A semi-automatic semantic method for mapping SNOMED CT concepts to VCM Icons

VCM (Visualization of Concept in Medicine) is an iconic language for representing key medical concepts by icons. However, the use of this language with reference terminologies, such as SNOMED CT, will require the mapping of its icons to the terms of these terminologies. Here, we present and evaluate a semi-automatic semantic method for the mapping of SNOMED CT concepts to VCM icons. Both SNOMED CT and VCM are compositional in nature; SNOMED CT is expressed in description logic and VCM semantics are formalized in an OWL ontology. The proposed method involves the manual mapping of a limited number of underlying concepts from the VCM ontology, followed by automatic generation of the rest of the mapping. We applied this method to the clinical findings of the SNOMED CT CORE subset, and 100 randomly-selected mappings were evaluated by three experts. The results obtained were promising, with 82 of the SNOMED CT concepts correctly linked to VCM icons according to the experts. Most of the errors were easy to fix

Holocene Event Record of Aysen Fjord (Chilean Patagonia): An Interplay of Volcanic Eruptions and Crustal and Megathrust Earthquakes

In the first months of 2007, the Aysen region in southern Chile was affected by a crustal seismic swarm. Its largest earthquake (M-w 6.2) occurred in April and had its epicenter in Aysen Fjord. Seismic intensities became so high that hundreds of onshore mass movements were triggered, several of which entered into the fjord, resulting in mass transport deposits (MTDs) preserved at the fjord bottom. Here we present a Holocene record of paleo-earthquakes in the previously unstudied Patagonian fjordland based on MTD stratigraphy. High-resolution seismic data retrieved using two different seismic systems (sparker and TOPAS) reveal multiple older MTDs on different stratigraphic levels. Correlation of the seismic stratigraphy with sedimentological data obtained from a long Calypso core (MD07-3117) allows conclusion on the seismic origin of these deposits. Additionally, radiocarbon dating permits constructing an age model, validated by tephrochronology, providing an age for the different MTD levels. We thus present a highly detailed paleoseismological history of the Aysen region, including at least six major Holocene earthquakes, one of which is likely related to a known megathrust earthquake. Other earthquakes are related to activity of the Liquine-Ofqui Fault Zone (LOFZ), forming the main source of seismic hazard in the area. We can infer a general average recurrence time for LOFZ earthquakes of -2,100years in the vicinity of Aysen Fjord with clustered events during the early and late Holocene. Finally, we argue that cascading events (causal link between volcanic and seismic events) may be a frequent phenomenon along the LOFZ

Une comparaison de récepteurs source-canal conjoint utilisant des codes LDPC

L'optimisation d'un récepteur utilisant un décodage source-canal conjoint (DSCC) impliquant un code LDPC sera considérée pour les systèmes itératifs suivant : (a) récepteur source-canal conjoint optimal, (b) récepteurs compatibles avec des applications non conjointes, (c) le récepteur tandem optimal supposant une compression de source parfaite. Des résultats d'optimisation et de simulation seront fournis pour différents rendements et longueurs de mots de code

Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC:A Comparison Study

Simple Summary We compared the UltraSEEK (TM) Lung Panel on the MassARRAY (R) System (Agena Bioscience) with the FDA-approved Cobas (R) EGFR Mutation Test v2 for the detection of EGFR mutations in liquid biopsies of NSCLC patients, accompanied with preanalytical sample assessment using the novel Liquid IQ (R) Panel. For the detection of relevant predictive mutations using the UltraSEEK (TM) Lung Panel, an input of over 10 ng showed 100% concordance with Cobas (R) EGFR Mutation Test v2 and detection of all tissue confirmed mutations. In case of lower ccfDNA input, the risk of missing clinically relevant mutations should be considered. The use of a preanalytical ccfDNA quality control assay such as the Liquid IQ (R) Panel is recommended to confidently interpret results, avoiding bias induced by non-specific genomic DNA and low input of specific tumoral ccfDNA fragments. Plasma-based tumor mutational profiling is arising as a reliable approach to detect primary and therapy-induced resistance mutations required for accurate treatment decision making. Here, we compared the FDA-approved Cobas (R) EGFR Mutation Test v2 with the UltraSEEK (TM) Lung Panel on the MassARRAY (R) System on detection of EGFR mutations, accompanied with preanalytical sample assessment using the novel Liquid IQ (R) Panel. 137 cancer patient-derived cell-free plasma samples were analyzed with the Cobas (R) and UltraSEEK (TM) tests. Liquid IQ (R) analysis was initially validated (n = 84) and used to determine ccfDNA input for all samples. Subsequently, Liquid IQ (R) results were applied to harmonize ccfDNA input for the Cobas (R) and UltraSEEK (TM) tests for 63 NSCLC patients. The overall concordance between the Cobas (R) and UltraSEEK (TM) tests was 86%. The Cobas (R) test detected more EGFR exon19 deletions and L858R mutations, while the UltraSEEK (TM) test detected more T790M mutations. A 100% concordance in both the clinical (n = 137) and harmonized (n = 63) cohorts was observed when >10 ng of ccfDNA was used as determined by the Liquid IQ (R) Panel. The Cobas (R) and UltraSEEK (TM) tests showed similar sensitivity in EGFR mutation detection, particularly when ccfDNA input was sufficient. It is recommended to preanalytically determine the ccfDNA concentration accurately to ensure sufficient input for reliable interpretation and treatment decision making

Joint coding/decoding techniques and diversity techniques for video and HTML transmission over wireless point/multipoint: a survey

I. Introduction The concomitant developments of the Internet, which offers to its users always larger and more evolved contents (from HTML (HyperText Markup Language) files to multimedia applications), and of wireless systems and handhelds integrating them, have progressively convinced a fair share of people of the interest to always be connected. Still, constraints of heterogeneity, reliability, quality and delay over the transmission channels are generally imposed to fulfill the requirements of these new needs and their corresponding economical goals. This implies different theoretical and practical challenges for the digital communications community of the present time. This paper presents a survey of the different techniques existing in the domain of HTML and video stream transmission over erroneous or lossy channels. In particular, the existing techniques on joint source and channel coding and decoding for multimedia or HTML applications are surveyed, as well as the related problems of streaming and downloading files over an IP mobile link. Finally, various diversity techniques that can be considered for such links, from antenna diversity to coding diversity, are presented...L’engouement du grand public pour les applications multimédia sans fil ne cesse de croître depuis le développement d’Internet. Des contraintes d’hétérogénéité de canaux de transmission, de fiabilité, de qualité et de délai sont généralement exigées pour satisfaire les nouveaux besoins applicatifs entraînant ainsi des enjeux économiques importants. À l’heure actuelle, il reste encore un certain nombre de défis pratiques et théoriques lancés par les chercheurs de la communauté des communications numériques. C’est dans ce cadre que s’inscrit le panorama présenté ici. Cet article présente d’une part un état de l’art sur les principales techniques de codage et de décodage conjoint développées dans la littérature pour des applications multimédia de type téléchargement et diffusion de contenu sur lien mobile IP. Sont tout d’abord rappelées des notions fondamentales des communications numériques à savoir le codage de source, le codage de canal ainsi que les théorèmes de Shannon et leurs principales limitations. Les techniques de codage décodage conjoint présentées dans cet article concernent essentiellement celles développées pour des schémas de codage de source faisant intervenir des codes à longueur variable (CLV) notamment les codes d’Huffman, arithmétiques et les codes entropiques universels de type Lempel-Ziv (LZ). Faisant face au problème de la transmission de données (Hypertext Markup Language (HTML) et vidéo) sur un lien sans fil, cet article présente d’autre part un panorama de techniques de diversités plus ou moins complexes en vue d’introduire le nouveau système à multiples antennes d’émission et de réception

Optimisation of multimedia over wireless IP links via X-layer design: an end-to-end transmission chain simulator

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Design of a graphical and interactive interface for facilitating access to drug contraindications, cautions for use, interactions and adverse effects

<p>Abstract</p> <p>Background</p> <p>Drug iatrogeny is important but could be decreased if contraindications, cautions for use, drug interactions and adverse effects of drugs described in drug monographs were taken into account. However, the physician's time is limited during consultations, and this information is often not consulted. We describe here the design of "Mister VCM", a graphical interface based on the VCM graphical language, facilitating access to drug monographs. We also provide an assessment of the usability of this interface.</p> <p>Methods</p> <p>The "Mister VCM" interface was designed by dividing the screen into two parts: a graphical interactive one including VCM icons and synthetizing drug properties, a textual one presenting on demand drug monograph excerpts. The interface was evaluated over 11 volunteer general practitioners, trained in the use of "Mister VCM". They were asked to answer clinical questions related to fictitious randomly generated drug monographs, using a textual interface or "Mister VCM". When answering the questions, correctness of the responses and response time were recorded.</p> <p>Results</p> <p>"Mister VCM" is an interactive interface that displays VCM icons organized around an anatomical diagram of the human body with additional mental, etiological and physiological areas. Textual excerpts of the drug monograph can be displayed by clicking on the VCM icons. The interface can explicitly represent information implicit in the drug monograph, such as the absence of a given contraindication. Physicians made fewer errors with "Mister VCM" than with text (factor of 1.7; <it>p </it>= 0.034) and responded to questions 2.2 times faster (<it>p </it>< 0.001). The time gain with "Mister VCM" was greater for long monographs and questions with implicit replies.</p> <p>Conclusion</p> <p>"Mister VCM" seems to be a promising interface for accessing drug monographs. Similar interfaces could be developed for other medical domains, such as electronic patient records.</p