Exemplar models and category specific effects

In recent years, there have been numerous reports of patients with brain damage who show selective identification or recognition deficits for objects from specific categories (see Forde, in press; Humphreys & Forde, 2000, for reviews). The most common deficit appears to be a selective impairment in the identification of living things, accompanied by relatively unimpaired recognition or identification of artificial or non-living objects. However, despite the large number of reported cases with category-specific processing deficits, there is still no agreement on the mechanisms that produce these deficits. It is not even clear whether all such cases can be understood in terms of a single process or mechanism, or whether categoryspecific deficits can be caused by a variety of different factors. In this chapter, we explore category-specific deficits from a theoretical viewpoint that evolved from recent research on perceptual categorization and identification. Although some efforts have been made to model category-specific deficits with connectionist models (e.g., Farah & McClelland, 1991; Humphreys, Lamote, & Lloyd-Jones, 1995), we are not aware of any attempts to apply classical models of categorization and identification1 to the neuropsychological data on category-specificity (with the exception of a study by Dixon, Bub, & Arguin, 1997, which will be discussed in detail later)

Merging massive black holes the right place and the right time

The LIGO/Virgo detections of gravitational waves from merging black holes of ≃ 30 solar mass suggest progenitor stars of low metallicity (Z/ZO ≤ 0.3). In this talk I will provide constrains on where the progenitors of GW150914 and GW170104 may have formed, based on advanced models of galaxy formation and evolution combined with binary population synthesis models. First I will combine estimates of galaxy properties (star-forming gas metallicity, star formation rate and merger rate) across cosmic time to predict the low redshift BBH merger rate as a function of present day host galaxy mass, formation redshift of the progenitor system and different progenitor metallicities. I will show that the signal is dominated by binaries formed at the peak of star formation in massive galaxies with and binaries formed recently in dwarf galaxies. Then, I will present what very high resolution hydrodynamic simulations of different galaxy types can learn us about their black hole populations

A narrative review on spinal deformities in people with cerebral palsy: Measurement, norm values, incidence, risk factors and treatment

Spinal deformities are common in people with cerebral palsy (CP), and there is a concern of an increase during the adult ageing period. There is especially a worry about the increase of scoliosis, thoracic hyperkyphosis, lumbar hyperlordosis, spondylolysis and spondylolisthesis incidence, though supporting literature is lacking. Therefore, the aim of this narrative review is to provide a scientific overview of how spinal curvatures should be measured, what the norm values are and the incidence in people with CP, as well as a description of the risk factors and the treatment regimens for these spinal abnormalities. This review can be used as a guideline relevant for a range of clinicians, including orthopaedic and neurosurgeons, radiologists, physiotherapists, and biokineticists, as well as academics

Energy justice in slum rehabilitation housing: An empirical exploration of built environment effects on socio-cultural energy demand

The interaction of energy and buildings institutes a complex socio-technical system that influences the eudemonic well-being of the occupants. Understanding these drivers become even more necessary in impoverished areas where occupants struggle to avail essential energy services. The literature indicates that energy injustice can be addressed through provisioning of comfort, cleanliness, and convenience (3Cs) as critical cultural energy services in low-income areas. This study investigates the socio-architectural influence for slum rehabilitation housing (SRH) on cultural energy services that can promote distributive justice. The methodology adopts an empirical route using data from 200 household surveys from SRH in Mumbai, India, and João Pessoa, Brazil. A model between the 3Cs and socio-architectural elements was established using Firth’s binary logistic regression. The survey results showed that the SRH in Brazil had twice the appliance ownership as compared to the Mumbai SRH. There were distinct energy service preferences in the study areas, despite common poverty burdens. The empirical results showed that the lack of socio-architectural design elements like open spaces, privacy, and walkability in the study areas demanded specific comfort and convenience appliances as a counter-response. A critical policy implication drawn was on the need for socio-architectural inclusive energy planning for distributive justice in poverty. Mitigating rising energy demand through appropriate built environment design of slum rehabilitation housing can contribute to fulfilling the UN’s SDG 7 (clean and affordable energy) and 11 (sustainable cities and communities) goals.</jats:p

Complex SCN8A DNA-abnormalities in an individual with therapy resistant absence epilepsy

Background De novo SCN8A missense mutations have been identified as a rare dominant cause of epileptic encephalopathy. We described a person with epileptic encephalopathy associated with a mosaic deletion of the SCN8A gene. Methods Array comparative genome hybridization was used to identify chromosomal abnormalities. Next Generation Sequencing was used to screen for variants in known and candidate epilepsy genes. A single nucleotide polymorphism array was used to test whether the SCN8A variants were in cis or in trans. Results We identified a de novo mosaic deletion of exons 2–14 of SCN8A, and a rare maternally inherited missense variant on the other allele in a woman presenting with absence seizures, challenging behavior, intellectual disability and QRS-fragmentation on the ECG. We also found a variant in SCN5A. Conclusions The combination of a rare missense variant with a de novo mosaic deletion of a large part of the SCN8A gene suggests that other possible mechanisms for SCN8A mutations may cause epilepsy; loss of function, genetic modifiers and cellular interference may play a role. This case expands the phenotype associated with SCN8A mutations, with absence epilepsy and regression in language and memory skills

Desempenho de habitações de interesse social frente às mudanças climáticas = Performance of social housing in relation to climate change

O objetivo deste artigo é realizar uma investigação inicial considerando impactos no desempenho termo energético em longo prazo frente às mudanças climáticas de projetos que estão sendo desenvolvidos para o setor de habitação social no país. Um projeto representativo estimado com base no levantamento de projetos nacionais foi usado como estudo de caso nas cidades de São Paulo e Salvador. A avaliação usou simulação termo energética considerando arquivos climáticos atuais e de previsão futura. Foi realizada uma caracterização de usos finais e padrão de uso de habitações de interesse social com base em pesquisas nacionais. Os resultados avaliados foram comparados usando-se indicadores de consumo de energia, emissões de carbono e conforto térmico do usuário e mostraram aumento acentuado com relação aos indicadores de resfriamento, refrigeração e desconforto por calor para os climas futuros. = This article seeks to carry out an initial investigation considering impacts on thermal and energy long-term performance of projects developed for national programs of social housing in view of climate change. A representative project estimated based on a survey of national projects was used as case study in São Paulo and Salvador. The evaluation used thermal and energy simulation considering current and future climate scenarios. It was conducted a characterization of end uses and usage pattern of social housing based on national surveys. Results were compared using as indicators, energy consumption, carbon emissions and user thermal comfort and showed an increase with respect to cooling indicators and discomfort for heat in future climates

Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome

Somatostatin (SS) and dopamine (DA) receptors are widely expressed in neuroendocrine tumours that cause Cushing's Syndrome (CS). Increasing knowledge of specific subtype expression within these tumours and the ability to target these receptor subtypes with high-affinity compounds, has driven the search for new SS- or DA-based medical therapies for the various forms of CS. In Cushing's disease, corticotroph adenomas mainly express dopamine receptor subtype 2 (D2) and somatostatin receptor subtype 5 (sst5), whereas sst2is expressed at lower levels. Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst5(pasireotide, or SOM230) or D2(cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies. Combination therapy, either by administration of both types of compounds separately or by treatment with novel somatostatin-dopamine chimeric molecules (e.g. BIM-23A760), appears to be a promising approach in this respect. In selected cases of Ectopic ACTH-producing Syndrome (EAS), the sst2-preferring compound octreotide is able to reduce cortisol levels effectively. A recent study showed that D2receptors are also significantly expressed in the majority of EAS and that cabergoline may decrease cortisol levels in subsets of these patients. In both normal adrenal tissue as well as in adrenal adenomas and carcinomas that cause CS, sst and DA receptor expression has been demonstrated. Although selected cases of adrenal CS may benefit from sst or DA-targeted treatment, its total contribution to the treatment of these patients is likely to be low as surgery is effective in most cases

Physiological and pathophysiological role of somatostatin receptors in the human thymus

This is a review summarizing the physiological and pathophysiological role of somatostatin receptors in the human thymus

Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis

<p>Abstract</p> <p>Background</p> <p>Injurious mechanical ventilation (MV) may augment organ injury remote from the lungs. During sepsis, myocardial dysfunction is common and increased endothelial activation and permeability can cause myocardial edema, which may, among other factors, hamper myocardial function. We investigated the effects of MV with injuriously high tidal volumes on the myocardium in an animal model of sepsis.</p> <p>Methods</p> <p>Normal rats and intraperitoneal (i.p.) lipopolysaccharide (LPS)-treated rats were ventilated with low (6 ml/kg) and high (19 ml/kg) tidal volumes (Vt) under general anesthesia. Non-ventilated animals served as controls. Mean arterial pressure (MAP), central venous pressure (CVP), cardiac output (CO) and pulmonary plateau pressure (P_plat) were measured. <it>Ex vivo </it>myocardial function was measured in isolated Langendorff-perfused hearts. Cardiac expression of endothelial vascular cell adhesion molecule (VCAM)-1 and edema were measured to evaluate endothelial inflammation and leakage.</p> <p>Results</p> <p>MAP decreased after LPS-treatment and Vt-dependently, both independent of each other and with interaction. MV Vt-dependently increased CVP and Pplat and decreased CO. LPS-induced peritonitis decreased myocardial function <it>ex vivo </it>but MV attenuated systolic dysfunction Vt-dependently. Cardiac endothelial VCAM-1 expression was increased by LPS treatment independent of MV. Cardiac edema was lowered Vt-dependently by MV, particularly after LPS, and correlated inversely with systolic myocardial function parameters <it>ex vivo</it>.</p> <p>Conclusion</p> <p>MV attenuated LPS-induced systolic myocardial dysfunction in a Vt-dependent manner. This was associated with a reduction in cardiac edema following a lower transmural coronary venous outflow pressure during LPS-induced coronary inflammation.</p