Cosmological Implications of the Tetron Model of Elementary Particles

Based on a possible solution to the tetron spin problem, a modification of the standard Big Bang scenario is suggested, where the advent of a spacetime manifold is connected to the appearance of tetronic bound states. The metric tensor is constructed from tetron constituents and the reason for cosmic inflation is elucidated. Furthermore, there are natural dark matter candidates in the tetron model. The ratio of ordinary to dark matter in the universe is calculated to be 1:5.Comment: 23 page

Cluster Algebras and Discrete Integrability

Cluster algebras are a class of commutative algebras whose generators are defined by a recursive process called mutation. We give a brief introduction to cluster algebras, and explain how discrete integrable systems can appear in the context of cluster mutation. In particular, we give examples of birational maps that are integrable in the Liouville sense and arise from cluster algebras with periodicity, as well as examples of discrete Painleve equations that are derived from Y-systems

Polarized deep inelastic scattering at high energies and parity violating structure functions

A comprehensive analysis of deep inelastic scattering of polarized charged leptons on polarized nucleons is presented; weak interaction contributions, both in neutral and charged current processes, are taken into account and the parity violating polarized nucleon structure functions are studied. Possible ways of their measurements and their interpretations in the parton model are discussed.Comment: (slightly modified version, includes a few new references and corrects few misprints for publication), 14 pages in TeX (needs harvmac) no figure, DFTT 80/9

Chirality and Symmetry Breaking in a discrete internal Space

In previous papers the permutation group S_4 has been suggested as an ordering scheme for elementary particles, and the appearance of this finite symmetry group was taken as indication for the existence of a discrete inner symmetry space underlying elementary particle interactions. Here it is pointed out that a more suitable choice than the tetrahedral group S_4 is the pyritohedral group A_4 x Z_2 because its vibrational spectrum exhibits exactly the mass multiplet structure of the 3 fermion generations. Furthermore it is noted that the same structure can also be obtained from a primordial symmetry breaking S_4 --> A_4. Since A_4 is a chiral group, while S_4 is achiral, an argument can be given why the chirality of the inner pyritohedral symmetry leads to parity violation of the weak interactions.Comment: 42 pages, 3 table

A Note on the QCD Corrections to Forward--Backward Asymmetries of Heavy--Quark Jets in Z Decays

The measurement of the forward-backward asymmetries of heavy quarks provides one of the most precise determinations of $\sin^2\theta_W$ in $Z$ decays. We discuss in detail the one--loop QCD radiative corrections to these asymmetries. Results are given for single heavy--quark jet asymmetries and asymmetries of the thrust axis, as well as for heavy--quark two--jet final states.}Comment: 11pp, latex, 1 uuencoded eps figur

"It All Ended in an Unsporting Way": Serbian Football and the Disintegration of Yugoslavia, 1989-2006

Part of a wider examination into football during the collapse of Eastern European Communism between 1989 and 1991, this article studies the interplay between Serbian football and politics during the period of Yugoslavia's demise. Research utilizing interviews with individuals directly involved in the Serbian game, in conjunction with contemporary Yugoslav media sources, indicates that football played an important proactive role in the revival of Serbian nationalism. At the same time the Yugoslav conflict, twinned with a complex transition to a market economy, had disastrous consequences for football throughout the territories of the former Yugoslavia. In the years following the hostilities the Serbian game has suffered decline, major financial hardship and continuing terrace violence, resulting in widespread nostalgia for the pre-conflict era

Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

Background Alcohol consumption is a known risk factor for liver disease in HIV-infected populations. Therefore, knowledge of alcohol consumption behaviour and risk of disease progression associated with hazardous drinking are important in the overall management of HIV disease. We aimed at assessing the usefulness of routine data collected on alcohol consumption in predicting risk of severe liver disease (SLD) among people living with HIV (PLWHIV) with or without hepatitis C infection seen for routine clinical care in Italy. Methods We included PLWHIV from two observational cohorts in Italy (ICONA and HepaICONA). Alcohol consumption was assessed by physician interview and categorized according to the National Institute for Food and Nutrition Italian guidelines into four categories: abstainer; moderate; hazardous and unknown. SLD was defined as presence of FIB4 > 3.25 or a clinical diagnosis of liver disease or liver-related death. Cox regression analysis was used to evaluate the association between level of alcohol consumption at baseline and risk of SLD. Results Among 9542 included PLWHIV the distribution of alcohol consumption categories was: abstainers 3422 (36%), moderate drinkers 2279 (23%), hazardous drinkers 637 (7%) and unknown 3204 (34%). Compared to moderate drinkers, hazardous drinking was associated with higher risk of SLD (adjusted hazard ratio, aHR = 1.45; 95% CI: 1.03–2.03). After additionally controlling for mode of HIV transmission, HCV infection and smoking, the association was attenuated (aHR = 1.32; 95% CI: 0.94–1.85). There was no evidence that the association was stronger when restricting to the HIV/HCV co-infected population. Conclusions Using a brief physician interview, we found evidence for an association between hazardous alcohol consumption and subsequent risk of SLD among PLWHIV, but this was not independent of HIV mode of transmission, HCV-infection and smoking. More efforts should be made to improve quality and validity of data on alcohol consumption in cohorts of HIV/HCV-infected individuals

Cluster structures on quantum coordinate rings

We show that the quantum coordinate ring of the unipotent subgroup N(w) of a symmetric Kac-Moody group G associated with a Weyl group element w has the structure of a quantum cluster algebra. This quantum cluster structure arises naturally from a subcategory C_w of the module category of the corresponding preprojective algebra. An important ingredient of the proof is a system of quantum determinantal identities which can be viewed as a q-analogue of a T-system. In case G is a simple algebraic group of type A, D, E, we deduce from these results that the quantum coordinate ring of an open cell of a partial flag variety attached to G also has a cluster structure.Comment: v2: minor corrections. v3: references updated, final version to appear in Selecta Mathematic

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-offunction mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC, with almost a third (32%, n¼40/123) undergoing chromothriptic events. WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3). Telomere shortening is more prominent in EACs bearing localized complex rearrangements. Mutational signature analysis also confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations. These findings suggest that genomic catastrophes have a significant role in the malignant transformation of EAC