission coefficients, anomalous backscattering enhancement, and speckle
pattern both in reflection and transmission, reflectance and transmittance, and
also in the conductance and its universal fluctuations. It is shown that, in
contrast to volume impurities, surface scattering in quasi-one-dimensional
structures (waveguides) gives rise to the coexistence of the ballistic,
diffusive, and localized regimes within the same sample.Comment: LaTeX (REVTeX), 12 pages with 14 EPS figures (epsf macro), minor
change
Inactivation of glycogen synthase kinase-3 beta (GSK-3 beta) enhances skeletal muscle oxidative metabolism
Background: Aberrant skeletal muscle mitochondrial oxidative metabolism is a debilitating feature of chronic diseases such as chronic obstructive pulmonary disease, type 2 diabetes and chronic heart failure. Evidence in non-muscle cells suggests that glycogen synthase kinase-3 beta (GSK-3 beta) represses mitochondrial biogenesis and inhibits PPAR-gamma co-activator 1 (PGC-1), a master regulator of cellular oxidative metabolism. The role of GSK-3 beta in the regulation of skeletal muscle oxidative metabolism is unknown. Aims: We hypothesized that inactivation of GSK-3 beta stimulates muscle oxidative metabolism by activating PGC-1 signaling and explored if GSK-3 beta inactivation could protect against physical inactivity-induced alterations in skeletal muscle oxidative metabolism. Methods: GSK-3 beta was modulated genetically and pharmacologically in C2C12 myotubes in vitro and in skeletal muscle in vivo. Wild-type and muscle-specific GSK-3 beta knock-out (KO) mice were subjected to hind limb suspension for 14 days. Key constituents of oxidative metabolism and PGC-1. signaling were investigated. Results: In vitro, knock-down of GSK-3 beta increased mitochondrial DNA copy number, protein and mRNA abundance of oxidative phosphorylation (OXPHOS) complexes and activity of oxidative metabolic enzymes but also enhanced protein and mRNA abundance of key PGC-1 signaling constituents. Similarly, pharmacological inhibition of GSK-3 beta increased transcript and protein abundance of key constituents and regulators of mitochondrial energy metabolism. Furthermore, GSK-3 beta KO animals were protected against unloading-induced decrements in expression levels of these constituents. Conclusion: Inactivation of GSK-3 beta up-regulates skeletal muscle mitochondrial metabolism and increases expression levels of PGC-1 signaling constituents. In vivo, GSK-3 beta KO protects against inactivity-induced reductions in muscle metabolic gene expression
Intensity distribution for waves in disordered media: deviations from Rayleigh statistics
We study the intensity distribution function, P(I), for monochromatic waves
propagating in quasi one-dimensional disordered medium, assuming that a point
source and a point detector are embedded in the bulk of the medium. We find
deviations from the Rayleigh statistics at moderately large I and a
logarithmically-normal asymptotic behavior of P(I). When the radiation source
and the detector are located close to the opposite edges of the sample (on a
distance much less then the sample length), an intermediate regime with a
stretched-exponential behavior of P(I) emerges.Comment: 4 pages Revtex, 3 figures included as eps file
Hard-Sphere Crystals with hcp and Non-Close-Packed Structure Grown by Colloidal Epitaxy
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