What the Textbooks Say About the Design of Experience

This report reviews classical experimental designs including single and multiple factor analysis of variance, analysis of covariance, and Latin squares designs. Assumptions used in the models are presented, and tests for violations of the assumptions are described. Examples illustrating primary designs and remarks discussing further model extensions and considerations are also included.Prepared under Grant Number 78NI-AX-0007 from the National Institute of Law Enforcement and Criminal Justice, Law Enforcement Assistance Administration, U.S. Department of Justice

Aerodynamic-center considerations of wings and wing-body combinations

Aerodynamic center shifts of rigid wing-body combinations at increased Mach number

Censusing and modeling the dynamics of a population of eastern hemlock (Tsuga canadensis L.) using remote sensing

A population of eastern hemlock (Tsuga canadensis L.) was censused from the ground using traditional field methods and from the air using large scale, high-resolution, aerial imagery in the early spring of 1997, 1998 and 1999. A manual crown survey map of the population, prepared from aerial imagery, was compared to a traditional field census. Over 60% of the individuals measured on the ground were not detected in the aerial census. Tree size, crown density and crown position all played roles in determining a crown\u27s visibility from the air. Nearly all large, upper canopy hemlocks were visible in the aerial census. An important minority of small, lower canopy hemlocks were also visible in the aerial census. An automated spatial segmentation procedure was developed to identify and measure individual population units, or blobs, within the forest population. A blob was defined as a distinct portion of crown segmented from its neighbors on the basis of size, shape, and connectivity. To ensure the comparability of multi-year segmentation maps, an automated blob reconciliation procedure was also developed to make certain that no hemlock pixels were assigned to different blobs in different years. Following spatial segmentation and reconciliation, a large majority of hemlock blobs (∼64--72%) were found to be closely associated with ground referenced, manually delineated, individual hemlock crowns. The remaining blobs consisted of spatially distinct parts of a crown or closely clumped multiple crowns. Matrix population models were constructed from the ground-derived and aerial-derived population data. Matrix analysis produced a number of useful population characteristics including overall population growth rate (lambda), stable stage distributions, reproductive values, and sensitivity values. lambda\u27s calculated from the aerial and ground-derived matrices were compared using randomization tests. While providing a different perspective and description of a population than traditional ground studies, demographic studies using remote sensing provide some promising advantages. The spatially explicit nature of the data permits more biologically realistic modeling of the population and the investigation of potential environmental influences on population dynamics. Automated extraction of demographic or megademographic data from remotely sensed images represents an important first step toward scaling population analysis to the landscape and regional levels

Sandra Parks and Lamar Puckett in a Joint Senior Recital

This is the program for the joint senior recital of pianist Sandra W. Parks and baritone Lamar Puckett. Flutist Jane Chu assisted Parks; pianist Cynthia McDonnough assisted Puckett. The recital took place on February 14, 1978, in the Mabee Fine Arts Center Recital Hall

Low-speed static wind-tunnel investigation of a half-span fuselage and variable sweep pressure wing model

Low speed static wind tunnel tests of half-span fuselage and variable sweep pressure wing mode

Long range sound transmission : interim report no. 1, March 1, 1944 - January 20, 1945

Experiments are described to demonstrate a new method of sonic signalling at extremely long ranges in the oceans, utilizing the natural sound channel. Signals were made by causing a four pound charge of TNT to explode at about 4000 feet depth. These signals have the following qualities: (a) Extremely long range transmission (probably 10,000 miles). (b) Signal is positively identifiable. (c) Abrupt termination of the signal allows the arrival time to be read with an accuracy better than l/20th second. This permits location of source to better than a mile, if the signal is received at three suitably located stations. (d) The signal duration is related in such a way to the distance that the distance may be estimated to 30 miles in 1000 from reception at a single station. The limitations are: (a) It is required that the great circle path which the sound follows between source and receiver lie entirely in deep water (probably at least 1000 fathoms). (b) Sound travels in water at a speed of roughly 1 mile per second so that the interval between the origin of the signal and its reception becomes sufficiently great to be a handicap for some uses, particularly with aircraft. The signals were received to distances up to 900 miles. Two receiving arrangements have been used, a hydrophone hung 4000 feet over the side of a ship which was hove to, and a shore connected. hydrophone which lay on bottom 4000 feet deep. Extrapolation of the results indicate a range of at least 10,000 miles from this size charge. Recommendation is made to utilize a network of monitoring stations to locate planes, ships, and life rafts in distress on the open oceans. Three or more stations receiving a signal could locate the source better than one mile.Con tract NObs - 2083, Formerly OEM: sr - 3

Paper Session III-B - Life Support Research & Development for the Department of Energy Space Exploration Initiative

Long-term, manned space missions of the future will require an approach to life support systems in which most of the waste materials must be processed and recycled and/or local resources are utilized. The requirement for a reliable life support system has been recognized as an important component of the Space Exploration Initiative, and the Department of Energy (DOE), in conjunction with the National Aeronautics and Space Agency, is organizing a program in support of the development of this type of technology. It is quite likely that bioprocesses will be important components of the integrated system, and this will be the primary area of research and development (R&D) within the DOE national laboratories. Microbial, enzymatic, and thermochemical processing of wastes will be investigated in the initial research studies. Other research areas of interest include water and air purification by plants, microbial detection systems, biophotochemical CO2 recycle, tissue cultures for food, single-cell protein, bioadsorbents for pollutant removal, and several others. The resulting innovative technology developed for space exploration could also serve as the basis for new approaches for the processing and recycle of waste materials on Earth

Signaling, Polyubiquitination, Trafficking, and Inclusions: Sequestosome 1/p62's Role in Neurodegenerative Disease

Aggregated misfolded proteins are hallmarks of most neurodegenerative diseases. In a chronic disease state, including pathologic situations of oxidative stress, these proteins are sequestered into inclusions. Accumulation of aggregated proteins can be prevented by chaperones, or by targeting their degradation to the UPS. If the accumulation of these proteins exceeds their degradation, they may impair the function of the proteasome. Alternatively, the function of the proteasome may be preserved by directing aggregated proteins to the autophagy-lysosome pathway for degradation. Sequestosome 1/p62 has recently been shown to interact with polyubiquitinated proteins through its UBA domain and may direct proteins to either the UPS or autophagosome. P62 is present in neuronal inclusions of individuals with Alzheimer's disease and other neurodegenerative diseases. Herein, we review p62's role in signaling, aggregation, and inclusion formation, and specifically as a possible contributor to Alzheimer's disease. The use of p62 as a potential target for the development of therapeutics and as a disease biomarker is also discussed

Oligosaccharides from placenta: early diagnosis of feline mannosidosis

AbstractHigh-pressure liquid chromatography analysis of oligosaccharides from placentas allowed the diagnosis of α-mannosidosis in three litters of kittens. The chromatography also afforded a detailed comparison of the oligosaccharide pattern and levels in placenta, liver, brain, urine and ocular fluid of the affected animals. In all cases, two series of compounds were observed, with one or two residues of N-acetylglucosamine at the reducing terminus, respectively, and between two and nine mannose residues. This pattern is unlike that of human mannosidosis, and resembles that of ruminants, except that the major oligosaccharide contains three mannose residues instead of two