Partitioning Clustering Based on Support Vector Ranking

Postprin

e-Distance Weighted Support Vector Regression

We propose a novel support vector regression approach called e-Distance Weighted Support Vector Regression (e-DWSVR).e-DWSVR specifically addresses two challenging issues in support vector regression: first, the process of noisy data; second, how to deal with the situation when the distribution of boundary data is different from that of the overall data. The proposed e-DWSVR optimizes the minimum margin and the mean of functional margin simultaneously to tackle these two issues. In addition, we use both dual coordinate descent (CD) and averaged stochastic gradient descent (ASGD) strategies to make e-DWSVR scalable to large scale problems. We report promising results obtained by e-DWSVR in comparison with existing methods on several benchmark datasets

Primary localized histoplasmosis with lesions restricted to the mouth in a Chinese HIV-negative patient

SummaryHistoplasmosis is a deep mycosis caused by Histoplasma capsulatum, which is endemic in many areas of the world but is relatively rare in China. Although the majority of cases present as a mild to moderate flu-like disease requiring only supportive therapy, approximately 1% of patients experience more serious pulmonary and extrapulmonary disease, which can be life-threatening if diagnosis is delayed or the treatment is not initiated rapidly. Definitive diagnosis is usually made by a combination of culture, detection of the organism in tissues, measurement of antibodies, and detection of antigen. We present the case of a 51-year-old patient who presented with histoplasmosis only, with several ulcerated lesions in the oral cavity and without HIV infection, who did not show any detectable signs and symptoms of systemic disease or extra-oral manifestations. Histopathological analysis indicated a chronic inflammatory process with granulomas with yeast-like organisms. Isolation of H. capsulatum and molecular identification provided the definitive diagnosis. Treatment with oral itraconazole led to remission of the oral lesions. This is the first Chinese case report of localized histoplasmosis with lesions restricted to the mouth in an HIV-negative patient

Density alteration in non-physiological cells

In the present study an important phenomenon of cells was discovered: the change of intracellular density in cell's response to drug and environmental factors. For convenience, this phenomenon is named as "density alteration in non-physiological cells" ( DANCE). DANCE was determined by discontinuous sucrose gradient centrifugation (DSGC), in which cells were separated into several bands. The number and position of the bands in DSGC varied with the change of cell culture conditions, drugs, and physical process, indicating that cell's response to these factors was associated with alteration of intracellular density. Our results showed that the bands of cells were molecularly different from each other, such as the expression of some mRNAs. For most cells tested, intracellular density usually decreased when the cells were in bad conditions, in presence of drugs, or undergoing pathological changes. However, unlike other tissue cells, brain cells showed increased intracellular density in 24 hrs after the animal death. In addition, DANCE was found to be related to drug resistance, with higher drug-resistance in cells of lower intracellular density. Further study found that DANCE also occurred in microorganisms including bacteria and fungus, suggesting that DANCE might be a sensitive and general response of cells to drugs and environmental change. The mechanisms for DANCE are not clear. Based on our study the following causes were hypothesized: change of metabolism mode, change of cell membrane function, and pathological change. DANCE could be important in medical and biological sciences. Study of DANCE might be helpful to the understanding of drug resistance, development of new drugs, separation of new subtypes from a cell population, forensic analysis, and importantly, discovery of new physiological or pathological properties of cells

The Zeroth Law of Thermodynamics and Volume-Preserving Conservative Dynamics with Equilibrium Stochastic Damping

We propose a mathematical formulation of the zeroth law of thermodynamics and develop a stochastic dynamical theory, with a consistent irreversible thermodynamics, for systems possessing sustained conservative stationary current in phase space while in equilibrium with a heat bath. The theory generalizes underdamped mechanical equilibrium: $dx=gdt+\{-D\nabla\phi dt+\sqrt{2D}dB(t)\}$, with $\nabla\cdot g=0$ and $\{\cdots\}$ respectively representing phase-volume preserving dynamics and stochastic damping. The zeroth law implies stationary distribution $u^{ss}(x)=e^{-\phi(x)}$. We find an orthogonality $\nabla\phi\cdot g=0$ as a hallmark of the system. Stochastic thermodynamics based on time reversal $\big(t,\phi,g\big)\rightarrow\big(-t,\phi,-g\big)$ is formulated: entropy production $e_p^{\#}(t)=-dF(t)/dt$; generalized "heat" $h_d^{\#}(t)=-dU(t)/dt$, $U(t)=\int_{\mathbb{R}^n} \phi(x)u(x,t)dx$ being "internal energy", and "free energy" $F(t)=U(t)+\int_{\mathbb{R}^n} u(x,t)\ln u(x,t)dx$ never increases. Entropy follows $\frac{dS}{dt}=e_p^{\#}-h_d^{\#}$. Our formulation is shown to be consistent with an earlier theory of P. Ao. Its contradistinctions to other theories, potential-flux decomposition, stochastic Hamiltonian system with even and odd variables, Klein-Kramers equation, Freidlin-Wentzell's theory, and GENERIC, are discussed.Comment: 25 page

The effective expression of xylanase gene in Candida utilis by 18S rDNA targeted homologous recombination in pGLR9K

In order to test whether 18S rDNA can influence positively xylanase gene effective expression in the yeast of Candida utilis, a targeting vector pGLR9K-XA was constructed by adding an interested gene xynA from Streptomyces olivaceoviridis into the vector pGLR9K which is constructed by ourselves. pGLR9K contains the 18S rDNA, GAP promoter and CYH resistance gene sequence, all of which is from C. utilis. Then the vector pGLR9K-XA was transformed into C. utilis. To test the vector and transformed system, PCR, Southern blot and DNS methods were used. The results showed that xylanase gene can be detected in the chromosome DNA of recombinant C. utilis and the enzyme activity of xylanase is up to 60 IU ml(-1) in the study. It is suggested that this system can be used to express exogenous genes in C. utilis as a bioreactors. This is the first report that xylanase gene was expressed in C. utilis