Little Boxes: A Dynamic Optimization Approach for Enhanced Cloud Infrastructures

The increasing demand for diverse, mobile applications with various degrees of Quality of Service requirements meets the increasing elasticity of on-demand resource provisioning in virtualized cloud computing infrastructures. This paper provides a dynamic optimization approach for enhanced cloud infrastructures, based on the concept of cloudlets, which are located at hotspot areas throughout a metropolitan area. In conjunction, we consider classical remote data centers that are rigid with respect to QoS but provide nearly abundant computation resources. Given fluctuating user demands, we optimize the cloudlet placement over a finite time horizon from a cloud infrastructure provider's perspective. By the means of a custom tailed heuristic approach, we are able to reduce the computational effort compared to the exact approach by at least three orders of magnitude, while maintaining a high solution quality with a moderate cost increase of 5.8% or less

Praxishandbuch Online-Fundraising

Die Tage der Spendenbüchsen sind gezählt. Immer mehr Vereine, soziale Initiativen, Projekte und Stiftungen möchten nicht mehr (nur) auf der Straße oder via Brief, sondern kostensparend und effektiv im Internet Spenden sammeln und Unterstützer mobilisieren. In diesem Buch lernen Sie, wie das geht. Anhand vieler Praxisbeispiele werden die Grundlagen für erfolgreiches Online-Fundraising erläutert: von der nutzerfreundlichen Website-Gestaltung über effizientes Social-Media-Management bis hin zur Planung und Evaluation von Fundraising-Kampagnen

The HTA Core Model: A novel method for producing and reporting health technology assessments

Objectives: The aim of this study was to develop and test a generic framework to enable international collaboration for producing and sharing results of health technology assessments (HTAs). Methods: Ten international teams constructed the HTA Core Model, dividing information contained in a comprehensive HTA into standardized pieces, the assessment elements. Each element contains a generic issue that is translated into practical research questions while performing an assessment. Elements were described in detail in element cards. Two pilot assessments, designated as Core HTAs were also produced. The Model and Core HTAs were both validated. Guidance on the use of the HTA Core Model was compiled into a Handbook. Results: The HTA Core Model considers health technologies through nine domains. Two applications of the Model were developed, one for medical and surgical interventions and another for diagnostic technologies. Two Core HTAs were produced in parallel with developing the model, providing the first real-life testing of the Model and input for further development. The results of formal validation and public feedback were primarily positive. Development needs were also identified and considered. An online Handbook is available. Conclusions: The HTA Core Model is a novel approach to HTA. It enables effective international production and sharing of HTA results in a structured format. The face validity of the Model was confirmed during the project, but further testing and refining are needed to ensure optimal usefulness and user-friendliness. Core HTAs are intended to serve as a basis for local HTA reports. Core HTAs do not contain recommendations on technology us

Opportunities and Limitations of Pelvic Exenteration Surgery

Purpose: The practice of exenterative surgery is sometimes controversial and has garnered a certain scepticism. Surgical studies are difficult to conduct due to insufficient data. The aim of this review is to present the current standing of pelvic exenteration from a surgical, gynaecological and urological point of view. Methods: This review is based upon a literature review (MEDLINE (PubMed), CENTRAL (Cochrane) and EMBASE (Elsevier)) of retrospective studies on exenterative surgery from 1993–2020. Using MeSH (Medical Subject Headings) search terms, 1572 publications were found. These were evaluated and screened with respect to their eligibility using algorithms and well-defined inclusion and exclusion criteria. Therefore, the guidelines for systematic reviews (PRISMA) were used. Results: A complete tumour resection (R0) often represents the only curative option for advanced pelvic carcinomas and their recurrences. A recent systematic review showed significant symptom relief in 80% of palliative patients after pelvic exenteration. Surgical limitations (distant metastases, involvement of the pelvic wall, etc.) are diminished by adequate surgical expertise and close interdisciplinary cooperation. While the mortality rate is low (2–5%), the still relatively high morbidity rate (32–84%) can be minimized by optimizing the perioperative setting. Following exenterations, roughly 79–82% of patients report satisfying results according to PROs (patient-reported outcomes). Conclusion: Due to multimodality treatment strategies combined with extended surgical expertise and patients’ preferences, pelvic exenteration can be offered nowadays with low mortality and acceptable postoperative quality of life. The possibilities of surgical treatment are often underestimated. A multi-centre database (PelvEx Collaborative) was established to collect data and experiences to optimize the research in this field